WO2003051841A3 - Compounds and uses thereof for decreasing activity of hormone-sensitive lipase - Google Patents

Compounds and uses thereof for decreasing activity of hormone-sensitive lipase Download PDF

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Publication number
WO2003051841A3
WO2003051841A3 PCT/DK2002/000852 DK0200852W WO03051841A3 WO 2003051841 A3 WO2003051841 A3 WO 2003051841A3 DK 0200852 W DK0200852 W DK 0200852W WO 03051841 A3 WO03051841 A3 WO 03051841A3
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WO
WIPO (PCT)
Prior art keywords
cholesterol
modulate
insulin
coa
sensitive lipase
Prior art date
Application number
PCT/DK2002/000852
Other languages
French (fr)
Other versions
WO2003051841A2 (en
Inventor
Soeren Ebdrup
De Jong Johannes Cornelis
Poul Jacobsen
Holger Claus Hansen
Per Vedsoe
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Novo Nordisk As
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Publication date
Priority to IL16227002A priority Critical patent/IL162270A0/en
Priority to HU0501011A priority patent/HUP0501011A3/en
Priority to CNB02828075XA priority patent/CN1326519C/en
Priority to CA002468413A priority patent/CA2468413A1/en
Priority to EP02787448A priority patent/EP1458374A2/en
Priority to KR10-2004-7009229A priority patent/KR20040068240A/en
Priority to AU2002351731A priority patent/AU2002351731A1/en
Priority to JP2003552728A priority patent/JP2005518376A/en
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Priority to MXPA04005790A priority patent/MXPA04005790A/en
Priority to BR0214967-2A priority patent/BR0214967A/en
Priority to TW091136995A priority patent/TW200305567A/en
Publication of WO2003051841A2 publication Critical patent/WO2003051841A2/en
Publication of WO2003051841A3 publication Critical patent/WO2003051841A3/en
Priority to NO20042962A priority patent/NO20042962L/en

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Abstract

Carbamates and related compounds of formula R1 R2NCO-Y or R1 R2NCS-Y wherein R1 and R2 are hydrogen, alkyl, aryl, heteroaryl or may together form a piperidine, piperazine, morpholine or other heterocyclic ring, are inhibitors of hormone sensitive lipase and are useful for the treatment of any disorder where it is desirable to modulate the plasma level of free fatty acids, glycerol, LDL-cholesterol, HDL-cholesterol, insulin and/or glucose; and or modulate intracellular triacylglycerol and cholesterol stores, intracellular level of fatty acids, fatty acid esters such as diacylglycerols, phosphatidic acids, long chain acyl-CoA's as well as citrate or malonyl-CoA; and or increase insulin sensitivity ; and or modulate insulin secretion from pancreatic beta cells. More particularly said disorders are selected from the group consisting of insulin resistance, diabetes type 1, diabetes type 2, metabolic syndrome X, impaired glucose tolerance, hyperclycemia, dislipidemia, obesity, abnormalities of lipoprotein metabolism and any combinations. thereof.
PCT/DK2002/000852 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase WO2003051841A2 (en)

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AU2002351731A AU2002351731A1 (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
CNB02828075XA CN1326519C (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
CA002468413A CA2468413A1 (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
EP02787448A EP1458374A2 (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
KR10-2004-7009229A KR20040068240A (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
IL16227002A IL162270A0 (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activityof hormone-sensitive lipase
JP2003552728A JP2005518376A (en) 2001-12-14 2002-12-13 Compounds and their use to reduce the activity of hormone sensitive lipases
HU0501011A HUP0501011A3 (en) 2001-12-14 2002-12-13 Carbamates as hormone-sensitive lipase inhibitors, process for producing them, pharmaceutical compositions containing them and their use
MXPA04005790A MXPA04005790A (en) 2001-12-14 2002-12-13 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase.
