WO2003051841A3 - Compounds and uses thereof for decreasing activity of hormone-sensitive lipase - Google Patents
Compounds and uses thereof for decreasing activity of hormone-sensitive lipase Download PDFInfo
- Publication number
- WO2003051841A3 WO2003051841A3 PCT/DK2002/000852 DK0200852W WO03051841A3 WO 2003051841 A3 WO2003051841 A3 WO 2003051841A3 DK 0200852 W DK0200852 W DK 0200852W WO 03051841 A3 WO03051841 A3 WO 03051841A3
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- WO
- WIPO (PCT)
- Prior art keywords
- cholesterol
- modulate
- insulin
- coa
- sensitive lipase
- Prior art date
Links
- 102000000019 Sterol Esterase Human genes 0.000 title abstract 2
- 108010055297 Sterol Esterase Proteins 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 230000003247 decreasing effect Effects 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 206010022489 Insulin Resistance Diseases 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 235000014113 dietary fatty acids Nutrition 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 229930195729 fatty acid Natural products 0.000 abstract 2
- 239000000194 fatty acid Substances 0.000 abstract 2
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 2
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 208000002705 Glucose Intolerance Diseases 0.000 abstract 1
- 108010023302 HDL Cholesterol Proteins 0.000 abstract 1
- 102000004877 Insulin Human genes 0.000 abstract 1
- 108090001061 Insulin Proteins 0.000 abstract 1
- 108010028554 LDL Cholesterol Proteins 0.000 abstract 1
- 238000008214 LDL Cholesterol Methods 0.000 abstract 1
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 abstract 1
- 208000001145 Metabolic Syndrome Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 201000010390 abdominal obesity-metabolic syndrome 1 Diseases 0.000 abstract 1
- 230000005856 abnormality Effects 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000004657 carbamic acid derivatives Chemical class 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 150000001982 diacylglycerols Chemical class 0.000 abstract 1
- -1 fatty acid esters Chemical class 0.000 abstract 1
- 150000004665 fatty acids Chemical class 0.000 abstract 1
- 235000021588 free fatty acids Nutrition 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 230000003914 insulin secretion Effects 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 230000037041 intracellular level Effects 0.000 abstract 1
- 230000008604 lipoprotein metabolism Effects 0.000 abstract 1
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 abstract 1
- 208000011661 metabolic syndrome X Diseases 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 150000008103 phosphatidic acids Chemical class 0.000 abstract 1
- 230000036470 plasma concentration Effects 0.000 abstract 1
- 201000009104 prediabetes syndrome Diseases 0.000 abstract 1
- QAQREVBBADEHPA-IEXPHMLFSA-N propionyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QAQREVBBADEHPA-IEXPHMLFSA-N 0.000 abstract 1
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 abstract 1
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Abstract
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
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HU0501011A HUP0501011A3 (en) | 2001-12-14 | 2002-12-13 | Carbamates as hormone-sensitive lipase inhibitors, process for producing them, pharmaceutical compositions containing them and their use |
CA002468413A CA2468413A1 (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
BR0214967-2A BR0214967A (en) | 2001-12-14 | 2002-12-13 | Compound, pharmaceutically acceptable salt, process for preparing a compound, pharmaceutical composition, use of a compound and method of treating a patient disorder |
IL16227002A IL162270A0 (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activityof hormone-sensitive lipase |
