WO2003013430A3 - Benzoquinone ansamycins - Google Patents

Benzoquinone ansamycins Download PDF

Info

Publication number
WO2003013430A3
WO2003013430A3 PCT/US2002/024891 US0224891W WO03013430A3 WO 2003013430 A3 WO2003013430 A3 WO 2003013430A3 US 0224891 W US0224891 W US 0224891W WO 03013430 A3 WO03013430 A3 WO 03013430A3
Authority
WO
WIPO (PCT)
Prior art keywords
useful
benzoquinone ansamycin
cancer
benzoquinone ansamycins
benzoquinone
Prior art date
Application number
PCT/US2002/024891
Other languages
French (fr)
Other versions
WO2003013430A2 (en
Inventor
Daniel Santi
David C Myles
Zong-Qiang Tian
C Richard Hutchinson
Robert Johnson
Yi-Qing Zhou
Li Feng
Original Assignee
Kosan Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Priority to CA002456175A priority Critical patent/CA2456175A1/en
Priority to EP02768436A priority patent/EP1420747A4/en
Priority to AU2002330998A priority patent/AU2002330998A1/en
Priority to JP2003518444A priority patent/JP2005515164A/en
Publication of WO2003013430A2 publication Critical patent/WO2003013430A2/en
Publication of WO2003013430A3 publication Critical patent/WO2003013430A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
    • C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D225/06—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems condensed with one six-membered ring

Abstract

The invention relates to benzoquinone ansamycin analogs useful for the treatment of cancer and other diseases or conditions characterized by undesired cellular proliferation or hyperproliferation. Therapies involving the administration of such benzoquinone ansamycin analogs, optionally in combination with an inhibitor of an HSP90 client protein, are useful to treat cancer and non-cancerous disease conditions.
PCT/US2002/024891 2001-08-06 2002-08-05 Benzoquinone ansamycins WO2003013430A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002456175A CA2456175A1 (en) 2001-08-06 2002-08-05 Benzoquinone ansamycins
EP02768436A EP1420747A4 (en) 2001-08-06 2002-08-05 Benzoquinone ansamycins
AU2002330998A AU2002330998A1 (en) 2001-08-06 2002-08-05 Benzoquinone ansamycins
JP2003518444A JP2005515164A (en) 2001-08-06 2002-08-05 Benzoquinone ansamycin

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31007901P 2001-08-06 2001-08-06
US60/310,079 2001-08-06
US38925502P 2002-06-14 2002-06-14
US60/389,255 2002-06-14
US39392902P 2002-07-03 2002-07-03
US60/393,929 2002-07-03
US39527502P 2002-07-12 2002-07-12

Publications (2)

Publication Number Publication Date
WO2003013430A2 WO2003013430A2 (en) 2003-02-20
WO2003013430A3 true WO2003013430A3 (en) 2004-03-04

Family

ID=31982570

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/024891 WO2003013430A2 (en) 2001-08-06 2002-08-05 Benzoquinone ansamycins

Country Status (3)

