WO2003040287A3 - Isotopencodierte affinitätsmarker - Google Patents

Isotopencodierte affinitätsmarker Download PDF

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Publication number
WO2003040287A3
WO2003040287A3 PCT/EP2002/012006 EP0212006W WO03040287A3 WO 2003040287 A3 WO2003040287 A3 WO 2003040287A3 EP 0212006 W EP0212006 W EP 0212006W WO 03040287 A3 WO03040287 A3 WO 03040287A3
Authority
WO
WIPO (PCT)
Prior art keywords
isotope
affinity tag
coded affinity
relates
novel
Prior art date
Application number
PCT/EP2002/012006
Other languages
English (en)
French (fr)
Other versions
WO2003040287A2 (de
Inventor
Oswald Lockhoff
Thomas Lehmann
Hans-Georg Lerchen
Dorian Immler
Hans-Ulrich Siegmund
Original Assignee
Bayer Ag
Oswald Lockhoff
Thomas Lehmann
Hans-Georg Lerchen
Dorian Immler
Hans-Ulrich Siegmund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag, Oswald Lockhoff, Thomas Lehmann, Hans-Georg Lerchen, Dorian Immler, Hans-Ulrich Siegmund filed Critical Bayer Ag
Priority to CA002466319A priority Critical patent/CA2466319A1/en
Priority to US10/494,997 priority patent/US20050069961A1/en
Priority to AU2002342864A priority patent/AU2002342864A1/en
Priority to EP02779513A priority patent/EP1448994A2/de
Publication of WO2003040287A2 publication Critical patent/WO2003040287A2/de
Publication of WO2003040287A3 publication Critical patent/WO2003040287A3/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
    • A61K47/665—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells the pre-targeting system, clearing therapy or rescue therapy involving biotin-(strept) avidin systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Optics & Photonics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Die Erfindung betrifft neue, isotopencodierte Affinitätsmarker zur massenspektrometrischen Analyse von Proteinen sowie deren Herstellung und Verwendung.
PCT/EP2002/012006 2001-11-09 2002-10-28 Isotopencodierte affinitätsmarker WO2003040287A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002466319A CA2466319A1 (en) 2001-11-09 2002-10-28 Isotope-coded affinity tag
US10/494,997 US20050069961A1 (en) 2001-11-09 2002-10-28 Isotope-coded affinity tag
AU2002342864A AU2002342864A1 (en) 2001-11-09 2002-10-28 Isotope-coded affinity tag
EP02779513A EP1448994A2 (de) 2001-11-09 2002-10-28 Isotopencodierte affinitätsmarker

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10154744.7 2001-11-09
DE10154744A DE10154744A1 (de) 2001-11-09 2001-11-09 Isotopencodierte Affinitätsmarker

Publications (2)

Publication Number Publication Date
WO2003040287A2 WO2003040287A2 (de) 2003-05-15
WO2003040287A3 true WO2003040287A3 (de) 2003-10-23

Family

ID=7704957

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/012006 WO2003040287A2 (de) 2001-11-09 2002-10-28 Isotopencodierte affinitätsmarker

Country Status (6)

Country Link
US (1) US20050069961A1 (de)
EP (1) EP1448994A2 (de)
AU (1) AU2002342864A1 (de)
CA (1) CA2466319A1 (de)
DE (1) DE10154744A1 (de)
WO (1) WO2003040287A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112125921B (zh) * 2020-09-28 2022-01-21 江苏省原子医学研究所 一种光敏剂前药化合物及其制备方法和应用

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1304845C (zh) * 2004-04-14 2007-03-14 中国科学院上海有机化学研究所 一种新型含碘树脂衍生物用在基于质谱的蛋白组学研究中的方法
US20070048752A1 (en) 2004-07-12 2007-03-01 Applera Corporation Mass tags for quantitative analyses
EP1776588A1 (de) * 2004-07-12 2007-04-25 Applera Corporation Massen-tags für quantitative analysen
GB0916881D0 (en) * 2009-09-25 2009-11-11 Electrophoretics Ltd Mass labels
US10008677B2 (en) 2011-01-13 2018-06-26 Universal Display Corporation Materials for organic light emitting diode

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0244055A2 (de) * 1986-04-28 1987-11-04 Bio-Affinity Systems, Inc. Verfahren zur Bestimmung der Aminosäuresequenz von Peptiden
WO2000011208A1 (en) * 1998-08-25 2000-03-02 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
WO2002066988A2 (en) * 2001-02-16 2002-08-29 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
WO2002090929A2 (en) * 2001-05-08 2002-11-14 Perseptive Biosystems, Inc. Process for analyzing protein samples

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1463291A (zh) * 2001-04-19 2003-12-24 赛弗根生物系统股份有限公司 用质谱法和亲和标记物鉴定生物分子的特性

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0244055A2 (de) * 1986-04-28 1987-11-04 Bio-Affinity Systems, Inc. Verfahren zur Bestimmung der Aminosäuresequenz von Peptiden
WO2000011208A1 (en) * 1998-08-25 2000-03-02 University Of Washington Rapid quantitative analysis of proteins or protein function in complex mixtures
WO2002066988A2 (en) * 2001-02-16 2002-08-29 Battelle Memorial Institute Phosphoprotein binding agents and methods of their use
WO2002090929A2 (en) * 2001-05-08 2002-11-14 Perseptive Biosystems, Inc. Process for analyzing protein samples

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GOSHE M B ET AL: "Phosphoprotein isotope-coded affinity tag approach for isolating and quantitating phosphopeptides in proteome-wide analyses", ANALYTICAL CHEMISTRY, AMERICAN CHEMICAL SOCIETY. COLUMBUS, US, vol. 73, no. 11, 1 June 2001 (2001-06-01), pages 2578 - 2586, XP002216845, ISSN: 0003-2700 *
GYGI S P ET AL: "QUANTITATIVE ANALYSIS OF COMPLEX PROTEIN MIXTURES USING ISOTOPE-CODED AFFINITY TAGS", NATURE BIOTECHNOLOGY, NATURE PUBLISHING, US, vol. 17, no. 10, October 1999 (1999-10-01), pages 994 - 999, XP001010578, ISSN: 1087-0156 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112125921B (zh) * 2020-09-28 2022-01-21 江苏省原子医学研究所 一种光敏剂前药化合物及其制备方法和应用

Also Published As

Publication number Publication date
WO2003040287A2 (de) 2003-05-15
US20050069961A1 (en) 2005-03-31
EP1448994A2 (de) 2004-08-25
AU2002342864A1 (en) 2003-05-19
DE10154744A1 (de) 2003-05-22
CA2466319A1 (en) 2003-05-15

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