WO2003013565A1 - Functional materials, sod agonists, hypotensives and thrombolytics, process for producing the same and microbial strains to be used therein - Google Patents

Functional materials, sod agonists, hypotensives and thrombolytics, process for producing the same and microbial strains to be used therein Download PDF

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Publication number
WO2003013565A1
WO2003013565A1 PCT/JP2002/003726 JP0203726W WO03013565A1 WO 2003013565 A1 WO2003013565 A1 WO 2003013565A1 JP 0203726 W JP0203726 W JP 0203726W WO 03013565 A1 WO03013565 A1 WO 03013565A1
Authority
WO
WIPO (PCT)
Prior art keywords
sod
functional materials
microbial strains
hypotensives
thrombolytics
Prior art date
Application number
PCT/JP2002/003726
Other languages
French (fr)
Japanese (ja)
Inventor
Akihiko Kimura
Yuji Harada
Atsushi Takada
Asao Shioda
Toshio Izawa
Toshitaka Okada
Kaoru Yamashita
Original Assignee
Toyo Hakko Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2001241363A external-priority patent/JP2002121141A/en
Application filed by Toyo Hakko Co., Ltd. filed Critical Toyo Hakko Co., Ltd.
Publication of WO2003013565A1 publication Critical patent/WO2003013565A1/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/07—Bacillus

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Beans For Foods Or Fodder (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

Functional materials having excellent thrombolytic effect, SOD function and ACE function which are obtained by culturing bean broth. Sterilized bean broth is inoculated with one of microbial strains TOYO-11 to 13 (Deposition Nos. FERM BP-8011 to 8013) followed by shaking culture. After centrifuging the culture, the supernatant thus obtained is used as a functional material. These functional materials are excellent in the SOD activity (32.7 to 37.2%), ACE inhibitory activity (92.0 to 97.2%) and thrombolytic activity (25.0 FU/g or above) and show favorable taste and properties (in particular, stringiness) in the sensory evaluation as natto (total score: 4 to 5).
PCT/JP2002/003726 2001-08-08 2002-04-15 Functional materials, sod agonists, hypotensives and thrombolytics, process for producing the same and microbial strains to be used therein WO2003013565A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001241363A JP2002121141A (en) 2000-08-10 2001-08-08 Functional material, sod agent, hypotensive agent, thrombolytic agent, method for producing the same and stain used for method for producing the same
JP2001-241363 2001-08-08

Publications (1)

Publication Number Publication Date
WO2003013565A1 true WO2003013565A1 (en) 2003-02-20

Family

ID=19071820

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003726 WO2003013565A1 (en) 2001-08-08 2002-04-15 Functional materials, sod agonists, hypotensives and thrombolytics, process for producing the same and microbial strains to be used therein

Country Status (1)

Country Link
WO (1) WO2003013565A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104274615A (en) * 2014-09-16 2015-01-14 田清峰 Traditional Chinese medicinal composition for treating hypertension and preparation method thereof
CN104490999A (en) * 2014-12-08 2015-04-08 黄平县兴且民族民间中草医药科学发展有限责任公司 Traditional Chinese medicine for treating hypertension
CN104606421A (en) * 2015-02-06 2015-05-13 苏州市天灵中药饮片有限公司 Traditional Chinese medicine composition for treating hypertension and preparation method of traditional Chinese medicine composition

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180834A (en) * 1988-01-13 1989-07-18 Nippon Chem Res Kk Thrombolytic agent
JPH04117330A (en) * 1990-09-07 1992-04-17 Yakult Honsha Co Ltd Water extract from cell having antihypertensive action and antihypertensive agent
JPH05246865A (en) * 1992-03-04 1993-09-24 Kikkoman Corp Production of nicotianamine and healthy food containing the same
JPH06284872A (en) * 1991-10-31 1994-10-11 Toyo Hakko:Kk Health and beauty promoter, blood pressure suppressor and constipation improver having sod action
JPH07289281A (en) * 1994-04-28 1995-11-07 Nichimo Co Ltd Product containing inhibitor of angiotensin-converting enzyme and its production
JPH0853364A (en) * 1994-08-10 1996-02-27 Nippon Chem Res Kk Thrombolytic agent for injection
JPH0881381A (en) * 1994-09-09 1996-03-26 Toyo Hakko:Kk Health and beauty-promoting agent having sod action, blood pressure-suppressing agent and constipation-improving agent
JPH08208512A (en) * 1995-02-03 1996-08-13 Nippon Chem Res Kk Medicine for inhibiting thrombogenesis
JPH09182583A (en) * 1995-12-29 1997-07-15 Chieko Yatagai Enzyme activating prourokinase and collection of the same
JPH09309839A (en) * 1996-05-21 1997-12-02 Hiroyuki Sumi Platelet coagulation inhibiting material
JP2000229996A (en) * 1999-02-08 2000-08-22 Toyo Hakko:Kk Octapeptide, angiotensin i converting enzyme inhibitory peptide and its production
JP2001299277A (en) * 2000-04-21 2001-10-30 Nippon Seibutsu Kagaku Kenkyusho:Kk Extract from bacillus natto culture mixture
JP2002065294A (en) * 2000-09-01 2002-03-05 Hiroyuki Sumi Fibrinolysis enhancing substance and method for obtaining the same