Country Link
EP (1) EP1420747A4 (en)
AU (1) AU2002330998A1 (en)
WO (1) WO2003013430A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7189549B2 (en) * 2002-06-14 2007-03-13 Kosan Biosciences, Inc. Recombinant polynucleotides encoding pro-geldanamycin producing polyketide synthase and accessory proteins, and uses thereof
AU2004226350A1 (en) * 2003-03-28 2004-10-14 Kosan Biosciences, Inc. Devices, methods, and compositions to prevent restenosis
US20050020557A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with enzyme inhibitors
US20050020534A1 (en) * 2003-05-30 2005-01-27 Kosan Biosciences, Inc. Method for treating diseases using HSP90-inhibiting agents in combination with antimetabolites
US6875863B1 (en) 2003-11-12 2005-04-05 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
JP4717003B2 (en) 2003-11-12 2011-07-06 コーサン バイオサイエンシーズ， インコーポレイテッド 11-O-methylgeldanamycin compound
US6855705B1 (en) 2003-11-12 2005-02-15 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US6887993B1 (en) 2003-11-12 2005-05-03 Kosan Biosciences, Inc. 11-O-methylgeldanamycin compounds
US7282493B2 (en) 2003-12-23 2007-10-16 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
US20060019941A1 (en) * 2003-12-23 2006-01-26 Infinity Pharmaceuticals, Inc. Analogs of benzoquinone-containing ansamycins and methods of use thereof
US7259156B2 (en) * 2004-05-20 2007-08-21 Kosan Biosciences Incorporated Geldanamycin compounds and method of use
JP4954083B2 (en) 2004-11-18 2012-06-13 シンタ ファーマスーティカルズ コーポレイション Triazole compounds that modulate HSP90 activity
WO2007001049A1 (en) * 2005-06-29 2007-01-04 Kyowa Hakko Kogyo Co., Ltd. Benzenoid ansamycin derivative
JP5118039B2 (en) 2005-08-18 2013-01-16 シンタ ファーマシューティカルズ コーポレーション Triazole compounds that modulate HSP90 activity
CA2646316C (en) 2006-03-15 2016-05-24 Theralogics, Inc. Methods of treating muscular wasting diseases using nf-kb activation inhibitors
WO2007113268A1 (en) * 2006-03-31 2007-10-11 Biotica Technology Ltd. 4, 5-dihydromacbecin derivatives and their use in the treatment of cancer or b-cell malignancies.
GB0606542D0 (en) * 2006-03-31 2006-05-10 Biotica Tech Ltd Novel compounds and methods for their production
EP2073807A1 (en) 2006-10-12 2009-07-01 Astex Therapeutics Limited Pharmaceutical combinations
WO2008044041A1 (en) 2006-10-12 2008-04-17 Astex Therapeutics Limited Pharmaceutical combinations
PE20081506A1 (en) 2006-12-12 2008-12-09 Infinity Discovery Inc ANSAMYCIN FORMULATIONS
WO2009036092A2 (en) 2007-09-10 2009-03-19 University Of Massachusetts Mitochondria-targeted anti-tumor agents
CN101220068B (en) * 2008-01-18 2012-06-13 中国医学科学院医药生物技术研究所 A set of geldanamycin derivant and method for preparing the same
ES2347619B1 (en) * 2008-05-13 2011-09-15 Consejo Superior De Investigaciones Cientificas (Csic) (50%) PROCEDURE TO DESIGN AN ANTITUMORAL INDIVIDUAL THERAPY BASED ON THE DETECTION OF HSP90 PROTEIN LEVELS, THE USE OF HSP90 PROTEIN INHIBITORS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS, THE COMPOSITIONS AS OBTAINED AND THEIR APPLICATIONS.
EP2348845A4 (en) 2008-10-15 2013-01-23 Infinity Pharmaceuticals Inc Ansamycin hydroquinone compositions
EP2560640A1 (en) 2010-04-19 2013-02-27 Synta Pharmaceuticals Corp. Cancer therapy using a combination of a hsp90 inhibitory compounds and a egfr inhibitor
CA2853806C (en) 2011-11-02 2020-07-14 Synta Pharmaceuticals Corp. Combination therapy of hsp90 inhibitors with platinum-containing agents
WO2013067162A1 (en) 2011-11-02 2013-05-10 Synta Pharmaceuticals Corp. Cancer therapy using a combination of hsp90 inhibitors with topoisomerase i inhibitors
CN112679374A (en) * 2021-01-12 2021-04-20 湖南复瑞生物医药技术有限责任公司 Preparation method of 2-fluoro-6- (trifluoromethyl) benzamide

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS55111419A (en) * 1979-02-20 1980-08-28 Kaken Pharmaceut Co Ltd Antitumorigenic agent
CA2166320A1 (en) * 1993-06-29 1995-01-12 Randall James Gallaschun Ansamycin derivatives as antioncogene and anticancer agents

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261989A (en) * 1979-02-19 1981-04-14 Kaken Chemical Co. Ltd. Geldanamycin derivatives and antitumor drug