BR0214967-2A BR0214967A (en) 2001-12-14 2002-12-13 Compound, pharmaceutically acceptable salt, process for preparing a compound, pharmaceutical composition, use of a compound and method of treating a patient disorder
TW091136995A TW200305567A (en) 2002-04-30 2002-12-23 Compounds and use thereof for decreasing activity of hormonesensitive lipase
NO20042962A NO20042962L (en) 2001-12-14 2004-07-13 Compounds and uses thereof to reduce hormone-sensitive lipase activity

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DKPA200101879 2001-12-14
DKPA200101879 2001-12-14
DKPA200200645 2002-04-30
DKPA200200645 2002-04-30
DKPA200201000 2002-06-27
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DKPA200201562 2002-10-11
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EP (2) EP1458374A2 (en)
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AU (2) AU2002351731A1 (en)
BR (1) BR0214967A (en)
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
US8841323B2 (en) 2006-03-15 2014-09-23 Janssen Pharmaceuticals, Inc. 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
US8906939B2 (en) 2007-03-07 2014-12-09 Janssen Pharmaceuticals, Inc. 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives

Families Citing this family (93)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020168761A1 (en) 2000-01-24 2002-11-14 Gour Barbara J. Peptidomimetic modulators of cell adhesion
KR20040068240A (en) * 2001-12-14 2004-07-30 노보 노르디스크 에이/에스 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase
WO2003105853A1 (en) * 2002-06-12 2003-12-24 Chemocentryx, Inc. 1-aryl-4-substituted piperazines derivatives for use as ccr1 antagonists for the treatment of inflammation and immune disorders
US20050256130A1 (en) * 2002-06-12 2005-11-17 Chemocentryx, Inc. Substituted piperazines
US7842693B2 (en) 2002-06-12 2010-11-30 Chemocentryx, Inc. Substituted piperazines
US7589199B2 (en) 2002-06-12 2009-09-15 Chemocentryx, Inc. Substituted piperazines
JP4515911B2 (en) 2002-10-07 2010-08-04 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Modulation of anxiety by blocking anandamide hydrolysis
DE10247680B4 (en) * 2002-10-12 2005-09-01 Aventis Pharma Deutschland Gmbh New bicyclic inhibitors of the hormone sensitive lipase
US7208504B2 (en) 2002-10-12 2007-04-24 Sanofi-Aventis Deutschland Gmbh Bicyclic inhibitors of hormone sensitive lipase
US7718692B2 (en) * 2004-02-13 2010-05-18 Carson John R Hetero-substituted acetanilide derivatives as analgesic agents
CA2515119A1 (en) 2003-02-07 2004-08-19 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivative
US7687625B2 (en) 2003-03-25 2010-03-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US8338120B2 (en) * 2003-05-05 2012-12-25 Probiodrug Ag Method of treating inflammation with glutaminyl cyclase inhibitors
CA2526204A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Pyridinyl carbamates as hormone-sensitive lipase inhibitors
WO2004111004A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Substituted piperazine carbamates for use as inhibitors of hormone sensitive lipase
EP1636201A1 (en) * 2003-06-12 2006-03-22 Novo Nordisk A/S Para-substituted phenyl carbamates as inhibitors of hormone sensitive lipase
WO2004111006A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S Para-subtituted phenyl carbamates as inhibitors of hormone sensitive lipase
AU2004247320A1 (en) * 2003-06-12 2004-12-23 Novo Nordisk A/S 1-aryl-4-(aryloxycarbonyl)-piperazine derivatives for use as inhibitors of hormone sensitive lipase
US7678909B1 (en) 2003-08-13 2010-03-16 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
US7169926B1 (en) 2003-08-13 2007-01-30 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
