WO2003049552A2 - Beverage treated with nicotine - Google Patents

Beverage treated with nicotine Download PDF

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Publication number
WO2003049552A2
WO2003049552A2 PCT/US2002/038655 US0238655W WO03049552A2 WO 2003049552 A2 WO2003049552 A2 WO 2003049552A2 US 0238655 W US0238655 W US 0238655W WO 03049552 A2 WO03049552 A2 WO 03049552A2
Authority
WO
WIPO (PCT)
Prior art keywords
nicotine
mixture
process according
water
filtering
Prior art date
Application number
PCT/US2002/038655
Other languages
French (fr)
Other versions
WO2003049552A3 (en
Inventor
Joseph Robert Knight
Original Assignee
Joseph Robert Knight
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26990875&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO2003049552(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to EP02791366A priority Critical patent/EP1461037B1/en
Priority to DE60221568T priority patent/DE60221568T2/en
Priority to CA002468785A priority patent/CA2468785A1/en
Priority to KR10-2004-7008386A priority patent/KR20040062666A/en
Priority to EA200400792A priority patent/EA010097B1/en
Priority to US10/497,375 priority patent/US7435749B2/en
Priority to MXPA04005549A priority patent/MXPA04005549A/en
Application filed by Joseph Robert Knight filed Critical Joseph Robert Knight
Priority to AU2002366598A priority patent/AU2002366598B2/en
Priority to BR0214820-0A priority patent/BR0214820A/en
Priority to JP2003550607A priority patent/JP2005526490A/en
Publication of WO2003049552A2 publication Critical patent/WO2003049552A2/en
Publication of WO2003049552A3 publication Critical patent/WO2003049552A3/en
Priority to HK05102233A priority patent/HK1069769A1/en
Priority to US11/319,898 priority patent/US20060105023A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/38—Other non-alcoholic beverages
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/52—Adding ingredients
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/70—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter
    • A23L2/72—Clarifying or fining of non-alcoholic beverages; Removing unwanted matter by filtration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Definitions

