WO2003054015A3 - Verwendung von koagulationsaktivem antithrombin iii zur therapie von angiogenese-abhängigen erkrankungen - Google Patents

Verwendung von koagulationsaktivem antithrombin iii zur therapie von angiogenese-abhängigen erkrankungen Download PDF

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Publication number
WO2003054015A3
WO2003054015A3 PCT/DE2002/004438 DE0204438W WO03054015A3 WO 2003054015 A3 WO2003054015 A3 WO 2003054015A3 DE 0204438 W DE0204438 W DE 0204438W WO 03054015 A3 WO03054015 A3 WO 03054015A3
Authority
WO
WIPO (PCT)
Prior art keywords
coagulant
active
therapy
iii
antitrhombin
Prior art date
Application number
PCT/DE2002/004438
Other languages
English (en)
French (fr)
Other versions
WO2003054015A2 (de
Inventor
Ilhan Celik
Oliver Kisker
Original Assignee
Transmit Technologietransfer
Ilhan Celik
Oliver Kisker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Transmit Technologietransfer, Ilhan Celik, Oliver Kisker filed Critical Transmit Technologietransfer
Priority to AU2002357964A priority Critical patent/AU2002357964A1/en
Priority to EP02791606A priority patent/EP1456236A2/de
Priority to DE20221790U priority patent/DE20221790U1/de
Priority to US10/497,724 priority patent/US20050070471A1/en
Publication of WO2003054015A2 publication Critical patent/WO2003054015A2/de
Publication of WO2003054015A3 publication Critical patent/WO2003054015A3/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8128—Antithrombin III
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

Die vorliegende Erfindung betrifft ein Verfahren zur Herstellung von antiangiogen wirksamem Antithrombin III aus koagulationsaktivem (nativem) Antithrombin III und die Verwendung von koagulationsaktivem Antithrombin III zu Prophylaxe und Therapie von Erkrankungen.
PCT/DE2002/004438 2001-12-07 2002-12-04 Verwendung von koagulationsaktivem antithrombin iii zur therapie von angiogenese-abhängigen erkrankungen WO2003054015A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002357964A AU2002357964A1 (en) 2001-12-07 2002-12-04 Use of coagulant-active antitrhombin iii for the therapy of angiogenesis-dependent diseases
EP02791606A EP1456236A2 (de) 2001-12-07 2002-12-04 Verwendung von koagulationsaktivem antithrombin iii zur therapie von angiogenese-abhängigen erkrankungen
DE20221790U DE20221790U1 (de) 2001-12-07 2002-12-04 Koagulationsaktives Antithrombin III und dessen Verwendung zur Prophylaxe und Therapie von Angiogenese-abhängigen Erkrankungen
US10/497,724 US20050070471A1 (en) 2001-12-07 2002-12-04 Use of coagulant-active antithrombin iii for the therapy of angiogenesis-dependent diseases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10160133A DE10160133A1 (de) 2001-12-07 2001-12-07 Verwendung von koagulationsaktivem Antithrombin III zur Therapie von Angiogenese-abhängigen Erkrankungen
DE10160133.6 2001-12-07

Publications (2)

Publication Number Publication Date
WO2003054015A2 WO2003054015A2 (de) 2003-07-03
WO2003054015A3 true WO2003054015A3 (de) 2003-09-18

Family

ID=7708356

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/004438 WO2003054015A2 (de) 2001-12-07 2002-12-04 Verwendung von koagulationsaktivem antithrombin iii zur therapie von angiogenese-abhängigen erkrankungen

Country Status (5)

Country Link
US (1) US20050070471A1 (de)
EP (1) EP1456236A2 (de)
AU (1) AU2002357964A1 (de)
DE (1) DE10160133A1 (de)
WO (1) WO2003054015A2 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2401842C2 (ru) 2004-10-08 2010-10-20 Домантис Лимитед Антагонисты и способы их применения
GB0621513D0 (en) 2006-10-30 2006-12-06 Domantis Ltd Novel polypeptides and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020026A2 (en) * 1998-10-08 2000-04-13 Children's Hospital Compositions and methods for inhibiting angiogenesis
EP1075840A2 (de) * 1999-08-13 2001-02-14 Aventis Behring GmbH Verwendung von Antithrombin III zur Prophylaxe und Therapie von Erkrankungen
EP1224941A2 (de) * 2001-01-17 2002-07-24 Aventis Behring GmbH Antithrombin III gegen durch Angiogenese verursachte Erkrankungen

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000020026A2 (en) * 1998-10-08 2000-04-13 Children's Hospital Compositions and methods for inhibiting angiogenesis
EP1075840A2 (de) * 1999-08-13 2001-02-14 Aventis Behring GmbH Verwendung von Antithrombin III zur Prophylaxe und Therapie von Erkrankungen
EP1224941A2 (de) * 2001-01-17 2002-07-24 Aventis Behring GmbH Antithrombin III gegen durch Angiogenese verursachte Erkrankungen

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
KISKER OLIVER ET AL: "Generation of multiple angiogenesis inhibitors by human pancreatic cancer.", CANCER RESEARCH, vol. 61, no. 19, 1 October 2001 (2001-10-01), pages 7298 - 7304, XP002244729, ISSN: 0008-5472 *
O'REILLY M S ET AL: "ANTIANGIOGENIC ACTIVITY OF THE CLEAVED CONFORMATION OF THE SERPIN ANTITHROMBIN", SCIENCE, AAAS. LANCASTER, PA, US, vol. 285, 17 September 1999 (1999-09-17), pages 1926 - 1928, XP002135982, ISSN: 0036-8075 *

Also Published As

Publication number Publication date
US20050070471A1 (en) 2005-03-31
AU2002357964A1 (en) 2003-07-09
EP1456236A2 (de) 2004-09-15
WO2003054015A2 (de) 2003-07-03
DE10160133A1 (de) 2003-06-26

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