EP1506967B1 (en) 2003-08-13 2007-11-21 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
JP2007505121A (en) 2003-09-08 2007-03-08 武田薬品工業株式会社 Dipeptidyl peptidase inhibitor
EP1697304B1 (en) * 2003-11-25 2008-02-20 Eli Lilly And Company Peroxisome proliferator activated receptor modulators
WO2005082343A2 (en) * 2004-02-25 2005-09-09 La Jolla Pharmaceutical Company Amines and amides for the treatment of diseases
EP1735302B1 (en) 2004-02-27 2010-06-16 Eli Lilly And Company 4-amino-piperidine derivatives as monoamine uptake inhibitors
EP1720545B1 (en) 2004-03-03 2014-10-29 ChemoCentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7435831B2 (en) 2004-03-03 2008-10-14 Chemocentryx, Inc. Bicyclic and bridged nitrogen heterocycles
US7732446B1 (en) 2004-03-11 2010-06-08 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
KR20120073287A (en) 2004-03-15 2012-07-04 피티씨 테라퓨틱스, 인크. Carboline derivatives useful in the inhibition of angiogenesis
US7767689B2 (en) 2004-03-15 2010-08-03 Ptc Therapeutics, Inc. Carboline derivatives useful in the treatment of cancer
CN102134229B (en) 2004-03-15 2020-08-04 武田药品工业株式会社 Dipeptidyl peptidase inhibitors
US8076352B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Administration of carboline derivatives useful in the treatment of cancer and other diseases
US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
US7269708B2 (en) * 2004-04-20 2007-09-11 Rambus Inc. Memory controller for non-homogenous memory system
WO2005118555A1 (en) 2004-06-04 2005-12-15 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2006019965A2 (en) 2004-07-16 2006-02-23 Takeda San Diego, Inc. Dipeptidyl peptidase inhibitors
US8143257B2 (en) * 2004-11-23 2012-03-27 Ptc Therapeutics, Inc. Substituted phenols as active agents inhibiting VEGF production
EP1828192B1 (en) 2004-12-21 2014-12-03 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
DE102005002130A1 (en) 2005-01-17 2006-07-27 Sanofi-Aventis Deutschland Gmbh New substituted aminomethylene sulfonamides useful as hormone sensitive lipase inhibitors in medicaments for treatment and/or prevention of non-insulin dependent diabetes mellitus, diabetic syndrome or obesity
KR20070107000A (en) * 2005-02-15 2007-11-06 노보 노르디스크 에이/에스 3,4-dihydro-1h-isoquinoline-2-carboxylic acid 5-aminopyridin-2-yl esters
JP4729738B2 (en) * 2005-02-16 2011-07-20 独立行政法人産業技術総合研究所 Novel N-sulfenylpyrrole compound and method for producing the same
US7919495B2 (en) * 2005-02-17 2011-04-05 Astellas Pharma, Inc. Pyridyl non-aromatic nitrogen-containing heterocyclic-1-carboxylate compound
DE102005018389A1 (en) 2005-04-20 2006-10-26 Sanofi-Aventis Deutschland Gmbh Azole derivatives as inhibitors of lipases and phospholipases
WO2006116773A2 (en) * 2005-04-28 2006-11-02 The Regents Of The University Of California Methods, compositions, and compounds for modulation of monoacylglycerol lipase, pain, and stress-related disorders
DE102005026808A1 (en) * 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzooxazol-2-one derivatives as inhibitors of lipases and phospholipases
DE102005026762A1 (en) * 2005-06-09 2006-12-21 Sanofi-Aventis Deutschland Gmbh Azolopyridin-2-one derivatives as inhibitors of lipases and phospholipases
DE102005026809A1 (en) * 2005-06-09 2006-12-14 Sanofi-Aventis Deutschland Gmbh Benzothiazol-2-one derivatives as inhibitors of lipases and phospholipases
EA015169B1 (en) 2005-09-14 2011-06-30 Такеда Фармасьютикал Компани Лимитед Use of dipeptidyl peptidase inhibitors
CN102675221A (en) 2005-09-16 2012-09-19 武田药品工业株式会社 Intermediate in method for preparing pyrimidinedione derivative
DE102005049953A1 (en) 2005-10-19 2007-04-26 Sanofi-Aventis Deutschland Gmbh Carbamoylbenzotriazole derivatives as inhibitors of lipases and phospholipases