  • This invention relates to beverages for suppressing the desire to ingest nicotine.
  • U.S. Patent 3,901,248 to Lichtneckert, et al. discloses a chew able smoking substitute composition which includes nicotine adsorbed on a cation exchange resin, which is incorporated in a chewing gum base. When chewed, nicotine is released to diminish the urge to smoke.
  • U.S. Patent No. 6,211,194 to Westman et al., and U.S. Patent No. 6,268,386 to Thompson disclose beverages which have nicotine dissolved in them, and are intended to provide the consumer with sufficient nicotine to suppress the urge to smoke.
  • This invention provides a beverage which has been treated with nicotine, but does not have any discemable nicotine taste or smell when consumed.
  • the beverage is prepared by dissolving nicotine in water, and thereafter filtering the mixture to remove the taste and smell of nicotine from the water.
  • a nicotine-containing substance is mixed with water, and the mixture is heated to a temperature above about 100°F, and preferably to the boiling point. The mixture is stirred while heating and preferably during boiling. Thereafter, the mixture is cooled, and filtered to eliminate the taste and smell of nicotine from the water.
  • the nicotine-containing substance is selected from a group consisting of tobacco alkaloids, which include nicotine and nicotine-like or related pharmacologically active compounds such as nor-nicotine, lobeline and the like, as well as the free-base substance nicotine and all pharmacologically acceptable salts of nicotine, including acid addition salts.
  • Nicotine salts are useful and include nicotine hydrogen tartrate and nicotine bitartrate, as well as nicotine hydrochlonde, nicotine dihydrochloride, nicotine sulfate, nicotine citrate, nicotine zinc chloride monohydrate and nicotine salicylate, either alone or in combination.
  • “Nicotine” is used herein to include all the foregoing tobacco alkaloids and nicotine salts.
  • Nicotine also includes the solid complex of one or more tobacco alkaloid compounds bound to an ion exchange resin, or other polymer release system, particularly a cation exchanger.
  • Examples of nicotine ion exchange resins are set forth in U.S. Patent No. 3,901,248 to Lichtneckert et al., referred to above. That patent is incorporated herein in full. Nicotine polacrilex is especially preferred as a source of nicotine. Other sources include cured tobacco leaves and other plants which contains sufficient nicotine to be effective.
  • the material When nicotine polacrilex (a powder) is mixed with water, the material does not readily go into solution at room temperature, but instead produces a slurry. Heating and stirring the slurry causes the nicotine polacrilex to go into solution or at least become thoroughly dispersed.
  • the solution is cooled, much of the ion exchange resin solidifies and forms a precipitate which settles out of the mixture, which is preferably cooled to about room temperature, and thereafter filtered through activated charcoal to remove so much of the nicotine that it can no longer be detected by taste or smell.
  • the cooled solution is passed through a mechanical filter before passing through the charcoal filter.
  • the processed water can also be filtered through an ionic filter, such as a semi-permeable membrane used in reverse osmosis processes.
  • Nicotine in any suitable form such as tobacco leaves, nicotine alkaloids, or the various other sources of nicotine mentioned above, is mixed with water, and heated, preferably to the boiling point, and stirred vigorously for about one to about thirty minutes. The mixture is allowed to cool, permitting any solids present to settle out. The supernatant liquid is then filtered to reduce the amount of nicotine in the liquid to a level so low that it cannot be detected by taste, odor, or color.
  • the nicotine is in the form of nicotine polacrilex in which nicotine is bound to an ion-exchange resin, as described in U.S. Patent No. 3 ,901 ,248 referred to above.
  • Nicotine polacrilex in powder form is commercially available from Spectrum Chemical Mfg. Corp. in Gardena, California 90248. Twenty-five grams of nicotine polacrilex (15%, U.S.P.) was mixed in three gallons of water to form a slurry, which was heated to the boiling point (about 210 °F) while stirring for five to ten minutes. The nicotine polacrilex powder appeared to dissolve, or at least liquefy, so that it was uniformly dispersed in the mixture.
  • the PES membrane filter is available from PTI Advanced Filtration h e. in Oxnard, California 93030.
  • the activated carbon filter is available from ResinTech Inc., in Cherry Hill, New Jersey 08034-1409.
  • the filtered product can be consumed as drinking water, and has proved useful in suppressing the urge to smoke cigarettes. For example, many smokers have suppressed the urge to smoke by drinking about 500 ml of the treated water when experiencing the urge to smoke.
  • the product of this invention can also be mixed with vitamins, fruit flavoring, cola mix, and natural fruit juices to provide a variety of beverages with the benefit described above.
  • the product of this invention may also be used in alleviating the symptoms of attention deficit hyperactive disorder (ADHD), attention deficit disorder (ADD), Toureete's Syndrome, Schizophrenia, Parkinson's Disease, Alzheimer's Disease, anxiety, and depression.
  • ADHD attention deficit hyperactive disorder
  • ADD attention deficit disorder
  • Toureete's Syndrome Schizophrenia
  • Parkinson's Disease Alzheimer's Disease
  • anxiety anxiety, and depression.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nutrition Science (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Non-Alcoholic Beverages (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

A beverage for suppressing the urge to smoke is made by heating a mixture of water and a substance containing nicotine. Thereafter the mixture is filtered to produce a beverage which has no discernible taste, smell or appearance of nicotine.

