WO2003016500A3 - Human toxicologically relevant genes and arrays - Google Patents

Human toxicologically relevant genes and arrays Download PDF

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Publication number
WO2003016500A3
WO2003016500A3 PCT/US2002/026514 US0226514W WO03016500A3 WO 2003016500 A3 WO2003016500 A3 WO 2003016500A3 US 0226514 W US0226514 W US 0226514W WO 03016500 A3 WO03016500 A3 WO 03016500A3
Authority
WO
WIPO (PCT)
Prior art keywords
human
methods
toxicological
human genes
genes
Prior art date
Application number
PCT/US2002/026514
Other languages
French (fr)
Other versions
WO2003016500A2 (en
Inventor
Robin E Neft
Robert T Ii Dunn
Karissa Adkins
Gavin G Pickett
Larry D Kier
Katja Schmeiser
Phillippe Alen
Original Assignee
Phase 1 Molecular Toxicology I
Robin E Neft
Robert T Ii Dunn
Karissa Adkins
Gavin G Pickett
Larry D Kier
Katja Schmeiser
Phillippe Alen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Phase 1 Molecular Toxicology I, Robin E Neft, Robert T Ii Dunn, Karissa Adkins, Gavin G Pickett, Larry D Kier, Katja Schmeiser, Phillippe Alen filed Critical Phase 1 Molecular Toxicology I
Priority to AU2002323286A priority Critical patent/AU2002323286A1/en
Priority to EP02757259A priority patent/EP1427850A4/en
Publication of WO2003016500A2 publication Critical patent/WO2003016500A2/en
Publication of WO2003016500A3 publication Critical patent/WO2003016500A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides for a set of toxicologically relevant human genes which may be used to predict toxicological responses on a cellular, organ, or system level. Methods of identifying, selecting, isolating, and evaluating toxicologically relevant human genes are provided. Arrays comprising human genes that are useful for toxicological screening of drugs, pharmaceutical compounds, or chemicals are also provided. The human array provides a method by which toxicological responses can analyzed in a rapid and efficient manner. Methods of identifying and isolating human genes for a human array are also provided. Further, methods of making a human gene array and using a human gene array are disclosed. These methods are also useful for isolating human genes and for discovery of novel human genes. Also provided is a database of human toxicological responses which are useful for predicting toxicological response to agents on a cellular level, organ-by-organ, and system-by-system. Methods of obtaining such databases containing human toxicological data and methods of use are also provided herein. Further, algorithms which allows for evaluation and/or 1 analysis of toxicological data are also provided herein.
PCT/US2002/026514 2001-08-16 2002-08-16 Human toxicologically relevant genes and arrays WO2003016500A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002323286A AU2002323286A1 (en) 2001-08-16 2002-08-16 Human toxicologically relevant genes and arrays
EP02757259A EP1427850A4 (en) 2001-08-16 2002-08-16 Human toxicologically relevant genes and arrays

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31308001P 2001-08-16 2001-08-16
US60/313,080 2001-08-16

Publications (2)

Publication Number Publication Date
WO2003016500A2 WO2003016500A2 (en) 2003-02-27
WO2003016500A3 true WO2003016500A3 (en) 2003-06-19

Family

ID=23214292

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/026514 WO2003016500A2 (en) 2001-08-16 2002-08-16 Human toxicologically relevant genes and arrays

Country Status (3)

Country Link
EP (1) EP1427850A4 (en)
AU (1) AU2002323286A1 (en)
WO (1) WO2003016500A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050283854A1 (en) 2003-05-23 2005-12-22 Anton Krumm Recombinant vectors for use in position-independent transgene expression within chromatin
US20050186577A1 (en) 2004-02-20 2005-08-25 Yixin Wang Breast cancer prognostics
US20100057368A1 (en) * 2004-11-30 2010-03-04 Noubar Afeyan Biological Systems Analysis
FR2890080B1 (en) * 2005-08-30 2012-12-14 Vigilent Technologies IN VITRO METHOD FOR TESTING THE TOXICITY OF A COMPOUND AND DEVICE FOR IMPLEMENTING SAID METHOD
CA2661647C (en) * 2006-08-24 2013-02-05 Hiroshima University Method for highly amplifying target gene in mammalian cell and vector therefor
KR20130101442A (en) 2010-05-03 2013-09-13 큐알엔에이, 인크. Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt)
KR102165245B1 (en) * 2013-05-21 2020-10-13 한양대학교 에리카산학협력단 Method for determining probability of exposure to toxic chemicals
GB2566516A (en) 2017-09-15 2019-03-20 Univ Oxford Innovation Ltd Electrochemical recognition and quantification of cytochrome c oxidase expression in bacteria
JP2023536385A (en) * 2020-05-29 2023-08-25 ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア Compositions and methods for detecting respiratory viruses, including coronaviruses

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160105A (en) * 1998-10-13 2000-12-12 Incyte Pharmaceuticals, Inc. Monitoring toxicological responses
US20020192671A1 (en) * 2001-01-23 2002-12-19 Castle Arthur L. Method and system for predicting the biological activity, including toxicology and toxicity, of substances

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0680517B2 (en) * 1993-01-21 2005-01-19 President And Fellows Of Harvard College Methods and diagnostic kits utilizing mammalian stress promoters to determine toxicity of a compound
WO2001011030A2 (en) * 1999-08-10 2001-02-15 Develogen Ag Für Entwicklungsbiologische Forschung Method and means for inducing cell-multiplication of non-active cells
AU1466001A (en) * 1999-11-05 2001-05-14 Phase-1 Molecular Toxicology Methods of determining individual hypersensitivity to an agent
EP1534739A4 (en) * 2002-01-18 2006-05-31 Bristol Myers Squibb Co Identification of polynucleotides and polypeptide for predicting activity of compounds that interact with protein tyrosine kinases and/or protein tyrosine kinase pathways

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6160105A (en) * 1998-10-13 2000-12-12 Incyte Pharmaceuticals, Inc. Monitoring toxicological responses
US20020192671A1 (en) * 2001-01-23 2002-12-19 Castle Arthur L. Method and system for predicting the biological activity, including toxicology and toxicity, of substances

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1427850A4 *

Also Published As

Publication number Publication date
AU2002323286A1 (en) 2003-03-03
WO2003016500A2 (en) 2003-02-27
EP1427850A4 (en) 2006-02-08
EP1427850A2 (en) 2004-06-16

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