WO2007089679A2 (en) * 2006-02-01 2007-08-09 Merck & Co., Inc. Potassium channel inhibitors
JP5268652B2 (en) 2006-02-01 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション Potassium channel inhibitor
WO2007112347A1 (en) 2006-03-28 2007-10-04 Takeda Pharmaceutical Company Limited Dipeptidyl peptidase inhibitors
WO2008024139A2 (en) * 2006-08-18 2008-02-28 N.V. Organon Inhibitors of fatty acid amide hydrolase
US8324383B2 (en) 2006-09-13 2012-12-04 Takeda Pharmaceutical Company Limited Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
WO2008042892A2 (en) * 2006-10-02 2008-04-10 N.V. Organon Fatty acid amide hydrolase inhibitors for energy metabolism disorders
TW200838536A (en) 2006-11-29 2008-10-01 Takeda Pharmaceutical Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
US20080186971A1 (en) * 2007-02-02 2008-08-07 Tarari, Inc. Systems and methods for processing access control lists (acls) in network switches using regular expression matching logic
JP5930573B2 (en) * 2007-03-01 2016-06-15 プロビオドルグ エージー New use of glutaminyl cyclase inhibitors
TW200900065A (en) 2007-03-07 2009-01-01 Janssen Pharmaceutica Nv 3-cyano-4-(4-pyridinyloxy-phenyl)-pyridin-2-one derivatives
US8093236B2 (en) 2007-03-13 2012-01-10 Takeda Pharmaceuticals Company Limited Weekly administration of dipeptidyl peptidase inhibitors
JP2009084269A (en) * 2007-09-05 2009-04-23 Sumitomo Chemical Co Ltd Coumarin compound and its use
MY152078A (en) 2007-09-14 2014-08-15 Ortho Mcneil Janssen Pharm 1',3'-disubstituted-4-phenyl-3,4,5,6-tetrahydro-2h,1'h-[1,4']bipyridinyl-2'-ones
KR101496435B1 (en) * 2007-12-27 2015-03-03 에스케이바이오팜 주식회사 Imidazole urea-based compound and cytochrome p450 activity inhibitor comprising thereof
MX2010007392A (en) * 2008-01-04 2010-10-05 Abbott Lab Trpa1 antagonists.
CN101959861A (en) 2008-01-04 2011-01-26 雅培制药有限公司 Trpa1 antagonists
TWI434842B (en) 2008-07-14 2014-04-21 Astellas Pharma Inc Azole compounds
JP5547194B2 (en) 2008-09-02 2014-07-09 ジャンセン ファーマシューティカルズ， インコーポレイテッド． 3-Azabicyclo [3.1.0] hexyl derivatives as modulators of metabotropic glutamate receptors
JP2012513464A (en) 2008-12-23 2012-06-14 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク Phosphodiesterase inhibitors and uses thereof
CN105399731A (en) * 2008-12-24 2016-03-16 比亚尔-珀特拉和Ca股份公司 Pharmaceutical Compounds
AU2010246607B2 (en) 2009-05-12 2012-09-27 Addex Pharma S.A. 1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mGluR2 receptors
MY153913A (en) 2009-05-12 2015-04-15 Janssen Pharmaceuticals Inc 7-aryl-1,2,4-triazolo[4,3-a]pyridine derivatives and their use as positive allosteric modulators of mglur2 receptors
MX2011011964A (en) 2009-05-12 2012-02-23 Janssen Pharmaceuticals Inc 1,2,4-triazolo [4,3-a] pyridine derivatives and their use for the treatment or prevention of neurological and psychiatric disorders.
TW201044234A (en) * 2009-06-08 2010-12-16 Chunghwa Picture Tubes Ltd Method of scanning touch panel
RU2400233C1 (en) 2009-07-07 2010-09-27 Общество с ограниченной ответственностью "Вирфарм" Method of treating liver diseases of various geneses
WO2012062759A1 (en) 2010-11-08 2012-05-18 Janssen Pharmaceuticals, Inc. 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
PL2649069T3 (en) 2010-11-08 2016-01-29 Janssen Pharmaceuticals Inc 1,2,4-TRIAZOLO[4,3-a]PYRIDINE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
CN103261195B (en) 2010-11-08 2015-09-02 杨森制药公司 The purposes of 1,2,4-triazolo [4,3-a] pyridine derivate and the positive allosteric modulators as MGLUR2 acceptor thereof
MX352861B (en) * 2011-12-30 2017-12-13 Ptc Therapeutics Inc Compounds for treating spinal muscular atrophy.
