WO2003013454A1 - New preservative systems and their use in cosmetic preparations - Google Patents
New preservative systems and their use in cosmetic preparations Download PDFInfo
- Publication number
- WO2003013454A1 WO2003013454A1 PCT/EP2001/009200 EP0109200W WO03013454A1 WO 2003013454 A1 WO2003013454 A1 WO 2003013454A1 EP 0109200 W EP0109200 W EP 0109200W WO 03013454 A1 WO03013454 A1 WO 03013454A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- ionic
- preservative
- weight
- preservative system
- cosmetic
- Prior art date
Links
- IOZMMUHGXBCNAO-UHFFFAOYSA-N CC1=CN=[IH](C)CN1 Chemical compound CC1=CN=[IH](C)CN1 IOZMMUHGXBCNAO-UHFFFAOYSA-N 0.000 description 1
- QYDKMKSHGQKMRW-PLNGDYQASA-N CCN/C(/C)=C\N Chemical compound CCN/C(/C)=C\N QYDKMKSHGQKMRW-PLNGDYQASA-N 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N33/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic nitrogen compounds
- A01N33/02—Amines; Quaternary ammonium compounds
- A01N33/12—Quaternary ammonium compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical at least one of the bonds to hetero atoms is to nitrogen
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/10—Aromatic or araliphatic carboxylic acids, or thio analogues thereof; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N39/00—Biocides, pest repellants or attractants, or plant growth regulators containing aryloxy- or arylthio-aliphatic or cycloaliphatic compounds, containing the group or, e.g. phenoxyethylamine, phenylthio-acetonitrile, phenoxyacetone
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/80—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,2
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/28—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N<
- A01N47/36—Ureas or thioureas containing the groups >N—CO—N< or >N—CS—N< containing the group >N—CO—N< directly attached to at least one heterocyclic ring; Thio analogues thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/52—Stabilizers
- A61K2800/524—Preservatives
Definitions
- This invention relates to new preservative systems for cosmetic preparations.
- LAE cationic surfactants derived from lauric acid and arginine are protective substances against micro-organisms, in particular, the ethyl ester of the lauramide of the arginine monohydrochloride, hereafter referred to as LAE.
- LAE has the chemical structure of formula (1).
- the compound LAE is remarkable for its activity against different micro-organism, like the bacteria, fungi and yeast which can be present in cosmetic formulations and preparations, and its innocuity for humans.
- a preservative system which comprises a cationic surfactant, derived from the condensation of fatty acids and esterified dibasic amino acids, having the formula: where:
- X " is Br " , Cf, or HS0 4 "
- R 1 is a straight alkyl chain from an acid or saturated fatty hydroxy acid from 8 to 14 atoms of carbon bonded to the ⁇ - amino acid group through amidic bond,
- R 2 is a straight or branched alkyl chain from 1 to 18 carbon atoms or an aromatic group and
- R 3 is:
- n is from 0 to 4, and at least one other ionic or non-ionic preservative agent.
- This preservative system is characterised for its synergetic activity. It has now been found that the antimicrobial activity of the combinations of LAE and the other compounds defined by the above formula (1) with most of the common ionic and non-ionic preservatives used to protect cosmetic formulations and preparations is higher than the activity displayed by each of the components when used alone at the same dosage. There has been observed synergism when the amounts of the compounds of formula (1) and the other antimicrobial are reduced. Thus, the adverse toxic effects and/or irritation and/or allergy displayed by the combinations of the preservatives have also been reduced.
- the cationic surfactant preservative derived from the condensation of fatty acids and esterified dibasic amino acid is LAE, since this compound displays the most effective properties with respect to the antimicrobial activity in the preservative system of the invention.
- LAE can be used in association with other ionic preservatives, such as 2-bromo-2-nitro-1,3- propanediol (bronopol) and/or parabens and/or imidazolidinyl urea and/or 2-phenoxyethanol and/or 1,3-dimethylol-5,5-dimethylhydantoin and/or 2-methyl-5-chloro-3,4-isothiazolinone / 2-methyl-3,4- isothiazolinone and/or quatemium-15, for cosmetic formulations and preparations that are applied to the epidermis, the capillary system, lips, nails, external genital organs, or on the teeth and in the mouth cavity mucous membranes, in order to clean, perfume, or modify their aspect and/or change body smells and/or protect a good physical state.