JP2003552728A JP2005518376A (en) | 2001-12-14 | 2002-12-13 | Compounds and their use to reduce the activity of hormone sensitive lipases |
KR10-2004-7009229A KR20040068240A (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
MXPA04005790A MXPA04005790A (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase. |
CNB02828075XA CN1326519C (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
EP02787448A EP1458374A2 (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
AU2002351731A AU2002351731A1 (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
TW091136995A TW200305567A (en) | 2002-04-30 | 2002-12-23 | Compounds and use thereof for decreasing activity of hormonesensitive lipase |
NO20042962A NO20042962L (en) | 2001-12-14 | 2004-07-13 | Compounds and uses thereof to reduce hormone-sensitive lipase activity |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
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DKPA200101879 | 2001-12-14 | ||
DKPA200101879 | 2001-12-14 | ||
DKPA200200645 | 2002-04-30 | ||
DKPA200200645 | 2002-04-30 | ||
DKPA200201000 | 2002-06-27 | ||
DKPA200201000 | 2002-06-27 | ||
DKPA200201562 | 2002-10-11 | ||
DKPA200201562 | 2002-10-11 |
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WO2003051841A2 WO2003051841A2 (en) | 2003-06-26 |
WO2003051841A3 true WO2003051841A3 (en) | 2004-06-24 |
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PCT/DK2002/000853 WO2003051842A2 (en) | 2001-12-14 | 2002-12-13 | Compositions decreasing activity of hormone-sensitive lipase |
PCT/DK2002/000852 WO2003051841A2 (en) | 2001-12-14 | 2002-12-13 | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
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PCT/DK2002/000853 WO2003051842A2 (en) | 2001-12-14 | 2002-12-13 | Compositions decreasing activity of hormone-sensitive lipase |
Country Status (15)
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US (2) | US7279470B2 (en) |
EP (2) | EP1458375A2 (en) |
JP (2) | JP2005518377A (en) |
KR (1) | KR20040068240A (en) |
CN (1) | CN1326519C (en) |
AU (2) | AU2002351731A1 (en) |
BR (1) | BR0214967A (en) |
CA (1) | CA2468413A1 (en) |
CZ (1) | CZ2004714A3 (en) |
HU (1) | HUP0501011A3 (en) |
IL (1) | IL162270A0 (en) |
MX (1) | MXPA04005790A (en) |
NO (1) | NO20042962L (en) |
PL (1) | PL373156A1 (en) |
WO (2) | WO2003051842A2 (en) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
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US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
US8841323B2 (en) | 2006-03-15 | 2014-09-23 | Janssen Pharmaceuticals, Inc. | 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors |
US8906939B2 (en) | 2007-03-07 | 2014-12-09 | Janssen Pharmaceuticals, Inc. | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
Families Citing this family (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001231154A1 (en) | 2000-01-24 | 2001-07-31 | Adherex Technologies Inc. | Peptidomimetic modulators of cell adhesion |
CZ2004714A3 (en) * | 2001-12-14 | 2004-10-13 | Novoánordiskáa@S | Compounds and uses thereof for decreasing activity of hormone-sensitive lipase |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
CN1867336B (en) * | 2002-06-12 | 2010-05-12 | 凯莫森特里克斯股份有限公司 | 1-aryl-4-substituted piperazines derivatives and pharmaceutical use thereof |
US7589199B2 (en) | 2002-06-12 | 2009-09-15 | Chemocentryx, Inc. | Substituted piperazines |
US20050256130A1 (en) * | 2002-06-12 | 2005-11-17 | Chemocentryx, Inc. | Substituted piperazines |
US7176201B2 (en) | 2002-10-07 | 2007-02-13 | The Regents Of The University Of California | Modulation of anxiety through blockade of anandamide hydrolysis |
DE10247680B4 (en) * | 2002-10-12 | 2005-09-01 | Aventis Pharma Deutschland Gmbh | New bicyclic inhibitors of the hormone sensitive lipase |