US8877766B2 (en) * 2013-02-15 2014-11-04 Peter F. Kador Neuroprotective multifunctional antioxidants and their monofunctional analogs
EP2968358A4 (en) * 2013-03-15 2016-08-10 Ariad Pharma Inc Novel choline kinase inhibitors
JO3368B1 (en) 2013-06-04 2019-03-13 Janssen Pharmaceutica Nv 6,7-DIHYDROPYRAZOLO[1,5-a]PYRAZIN-4(5H)-ONE COMPOUNDS AND THEIR USE AS NEGATIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
JO3367B1 (en) 2013-09-06 2019-03-13 Janssen Pharmaceutica Nv 1,2,4-TRIAZOLO[4,3-a]PYRIDINE COMPOUNDS AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 RECEPTORS
UA119247C2 (en) 2013-09-06 2019-05-27 РОЙВЕНТ САЙЕНСИЗ ҐмбГ Spirocyclic compounds as tryptophan hydroxylase inhibitors
WO2015089137A1 (en) 2013-12-11 2015-06-18 Karos Pharmaceuticals, Inc. Acylguanidines as tryptophan hydroxylase inhibitors
EA033889B1 (en) 2014-01-21 2019-12-05 Янссен Фармацевтика Нв Combination comprising sv2a ligand and positive allosteric modulator of metabotropic glutamatergic receptor subtype 2
HUE045610T2 (en) 2014-01-21 2020-01-28 Janssen Pharmaceutica Nv Combinations comprising positive allosteric modulators or orthosteric agonists of metabotropic glutamatergic receptor subtype 2 and their use
WO2016109501A1 (en) 2014-12-30 2016-07-07 Karos Pharmaceuticals, Inc. Amide compounds as tryptophan hydroxylase inhibitors
US9611201B2 (en) 2015-03-05 2017-04-04 Karos Pharmaceuticals, Inc. Processes for preparing (R)-1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanol and 1-(5-chloro-[1,1′-biphenyl]-2-yl)-2,2,2-trifluoroethanone
CN113227093A (en) 2018-11-14 2021-08-06 阿尔塔万特科学公司 Crystalline spiro compounds, dosage forms comprising the compounds, methods for treatment of disease, and methods of recrystallization
JP2023516235A (en) * 2019-12-03 2023-04-19 キャリーオペ，インク． SSTR5 antagonist
CN111088297B (en) * 2019-12-26 2022-04-08 广州市幕之时实业有限公司 Method for preparing fatty amide by enzyme method
WO2024033374A1 (en) 2022-08-11 2024-02-15 Syngenta Crop Protection Ag Novel arylcarboxamide or arylthioamide compounds

Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2449440A (en) * 1946-06-25 1948-09-14 Hoffmann La Roche Aryl esters of tertiary carbamic acid
GB982235A (en) * 1962-05-24 1965-02-03 Boots Pure Drug Co Ltd New carbamate compounds and pesticidal compositions thereof
BE665273A (en) * 1964-06-12 1965-10-01
GB1307923A (en) * 1969-05-06 1973-02-21 Bayer Ag 2-alkyl-4,6-dinitropehnol derivatives
DE2336526A1 (en) * 1973-07-18 1975-02-06 Hoechst Ag Anthelmintic 2,6-diacyloxy-benzanilides - prepd. by acylation of 2,6-dihydroxy-3,5-dichloro-benzanilides
US4016278A (en) * 1974-07-17 1977-04-05 Pfizer Inc. Pesticidal carbamates
US4081461A (en) * 1975-07-07 1978-03-28 Aktiebolaget Leo Acylation process for the preparation of phenolic N-disubstituted carbamate esters, and ion pair solution for use in the process
DE2801187A1 (en) * 1977-01-14 1978-07-20 Metabio Joullie Meudon Fa AMIDE DERIVATIVES OF TRIMETHOXY-3,4,5-BENZOLE AND THE USE THEREOF AS A MEDICINAL PRODUCT
WO1992006075A1 (en) * 1990-09-25 1992-04-16 The Wellcome Foundation Limited Anti-atherosclerotic aryl compounds
WO1992007838A1 (en) * 1990-10-30 1992-05-14 Beecham Group Plc Thiazolidine dione derivatives
EP0587311A1 (en) * 1992-08-07 1994-03-16 Sankyo Company Limited Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
