WO2003040392A3 - Nucleic acids encoding very long chain fatty acid biosynthesis enzymes - Google Patents

Nucleic acids encoding very long chain fatty acid biosynthesis enzymes Download PDF

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Publication number
WO2003040392A3
WO2003040392A3 PCT/IB2002/004610 IB0204610W WO03040392A3 WO 2003040392 A3 WO2003040392 A3 WO 2003040392A3 IB 0204610 W IB0204610 W IB 0204610W WO 03040392 A3 WO03040392 A3 WO 03040392A3
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WO
WIPO (PCT)
Prior art keywords
fatty acid
long chain
chain fatty
acid biosynthesis
nucleic acids
Prior art date
Application number
PCT/IB2002/004610
Other languages
French (fr)
Other versions
WO2003040392A2 (en
Inventor
Matthew Betts
Gunnar Thor Sigurdsson
Original Assignee
Decode Genetics Ehf
Matthew Betts
Gunnar Thor Sigurdsson
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Decode Genetics Ehf, Matthew Betts, Gunnar Thor Sigurdsson filed Critical Decode Genetics Ehf
Priority to AU2002351007A priority Critical patent/AU2002351007A1/en
Publication of WO2003040392A2 publication Critical patent/WO2003040392A2/en
Publication of WO2003040392A3 publication Critical patent/WO2003040392A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Nucleic acids encoding very long chain fatty acid biosynthesis enzymes and uses thereof, e.g. in methods for identifying agents that alter the activity or expression of said enzymes. Further disclosed are antibodies, therapeutic agents, and methods for diagnosing or treating a condition associated with a very long chain fatty acid biosynthesis enzyme.
PCT/IB2002/004610 2001-11-06 2002-11-04 Nucleic acids encoding very long chain fatty acid biosynthesis enzymes WO2003040392A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002351007A AU2002351007A1 (en) 2001-11-06 2002-11-04 Nucleic acids encoding very long chain fatty acid biosynthesis enzymes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33286401P 2001-11-06 2001-11-06
US60/332,864 2001-11-06

Publications (2)

Publication Number Publication Date
WO2003040392A2 WO2003040392A2 (en) 2003-05-15
WO2003040392A3 true WO2003040392A3 (en) 2004-06-17

Family

ID=23300183

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/004610 WO2003040392A2 (en) 2001-11-06 2002-11-04 Nucleic acids encoding very long chain fatty acid biosynthesis enzymes

Country Status (2)

Country Link
AU (1) AU2002351007A1 (en)
WO (1) WO2003040392A2 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012720A2 (en) * 1998-09-02 2000-03-09 Abbott Laboratories Elongase genes and uses thereof
WO2000070945A2 (en) * 1999-05-20 2000-11-30 Karolinska Innovations Ab Fatty acid elongation genes and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000012720A2 (en) * 1998-09-02 2000-03-09 Abbott Laboratories Elongase genes and uses thereof
WO2000070945A2 (en) * 1999-05-20 2000-11-30 Karolinska Innovations Ab Fatty acid elongation genes and uses thereof

Non-Patent Citations (12)

* Cited by examiner, † Cited by third party
Title
BIOCHEMICAL JOURNAL, vol. 350, no. 3, 2000, pages 765 - 770, XP002233866, ISSN: 0264-6021 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1 May 2000 (2000-05-01), TVRDIK PETR ET AL: "Role of a new mammalian gene family in the biosynthesis of very long chain fatty acids and sphingolipids.", XP002902839, Database accession no. PREV200000271457 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1997, OH CHAN-SEOK ET AL: "ELO2 and ELO3, homologues of the Saccharomyces cerevisiae ELO1 gene, function in fatty acid elongation and are required for sphingolipid formation.", XP002902837, Database accession no. PREV199799658602 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 2000, LEONARD AMANDA E ET AL: "Cloning of a human cDNA encoding a novel enzyme involved in the elongation of long-chain polyunsaturated fatty acids.", XP002902840, Database accession no. PREV200000490660 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 2001 (2001-01-01), ZHANG KANG ET AL: "A 5-bp deletion in ELOVL4 is associated with two related forms of autosomal dominant macular dystrophy.", XP002902838, Database accession no. PREV200100080066 *
DATABASE EMBL [online] 9 March 2001 (2001-03-09), XP002902841, retrieved from EMBL Database accession no. BC000618 *
DATABASE GENESEQ [online] 27 March 2001 (2001-03-27), XP002233867, retrieved from GENESEQ Database accession no. AAB48957 *
DATABASE GENESEQ [online] 27 March 2001 (2001-03-27), XP002233868, retrieved from GENESEQ Database accession no. AAC91701 *
DATABASE GENESEQ [online] 3 July 2000 (2000-07-03), XP002233869, retrieved from GENESEQ Database accession no. AAY79252 *
JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 28, 1997, pages 17376 - 17384, XP002233863, ISSN: 0021-9258 *
JOURNAL OF CELL BIOLOGY, vol. 149, no. 3, 1 May 2000 (2000-05-01), pages 707 - 717, XP002233865, ISSN: 0021-9525 *
NATURE GENETICS, vol. 27, no. 1, January 2001 (2001-01-01), pages 89 - 93, XP002233864, ISSN: 1061-4036 *

Also Published As

Publication number Publication date
WO2003040392A2 (en) 2003-05-15
AU2002351007A1 (en) 2003-05-19

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