Description

BEVERAGE TREATED WITH NICOTINE
CROSS-REFERENCE TO RELATED APPLICATION(S)
This application claims the benefit of Pro visional U.S. Patent Application No. 60/337,790, filed 12/10/2001 and Provisional U.S. Patent Application No. 60/372,385, filed 04/15/2002.
FIELD OF THE INVENTION
This invention relates to beverages for suppressing the desire to ingest nicotine.
BACKGROUND OF THE INVENTION
With the wide understanding of the health hazards caused by cigarette smoking, many efforts have been made to produce safer products which eliminate or reduce the need to smoke. For example, U.S. Patent 3,901,248 to Lichtneckert, et al., discloses a chew able smoking substitute composition which includes nicotine adsorbed on a cation exchange resin, which is incorporated in a chewing gum base. When chewed, nicotine is released to diminish the urge to smoke.
More recently, U.S. Patent No. 6,211,194 to Westman et al., and U.S. Patent No. 6,268,386 to Thompson disclose beverages which have nicotine dissolved in them, and are intended to provide the consumer with sufficient nicotine to suppress the urge to smoke.
The problem with the prior art products is that the dissolved nicotine imparts a harsh or unpleasant taste.
SUMMARY OF THE INVENTION
This invention provides a beverage which has been treated with nicotine, but does not have any discemable nicotine taste or smell when consumed. In brief, the beverage is prepared by dissolving nicotine in water, and thereafter filtering the mixture to remove the taste and smell of nicotine from the water. In the preferred form, a nicotine-containing substance is mixed with water, and the mixture is heated to a temperature above about 100°F, and preferably to the boiling point. The mixture is stirred while heating and preferably during boiling. Thereafter, the mixture is cooled, and filtered to eliminate the taste and smell of nicotine from the water.
The nicotine-containing substance is selected from a group consisting of tobacco alkaloids, which include nicotine and nicotine-like or related pharmacologically active compounds such as nor-nicotine, lobeline and the like, as well as the free-base substance nicotine and all pharmacologically acceptable salts of nicotine, including acid addition salts. Nicotine salts are useful and include nicotine hydrogen tartrate and nicotine bitartrate, as well as nicotine hydrochlonde, nicotine dihydrochloride, nicotine sulfate, nicotine citrate, nicotine zinc chloride monohydrate and nicotine salicylate, either alone or in combination. "Nicotine" is used herein to include all the foregoing tobacco alkaloids and nicotine salts.
"Nicotine" also includes the solid complex of one or more tobacco alkaloid compounds bound to an ion exchange resin, or other polymer release system, particularly a cation exchanger. Examples of nicotine ion exchange resins are set forth in U.S. Patent No. 3,901,248 to Lichtneckert et al., referred to above. That patent is incorporated herein in full. Nicotine polacrilex is especially preferred as a source of nicotine. Other sources include cured tobacco leaves and other plants which contains sufficient nicotine to be effective.
When nicotine polacrilex (a powder) is mixed with water, the material does not readily go into solution at room temperature, but instead produces a slurry. Heating and stirring the slurry causes the nicotine polacrilex to go into solution or at least become thoroughly dispersed. When the solution is cooled, much of the ion exchange resin solidifies and forms a precipitate which settles out of the mixture, which is preferably cooled to about room temperature, and thereafter filtered through activated charcoal to remove so much of the nicotine that it can no longer be detected by taste or smell. Preferably, the cooled solution is passed through a mechanical filter before passing through the charcoal filter. The processed water can also be filtered through an ionic filter, such as a semi-permeable membrane used in reverse osmosis processes.
DETAILED DESCRIPTION OF THE INVENTION
Nicotine in any suitable form, such as tobacco leaves, nicotine alkaloids, or the various other sources of nicotine mentioned above, is mixed with water, and heated, preferably to the boiling point, and stirred vigorously for about one to about thirty minutes. The mixture is allowed to cool, permitting any solids present to settle out. The supernatant liquid is then filtered to reduce the amount of nicotine in the liquid to a level so low that it cannot be detected by taste, odor, or color.
In one presently preferred form of the invention, the nicotine is in the form of nicotine polacrilex in which nicotine is bound to an ion-exchange resin, as described in U.S. Patent No. 3 ,901 ,248 referred to above. Nicotine polacrilex in powder form is commercially available from Spectrum Chemical Mfg. Corp. in Gardena, California 90248. Twenty-five grams of nicotine polacrilex (15%, U.S.P.) was mixed in three gallons of water to form a slurry, which was heated to the boiling point (about 210 °F) while stirring for five to ten minutes. The nicotine polacrilex powder appeared to dissolve, or at least liquefy, so that it was uniformly dispersed in the mixture. Thereafter, the mixture was allowed to stand and cool to about room temperature. During the cooling process, a precipitate formed and settled to the bottom of the mixture. Supernatant liquid, which had a brownish color was taken from the mixture and passed through a 0.2 μ polyethersulfone (PES) membrane filter, and then through a medical grade granular activated carbon filter, producing a water-white filtrate, which was tasteless, odorless and colorless. Analysis of the filtrate for nicotine with high pressure liquid chromatography did not show any measurable amount of nicotine.
The PES membrane filter is available from PTI Advanced Filtration h e. in Oxnard, California 93030. The activated carbon filter is available from ResinTech Inc., in Cherry Hill, New Jersey 08034-1409.
The filtered product can be consumed as drinking water, and has proved useful in suppressing the urge to smoke cigarettes. For example, many smokers have suppressed the urge to smoke by drinking about 500 ml of the treated water when experiencing the urge to smoke.
The product of this invention can also be mixed with vitamins, fruit flavoring, cola mix, and natural fruit juices to provide a variety of beverages with the benefit described above.
The product of this invention may also be used in alleviating the symptoms of attention deficit hyperactive disorder (ADHD), attention deficit disorder (ADD), Toureete's Syndrome, Schizophrenia, Parkinson's Disease, Alzheimer's Disease, anxiety, and depression.

Claims

WHAT IS CLAIMED IS:
1. A process for preparing a beverage treated with nicotine, the process including the steps of: a) mixing nicotine with water; and b) filtering the mixture to remove the taste of nicotine from the water.
2. A process for preparing a beverage treated with nicotine, the process including the steps of: a) mixing nicotine with water; b) heating the mixture of nicotine and water to a temperature above about 100°F; c) cooling the mixture; and d) filtering the mixture to eliminate the taste of nicotine from the water.
3. A process according to claim 1 or 2 in which: a) the water and nicotine mixture is heated above about 150 °F; and b) cooled to about room temperature before filtering.
4. A process according to claim 2 or 3 in which the mixture is stirred during the heating step.
5. A process according to claim 1 or 2 in which the mixture is in the form of nicotine polacrilex.
6. A process according to claim 3 in which the nicotine is in the form of nicotine polacrilex.
7. A process according to claim 3 in which the mixture is boiled at about 212 °F for at least about five minutes during the heating step.
8. A process according to claim 6 in which the mixture is boiled for at least about five minutes during the heating step.
9. A process according to claim 1 or 2 in which the filtering step includes filtering the mixture through activated carbon.
10. A process according to claim 1 or 2 in which the filtering step includes filtering the mixture through a permeable membrane, and through activated carbon.
11. A process according to claim 1 or 2 in which the mixture is in the form of nicotine polacrilex.
12. A process according to claim 3 in which the nicotine is in the form of nicotine polacrilex.
PCT/US2002/038655 2001-12-10 2002-12-04 Beverage treated with nicotine WO2003049552A2 (en)

Priority Applications (12)

Application Number Priority Date Filing Date Title
JP2003550607A JP2005526490A (en) 2001-12-10 2002-12-04 Beverages treated with nicotine
MXPA04005549A MXPA04005549A (en) 2001-12-10 2002-12-04 Beverage treated with nicotine.
CA002468785A CA2468785A1 (en) 2001-12-10 2002-12-04 Beverage treated with nicotine
KR10-2004-7008386A KR20040062666A (en) 2001-12-10 2002-12-04 Beverage treated with nicotine
EA200400792A EA010097B1 (en) 2001-12-10 2002-12-04 A process for preparing beverage treated with nicotine or derivative thereof
US10/497,375 US7435749B2 (en) 2001-12-10 2002-12-04 Beverage treated with nicotine
AU2002366598A AU2002366598B2 (en) 2001-12-10 2002-12-04 Beverage treated with nicotine
EP02791366A EP1461037B1 (en) 2001-12-10 2002-12-04 Process for preparation of a beverage treated with a nicotine containing substance
DE60221568T DE60221568T2 (en) 2001-12-10 2002-12-04 METHOD FOR PRODUCING A BEVERAGE TREATED WITH A NICOTINE-CONTAINING SUBSTANCE
BR0214820-0A BR0214820A (en) 2001-12-10 2002-12-04 Nicotine Treated Drink
HK05102233A HK1069769A1 (en) 2001-12-10 2005-03-15 Process for preparation of a beverage treated witha nicotine containing substance
US11/319,898 US20060105023A1 (en) 2001-12-10 2005-12-27 Treatment of neurological disorders with nicotine

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33779001P 2001-12-10 2001-12-10
US60/337,790 2001-12-10
US37238502P 2002-04-15 2002-04-15
US60/372,385 2002-04-15