US5463062A (en) * 1992-09-09 1995-10-31 Hoechst Aktiengesellschaft Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases
WO1995029155A1 (en) * 1994-04-21 1995-11-02 Pharmacia Ab Novel antitumour compounds with antimitotic activity
WO1997001533A1 (en) * 1995-06-27 1997-01-16 The Green Cross Corporation Thiocarbamic acid derivatives
US5837727A (en) * 1990-03-16 1998-11-17 Astra Aktiebolag Method for altering blood lipid levels
WO1998053814A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
WO1999062870A1 (en) * 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative iii
WO2000054759A2 (en) * 1999-03-15 2000-09-21 Tularik Inc. Lxr modulators
WO2000063208A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Substituted imidazoles, their preparation and use
WO2000069810A1 (en) * 1999-05-17 2000-11-23 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO2001021602A1 (en) * 1999-09-22 2001-03-29 Bristol-Myers Squibb Company Oxa- and thiazole derivatives useful as antidiabetic and antiobesity agents
WO2001021584A1 (en) * 1999-09-24 2001-03-29 Genentech, Inc. Tyrosine derivatives
WO2001087843A1 (en) * 2000-05-15 2001-11-22 Novo Nordisk A/S Compounds for treating disorders where a decreased level of plasma ffa is desired
WO2002006189A2 (en) * 2000-07-18 2002-01-24 F. Hoffmann-La Roche Ag Aniline derivatives
WO2002012210A1 (en) * 2000-08-08 2002-02-14 Galderma Research & Development Biphenyl derivatives and their use as ppar-gamma receptor activators
WO2002020483A1 (en) * 2000-09-08 2002-03-14 F. Hoffmann-La Roche Ag Piperidine derivatives for use 2,3-oxidosqualene-lanosterol cyclase inhibitors
EP1201649A1 (en) * 2000-10-28 2002-05-02 Pfizer Products Inc. Glucocorticoid receptor modulators
WO2002038153A1 (en) * 2000-11-09 2002-05-16 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives
WO2002042257A1 (en) * 2000-11-24 2002-05-30 Bayer Aktiengesellschaft Substituted cyclohexane derivates and the use thereof in medicaments for treating cardiovascular diseases
WO2003051842A2 (en) * 2001-12-14 2003-06-26 Novo Nordisk A/S Compositions decreasing activity of hormone-sensitive lipase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4643991A (en) * 1984-12-18 1987-02-17 The University Of Kentucky Research Foundation Peptide elastase inhibitors and methods
TW200462B (en) * 1990-09-27 1993-02-21 Hoechst Roussel Pharma
DE4324060A1 (en) * 1993-07-17 1995-01-19 Hoechst Schering Agrevo Gmbh N-Heteroaryl-N'-(pyrid-2-yl-sulphonyl)ureas, their preparation, and their use as herbicides and plant growth regulators
US5721236A (en) * 1993-10-15 1998-02-24 Schering Corporation Tricyclic carbamate compounds useful for inhibition of G-protein function and for treatment of proliferative diseases
IT1271679B (en) 1994-07-18 1997-06-04 Mediolanum Farmaceutici Srl PHENYL CARBAMATE DERIVATIVES FOR USE AS AN ANTICOLINESTERASIC
CZ288002B6 (en) * 1995-01-11 2001-03-14 Samjin Pharmaceutical Co., Ltd. Piperazine derivatives and pharmaceutical preparation exhibiting antitumor activity, in which the derivatives are comprised
JPH1087485A (en) 1996-09-11 1998-04-07 Tsumura & Co Agent for suppressing death of nerve cell
UA71951C2 (en) * 1999-04-01 2005-01-17 Pfizer Prod Inc Pyrimidines as sorbitol dehydrogenase inhibitors, a pharmaceutical composition containing them, intermediate compounds and a method for the preparation of intermediate compound