US7208504B2 (en) | 2002-10-12 | 2007-04-24 | Sanofi-Aventis Deutschland Gmbh | Bicyclic inhibitors of hormone sensitive lipase |
US7718692B2 (en) * | 2004-02-13 | 2010-05-18 | Carson John R | Hetero-substituted acetanilide derivatives as analgesic agents |
TW200505447A (en) | 2003-02-07 | 2005-02-16 | Daiichi Seiyaku Co | Pyrazole derivative |
KR20050122220A (en) | 2003-03-25 | 2005-12-28 | 다케다 샌디에고, 인코포레이티드 | Dipeptidyl peptidase inhibitors |
US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
KR20060017791A (en) * | 2003-06-12 | 2006-02-27 | 노보 노르디스크 에이/에스 | Pyridinyl carbamates as hormone-sensitive lipase inhibitors |
EP1636187A1 (en) * | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase |
EP1636201A1 (en) * | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | Para-substituted phenyl carbamates as inhibitors of hormone sensitive lipase |
JP2006527214A (en) * | 2003-06-12 | 2006-11-30 | ノボ ノルディスク アクティーゼルスカブ | Para-substituted phenyl carbamate |
EP1636189A1 (en) * | 2003-06-12 | 2006-03-22 | Novo Nordisk A/S | 1-aryl-4-(aryloxycarbonyl)-piperazine derivatives for use as inhibitors of hormone sensitive lipase |
US7678909B1 (en) | 2003-08-13 | 2010-03-16 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7169926B1 (en) | 2003-08-13 | 2007-01-30 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
RU2006107553A (en) | 2003-08-13 | 2007-09-20 | Такеда Фармасьютикал Компани Лимитед (Jp) | 4-Pyrimidone derivatives and their use as peptidyl peptidase inhibitors |
US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
CA2547212A1 (en) * | 2003-11-25 | 2005-06-16 | Eli Lilly And Company | Peroxisome proliferator activated receptor modulators |
EP1732531A2 (en) * | 2004-02-25 | 2006-12-20 | La Jolla Pharmaceutical Company | Amines and amides for the treatment of diseases |
ATE471320T1 (en) | 2004-02-27 | 2010-07-15 | Lilly Co Eli | 4-AMINOPIPERIDINE DERIVATIVES AS INHIBITORS OF MONOAMINE ABSORPTION |
US7435831B2 (en) | 2004-03-03 | 2008-10-14 | Chemocentryx, Inc. | Bicyclic and bridged nitrogen heterocycles |
JP4845873B2 (en) | 2004-03-03 | 2011-12-28 | ケモセントリックス インコーポレーティッド | Bicyclic and bridged nitrogen heterocycles |
US7732446B1 (en) | 2004-03-11 | 2010-06-08 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7767689B2 (en) | 2004-03-15 | 2010-08-03 | Ptc Therapeutics, Inc. | Carboline derivatives useful in the treatment of cancer |
US8076353B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Inhibition of VEGF translation |
US8076352B2 (en) | 2004-03-15 | 2011-12-13 | Ptc Therapeutics, Inc. | Administration of carboline derivatives useful in the treatment of cancer and other diseases |
EA013427B1 (en) | 2004-03-15 | 2010-04-30 | Такеда Фармасьютикал Компани Лимитед | Dipeptidyl peptidase inhibitors |
KR20120073287A (en) | 2004-03-15 | 2012-07-04 | 피티씨 테라퓨틱스, 인크. | Carboline derivatives useful in the inhibition of angiogenesis |
US7269708B2 (en) * | 2004-04-20 | 2007-09-11 | Rambus Inc. | Memory controller for non-homogenous memory system |
WO2005118555A1 (en) | 2004-06-04 | 2005-12-15 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2006019965A2 (en) | 2004-07-16 | 2006-02-23 | Takeda San Diego, Inc. | Dipeptidyl peptidase inhibitors |
US8946444B2 (en) * | 2004-11-23 | 2015-02-03 | Ptc Therapeutics, Inc. | Tetrahydrocarbazoles as active agents for inhibiting VEGF production by translational control |
JP2008524331A (en) | 2004-12-21 | 2008-07-10 | 武田薬品工業株式会社 | Dipeptidyl peptidase inhibitor |
DE102005002130A1 (en) * | 2005-01-17 | 2006-07-27 | Sanofi-Aventis Deutschland Gmbh | New substituted aminomethylene sulfonamides useful as hormone sensitive lipase inhibitors in medicaments for treatment and/or prevention of non-insulin dependent diabetes mellitus, diabetic syndrome or obesity |
