WO2003035614A3 - Inhibiteurs de la tyrosine kinase - Google Patents

Inhibiteurs de la tyrosine kinase Download PDF

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Publication number
WO2003035614A3
WO2003035614A3 PCT/US2002/033919 US0233919W WO03035614A3 WO 2003035614 A3 WO2003035614 A3 WO 2003035614A3 US 0233919 W US0233919 W US 0233919W WO 03035614 A3 WO03035614 A3 WO 03035614A3
Authority
WO
WIPO (PCT)
Prior art keywords
compounds
tyrosine kinase
kinase inhibitors
present
receptor
Prior art date
Application number
PCT/US2002/033919
Other languages
English (en)
Other versions
WO2003035614A2 (fr
Inventor
B Wesley Trotter
Ian M Bell
C Blair Zartman
Original Assignee
Merck & Co Inc
B Wesley Trotter
Ian M Bell
C Blair Zartman
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, B Wesley Trotter, Ian M Bell, C Blair Zartman filed Critical Merck & Co Inc
Priority to AU2002348393A priority Critical patent/AU2002348393A1/en
Publication of WO2003035614A2 publication Critical patent/WO2003035614A2/fr
Publication of WO2003035614A3 publication Critical patent/WO2003035614A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne des composés capables d'inhiber, moduler et/ou réguler la transduction des signaux des tyrosine kinases de type récepteurs et de type non récepteurs. Les composés de l'invention possèdent une structure centrale qui contient un 2-carboxy-5-formyl pyrrole. Par ailleurs, l'invention concerne des sels acceptables sur le plan pharmaceutique, des hydrates et des stéréo-isomères de ces composés.
PCT/US2002/033919 2001-10-25 2002-10-21 Inhibiteurs de la tyrosine kinase WO2003035614A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002348393A AU2002348393A1 (en) 2001-10-25 2002-10-21 Tyrosine kinase inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34290201P 2001-10-25 2001-10-25
US60/342,902 2001-10-25

Publications (2)

Publication Number Publication Date
WO2003035614A2 WO2003035614A2 (fr) 2003-05-01
WO2003035614A3 true WO2003035614A3 (fr) 2004-03-18

Family

ID=23343779

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/033919 WO2003035614A2 (fr) 2001-10-25 2002-10-21 Inhibiteurs de la tyrosine kinase

Country Status (2)

Country Link
AU (1) AU2002348393A1 (fr)
WO (1) WO2003035614A2 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1651209A4 (fr) * 2003-07-24 2009-03-04 Merck & Co Inc Inhibiteurs de tyrosine kinase
WO2007035744A1 (fr) 2005-09-20 2007-03-29 Osi Pharmaceuticals, Inc. Marqueurs biologiques predictifs d'une reaction anticancereuse aux inhibiteurs kinase du recepteur du facteur de croissance 1 analogue a l'insuline
US20120189641A1 (en) 2009-02-25 2012-07-26 OSI Pharmaceuticals, LLC Combination anti-cancer therapy
EP2400990A2 (fr) 2009-02-26 2012-01-04 OSI Pharmaceuticals, LLC Procédés in situ pour surveiller l'état emt de cellules tumorales in vivo
EP2401614A1 (fr) 2009-02-27 2012-01-04 OSI Pharmaceuticals, LLC Méthodes d'identification d'agents qui inhibent les cellules cancéreuses mésenchymateuses ou leur formation
US8465912B2 (en) 2009-02-27 2013-06-18 OSI Pharmaceuticals, LLC Methods for the identification of agents that inhibit mesenchymal-like tumor cells or their formation
WO2010099138A2 (fr) 2009-02-27 2010-09-02 Osi Pharmaceuticals, Inc. Procédés pour l'identification d'agents qui inhibent les cellules tumorales de type mésenchymateuses ou leur formation
WO2010146059A2 (fr) 2009-06-16 2010-12-23 F. Hoffmann-La Roche Ag Biomarqueurs pour une thérapie par inhibiteur d'igf-1r
WO2011109584A2 (fr) 2010-03-03 2011-09-09 OSI Pharmaceuticals, LLC Marqueurs biologiques prédictifs d'une réponse anticancéreuse aux inhibiteurs de kinase du récepteur du facteur de croissance insulinique 1
US20110275644A1 (en) 2010-03-03 2011-11-10 Buck Elizabeth A Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors
EP2544672A1 (fr) 2010-03-09 2013-01-16 OSI Pharmaceuticals, LLC Thérapie anticancéreuse combinatoire
US20120214830A1 (en) 2011-02-22 2012-08-23 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to insulin-like growth factor-1 receptor kinase inhibitors in hepatocellular carcinoma
US9896730B2 (en) 2011-04-25 2018-02-20 OSI Pharmaceuticals, LLC Use of EMT gene signatures in cancer drug discovery, diagnostics, and treatment
WO2013152252A1 (fr) 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Polythérapie antinéoplasique
JP6255038B2 (ja) 2013-02-26 2017-12-27 トリアクト セラピューティクス，インク． 癌治療
EP3044593A4 (fr) 2013-09-09 2017-05-17 Triact Therapeutics, Inc. Traitement du cancer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038519A1 (fr) * 1998-12-31 2000-07-06 Sugen, Inc. Composes 3-heteroarylidenyl-2-indolinone utilises pour modulation de l'activite de la proteine kinase et dans la chimiotherapie du cancer

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000038519A1 (fr) * 1998-12-31 2000-07-06 Sugen, Inc. Composes 3-heteroarylidenyl-2-indolinone utilises pour modulation de l'activite de la proteine kinase et dans la chimiotherapie du cancer

Also Published As

Publication number Publication date
WO2003035614A2 (fr) 2003-05-01
AU2002348393A1 (en) 2003-05-06

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