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/319,898 Continuation-In-Part US20060105023A1 (en) 2001-12-10 2005-12-27 Treatment of neurological disorders with nicotine

Publications (2)

Publication Number Publication Date
WO2003049552A2 true WO2003049552A2 (en) 2003-06-19
WO2003049552A3 WO2003049552A3 (en) 2003-10-30

Family

ID=26990875

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/038655 WO2003049552A2 (en) 2001-12-10 2002-12-04 Beverage treated with nicotine

Country Status (14)

Country Link
US (1) US7435749B2 (en)
EP (1) EP1461037B1 (en)
JP (1) JP2005526490A (en)
KR (1) KR20040062666A (en)
CN (1) CN1602193A (en)
AT (1) ATE368460T1 (en)
BR (1) BR0214820A (en)
CA (1) CA2468785A1 (en)
DE (1) DE60221568T2 (en)
EA (1) EA010097B1 (en)
ES (1) ES2292837T3 (en)
HK (1) HK1069769A1 (en)
MX (1) MXPA04005549A (en)
WO (1) WO2003049552A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
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JP2011142926A (en) * 2004-06-29 2011-07-28 Fertin Pharma As Tobacco alkaloid releasing chewing gum

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US20060105023A1 (en) * 2001-12-10 2006-05-18 Knight Joseph R Treatment of neurological disorders with nicotine
WO2005018348A2 (en) * 2003-08-11 2005-03-03 William Whalen Chewing tobacco substitute with nicotine
US20110268809A1 (en) 2010-04-28 2011-11-03 Paul Andrew Brinkley Nicotine-Containing Pharmaceutical Compositions
US20110274628A1 (en) 2010-05-07 2011-11-10 Borschke August J Nicotine-containing pharmaceutical compositions
US20130078307A1 (en) 2011-09-22 2013-03-28 Niconovum Usa, Inc. Nicotine-containing pharmaceutical composition
US9907748B2 (en) 2011-10-21 2018-03-06 Niconovum Usa, Inc. Excipients for nicotine-containing therapeutic compositions
US9763928B2 (en) 2012-02-10 2017-09-19 Niconovum Usa, Inc. Multi-layer nicotine-containing pharmaceutical composition
WO2016187277A1 (en) * 2015-05-19 2016-11-24 Joseph Robert Knight Method for isolation of alkaloids and amino acids, and compositions containing isolated alkaloids and amino acids
US10532046B2 (en) 2015-12-03 2020-01-14 Niconovum Usa, Inc. Multi-phase delivery compositions and products incorporating such compositions
US20170165252A1 (en) 2015-12-10 2017-06-15 Niconovum Usa Inc. Protein-enriched therapeutic composition
BR112020025604A2 (en) 2018-06-15 2021-03-23 R.J. Reynolds Tobacco Company nicotine purification
BR102020002169A2 (en) * 2020-01-31 2021-08-10 Bruno Ghizoni Da Silva Comércio De Produtos E Serviços Inovadores-Me STIMULATING DRINK

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Non-Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
JP2011142926A (en) * 2004-06-29 2011-07-28 Fertin Pharma As Tobacco alkaloid releasing chewing gum

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Publication number Publication date
ATE368460T1 (en) 2007-08-15
DE60221568T2 (en) 2008-04-17
EP1461037A4 (en) 2005-09-21
BR0214820A (en) 2005-08-30
DE60221568D1 (en) 2007-09-13
AU2002366598A1 (en) 2003-06-23
EP1461037A2 (en) 2004-09-29
US20040248946A1 (en) 2004-12-09
MXPA04005549A (en) 2005-05-17
US7435749B2 (en) 2008-10-14
CN1602193A (en) 2005-03-30
JP2005526490A (en) 2005-09-08
ES2292837T3 (en) 2008-03-16
CA2468785A1 (en) 2003-06-19
WO2003049552A3 (en) 2003-10-30
EA200400792A1 (en) 2004-10-28
KR20040062666A (en) 2004-07-07
EP1461037B1 (en) 2007-08-01
EA010097B1 (en) 2008-06-30
HK1069769A1 (en) 2005-06-03

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