WO2003029467A1 - Candidate proteine pour nouveau facteur de polarisation cellulaire et polynucleotide codant cette proteine - Google Patents

Candidate proteine pour nouveau facteur de polarisation cellulaire et polynucleotide codant cette proteine Download PDF

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Publication number
WO2003029467A1
WO2003029467A1 PCT/JP2002/009015 JP0209015W WO03029467A1 WO 2003029467 A1 WO2003029467 A1 WO 2003029467A1 JP 0209015 W JP0209015 W JP 0209015W WO 03029467 A1 WO03029467 A1 WO 03029467A1
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WO
WIPO (PCT)
Prior art keywords
protein
novel cell
cell polarization
polarization factor
polynucleotide encoding
Prior art date
Application number
PCT/JP2002/009015
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English (en)
Japanese (ja)
Inventor
Mototsugu Eiraku
Mineko Kengaku
Original Assignee
Japan Science And Technology Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Science And Technology Corporation filed Critical Japan Science And Technology Corporation
Publication of WO2003029467A1 publication Critical patent/WO2003029467A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La présente invention concerne une protéine DNER, qui, du fait qu'elle possède des séquences d'acides aminés hydrophobes constitués d'environ 30 résidus du côté de la terminaison C, est susceptible d'être une protéine membranaire du type transmembranaire 1. Sa séquence d'acides aminés et son profil d'expression, notamment, font que cette protéine DNER est vraisemblablement une candidate protéine pour un nouveau facteur de polarisation cellulaire participant au contrôle de la différentiation morphologique et de la migration des neurones du système nerveux central.
PCT/JP2002/009015 2001-09-05 2002-09-05 Candidate proteine pour nouveau facteur de polarisation cellulaire et polynucleotide codant cette proteine WO2003029467A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-269456 2001-09-05
JP2001269456 2001-09-05

Publications (1)

Publication Number Publication Date
WO2003029467A1 true WO2003029467A1 (fr) 2003-04-10

Family

ID=19095268

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/009015 WO2003029467A1 (fr) 2001-09-05 2002-09-05 Candidate proteine pour nouveau facteur de polarisation cellulaire et polynucleotide codant cette proteine

Country Status (1)

Country Link
WO (1) WO2003029467A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1036395A (ja) * 1996-07-24 1998-02-10 Asahi Chem Ind Co Ltd 新規膜蛋白質
WO1999028462A2 (fr) * 1997-12-03 1999-06-10 Genentech, Inc. Polypeptides et acides nucleiques codant ces derniers
WO2000032776A2 (fr) * 1998-12-01 2000-06-08 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques les codant

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH1036395A (ja) * 1996-07-24 1998-02-10 Asahi Chem Ind Co Ltd 新規膜蛋白質
WO1999028462A2 (fr) * 1997-12-03 1999-06-10 Genentech, Inc. Polypeptides et acides nucleiques codant ces derniers
WO2000032776A2 (fr) * 1998-12-01 2000-06-08 Genentech, Inc. Polypeptides secretes et transmembranaires et acides nucleiques les codant

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