- ionic preservatives such as 2-bromo-2-nitro-1,3- propanediol (bronopol) and/or parabens and/or
- these preservative systems based on LAE protect against the growth of micro-organisms in the cosmetic formulations and preparations in which these are susceptible to grow, and against contamination with micro-organisms which are introduced without purpose by the customer during normal use.
- the preservative system of the invention comprises the cationic surfactant of formula (1) in an amount from 0,001 to 2 % by weight and the concentration of the other ionic or non ionic preservative agent from 0,0001% to 3 % by weight relative to whole weight of the preservative system.
- the preservative system of the invention comprises more in particular a preferred amount of the ionic or non-ionic preservative agent from 0,001 to 0,1 % by weight of 2-bromo-2-nitro-1 ,3- propanediol (bronopol) and/or from 0,002 to 0,8% by weight of parabens and/or from 0,005 to 0,6% by weight of imidazolidinyl urea and/or from 0,01 to 1% by weight of 2-phenoxyethanoi and/or from 0,003 to 0,6% by weight of 1,3-dimethylol-5,5-dimethylhydantoin and/or from 0,00015% to 0,0015% by weight of 2-methyl 5-chloro-3,4-isothiazolinone / 2-methyl-3,4-isothiazolinone and/or from 0,001 to 0,2% by weight of quaternium-15.
- composition of this invention comprises a medium which is compatible with the skin, the mucous membranes, and hair.
- These compositions may contain the usual components such as: fatty compounds such as mineral oil, animal oil, vegetal oil, from synthesis and silicon, and also alcohols, fatty acids and waxes; organic solvents, surface active agents, solubilizers and ionic and non ionic emulsifiers, thickening agents and jellying hydrophilic agents such as carboxyvinylic polymers (e.g. carbomer), acrylic copolymers (e.g. acrylates and alkylacrylates), polyacrylamides, polysaccharides, natural gums (e.g.
- compositions can also contain preservatives which are different from the ones defined in the claims.
- preservatives which are different from the ones defined in the claims. The amounts of these usual components mentioned in the previous paragraph are the normal ones as used in the art. These components are added to the preservative systems of the invention without having any influence on their composition.
- compositions can be in different cosmetic forms suitable for a topic application, such as:
- compositions previously mentioned can also be used as a spray, or as aerosol compositions and can contain a propulsion agent under pressure.
- compositions of the invention can have the aspect of a cream, a lotion, a milk, an emulsion, a gel or an oil for the skin, a beauty mask, a salt, a gel, a foam/spray or an oil for a bath and shower, or for make-up and make-up cleaner of the face and eyes and anyway aspect to be shown.
- compositions according to the invention have been prepared according to usual techniques well known for an expert in the matter.
- the method used to evaluate the efficacy is based on the Antimicrobial Effectiveness Testing USP 24 th Edition, 1999 (pp. 1809-1811), in order to demonstrate that the antimicrobial activity of the composition of the invention is effective in avoiding microbial growth which might be present during storage and use of the preparation, and preventing the adverse effects of the contamination (Real Farmacopea Espanola, 1 st Edici ⁇ n, 1997).
- This assay consists on the contamination of the formulations to be protected with a mixed inoculum of 10 8 cfu/ml concentration, in each of the micro-organisms, and see the variation of the viable cells in time.
- This mixed inoculum is composed of the following micro-organisms:
- the cosmetic composition which is the subject of the investigation is divided into containers with 50 g of product for each flask. Each container is inoculated with 0.5 ml of the inoculum (10 8 cfu/ml). The target concentration is 10 6 cfu/mL, approximately. All the containers are kept at a temperature between 20-25° C and are protected against light. The level of the microbial contamination is determined at 0 hours and after 7 days, 14 days and 28 days. The number of colonies is determined by dilution in buffer peptone with the appropriate neutraliser agent of the preservative.
- the culture media used for counting the micro-organisms were: Soya triptone agar (35-37 °C, 48 hours) for the determination of bacteria; and Sabouraud agar with chloramphenicol for fungi and yeast (25°C, 3-5 days).
- an antimicrobial preservative is considered to be effective in topically used products made with aqueous bases or vehicles, non-sterile nasal products and emulsions, including those applied to mucous membranes, if:
- composition of the cosmetic formulation in oil in water emulsion with non-ionic surfactant is (in g):
- composition of a cosmetic formulation in oil in water emulsion with an ionic emulsifier is (in g):
- This formulation was completed with a suitable amount of the preservative system of the invention and its capacity of preservation was evaluated against the formulations with preservatives used alone.
- composition of a cosmetic formulation containing a water in oil emulsion with non- ionic emulsifier is (in g)
- composition of a formulation to obtain an aqueous solution with a mixture of surfactants is (in g):
- This formulation is applied in bath gels.
- composition of a formulation to obtain an aqueous solution with a mixture of surfactants is (in g):
- composition of a formulation to obtain a hydro-alcoholic gel is (in g):
- This formulation is applied in lotions for skin care after shaving.
- composition of a formulation to obtain a tonic for the face is (in g):
- composition of a formulation to obtain a mask-up cleaner is (in g):
- composition of a formulation to obtain a fluid oil-in-water emulsion with non-ionic surfactants is (in g):
- composition of a toothpaste formulation is (in g):
- composition to obtain an aqueous solution with surfactants is (in g):
- This formulation is applied as a shampoo.
- composition of a formulation to obtain an oil-in-water emulsion with non-ionic surfactants (in g):
- This formulation is applied as a face cream for skin care.
- composition of a formulation to obtain an oil-in-water emulsion with non-ionic surfactants (in g):
- composition of a formulation to obtain an oil in water emulsion with non-ionic surfactants is n g):
- This formulation is applied as a sun protector cosmetic product.
- composition of a formulation to obtain an emulsion for hands care is (in g):
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Environmental Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- Plant Pathology (AREA)
- Agronomy & Crop Science (AREA)
- Zoology (AREA)
- Pest Control & Pesticides (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
Claims
Priority Applications (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2455983A CA2455983C (en) | 2001-08-09 | 2001-08-09 | Preservative systems and their use in cosmetic preparations |
DE60139032T DE60139032D1 (en) | 2001-08-09 | 2001-08-09 | NEW CONSERVATION SYSTEMS AND THEIR USE IN COSMETIC MEANS |
US10/484,226 US7758851B2 (en) | 2001-08-09 | 2001-08-09 | Preservative systems and their use in cosmetic preparations |
BRPI0114154-6A BR0114154B1 (en) | 2001-08-09 | 2001-08-09 | Cosmetic and / or dermatological composition comprising a preservative system and use of said preservative system |
PCT/EP2001/009200 WO2003013454A1 (en) | 2001-08-09 | 2001-08-09 | New preservative systems and their use in cosmetic preparations |
AT01962924T ATE433663T1 (en) | 2001-08-09 | 2001-08-09 | NEW PRESERVATION SYSTEMS AND THEIR USE IN COSMETIC PRODUCTS |
MXPA04001169A MXPA04001169A (en) | 2001-08-09 | 2001-08-09 | New preservative systems and their use in cosmetic preparations. |
EP01962924A EP1414394B1 (en) | 2001-08-09 | 2001-08-09 | New preservative systems and their use in cosmetic preparations |
ES01962924T ES2324979T3 (en) | 2001-08-09 | 2001-08-09 | NEW CONSERVATIVE SYSTEMS AND THEIR USE IN COSMETIC PREPARATIONS. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2001/009200 WO2003013454A1 (en) | 2001-08-09 | 2001-08-09 | New preservative systems and their use in cosmetic preparations |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003013454A1 true WO2003013454A1 (en) | 2003-02-20 |
Family
ID=8164535