WO2006087309A1 (en) * | 2005-02-15 | 2006-08-24 | Novo Nordisk A/S | 3,4-dihydro-1h-isoquinoline-2-carboxylic acid 5-aminopyridin-2-yl esters |
JP4729738B2 (en) * | 2005-02-16 | 2011-07-20 | 独立行政法人産業技術総合研究所 | Novel N-sulfenylpyrrole compound and method for producing the same |
TWI385152B (en) | 2005-02-17 | 2013-02-11 | Astellas Pharma Inc | Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate derivatives (I) |
DE102005018389A1 (en) * | 2005-04-20 | 2006-10-26 | Sanofi-Aventis Deutschland Gmbh | Azole derivatives as inhibitors of lipases and phospholipases |
WO2006116773A2 (en) * | 2005-04-28 | 2006-11-02 | The Regents Of The University Of California | Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders |
DE102005026762A1 (en) * | 2005-06-09 | 2006-12-21 | Sanofi-Aventis Deutschland Gmbh | Azolopyridin-2-one derivatives as inhibitors of lipases and phospholipases |
DE102005026808A1 (en) * | 2005-06-09 | 2006-12-14 | Sanofi-Aventis Deutschland Gmbh | Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases |
DE102005026809A1 (en) * | 2005-06-09 | 2006-12-14 | Sanofi-Aventis Deutschland Gmbh | Benzothiazol-2-one derivatives as inhibitors of lipases and phospholipases |
ME02005B (en) | 2005-09-14 | 2012-08-31 | Takeda Pharmaceuticals Co | Dipeptidyl peptidase inhibitors for treating diabetes |
CN101360723A (en) | 2005-09-16 | 2009-02-04 | 武田药品工业株式会社 | Process for the preparation of pyrimidinedione derivatives |
DE102005049953A1 (en) | 2005-10-19 | 2007-04-26 | Sanofi-Aventis Deutschland Gmbh | Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases |
US8030332B2 (en) | 2006-02-01 | 2011-10-04 | Merck Sharp & Dohme Corp. | Potassium channel inhibitors |
JP5190381B2 (en) * | 2006-02-01 | 2013-04-24 | メルク・シャープ・エンド・ドーム・コーポレイション | Potassium channel inhibitor |
WO2007112347A1 (en) | 2006-03-28 | 2007-10-04 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
WO2008024139A2 (en) * | 2006-08-18 | 2008-02-28 | N.V. Organon | Inhibitors of fatty acid amide hydrolase |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
US20090099240A1 (en) * | 2006-10-02 | 2009-04-16 | N.V. Organon | Methods for treating energy metabolism disorders by inhibiting fatty acid amide hydrolase activity |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
US20080186971A1 (en) * | 2007-02-02 | 2008-08-07 | Tarari, Inc. | Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic |
AU2008220785B2 (en) * | 2007-03-01 | 2013-02-21 | Vivoryon Therapeutics N.V. | New use of glutaminyl cyclase inhibitors |
TW200900065A (en) | 2007-03-07 | 2009-01-01 | Janssen Pharmaceutica Nv | 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
JP2009084269A (en) * | 2007-09-05 | 2009-04-23 | Sumitomo Chemical Co Ltd | Coumarin compound and its use |
KR101520086B1 (en) | 2007-09-14 | 2015-05-14 | 얀센 파마슈티칼스 인코포레이티드 | 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2H,1'H-[1,4']bipyridinyl-2'-ones |
KR101496435B1 (en) * | 2007-12-27 | 2015-03-03 | 에스케이바이오팜 주식회사 | Imidazole urea-based compound and cytochrome p450 activity inhibitor comprising thereof |
US9108905B2 (en) | 2008-01-04 | 2015-08-18 | Abbvie Inc. | TRPA1 antagonists |
JP2011508784A (en) | 2008-01-04 | 2011-03-17 | アボット・ラボラトリーズ | TRPA1 antagonist |
TWI434842B (en) | 2008-07-14 | 2014-04-21 | Astellas Pharma Inc | Azole compounds |
AU2009289784B2 (en) | 2008-09-02 | 2012-03-22 | Addex Pharma S.A. | 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors |
JP2012513464A (en) | 2008-12-23 | 2012-06-14 | ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク | Phosphodiesterase inhibitors and uses thereof |
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MY153913A (en) | 2009-05-12 | 2015-04-15 | Janssen Pharmaceuticals Inc | 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors |
SG10201402250TA (en) | 2009-05-12 | 2014-07-30 | Janssen Pharmaceuticals Inc | 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders |
EA020671B1 (en) | 2009-05-12 | 2014-12-30 | Янссен Фармасьютикалз, Инк. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF mGluR2 RECEPTORS |
TW201044234A (en) * | 2009-06-08 | 2010-12-16 | Chunghwa Picture Tubes Ltd | Method of scanning touch panel |
RU2400233C1 (en) | 2009-07-07 | 2010-09-27 | Общество с ограниченной ответственностью "Вирфарм" | Method of treating liver diseases of various geneses |
US9012448B2 (en) | 2010-11-08 | 2015-04-21 | Janssen Pharmaceuticals, Inc. | 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of MGLUR2 receptors |
ES2552455T3 (en) | 2010-11-08 | 2015-11-30 | Janssen Pharmaceuticals, Inc. | 1,2,4-Triazolo [4,3-a] pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors |
EP2661435B1 (en) | 2010-11-08 | 2015-08-19 | Janssen Pharmaceuticals, Inc. | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
USRE47689E1 (en) | 2011-12-30 | 2019-11-05 | Ptc Therapeutics, Inc. | Compounds for treating spinal muscular atrophy |
US8877766B2 (en) * | 2013-02-15 | 2014-11-04 | Peter F. Kador | Neuroprotective multifunctional antioxidants and their monofunctional analogs |
WO2014151761A1 (en) * | 2013-03-15 | 2014-09-25 | Ariad Pharmaceuticals, Inc. | Novel choline kinase inhibitors |
JO3368B1 (en) | 2013-06-04 | 2019-03-13 | Janssen Pharmaceutica Nv | 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
JO3367B1 (en) | 2013-09-06 | 2019-03-13 | Janssen Pharmaceutica Nv | 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS |
UA119247C2 (en) | 2013-09-06 | 2019-05-27 | РОЙВЕНТ САЙЕНСИЗ ҐмбГ | Spirocyclic compounds as tryptophan hydroxylase inhibitors |
WO2015089137A1 (en) | 2013-12-11 | 2015-06-18 | Karos Pharmaceuticals, Inc. | Acylguanidines as tryptophan hydroxylase inhibitors |
CN109999033B (en) | 2014-01-21 | 2022-12-23 | 詹森药业有限公司 | Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and uses thereof |
DK3096790T3 (en) | 2014-01-21 | 2019-10-07 | Janssen Pharmaceutica Nv | COMBINATIONS INCLUDING POSITIVE ALLOSTERIC MODULATORS OR ORTHOSTERIC AGONISTS OF METABOTROP GLUTAMATERG SUBTYPE 2 RECEPTOR AND APPLICATION OF THESE |
WO2016109501A1 (en) | 2014-12-30 | 2016-07-07 | Karos Pharmaceuticals, Inc. | Amide compounds as tryptophan hydroxylase inhibitors |
US9611201B2 (en) | 2015-03-05 | 2017-04-04 | Karos Pharmaceuticals, Inc. | Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone |
JP2021535192A (en) | 2018-11-14 | 2021-12-16 | アルタバント・サイエンシズ・ゲーエムベーハーALTAVANT SCIENCES GmbH | A crystalline spirocyclic compound inhibitor of tryptophan hydroxylase 1 (TPH1) for treating diseases or disorders associated with peripheral serotonin. |
UY38976A (en) * | 2019-12-03 | 2021-06-30 | Kallyope Inc | SSTR5 ANTAGONISTS |
CN111088297B (en) * | 2019-12-26 | 2022-04-08 | 广州市幕之时实业有限公司 | Method for preparing fatty amide by enzyme method |
WO2024033374A1 (en) | 2022-08-11 | 2024-02-15 | Syngenta Crop Protection Ag | Novel arylcarboxamide or arylthioamide compounds |
WO2024084360A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Patatin-like phospholipase domain-containing protein 3 (pnpla3) modifiers |
WO2024084363A1 (en) | 2022-10-18 | 2024-04-25 | Pfizer Inc. | Use of patatin-like phospholipase domain-containing protein 3 compounds |
WO2024089216A1 (en) | 2022-10-27 | 2024-05-02 | Syngenta Crop Protection Ag | Novel sulfur-containing heteroaryl carboxamide compounds |
WO2024126650A1 (en) | 2022-12-15 | 2024-06-20 | Syngenta Crop Protection Ag | Novel bicyclic-carboxamide compounds useful as pesticides |
Citations (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2449440A (en) * | 1946-06-25 | 1948-09-14 | Hoffmann La Roche | Aryl esters of tertiary carbamic acid |
