WO2003040144A3 - Heterocyclic compound based on n6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds - Google Patents

Heterocyclic compound based on n6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds Download PDF

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Publication number
WO2003040144A3
WO2003040144A3 PCT/CZ2002/000045 CZ0200045W WO03040144A3 WO 2003040144 A3 WO2003040144 A3 WO 2003040144A3 CZ 0200045 W CZ0200045 W CZ 0200045W WO 03040144 A3 WO03040144 A3 WO 03040144A3
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WO
WIPO (PCT)
Prior art keywords
preparation
growth regulators
cosmetic preparations
preparations
drugs
Prior art date
Application number
PCT/CZ2002/000045
Other languages
French (fr)
Other versions
WO2003040144A2 (en
Inventor
Karel Dolezal
Igor Popa
Jan Holub
Rene Lenobel
Stefaan Werbrouck
Miroslav Strnad
Marek Zatloukal
Original Assignee
Ustav Ex Botan Akademie Ved Ce
Karel Dolezal
Igor Popa
Jan Holub
Rene Lenobel
Stefaan Werbrouck
Miroslav Strnad
Marek Zatloukal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BR0211597-2A priority Critical patent/BR0211597A/en
Priority to HU0401407A priority patent/HUP0401407A3/en
Application filed by Ustav Ex Botan Akademie Ved Ce, Karel Dolezal, Igor Popa, Jan Holub, Rene Lenobel, Stefaan Werbrouck, Miroslav Strnad, Marek Zatloukal filed Critical Ustav Ex Botan Akademie Ved Ce
Priority to MXPA04000936A priority patent/MXPA04000936A/en
Priority to AU2002363362A priority patent/AU2002363362B2/en
Priority to IL16013602A priority patent/IL160136A0/en
Priority to CN028185528A priority patent/CN1556808B/en
Priority to YU8904A priority patent/RS52389B/en
Priority to EP02750769.8A priority patent/EP1419157B1/en
Priority to NZ531086A priority patent/NZ531086A/en
Priority to JP2003542190A priority patent/JP2005508386A/en
Priority to US10/485,091 priority patent/US7279482B2/en
Priority to KR1020047001539A priority patent/KR100939147B1/en
Priority to CA2455972A priority patent/CA2455972C/en
Publication of WO2003040144A2 publication Critical patent/WO2003040144A2/en
Priority to NO20040469A priority patent/NO329434B1/en
Priority to ZA2004/01461A priority patent/ZA200401461B/en
Publication of WO2003040144A3 publication Critical patent/WO2003040144A3/en
Priority to US11/779,828 priority patent/US8552013B2/en
Priority to AU2008203837A priority patent/AU2008203837A1/en
Priority to AU2008203838A priority patent/AU2008203838B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Gerontology & Geriatric Medicine (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Birds (AREA)
  • Environmental Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Plant Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychiatry (AREA)