AU2566101A (en) 1999-12-23 2001-07-09 Astrazeneca Ab Compounds and methods for the treatment of pain
US6673815B2 (en) 2001-11-06 2004-01-06 Bristol-Myers Squibb Company Substituted acid derivatives useful as antidiabetic and antiobesity agents and method

Patent Citations (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2449440A (en) * 1946-06-25 1948-09-14 Hoffmann La Roche Aryl esters of tertiary carbamic acid
GB982235A (en) * 1962-05-24 1965-02-03 Boots Pure Drug Co Ltd New carbamate compounds and pesticidal compositions thereof
BE665273A (en) * 1964-06-12 1965-10-01
GB1307923A (en) * 1969-05-06 1973-02-21 Bayer Ag 2-alkyl-4,6-dinitropehnol derivatives
DE2336526A1 (en) * 1973-07-18 1975-02-06 Hoechst Ag Anthelmintic 2,6-diacyloxy-benzanilides - prepd. by acylation of 2,6-dihydroxy-3,5-dichloro-benzanilides
US4016278A (en) * 1974-07-17 1977-04-05 Pfizer Inc. Pesticidal carbamates
US4081461A (en) * 1975-07-07 1978-03-28 Aktiebolaget Leo Acylation process for the preparation of phenolic N-disubstituted carbamate esters, and ion pair solution for use in the process
DE2801187A1 (en) * 1977-01-14 1978-07-20 Metabio Joullie Meudon Fa AMIDE DERIVATIVES OF TRIMETHOXY-3,4,5-BENZOLE AND THE USE THEREOF AS A MEDICINAL PRODUCT
US5837727A (en) * 1990-03-16 1998-11-17 Astra Aktiebolag Method for altering blood lipid levels
WO1992006075A1 (en) * 1990-09-25 1992-04-16 The Wellcome Foundation Limited Anti-atherosclerotic aryl compounds
WO1992007838A1 (en) * 1990-10-30 1992-05-14 Beecham Group Plc Thiazolidine dione derivatives
EP0587311A1 (en) * 1992-08-07 1994-03-16 Sankyo Company Limited Peptides capable of inhibiting the activity of HIV protease, their preparation and their therapeutic use
US5463062A (en) * 1992-09-09 1995-10-31 Hoechst Aktiengesellschaft Substituted cyclohexane derivatives, processes for their preparation and the use of the compounds for treating diseases
WO1995029155A1 (en) * 1994-04-21 1995-11-02 Pharmacia Ab Novel antitumour compounds with antimitotic activity
WO1997001533A1 (en) * 1995-06-27 1997-01-16 The Green Cross Corporation Thiocarbamic acid derivatives
WO1998053814A1 (en) * 1997-05-29 1998-12-03 Merck & Co., Inc. Heterocyclic amide compounds as cell adhesion inhibitors
WO1999062870A1 (en) * 1998-06-04 1999-12-09 Astrazeneca Ab New 3-aryl-2-hydroxypropionic acid derivative iii
WO2000054759A2 (en) * 1999-03-15 2000-09-21 Tularik Inc. Lxr modulators
WO2000063208A1 (en) * 1999-04-16 2000-10-26 Novo Nordisk A/S Substituted imidazoles, their preparation and use
WO2000069810A1 (en) * 1999-05-17 2000-11-23 Novo Nordisk A/S Glucagon antagonists/inverse agonists
WO2001021602A1 (en) * 1999-09-22 2001-03-29 Bristol-Myers Squibb Company Oxa- and thiazole derivatives useful as antidiabetic and antiobesity agents
WO2001021584A1 (en) * 1999-09-24 2001-03-29 Genentech, Inc. Tyrosine derivatives
WO2001087843A1 (en) * 2000-05-15 2001-11-22 Novo Nordisk A/S Compounds for treating disorders where a decreased level of plasma ffa is desired
WO2002006189A2 (en) * 2000-07-18 2002-01-24 F. Hoffmann-La Roche Ag Aniline derivatives
WO2002012210A1 (en) * 2000-08-08 2002-02-14 Galderma Research & Development Biphenyl derivatives and their use as ppar-gamma receptor activators