GB982235A (en) * | 1962-05-24 | 1965-02-03 | Boots Pure Drug Co Ltd | New carbamate compounds and pesticidal compositions thereof |
BE665273A (en) * | 1964-06-12 | 1965-10-01 | ||
GB1307923A (en) * | 1969-05-06 | 1973-02-21 | Bayer Ag | 2-alkyl-4,6-dinitropehnol derivatives |
DE2336526A1 (en) * | 1973-07-18 | 1975-02-06 | Hoechst Ag | Anthelmintic 2,6-diacyloxy-benzanilides - prepd. by acylation of 2,6-dihydroxy-3,5-dichloro-benzanilides |
US4016278A (en) * | 1974-07-17 | 1977-04-05 | Pfizer Inc. | Pesticidal carbamates |
US4081461A (en) * | 1975-07-07 | 1978-03-28 | Aktiebolaget Leo | Acylation process for the preparation of phenolic N-disubstituted carbamate esters, and ion pair solution for use in the process |
DE2801187A1 (en) * | 1977-01-14 | 1978-07-20 | Metabio Joullie Meudon Fa | AMIDE DERIVATIVES OF TRIMETHOXY-3,4,5-BENZOLE AND THE USE THEREOF AS A MEDICINAL PRODUCT |
WO1992006075A1 (en) * | 1990-09-25 | 1992-04-16 | The Wellcome Foundation Limited | Anti-atherosclerotic aryl compounds |
WO1992007838A1 (en) * | 1990-10-30 | 1992-05-14 | Beecham Group Plc | Thiazolidine dione derivatives |
EP0587311A1 (en) * | 1992-08-07 | 1994-03-16 | Sankyo Company Limited | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use |
US5463062A (en) * | 1992-09-09 | 1995-10-31 | Hoechst Aktiengesellschaft | Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases |
WO1995029155A1 (en) * | 1994-04-21 | 1995-11-02 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
WO1997001533A1 (en) * | 1995-06-27 | 1997-01-16 | The Green Cross Corporation | Thiocarbamic acid derivatives |
US5837727A (en) * | 1990-03-16 | 1998-11-17 | Astra Aktiebolag | Method for altering blood lipid levels |
WO1998053814A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
WO1999062870A1 (en) * | 1998-06-04 | 1999-12-09 | Astrazeneca Ab | New 3-aryl-2-hydroxypropionic acid derivative iii |
WO2000054759A2 (en) * | 1999-03-15 | 2000-09-21 | Tularik Inc. | Lxr modulators |
WO2000063208A1 (en) * | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000069810A1 (en) * | 1999-05-17 | 2000-11-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO2001021602A1 (en) * | 1999-09-22 | 2001-03-29 | Bristol-Myers Squibb Company | Oxa- and thiazole derivatives useful as antidiabetic and antiobesity agents |
WO2001021584A1 (en) * | 1999-09-24 | 2001-03-29 | Genentech, Inc. | Tyrosine derivatives |
WO2001087843A1 (en) * | 2000-05-15 | 2001-11-22 | Novo Nordisk A/S | Compounds for treating disorders where a decreased level of plasma ffa is desired |
WO2002006189A2 (en) * | 2000-07-18 | 2002-01-24 | F. Hoffmann-La Roche Ag | Aniline derivatives |
WO2002012210A1 (en) * | 2000-08-08 | 2002-02-14 | Galderma Research & Development | Biphenyl derivatives and their use as ppar-gamma receptor activators |
WO2002020483A1 (en) * | 2000-09-08 | 2002-03-14 | F. Hoffmann-La Roche Ag | Piperidine derivatives for use 2,3-oxidosqualene-lanosterol cyclase inhibitors |
EP1201649A1 (en) * | 2000-10-28 | 2002-05-02 | Pfizer Products Inc. | Glucocorticoid receptor modulators |
WO2002038153A1 (en) * | 2000-11-09 | 2002-05-16 | Biovitrum Ab | New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives |
WO2002042257A1 (en) * | 2000-11-24 | 2002-05-30 | Bayer Aktiengesellschaft | Substituted cyclohexane derivates and the use thereof in medicaments for treating cardiovascular diseases |
WO2003051842A2 (en) * | 2001-12-14 | 2003-06-26 | Novo Nordisk A/S | Compositions decreasing activity of hormone-sensitive lipase |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4643991A (en) | 1984-12-18 | 1987-02-17 | The University Of Kentucky Research Foundation | Peptide elastase inhibitors and methods |
TW200462B (en) * | 1990-09-27 | 1993-02-21 | Hoechst Roussel Pharma | |