Abstract

New heterocyclic derivatives of formula (1) based on N6-substituted adenine, having anticancer, mitotic, imunosuppressive and antisenescent propoerties for plant, animal and human cells and methods of their preparation. Included are also pharmaceutical compositions, cosmetic preparations and growth regulators, which contain these derivatives as active compound and the use of these derivatives for the preparation of drugs, cosmetic preparations, in biotechnological processes, in cosmetics and in agriculture.
PCT/CZ2002/000045 2001-08-02 2002-08-01 Heterocyclic compound based on n6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds WO2003040144A2 (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
US10/485,091 US7279482B2 (en) 2001-08-02 2002-08-01 Heterocyclic compound based on N6-substituted adenine, methods, of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
JP2003542190A JP2005508386A (en) 2001-08-02 2002-08-01 Heterocyclic compounds based on N6-substituted adenines and methods for their preparation and use for the preparation of drugs, cosmetics, growth regulators and pharmaceuticals, cosmetics, growth regulators containing the compounds
KR1020047001539A KR100939147B1 (en) 2001-08-02 2002-08-01 Heterocyclic compounds based on ?6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
HU0401407A HUP0401407A3 (en) 2001-08-02 2002-08-01 Heterocyclic compound based on n6- substituted adenine, methods of their preparation, their use for preparation cosmetic preparations and growth regulators, pharmaceutical preparations
IL16013602A IL160136A0 (en) 2001-08-02 2002-08-01 Heterocyclic compounds based on n6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
CN028185528A CN1556808B (en) 2001-08-02 2002-08-01 Cosmetic comprising heterocyclic compound based on N6-substituted adenine,
YU8904A RS52389B (en) 2001-08-02 2002-08-01 Heterocyclic compound based on n6-substituted adenine methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing thes
EP02750769.8A EP1419157B1 (en) 2001-08-02 2002-08-01 6-(4-hydroxybenzylamino)purine and its use in cosmetics
NZ531086A NZ531086A (en) 2001-08-02 2002-08-01 Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
BR0211597-2A BR0211597A (en) 2001-08-02 2002-08-01 Unsubstituted adenine-based heterocyclic compounds, methods of preparing them, their use in drug preparation, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing such compounds
AU2002363362A AU2002363362B2 (en) 2001-08-02 2002-08-01 Heterocyclic compound based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
MXPA04000936A MXPA04000936A (en) 2001-08-02 2002-08-01 Heterocyclic compound based on n6.
CA2455972A CA2455972C (en) 2001-08-02 2002-08-01 N6-benzyl and phenyl substituted adenines and their use as cosmetics, pharmaceutical preparations and plant growth regulators
NO20040469A NO329434B1 (en) 2001-08-02 2004-02-02 Use of 6- (4-hydroxybenzylamino) purine for cosmetic purposes
ZA2004/01461A ZA200401461B (en) 2001-08-02 2004-02-23 Heterocyclic compound based on n6 substituted adenine methods of their preparation their use for preparation of drugs cosmetic preparations and growth regulators pharmaceutical prepartion cosmetic preparations and growth regulators containing these compou
US11/779,828 US8552013B2 (en) 2001-08-02 2007-07-18 Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
AU2008203837A AU2008203837A1 (en) 2001-08-02 2008-08-12 Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds
AU2008203838A AU2008203838B2 (en) 2001-08-02 2008-08-12 Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20012818A CZ294535B6 (en) 2001-08-02 2001-08-02 Heterocyclic compounds based on N6-substituted adenine, processes of their preparation, their use in the preparation of medicaments, cosmetic compositions and growth regulators, as well as pharmaceutical preparations, cosmetic compositions and growth regulators in which these compounds are comprised
CZPV2001-2818 2001-08-02

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10485091 A-371-Of-International 2002-08-01
US11/779,828 Continuation-In-Part US8552013B2 (en) 2001-08-02 2007-07-18 Heterocyclic compounds based on N6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds

Publications (2)

Publication Number Publication Date
WO2003040144A2 WO2003040144A2 (en) 2003-05-15
WO2003040144A3 true WO2003040144A3 (en) 2004-02-26

Family

ID=5473504

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CZ2002/000045 WO2003040144A2 (en) 2001-08-02 2002-08-01 Heterocyclic compound based on n6-substituted adenine, methods of their preparation, their use for preparation of drugs, cosmetic preparations and growth regulators, pharmaceutical preparations, cosmetic preparations and growth regulators containing these compounds

Country Status (20)

Country Link
US (2) US7279482B2 (en)
EP (1) EP1419157B1 (en)
JP (1) JP2005508386A (en)
KR (1) KR100939147B1 (en)
CN (1) CN1556808B (en)
AU (3) AU2002363362B2 (en)
BR (1) BR0211597A (en)
CA (1) CA2455972C (en)
CZ (1) CZ294535B6 (en)
HU (1) HUP0401407A3 (en)
IL (1) IL160136A0 (en)
MX (1) MXPA04000936A (en)
NO (1) NO329434B1 (en)
NZ (1) NZ531086A (en)
PL (1) PL368299A1 (en)
RS (1) RS52389B (en)
RU (1) RU2302421C2 (en)
SG (2) SG127738A1 (en)
WO (1) WO2003040144A2 (en)
ZA (1) ZA200401461B (en)

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