EP1421097A4 - Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine - Google Patents

Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine

Info

Publication number
EP1421097A4
EP1421097A4 EP02759231A EP02759231A EP1421097A4 EP 1421097 A4 EP1421097 A4 EP 1421097A4 EP 02759231 A EP02759231 A EP 02759231A EP 02759231 A EP02759231 A EP 02759231A EP 1421097 A4 EP1421097 A4 EP 1421097A4
Authority
EP
European Patent Office
Prior art keywords
compositions
gene cluster
methods relating
biosynthetic gene
daptomycin biosynthetic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP02759231A
Other languages
German (de)
English (en)
Other versions
EP1421097A2 (fr
Inventor
Vivian Pak Woon Miao
Paul Brian
Richard H Baltz
Marie Francoise Coeffet-Legal
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cubist Pharmaceuticals LLC
Original Assignee
Cubist Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2001/032354 external-priority patent/WO2002059322A2/fr
Application filed by Cubist Pharmaceuticals LLC filed Critical Cubist Pharmaceuticals LLC
Publication of EP1421097A2 publication Critical patent/EP1421097A2/fr
Publication of EP1421097A4 publication Critical patent/EP1421097A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
EP02759231A 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine Withdrawn EP1421097A4 (fr)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31038501P 2001-08-06 2001-08-06
US310385P 2001-08-06
WOPCT/US01/32354 2001-10-17
PCT/US2001/032354 WO2002059322A2 (fr) 2000-10-17 2001-10-17 Compositions et methodes liees a la famille de genes biosynthetiques de la daptomycine
US37986602P 2002-05-10 2002-05-10
US379866P 2002-05-10
PCT/US2002/024310 WO2003014297A2 (fr) 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine

Publications (2)

Publication Number Publication Date
EP1421097A2 EP1421097A2 (fr) 2004-05-26
EP1421097A4 true EP1421097A4 (fr) 2005-07-06

Family

ID=27359112

Family Applications (1)

Application Number Title Priority Date Filing Date
EP02759231A Withdrawn EP1421097A4 (fr) 2001-08-06 2002-07-31 Compositions et procedes relatifs a la famille multigenique biosynthetique de la daptomycine

Country Status (3)

Country Link
EP (1) EP1421097A4 (fr)
CA (1) CA2456552A1 (fr)
WO (1) WO2003014297A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0517830A (pt) * 2004-11-12 2008-10-21 Cubist Pharm Inc lipopeptìdeos antiinfecciosos
CN101830970B (zh) * 2009-03-12 2012-06-27 成都雅途生物技术有限公司 一种高纯度达托霉素(Daptomycin)的纯化制备方法
CN102260700B (zh) * 2010-09-24 2014-03-26 天津大学 玫瑰孢链霉菌基因工程菌hp-orf53-55的构建方法及其应用
CN102206694B (zh) * 2011-04-06 2013-10-16 山东新时代药业有限公司 一种含有癸酸的缓释组合物
EP2970928A4 (fr) 2013-03-15 2017-02-15 Modular Genetics, Inc. Production d'acides aminés acylés
US11371066B2 (en) 2015-07-13 2022-06-28 Modular Genetics, Inc. Generation of acyl alcohols
CN110408603B (zh) * 2019-08-01 2022-09-23 上海交通大学 脂酰选择性改变的a54145c1突变体及其构建和应用
CN113717909A (zh) * 2020-05-26 2021-11-30 杭州中美华东制药有限公司 一种达托霉素高产菌株及其应用
CN111575251B (zh) * 2020-05-29 2022-03-11 上海交通大学 一种用于达托霉素生物合成的dptC1突变体的构建
CN112089823B (zh) * 2020-09-25 2024-02-06 珠海中科先进技术研究院有限公司 一种短梗霉素a和制霉菌素组合物及其复合软膏、凝胶剂以及喷剂

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827689A (en) * 1996-11-13 1998-10-27 Smithkline Beecham Corporation FabD polynucleotides
US6258934B1 (en) * 1997-01-24 2001-07-10 Smithkline Beecham Corporation FabD

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827689A (en) * 1996-11-13 1998-10-27 Smithkline Beecham Corporation FabD polynucleotides
US6258934B1 (en) * 1997-01-24 2001-07-10 Smithkline Beecham Corporation FabD

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL [online] 15 October 1997 (1997-10-15), "Streptomyces roseosporus daptomycin biosynthetic protein subunit gene, partial cds.", XP002313744, retrieved from EBI accession no. EM_PRO:AF021262 Database accession no. AF021262 *
MCHENNEY M A ET AL: "Molecular cloning and physical mapping of the daptomycin gene cluster from streptomyces roseosporus", JOURNAL OF BACTERIOLOGY, WASHINGTON, DC, US, vol. 180, no. 1, January 1998 (1998-01-01), pages 143 - 151, XP002961809, ISSN: 0021-9193 *
See also references of WO03014297A2 *

Also Published As

Publication number Publication date
EP1421097A2 (fr) 2004-05-26
WO2003014297A3 (fr) 2003-05-22
WO2003014297A2 (fr) 2003-02-20
CA2456552A1 (fr) 2003-02-20

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