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SCHNUR ET AL.: "ervB-2 oncogene inhibition by geldanamycin derivatives: Synthesis, mechanism of action and structure-activity relationships", JOURNAL OF MEDICINAL CHEMISTRY, vol. 38, no. 19, 15 September 1995 (1995-09-15), pages 3813 - 3820, XP002193280 *
See also references of EP1420747A4 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9402831B2 (en) 2011-11-14 2016-08-02 Synta Pharmaceutical Corp. Combination therapy of HSP90 inhibitors with BRAF inhibitors

Also Published As

Publication number Publication date
EP1420747A4 (en) 2010-06-02
AU2002330998A1 (en) 2003-02-24
EP1420747A2 (en) 2004-05-26
WO2003013430A2 (en) 2003-02-20

Similar Documents

Publication Publication Date Title
WO2003013430A3 (en) Benzoquinone ansamycins
WO2003030934A3 (en) Cpg formulations and related methods
TW200630096A (en) Compounds and compositions as inhibitors of cannabinoid receptor 1 activity
WO2004028454A3 (en) 1, 3, 5-triazines for treatment of viral diseases
WO2005120557A3 (en) Inhibition of macrophage-stimulating protein receptor (ron)
CY1116463T1 (en) Combination therapy for the therapeutic treatment of Protein Deficiency Disorders
MXPA04001523A (en) Rapamycin dialdehydes.
WO2003096990A3 (en) Protein cages for the delivery of medical imaging and therapy
WO2006037106A3 (en) Carboxy-amido-triazoles for the localized treatment of ocular diseases
WO2003016467A3 (en) Use of antibodies having high affinity for soluble ass to treat conditions and diseases related to ass
MXPA04001524A (en) Rapamycin 29-enols.
BR0209147A (en) Combination therapy using anti-egfr antibodies and antihormonal agents
WO2003047504A3 (en) Prevention and treatment of androgen-deprivation induced osteoporosis
AU2003256755A1 (en) Ureido substituted benzoic acid compounds, their use for nonsense suppression and the treatment of diseases caused by such mutations
DE60137337D1 (en) PREVENTIVE AND THERAPEUTIC MONOCLONAL ANTIBODIES AGAINST VACCINIAVIRUSANTIGENE
WO2004009610A3 (en) Use of nucleoside compounds for nonsense suppression and the treatment of genetic diseases
IL171974A0 (en) Tetrahydrocarbazole derivatives and their pharmaceutical use
EA200500244A1 (en) TETRAPROPILAMMONIA TETRATIOMOLYBDAT AND RELATED COMPOUNDS FOR ANTIANGIOGENIC THERAPY
WO2003106381A3 (en) Human adam-10 inhibitors
HK1064950A1 (en) Methods for treating or preventing vascular inflammation using sterol absorption inhibitor(s)
WO2010042489A3 (en) Aminoquinoline derived heat shock protein 90 inhibitors, methods of preparing same, and methods for their use
WO2006019982A3 (en) Pin1-modulating compounds and methods of use thereof
AP2004002995A0 (en) Combination therapy for the treatment of cancer
MY137766A (en) Exemestane as chemopreventing agent
YU24403A (en) New retinoids for the treatment of emphysema

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG UZ VN YU ZA ZM ZW

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BY BZ CA CH CN CO CR CU CZ DE DM DZ EC EE ES FI GB GD GE GH HR HU ID IL IN IS JP KE KG KP KR LC LK LR LS LT LU LV MA MD MG MN MW MX MZ NO NZ OM PH PL PT RU SD SE SG SI SK SL TJ TM TN TR TZ UA UG UZ VN YU ZA ZM

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR IE IT LU MC NL PT SE SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ UG ZM ZW AM AZ BY KG KZ RU TJ TM AT BE BG CH CY CZ DK EE ES FI FR GB GR IE IT LU MC PT SE SK TR BF BJ CF CG CI GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2456175

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003518444

Country of ref document: JP

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
WWE Wipo information: entry into national phase

Ref document number: 2002768436

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002768436

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642