WO2002010456A3 - Multiparameter analysis for predictive medicine - Google Patents

Multiparameter analysis for predictive medicine Download PDF

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Publication number
WO2002010456A3
WO2002010456A3 PCT/US2001/024036 US0124036W WO0210456A3 WO 2002010456 A3 WO2002010456 A3 WO 2002010456A3 US 0124036 W US0124036 W US 0124036W WO 0210456 A3 WO0210456 A3 WO 0210456A3
Authority
WO
WIPO (PCT)
Prior art keywords
expression
molecules
health
sample
individual
Prior art date
Application number
PCT/US2001/024036
Other languages
French (fr)
Other versions
WO2002010456A2 (en
Inventor
Leroy E Hood
Andrew F Siegel
Original Assignee
Inst Systems Biology
Leroy E Hood
Andrew F Siegel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/724,898 external-priority patent/US7567870B1/en
Application filed by Inst Systems Biology, Leroy E Hood, Andrew F Siegel filed Critical Inst Systems Biology
Priority to EP01956060A priority Critical patent/EP1346063A2/en
Priority to AU2001278097A priority patent/AU2001278097A1/en
Publication of WO2002010456A2 publication Critical patent/WO2002010456A2/en
Publication of WO2002010456A3 publication Critical patent/WO2002010456A3/en

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
    • G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
    • G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10—Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6851—Quantitative amplification
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00—ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Theoretical Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Molecular Biology (AREA)
  • Evolutionary Biology (AREA)
  • Data Mining & Analysis (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Databases & Information Systems (AREA)
  • Biomedical Technology (AREA)
  • Primary Health Care (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The invention provides a method of determining a comparative expression profile in an individual by comparing the expression levels of a sample of molecules in a population of molecules in a speciment from the individual with a health-associated reference expression region of the sample of molecules, wherein expression levels within the health-associated reference expression region indicate a reference expression profile and wherein expression levels outside the health-associated reference expression region indicate a perturbed expression profile. The invention also provides methods of diagnosing a disease or a health state in an individual by comparing the expression level of a sample of molecules in a specimen from the individual with a health-associated reference expression region of the sample of molecules. The invention additionally provides a method of classifying a population by drug responsiveness.
PCT/US2001/024036 2000-07-31 2001-07-30 Multiparameter analysis for predictive medicine WO2002010456A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP01956060A EP1346063A2 (en) 2000-07-31 2001-07-30 Multiparameter analysis for predictive medicine
AU2001278097A AU2001278097A1 (en) 2000-07-31 2001-07-30 Multiparameter analysis for predictive medicine

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22180300P 2000-07-31 2000-07-31
US60/221,803 2000-07-31
US22632800P 2000-08-17 2000-08-17
US60/226,328 2000-08-17
US09/724,898 US7567870B1 (en) 2000-07-31 2000-11-28 Multiparameter analysis for predictive medicine
US09/724,898 2000-11-28

Publications (2)

Publication Number Publication Date
WO2002010456A2 WO2002010456A2 (en) 2002-02-07
WO2002010456A3 true WO2002010456A3 (en) 2003-06-26

Family

ID=27396998

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/024036 WO2002010456A2 (en) 2000-07-31 2001-07-30 Multiparameter analysis for predictive medicine

Country Status (3)

Country Link
EP (1) EP1346063A2 (en)
AU (1) AU2001278097A1 (en)
WO (1) WO2002010456A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6873914B2 (en) 2001-11-21 2005-03-29 Icoria, Inc. Methods and systems for analyzing complex biological systems
WO2003100541A2 (en) * 2002-05-24 2003-12-04 Global Genomics Ab Methods for profiling molecules with an objective function
AU2003245035A1 (en) * 2003-05-14 2004-12-03 Clinigene International Private Limited Disease predictions
US20050250125A1 (en) * 2003-12-19 2005-11-10 Novakoff James L Method for conducting pharmacogenomics-based studies
US20080228699A1 (en) 2007-03-16 2008-09-18 Expanse Networks, Inc. Creation of Attribute Combination Databases
US20090043752A1 (en) 2007-08-08 2009-02-12 Expanse Networks, Inc. Predicting Side Effect Attributes
US7917438B2 (en) 2008-09-10 2011-03-29 Expanse Networks, Inc. System for secure mobile healthcare selection
US8200509B2 (en) 2008-09-10 2012-06-12 Expanse Networks, Inc. Masked data record access
US8108406B2 (en) 2008-12-30 2012-01-31 Expanse Networks, Inc. Pangenetic web user behavior prediction system
EP3276526A1 (en) 2008-12-31 2018-01-31 23Andme, Inc. Finding relatives in a database
CN103392183B (en) 2010-12-20 2017-05-10 皇家飞利浦电子股份有限公司 Systems for identifying patients with mild cognitive impairment at risk of converting to alzheimer's