DE4324060A1 (en) * | 1993-07-17 | 1995-01-19 | Hoechst Schering Agrevo Gmbh | N-Heteroaryl-N'-(pyrid-2-yl-sulphonyl)ureas, their preparation, and their use as herbicides and plant growth regulators |
US5721236A (en) * | 1993-10-15 | 1998-02-24 | Schering Corporation | Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases |
IT1271679B (en) | 1994-07-18 | 1997-06-04 | Mediolanum Farmaceutici Srl | PHENYL CARBAMATE DERIVATIVES FOR USE AS AN ANTICOLINESTERASIC |
PL183865B1 (en) * | 1995-01-11 | 2002-07-31 | Samjin Pharmaceutical Co | Novel derivatives of piperazine, methods of obtaining them and agents containing such derivatives |
JPH1087485A (en) | 1996-09-11 | 1998-04-07 | Tsumura & Co | Agent for suppressing death of nerve cell |
JP3581103B2 (en) * | 1999-04-01 | 2004-10-27 | ファイザー・プロダクツ・インク | Aminopyrimidines as sorbitol dehydrogenase inhibitors |
ATE274513T1 (en) | 1999-12-23 | 2004-09-15 | Astrazeneca Ab | COMPOUNDS AND METHODS FOR TREATING PAIN |
EP1442028A4 (en) | 2001-11-06 | 2009-11-04 | Bristol Myers Squibb Co | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
-
2002
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-
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Patent Citations (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2449440A (en) * | 1946-06-25 | 1948-09-14 | Hoffmann La Roche | Aryl esters of tertiary carbamic acid |
GB982235A (en) * | 1962-05-24 | 1965-02-03 | Boots Pure Drug Co Ltd | New carbamate compounds and pesticidal compositions thereof |
BE665273A (en) * | 1964-06-12 | 1965-10-01 | ||
GB1307923A (en) * | 1969-05-06 | 1973-02-21 | Bayer Ag | 2-alkyl-4,6-dinitropehnol derivatives |
DE2336526A1 (en) * | 1973-07-18 | 1975-02-06 | Hoechst Ag | Anthelmintic 2,6-diacyloxy-benzanilides - prepd. by acylation of 2,6-dihydroxy-3,5-dichloro-benzanilides |
US4016278A (en) * | 1974-07-17 | 1977-04-05 | Pfizer Inc. | Pesticidal carbamates |
US4081461A (en) * | 1975-07-07 | 1978-03-28 | Aktiebolaget Leo | Acylation process for the preparation of phenolic N-disubstituted carbamate esters, and ion pair solution for use in the process |
DE2801187A1 (en) * | 1977-01-14 | 1978-07-20 | Metabio Joullie Meudon Fa | AMIDE DERIVATIVES OF TRIMETHOXY-3,4,5-BENZOLE AND THE USE THEREOF AS A MEDICINAL PRODUCT |
US5837727A (en) * | 1990-03-16 | 1998-11-17 | Astra Aktiebolag | Method for altering blood lipid levels |
WO1992006075A1 (en) * | 1990-09-25 | 1992-04-16 | The Wellcome Foundation Limited | Anti-atherosclerotic aryl compounds |
WO1992007838A1 (en) * | 1990-10-30 | 1992-05-14 | Beecham Group Plc | Thiazolidine dione derivatives |
EP0587311A1 (en) * | 1992-08-07 | 1994-03-16 | Sankyo Company Limited | Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use |
US5463062A (en) * | 1992-09-09 | 1995-10-31 | Hoechst Aktiengesellschaft | Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases |
WO1995029155A1 (en) * | 1994-04-21 | 1995-11-02 | Pharmacia Ab | Novel antitumour compounds with antimitotic activity |
WO1997001533A1 (en) * | 1995-06-27 | 1997-01-16 | The Green Cross Corporation | Thiocarbamic acid derivatives |
WO1998053814A1 (en) * | 1997-05-29 | 1998-12-03 | Merck & Co., Inc. | Heterocyclic amide compounds as cell adhesion inhibitors |
WO1999062870A1 (en) * | 1998-06-04 | 1999-12-09 | Astrazeneca Ab | New 3-aryl-2-hydroxypropionic acid derivative iii |
WO2000054759A2 (en) * | 1999-03-15 | 2000-09-21 | Tularik Inc. | Lxr modulators |
WO2000063208A1 (en) * | 1999-04-16 | 2000-10-26 | Novo Nordisk A/S | Substituted imidazoles, their preparation and use |
WO2000069810A1 (en) * | 1999-05-17 | 2000-11-23 | Novo Nordisk A/S | Glucagon antagonists/inverse agonists |
WO2001021602A1 (en) * | 1999-09-22 | 2001-03-29 | Bristol-Myers Squibb Company | Oxa- and thiazole derivatives useful as antidiabetic and antiobesity agents |