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01180834A (en) * 1988-01-13 1989-07-18 Nippon Chem Res Kk Thrombolytic agent
JPH04117330A (en) * 1990-09-07 1992-04-17 Yakult Honsha Co Ltd Water extract from cell having antihypertensive action and antihypertensive agent
JPH06284872A (en) * 1991-10-31 1994-10-11 Toyo Hakko:Kk Health and beauty promoter, blood pressure suppressor and constipation improver having sod action
JPH05246865A (en) * 1992-03-04 1993-09-24 Kikkoman Corp Production of nicotianamine and healthy food containing the same
JPH07289281A (en) * 1994-04-28 1995-11-07 Nichimo Co Ltd Product containing inhibitor of angiotensin-converting enzyme and its production
JPH0853364A (en) * 1994-08-10 1996-02-27 Nippon Chem Res Kk Thrombolytic agent for injection
JPH0881381A (en) * 1994-09-09 1996-03-26 Toyo Hakko:Kk Health and beauty-promoting agent having sod action, blood pressure-suppressing agent and constipation-improving agent
JPH08208512A (en) * 1995-02-03 1996-08-13 Nippon Chem Res Kk Medicine for inhibiting thrombogenesis
JPH09182583A (en) * 1995-12-29 1997-07-15 Chieko Yatagai Enzyme activating prourokinase and collection of the same
JPH09309839A (en) * 1996-05-21 1997-12-02 Hiroyuki Sumi Platelet coagulation inhibiting material
JP2000229996A (en) * 1999-02-08 2000-08-22 Toyo Hakko:Kk Octapeptide, angiotensin i converting enzyme inhibitory peptide and its production
JP2001299277A (en) * 2000-04-21 2001-10-30 Nippon Seibutsu Kagaku Kenkyusho:Kk Extract from bacillus natto culture mixture
JP2002065294A (en) * 2000-09-01 2002-03-05 Hiroyuki Sumi Fibrinolysis enhancing substance and method for obtaining the same

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
AKIKO OKAMOTO ET AL.: "Angiotensin I converting enzyme inhibitory activities of various fermented foods", BIOSCI. BIOTECH. BIOCHEM., vol. 59, no. 3, 1995, pages 1147 - 1149, XP002955071 *
HIROYUKI SUMI ET AL.: "Hakko daizu no kassei sanso shokyokei, tokuni SOD-zai to shiteno natto", THE FOOD INDUSTRY, vol. 41, no. 14, 1998, pages 49 - 55, XP002955073 *
YOKO MIYAMOTO ET AL.: "SOD-like activities of rice bran extracts fermentation", NIPPON SHOKUHIN KAGAKU KOGAKU KAISHI, vol. 47, no. 3, 2000, pages 214 - 219, XP002955072 *
YOUKOU SUMI ET AL.: "The method of determination of thrombolytic enzyme nattokinese", J. BREW. SOC. JAPAN, vol. 88, no. 6, 1993, pages 482 - 486, XP002955074 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104274615A (en) * 2014-09-16 2015-01-14 田清峰 Traditional Chinese medicinal composition for treating hypertension and preparation method thereof
CN104490999A (en) * 2014-12-08 2015-04-08 黄平县兴且民族民间中草医药科学发展有限责任公司 Traditional Chinese medicine for treating hypertension
CN104606421A (en) * 2015-02-06 2015-05-13 苏州市天灵中药饮片有限公司 Traditional Chinese medicine composition for treating hypertension and preparation method of traditional Chinese medicine composition

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