WO2003014297A3 - Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine - Google Patents

Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine Download PDF

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Publication number
WO2003014297A3
WO2003014297A3 PCT/US2002/024310 US0224310W WO03014297A3 WO 2003014297 A3 WO2003014297 A3 WO 2003014297A3 US 0224310 W US0224310 W US 0224310W WO 03014297 A3 WO03014297 A3 WO 03014297A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene cluster
biosynthetic gene
compositions
nucleic acid
acid molecules
Prior art date
Application number
PCT/US2002/024310
Other languages
English (en)
Other versions
WO2003014297A2 (fr
Inventor
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Marie Francoise Coeffet-Legal
Original Assignee
Cubist Pharm Inc
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Marie Francoise Coeffet-Legal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/032354 external-priority patent/WO2002059322A2/fr
Application filed by Cubist Pharm Inc, Vivian Pak Woon Miao, Paul Brian, Richard H Baltz, Marie Francoise Coeffet-Legal filed Critical Cubist Pharm Inc
Priority to IL16016902A priority Critical patent/IL160169A0/xx
Priority to CA002456552A priority patent/CA2456552A1/fr
Priority to JP2003519229A priority patent/JP2005508622A/ja
Priority to KR10-2004-7001843A priority patent/KR20040032891A/ko
Priority to EP02759231A priority patent/EP1421097A4/fr
Priority to AU2002324580A priority patent/AU2002324580A1/en
Publication of WO2003014297A2 publication Critical patent/WO2003014297A2/fr
Publication of WO2003014297A3 publication Critical patent/WO2003014297A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes

Abstract

L'invention concerne des molécules d'acide nucléique comportant tout ou partie de la famille multigénique biosynthétique de la daptomycine. La famille multigénique biosynthétique de la daptomycine peut provenir des Streptomyces, de préférence des S. roseosporus. L'invention concerne par ailleurs d'autres molécules d'acides nucléiques issues de S. roseosporus. De plus, l'invention concerne des polypeptides codés par les molécules d'acides nucléiques précités, des anticorps qui se lient spécifiquement audits polypeptides, ainsi que des procédés d'utilisation de ces molécules d'acides nucléiques, polypeptides et anticorps pour produire de la daptomycine et d'autres composés encore.
PCT/US2002/024310 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine WO2003014297A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
IL16016902A IL160169A0 (en) 2001-08-06 2002-07-31 Nucleic acid molecules that encode a daptomycin non-ribosomal peptide synthetase and methods for the production thereof
CA002456552A CA2456552A1 (fr) 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine
JP2003519229A JP2005508622A (ja) 2001-08-06 2002-07-31 ダプトマイシン生合成遺伝子クラスターに関する組成物および方法
KR10-2004-7001843A KR20040032891A (ko) 2001-08-06 2002-07-31 답토마이신 생합성 유전자 클러스터에 관련된 조성물 및방법
EP02759231A EP1421097A4 (fr) 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine
AU2002324580A AU2002324580A1 (en) 2001-08-06 2002-07-31 Compositions and methods relating to the daptomycin biosynthetic gene cluster

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US31038501P 2001-08-06 2001-08-06
US60/310,385 2001-08-06
PCT/US2001/032354 WO2002059322A2 (fr) 2000-10-17 2001-10-17 Compositions et methodes liees a la famille de genes biosynthetiques de la daptomycine
USPCT/US01/32354 2001-10-17
US37986602P 2002-05-10 2002-05-10
US60/379,866 2002-05-10

Publications (2)

Publication Number Publication Date
WO2003014297A2 WO2003014297A2 (fr) 2003-02-20
WO2003014297A3 true WO2003014297A3 (fr) 2003-05-22

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024310 WO2003014297A2 (fr) 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine

Country Status (3)

Country Link
EP (1) EP1421097A4 (fr)
CA (1) CA2456552A1 (fr)
WO (1) WO2003014297A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0517830A (pt) * 2004-11-12 2008-10-21 Cubist Pharm Inc lipopeptìdeos antiinfecciosos
CN101830970B (zh) * 2009-03-12 2012-06-27 成都雅途生物技术有限公司 一种高纯度达托霉素(Daptomycin)的纯化制备方法
CN102260700B (zh) * 2010-09-24 2014-03-26 天津大学 玫瑰孢链霉菌基因工程菌hp-orf53-55的构建方法及其应用
CN102206694B (zh) * 2011-04-06 2013-10-16 山东新时代药业有限公司 一种含有癸酸的缓释组合物
EP2970928A4 (fr) 2013-03-15 2017-02-15 Modular Genetics, Inc. Production d'acides aminés acylés
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
CN110408603B (zh) * 2019-08-01 2022-09-23 上海交通大学 脂酰选择性改变的a54145c1突变体及其构建和应用
CN113717909A (zh) * 2020-05-26 2021-11-30 杭州中美华东制药有限公司 一种达托霉素高产菌株及其应用
CN111575251B (zh) * 2020-05-29 2022-03-11 上海交通大学 一种用于达托霉素生物合成的dptC1突变体的构建
CN112089823B (zh) * 2020-09-25 2024-02-06 珠海中科先进技术研究院有限公司 一种短梗霉素a和制霉菌素组合物及其复合软膏、凝胶剂以及喷剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827689A (en) * 1996-11-13 1998-10-27 Smithkline Beecham Corporation FabD polynucleotides
US6258934B1 (en) * 1997-01-24 2001-07-10 Smithkline Beecham Corporation FabD

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MCHENNEY M.A. ET AL.: "Gene transfer and transposition mutagenesis in streptomyces roseosporus: mapping of insertions that influence daptomycin or pigment production", MICROBIOLOGY, vol. 142, September 1996 (1996-09-01), pages 2363 - 2373, XP000946801 *
MCHENNEY M.A. ET AL.: "Molecular cloning and physical mapping of the daptomycin gene cluster from streptomyces roseosporus", J. BACTERIOL., vol. 180, no. 1, January 1998 (1998-01-01), pages 143 - 151, XP002961809 *
MOOTZ H.D. ET AL.: "Design and application of multimodular peptide synthetases", CURRENT OPINION IN BIOTECHNOLOGY, vol. 10, no. 4, 1999, pages 341 - 348, XP000892842 *
See also references of EP1421097A4 *

Also Published As

Publication number Publication date
EP1421097A2 (fr) 2004-05-26
EP1421097A4 (fr) 2005-07-06
WO2003014297A2 (fr) 2003-02-20
CA2456552A1 (fr) 2003-02-20

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