WO2002020483A1 (en) * 2000-09-08 2002-03-14 F. Hoffmann-La Roche Ag Piperidine derivatives for use 2,3-oxidosqualene-lanosterol cyclase inhibitors
EP1201649A1 (en) * 2000-10-28 2002-05-02 Pfizer Products Inc. Glucocorticoid receptor modulators
WO2002038153A1 (en) * 2000-11-09 2002-05-16 Biovitrum Ab New use of 4, 5, 6, 7-tetrahydroimidazo-[4,5-c]pyridine derivatives
WO2002042257A1 (en) * 2000-11-24 2002-05-30 Bayer Aktiengesellschaft Substituted cyclohexane derivates and the use thereof in medicaments for treating cardiovascular diseases
WO2003051842A2 (en) * 2001-12-14 2003-06-26 Novo Nordisk A/S Compositions decreasing activity of hormone-sensitive lipase

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 199709, Derwent World Patents Index; Class B03, AN 1997-100136, XP002230558 *
NICULESCU-DUVA, I. ET AL: "Potential anticancer agents. III. Urethan-type nitrogen mustards of some synthetic estrogens. I", CANADIAN JOURNAL OF CHEMISTRY (1966), 44(9), 1102-5, XP008025959 *
NICULESCU-DUVAZ, ION ET AL: "Hypothesis concerning the mechanism of action of some new alkylating agents from synthetic estrogens", NEOPLASMA (1966), 13(6), 583-9, XP008025904 *
NICULESCU-DUVAZ, ION ET AL: "New N-yperites of the urethane type from natural and synthetic hormones", REVISTADE CHIMIE (BUCHAREST, ROMANIA) (1967), 18(5), 296-9, XP008025905 *
SCHMIDT F ET AL: "Glucuronide prodrugs of hydroxy compounds for antibody directed enzyme prodrug therapy (adept): a phenol nitrogen mustard carbamate", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, OXFORD, GB, vol. 7, no. 8, 22 April 1997 (1997-04-22), pages 1071 - 1076, XP004136187, ISSN: 0960-894X *
WHEATLEY W.B. ET. AL.: "Benzylphenol Derivatives. VIII. Carbamates", J. AMER. CHEM. SOC., vol. 79, 1957, pages 747 - 749, XP002265513 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841323B2 (en) 2006-03-15 2014-09-23 Janssen Pharmaceuticals, Inc. 1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
US8906939B2 (en) 2007-03-07 2014-12-09 Janssen Pharmaceuticals, Inc. 3-cyano-4-(4-tetrahydropyran-phenyl)-pyridin-2-one derivatives
US8697689B2 (en) 2008-10-16 2014-04-15 Janssen Pharmaceuticals, Inc. Indole and benzomorpholine derivatives as modulators of metabotropic glutamate receptors
US8691813B2 (en) 2008-11-28 2014-04-08 Janssen Pharmaceuticals, Inc. Indole and benzoxazine derivatives as modulators of metabotropic glutamate receptors

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WO2003051842A2 (en) 2003-06-26
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CN1602191A (en) 2005-03-30
PL373156A1 (en) 2005-08-22
CN1326519C (en) 2007-07-18
BR0214967A (en) 2005-05-10
HUP0501011A2 (en) 2006-01-30
EP1458374A2 (en) 2004-09-22
KR20040068240A (en) 2004-07-30
US20030166644A1 (en) 2003-09-04
JP2005518377A (en) 2005-06-23
CZ2004714A3 (en) 2004-10-13
US20030166690A1 (en) 2003-09-04
HUP0501011A3 (en) 2009-04-28
US7279470B2 (en) 2007-10-09
WO2003051842A3 (en) 2004-06-03
AU2002351732A1 (en) 2003-06-30
MXPA04005790A (en) 2004-09-13
WO2003051841A2 (en) 2003-06-26
CA2468413A1 (en) 2003-06-26
NO20042962L (en) 2004-09-08
JP2005518376A (en) 2005-06-23
AU2002351732A8 (en) 2003-06-30
IL162270A0 (en) 2005-11-20
AU2002351731A1 (en) 2003-06-30

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