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053319A2 (en) * 1997-05-21 1998-11-26 The Johns Hopkins University Gene expression profiles in normal and cancer cells
WO2000070340A2 (en) * 1999-05-14 2000-11-23 Karolinska Innovations Ab Materials and methods relating to disease diagnosis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998053319A2 (en) * 1997-05-21 1998-11-26 The Johns Hopkins University Gene expression profiles in normal and cancer cells
WO2000070340A2 (en) * 1999-05-14 2000-11-23 Karolinska Innovations Ab Materials and methods relating to disease diagnosis

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ABE S: "Training of a fuzzy classifier with ellipsoidal regions by dynamic cluster generation", KNOWLEDGE-BASED INTELLIGENT ELECTRONIC SYSTEMS, 1998. PROCEEDINGS KES '98. 1998 SECOND INTERNATIONAL CONFERENCE ON ADELAIDE, SA, AUSTRALIA 21-23 APRIL 1998, NEW YORK, NY, USA,IEEE, US, 21 April 1998 (1998-04-21), pages 126 - 131, XP010310114, ISBN: 0-7803-4316-6 *
ALON U ET AL: "BROAD PATTERNS OF GENE EXPRESSION REVEALED BY CLUSTERING ANALYSIS OF TUMOR AND NORMAL COLON TISSUES PROBED BY OLIGONUCLEOTIDE ARRAYS", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, 1999, pages 6745 - 6750, XP000900484, ISSN: 0027-8424 *
BEN-DOR A ET AL: "TISSUE CLASSIFICATION WITH GENE EXPRESSION PROFILES", RECOMB 2000. PROCEEDINGS OF THE 4TH. ANNUAL INTERNATIONAL CONFERENCE ON COMPUTATIONAL MOLECULAR BIOLOGY. TOKYO, JAPAN, APRIL 8 - 11, 2000, PROCEEDINGS OF THE ANNUAL INTERNATIONAL CONFERENCE ON COMPUTATIONAL MOLECULAR BIOLOGY, NEW YORK, NY: ACM, US, vol. CONF.4, 8 April 2000 (2000-04-08), pages 54 - 64, XP001049478, ISBN: 1-58113-186-0 *
CLAVERIE J-M: "COMPUTATIONAL METHODS FOR THE IDENTIFICATION OF DIFFERENTIAL AND COORDINATED GENE EXPRESSION", HUMAN MOLECULAR GENETICS, OXFORD UNIVERSITY PRESS, SURREY, GB, vol. 8, no. 10, 1999, pages 1821 - 1832, XP001061494, ISSN: 0964-6906 *
GOLUB T R ET AL: "Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 286, no. 5439, 15 October 1999 (1999-10-15), pages 531 - 537, XP002207658, ISSN: 0036-8075 *
SCHERF U ET AL: "A gene expression database for the molecular pharmacology of cancer", NATURE GENETICS, NATURE AMERICA, NEW YORK, US, vol. 24, no. 3, March 2000 (2000-03-01), pages 236 - 244, XP002224798, ISSN: 1061-4036 *
TAMAYO P ET AL: "INTERPRETING PATTERNS OF GENE EXPRESSION WITH SELF-ORGANIZING MAPS:METHODS AND APPLICATION TO HEMATOPOIETIC DIFFERENTIATION", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, NATIONAL ACADEMY OF SCIENCE. WASHINGTON, US, vol. 96, March 1999 (1999-03-01), pages 2907 - 2912, XP000942169, ISSN: 0027-8424 *

Also Published As

Publication number Publication date
WO2002010456A2 (en) 2002-02-07
AU2001278097A1 (en) 2002-02-13
EP1346063A2 (en) 2003-09-24

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