WO2001021584A1 (en) * | 1999-09-24 | 2001-03-29 | Genentech, Inc. | Tyrosine derivatives |
WO2001087843A1 (en) * | 2000-05-15 | 2001-11-22 | Novo Nordisk A/S | Compounds for treating disorders where a decreased level of plasma ffa is desired |
WO2002006189A2 (en) * | 2000-07-18 | 2002-01-24 | F. Hoffmann-La Roche Ag | Aniline derivatives |
WO2002012210A1 (en) * | 2000-08-08 | 2002-02-14 | Galderma Research & Development | Biphenyl derivatives and their use as ppar-gamma receptor activators |
WO2002020483A1 (en) * | 2000-09-08 | 2002-03-14 | F. Hoffmann-La Roche Ag | Piperidine derivatives for use 2,3-oxidosqualene-lanosterol cyclase inhibitors |
EP1201649A1 (en) * | 2000-10-28 | 2002-05-02 | Pfizer Products Inc. | Glucocorticoid receptor modulators |
WO2002038153A1 (en) * | 2000-11-09 | 2002-05-16 | Biovitrum Ab | New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives |
WO2002042257A1 (en) * | 2000-11-24 | 2002-05-30 | Bayer Aktiengesellschaft | Substituted cyclohexane derivates and the use thereof in medicaments for treating cardiovascular diseases |
WO2003051842A2 (en) * | 2001-12-14 | 2003-06-26 | Novo Nordisk A/S | Compositions decreasing activity of hormone-sensitive lipase |
Non-Patent Citations (6)
Title |
---|
DATABASE WPI Section Ch Week 199709, Derwent World Patents Index; Class B03, AN 1997-100136, XP002230558 * |
NICULESCU-DUVA, I. ET AL: "Potential anticancer agents. III. Urethan-type nitrogen mustards of some synthetic estrogens. I", CANADIAN JOURNAL OF CHEMISTRY (1966), 44(9), 1102-5, XP008025959 * |
NICULESCU-DUVAZ, ION ET AL: "Hypothesis concerning the mechanism of action of some new alkylating agents from synthetic estrogens", NEOPLASMA (1966), 13(6), 583-9, XP008025904 * |
NICULESCU-DUVAZ, ION ET AL: "New N-yperites of the urethane type from natural and synthetic hormones", REVISTADE CHIMIE (BUCHAREST, ROMANIA) (1967), 18(5), 296-9, XP008025905 * |
SCHMIDT F ET AL: "Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): a phenol nitrogen mustard carbamate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 1071 - 1076, XP004136187, ISSN: 0960-894X * |
WHEATLEY W.B. ET. AL.: "Benzylphenol Derivatives. VIII. Carbamates", J. AMER. CHEM. SOC., vol. 79, 1957, pages 747 - 749, XP002265513 * |
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US8841323B2 (en) | 2006-03-15 | 2014-09-23 | Janssen Pharmaceuticals, Inc. | 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors |
US8906939B2 (en) | 2007-03-07 | 2014-12-09 | Janssen Pharmaceuticals, Inc. | 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives |
US8697689B2 (en) | 2008-10-16 | 2014-04-15 | Janssen Pharmaceuticals, Inc. | Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors |
US8691813B2 (en) | 2008-11-28 | 2014-04-08 | Janssen Pharmaceuticals, Inc. | Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors |
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JP2005518377A (en) | 2005-06-23 |
US20030166644A1 (en) | 2003-09-04 |
CZ2004714A3 (en) | 2004-10-13 |
PL373156A1 (en) | 2005-08-22 |
AU2002351732A8 (en) | 2003-06-30 |
US7279470B2 (en) | 2007-10-09 |
CA2468413A1 (en) | 2003-06-26 |
AU2002351731A1 (en) | 2003-06-30 |
CN1326519C (en) | 2007-07-18 |
MXPA04005790A (en) | 2004-09-13 |
US7067517B2 (en) | 2006-06-27 |
JP2005518376A (en) | 2005-06-23 |
BR0214967A (en) | 2005-05-10 |
HUP0501011A3 (en) | 2009-04-28 |
KR20040068240A (en) | 2004-07-30 |
NO20042962L (en) | 2004-09-08 |
US20030166690A1 (en) | 2003-09-04 |
WO2003051842A3 (en) | 2004-06-03 |
WO2003051841A2 (en) | 2003-06-26 |
EP1458374A2 (en) | 2004-09-22 |
HUP0501011A2 (en) | 2006-01-30 |
EP1458375A2 (en) | 2004-09-22 |
AU2002351732A1 (en) | 2003-06-30 |
CN1602191A (en) | 2005-03-30 |
WO2003051842A2 (en) | 2003-06-26 |
IL162270A0 (en) | 2005-11-20 |
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