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2001/009200 WO2003013454A1 (en) | 2001-08-09 | 2001-08-09 | New preservative systems and their use in cosmetic preparations |
Country Status (9)
Country | Link |
---|---|
US (1) | US7758851B2 (en) |
EP (1) | EP1414394B1 (en) |
AT (1) | ATE433663T1 (en) |
BR (1) | BR0114154B1 (en) |
CA (1) | CA2455983C (en) |
DE (1) | DE60139032D1 (en) |
ES (1) | ES2324979T3 (en) |
MX (1) | MXPA04001169A (en) |
WO (1) | WO2003013454A1 (en) |
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2007014580A1 (en) * | 2005-08-01 | 2007-02-08 | Laboratorios Miret, S.A. | Preservative systems comprising cationic surfactants |
WO2007112379A2 (en) * | 2006-03-27 | 2007-10-04 | Ethicon, Inc. | Antimicrobial composition |
WO2009033508A2 (en) | 2007-09-13 | 2009-03-19 | Laboratorios Miret, S.A. | Combinations of polyene fungicide with cationic surfactants |
US20090163445A1 (en) * | 2007-12-20 | 2009-06-25 | Diehl Megan A | Synergistic microbicidal compositions |
WO2010000744A2 (en) | 2008-07-02 | 2010-01-07 | Laboratorios Miret, S.A. | Use of cationic surfactants as sporicidal agents |
WO2010057966A1 (en) * | 2008-11-21 | 2010-05-27 | Vedeqsa Inc. | Use of cationic surfactants for the inactivation of toxins |
WO2010084052A2 (en) | 2009-01-22 | 2010-07-29 | Laboratorios Miret, S. A. | Use of cationic surfactants as acaricidal agents |
DE102010002195A1 (en) | 2010-02-22 | 2011-08-25 | Henkel AG & Co. KGaA, 40589 | Oral and dental care and cleanser with ethyl laurolginate |
DE102010002194A1 (en) | 2010-02-22 | 2011-08-25 | Henkel AG & Co. KGaA, 40589 | Desensitizing oral and dental care and cleaning products containing ethyl lauroylarginate |
WO2011119517A2 (en) | 2010-03-23 | 2011-09-29 | Gojo Industries, Inc. | Antimicrobial compositions |
KR101102491B1 (en) * | 2007-07-18 | 2012-01-05 | 롬 앤드 하아스 컴패니 | Microbicidal Composition |
WO2012013577A1 (en) | 2010-07-26 | 2012-02-02 | Laboratorios Miret, S.A. | Composition for coating medical devices containing lae and a polycationic amphoteric polymer |
WO2012055855A1 (en) * | 2010-10-29 | 2012-05-03 | Laboratorios Miret, S.A. | Concentrated preparations of lae and their use |
WO2011124245A3 (en) * | 2010-03-29 | 2012-07-05 | Beiersdorf Ag | Microbiologically stable, easily applicable preparations comprising anionic or cationic active substances |
WO2011124241A3 (en) * | 2010-03-29 | 2012-07-05 | Beiersdorf Ag | Microbiologically stable, easily applicable preparations |
US8287843B2 (en) | 2003-06-23 | 2012-10-16 | Colgate-Palmolive Company | Antiplaque oral care compositions |
WO2011124242A3 (en) * | 2010-03-29 | 2013-01-31 | Beiersdorf Ag | Microbiologically stable, easily applicable w/o preparations |
WO2011124243A3 (en) * | 2010-03-29 | 2013-01-31 | Beiersdorf Ag | Microbiologically stable, easily applicable preparation comprising thickening agents |
EP2666357A1 (en) * | 2008-01-25 | 2013-11-27 | Rhodia Opérations | Liquid preservative compositions |
US8795638B1 (en) | 2003-08-26 | 2014-08-05 | Nevada Naturals Inc. | Compositions for dental care |
WO2012164061A3 (en) * | 2011-06-03 | 2014-09-12 | Laboratorios Miret, S.A. | Cosmetic preparations against dandruff |
US8865135B2 (en) | 2003-06-23 | 2014-10-21 | Colgate-Palmolive Company | Stable dentifrice compositions |
WO2014197344A1 (en) | 2013-06-06 | 2014-12-11 | 3M Innovative Properties Company | Successively peelable coextruded polymer film with embedded antimicrobial layer(s) |
EP2907387A1 (en) | 2006-12-11 | 2015-08-19 | 3M Innovative Properties Company of 3M Center | Biocompatible antimicrobial compositions |
WO2016077464A1 (en) | 2014-11-11 | 2016-05-19 | Johnson & Johnson Consumer Inc. | Amino acid derivatives and their uses |
