AU2003258922A1 - PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY - Google Patents

PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY

Info

Publication number
AU2003258922A1
AU2003258922A1 AU2003258922A AU2003258922A AU2003258922A1 AU 2003258922 A1 AU2003258922 A1 AU 2003258922A1 AU 2003258922 A AU2003258922 A AU 2003258922A AU 2003258922 A AU2003258922 A AU 2003258922A AU 2003258922 A1 AU2003258922 A1 AU 2003258922A1
Authority
AU
Australia
Prior art keywords
pyrazolo
inhibitors
kinase activity
itk kinase
cinnoline compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003258922A
Inventor
Jan Dahmen
Martin Hemmerling
Tomas Klingstedt
Peter Sjo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Publication of AU2003258922A1 publication Critical patent/AU2003258922A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003258922A 2002-08-14 2003-08-13 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY Abandoned AU2003258922A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
SE0202461A SE0202461D0 (en) 2002-08-14 2002-08-14 Novel compounds
SE0202461-0 2002-08-14
PCT/SE2003/001278 WO2004016615A1 (en) 2002-08-14 2003-08-13 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY

Publications (1)

Publication Number Publication Date
AU2003258922A1 true AU2003258922A1 (en) 2004-03-03

Family

ID=20288749

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003258922A Abandoned AU2003258922A1 (en) 2002-08-14 2003-08-13 PYRAZOLO (4,3c) CINNOLINE COMPOUNDS AS INHIBITORS OF ITK KINASE ACTIVITY

Country Status (3)

Country Link
AU (1) AU2003258922A1 (en)
SE (1) SE0202461D0 (en)
WO (1) WO2004016615A1 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7465795B2 (en) 2005-12-20 2008-12-16 Astrazeneca Ab Compounds and uses thereof
WO2007073283A1 (en) * 2005-12-20 2007-06-28 Astrazeneca Ab Substituted cinnoline derivatives as gabaa-receptor modulators and method for their synthesis
WO2007126913A1 (en) * 2006-03-27 2007-11-08 The Government Of The U.S.A. As Represented By The Secretary Department Of Health & Human Services Methods for prevention or treatment of viral disease
WO2013153539A1 (en) 2012-04-13 2013-10-17 Glenmark Pharmaceuticals S.A. Tricyclic compounds as tec kinase inhibitors
CA2928721C (en) 2013-10-25 2020-12-22 Pharmacyclics Llc Use of ibrutinib for treating and preventing chronic graft versus host disease
MA45973A (en) 2015-08-31 2019-06-26 Pharmacyclics Llc BTK INHIBITOR COMBINATIONS FOR THE TREATMENT OF MULTIPLE MYELOMA
CN110139669A (en) 2016-11-03 2019-08-16 朱诺治疗学股份有限公司 The combination treatment of T cell therapy and BTK inhibitor
PE20200608A1 (en) 2017-06-30 2020-03-10 Bayer Animal Health Gmbh NEW DERIVATIVES OF AZAQUINOLINE
JP7410877B2 (en) 2018-05-03 2024-01-10 ジュノー セラピューティクス インコーポレイテッド Combination therapy of chimeric antigen receptor (CAR) T cell therapy and kinase inhibitors
WO2023220655A1 (en) 2022-05-11 2023-11-16 Celgene Corporation Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2549833B1 (en) * 1983-07-26 1985-11-08 Roussel Uclaf PYRAZOLO / 4,3-C / CINNOLIN-3-ONE DERIVATIVES, SALTS THEREOF, PROCESS FOR PREPARATION, APPLICATION AS MEDICAMENTS, COMPOSITIONS CONTAINING THEM AND INTERMEDIATES
JPS61112075A (en) * 1984-11-05 1986-05-30 Shionogi & Co Ltd Thienylpyrazoloquinoline derivative
US4591589A (en) * 1985-01-16 1986-05-27 Roussel Uclaf 2-aryl pyrazolo[4,3-c]cinnolin-3-ones

Also Published As

Publication number Publication date
SE0202461D0 (en) 2002-08-14
WO2004016615A1 (en) 2004-02-26

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase