WO2003017948A3 - Aryl tetrahydronaphthalene derivatives - Google Patents

Aryl tetrahydronaphthalene derivatives Download PDF

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Publication number
WO2003017948A3
WO2003017948A3 PCT/US2002/027932 US0227932W WO03017948A3 WO 2003017948 A3 WO2003017948 A3 WO 2003017948A3 US 0227932 W US0227932 W US 0227932W WO 03017948 A3 WO03017948 A3 WO 03017948A3
Authority
WO
WIPO (PCT)
Prior art keywords
aryl
compounds
tetrahydronaphthalene derivatives
disclosed
tetrahydronaphthalene
Prior art date
Application number
PCT/US2002/027932
Other languages
French (fr)
Other versions
WO2003017948A2 (en
Inventor
Anita Melikian-Badalian
Original Assignee
Avlan Ltd
Anita Melikian-Badalian
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Avlan Ltd, Anita Melikian-Badalian filed Critical Avlan Ltd
Priority to AU2002329955A priority Critical patent/AU2002329955A1/en
Publication of WO2003017948A2 publication Critical patent/WO2003017948A2/en
Publication of WO2003017948A3 publication Critical patent/WO2003017948A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/16—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with acylated ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
    • C07D295/205—Radicals derived from carbonic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
    • C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
    • C07D317/58—Radicals substituted by nitrogen atoms

Abstract

A new family of compounds, particularly aryl 1,2,3,4-tetrahydronaphthalene derivatives, is disclosed. The compounds may be used as inhibitors of P- glycoprotein-mediated transport. Use of the compounds to enhance bioavailability and to modulate multi-drug resistance to chemotherapeutic agents is disclosed.
PCT/US2002/027932 2001-08-29 2002-08-28 Aryl tetrahydronaphthalene derivatives WO2003017948A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002329955A AU2002329955A1 (en) 2001-08-29 2002-08-28 Aryl tetrahydronaphthalene derivatives

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31588001P 2001-08-29 2001-08-29
US60/315,880 2001-08-29

Publications (2)

Publication Number Publication Date
WO2003017948A2 WO2003017948A2 (en) 2003-03-06
WO2003017948A3 true WO2003017948A3 (en) 2004-02-12

Family

ID=23226460

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/027932 WO2003017948A2 (en) 2001-08-29 2002-08-28 Aryl tetrahydronaphthalene derivatives

Country Status (2)

Country Link
AU (1) AU2002329955A1 (en)
WO (1) WO2003017948A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2756376A1 (en) * 2009-03-23 2010-09-30 Cipla Limited Process for the preparation of doxazosin and salts thereof
US20130035555A1 (en) 2011-08-05 2013-02-07 Alexander James A Systems, implants, tools, and methods for treatment of pelvic conditions

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE CA [online] CISNEY M. ET AL.: "Cordendrin. II. The stereochemistry and reactions of the lactone ring", XP002973720, accession no. STN Database accession no. 49:69032 *
DATABASE CA [online] HOLLWEDEL F. ET AL.: "Novel isochroman-3-ones for the curing of unsaturated polyester via Diels-Alder reaction", XP002973719, accession no. STN Database accession no. 132:137749 *
JOURNAL OF AMER. CHEM. SOCIETY, vol. 76, 1954, pages 5083 - 5087 *
MACROMOLECULAR CHEMISTRY AND PHYSICS, vol. 200, no. 12, 1999, pages 2612 - 2622 *

Also Published As

Publication number Publication date
WO2003017948A2 (en) 2003-03-06
AU2002329955A1 (en) 2003-03-10

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