EP3527192A1 (en) | 2014-11-11 | 2019-08-21 | Johnson & Johnson Consumer Inc. | Amino acid derivatives and their uses |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2455981C (en) * | 2001-08-09 | 2012-10-09 | Joan Baptista Urgell Beltran | Use of cationic surfactants in cosmetic preparations |
US7758851B2 (en) | 2001-08-09 | 2010-07-20 | Laboratorios Miret, S.A. | Preservative systems and their use in cosmetic preparations |
CA2464388C (en) * | 2001-10-25 | 2010-07-06 | Laboratorios Miret, S.A. | Use of cationic preservative in food products |
WO2003064669A1 (en) * | 2002-02-01 | 2003-08-07 | Laboratorios Miret, S.A. | ENZYMATIC SYNTHESIS OF Nα-ACYL-L-ARGININE ESTERS |
DE60223598T2 (en) * | 2002-05-08 | 2008-03-06 | Laboratorios Miret, S.A., Les Fonts-Terrassa | NEW PRESERVATIVES AND PRESERVATION SYSTEMS |
US8926997B1 (en) | 2003-02-06 | 2015-01-06 | Richard F. Stockel | Polymeric biocidal salts |
US20100173993A1 (en) * | 2003-02-06 | 2010-07-08 | Sawyer Anthony J | Controlled release biocidal salts |
US20100056628A1 (en) * | 2006-09-07 | 2010-03-04 | Stockel Richard F | Preservative compositions |
US8193244B1 (en) | 2008-05-29 | 2012-06-05 | Nevada Naturals, Inc. | Antimicrobial agents |
US9023891B2 (en) | 2008-05-29 | 2015-05-05 | Nevada Naturals, Inc. | Synergistic antimicrobial agents |
GB0822823D0 (en) * | 2008-12-15 | 2009-01-21 | Dow Corning | Silicone oi-in-water emulsions |
DE102010013277A1 (en) * | 2010-03-29 | 2011-09-29 | Beiersdorf Ag | Microbiologically stable application-friendly preparation with degradation-susceptible active ingredients |
DE102010038952A1 (en) | 2010-08-05 | 2012-02-09 | Henkel Ag & Co. Kgaa | Preservative compositions and cosmetics containing these |
US8834857B1 (en) | 2011-01-18 | 2014-09-16 | Nevada Naturals Inc. | Deodorizing and skin cleaning |
DE102011089407A1 (en) | 2011-12-21 | 2013-06-27 | Henkel Ag & Co. Kgaa | Preservative compositions and cosmetics containing these |
WO2013103556A1 (en) * | 2012-01-05 | 2013-07-11 | The Trustees Of Columbia University In The City Of New York | Antimicrobial composition |
DE102012223401A1 (en) | 2012-12-17 | 2014-06-18 | Henkel Ag & Co. Kgaa | Emulsion with antibacterial agent |
DE102013226874A1 (en) | 2013-12-20 | 2014-04-17 | Henkel Ag & Co. Kgaa | Use of monoglyceryl ether compound, for killing gram-positive bacteria of the Lactobacillaceae family including Lactobacillus and Lactobacillus plantarum in a cosmetic product |
GB201505701D0 (en) * | 2015-04-02 | 2015-05-20 | Byotrol Plc | Anti-microbial composition |
US10646676B1 (en) | 2015-10-21 | 2020-05-12 | Breathe Safely, Inc. | CPAP living seal |
DE102015225006A1 (en) | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Surfactant-containing cleaning agents with special preservative combinations |
DE102015225003A1 (en) | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Emulsions containing at least three different preservatives |
DE102015225004A1 (en) | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Surfactant-containing cleaning agents with at least three different preservatives |
DE102015225005A1 (en) | 2015-12-11 | 2017-06-14 | Henkel Ag & Co. Kgaa | Emulsions containing at least one special preservative combination |
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DE102015225694A1 (en) | 2015-12-17 | 2017-06-22 | Henkel Ag & Co. Kgaa | Propellant-containing deodorant and / or antiperspirants with special preservative combinations |
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Also Published As
Publication number | Publication date |
---|---|
US20040166082A1 (en) | 2004-08-26 |
BR0114154B1 (en) | 2014-05-27 |
ATE433663T1 (en) | 2009-07-15 |
EP1414394B1 (en) | 2009-06-17 |
US7758851B2 (en) | 2010-07-20 |
DE60139032D1 (en) | 2009-07-30 |
CA2455983C (en) | 2010-06-01 |
MXPA04001169A (en) | 2005-02-17 |
ES2324979T3 (en) | 2009-08-21 |
EP1414394A1 (en) | 2004-05-06 |
BR0114154A (en) | 2003-07-29 |
CA2455983A1 (en) | 2003-02-20 |
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