WO2003008562A3 - Methods for detecting genes associated with bone properties, height, and/or body mass properties - Google Patents

Methods for detecting genes associated with bone properties, height, and/or body mass properties Download PDF

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Publication number
WO2003008562A3
WO2003008562A3 PCT/US2002/023293 US0223293W WO03008562A3 WO 2003008562 A3 WO2003008562 A3 WO 2003008562A3 US 0223293 W US0223293 W US 0223293W WO 03008562 A3 WO03008562 A3 WO 03008562A3
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WO
WIPO (PCT)
Prior art keywords
bone
properties
subject
methods
polymorphism
Prior art date
Application number
PCT/US2002/023293
Other languages
French (fr)
Other versions
WO2003008562A2 (en
Inventor
Robert R Recker
Hong-Wen Deng
Original Assignee
Univ Creighton
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Creighton filed Critical Univ Creighton
Priority to AU2002322584A priority Critical patent/AU2002322584A1/en
Publication of WO2003008562A2 publication Critical patent/WO2003008562A2/en
Publication of WO2003008562A3 publication Critical patent/WO2003008562A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Disclosed are methods for detecting the presence in a subject of a polymorphism linked to a gene associated with one or more bone properties, such as spine bone mineral density, hip bone mineral density, wrist bone mineral density, spine bone size, hip bone size, and wrist bone size. The method includes analyzing at least a portion of the subject's genome and detecting the presence of a polymorphism which is located in or near various specified regions of the subject's genome and which is linked to the gene associated with the bone property of interest. The presence of the polymorphism is indicative of the subject having or being susceptible to having aberrant bone properties. Also disclosed are methods for detecting the presence in a subject of a polymorphism linked to a gene associates with height or with one or more body mass properties, such as body mass index, percentage fat mass, fat mass, and lean mass. The methods can be used, for example, to screen for a subject's having or being susceptible to conditions such as osteoporosis and obesity.
PCT/US2002/023293 2001-07-20 2002-07-22 Methods for detecting genes associated with bone properties, height, and/or body mass properties WO2003008562A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002322584A AU2002322584A1 (en) 2001-07-20 2002-07-22 Methods for detecting genes associated with bone properties, height, and/or body mass properties

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US30669001P 2001-07-20 2001-07-20
US60/306,690 2001-07-20
US33682901P 2001-10-26 2001-10-26
US60/336,829 2001-10-26

Publications (2)

Publication Number Publication Date
WO2003008562A2 WO2003008562A2 (en) 2003-01-30
WO2003008562A3 true WO2003008562A3 (en) 2003-05-22

Family

ID=26975295

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023293 WO2003008562A2 (en) 2001-07-20 2002-07-22 Methods for detecting genes associated with bone properties, height, and/or body mass properties

Country Status (2)

Country Link
AU (1) AU2002322584A1 (en)
WO (1) WO2003008562A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7524664B2 (en) 2003-06-17 2009-04-28 California Institute Of Technology Regio- and enantioselective alkane hydroxylation with modified cytochrome P450
EP2415868A4 (en) * 2009-05-15 2012-11-28 Univ Tokyo Method and kit for evaluation of predisposition to development of obesity, anti-obesity agent and method for screening thereof, non-human animal, adipose tissue, adipocyte, method for production of transgenic mouse, antigen, and antibody

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
STINE C. ET AL.: "Vitamin D receptor polymorphisms and hip bone mineral density in baltimore women", JBMR, vol. 14, September 1999 (1999-09-01), pages S456, ABSTRACT NO. SU100, XP002959965 *

Also Published As

Publication number Publication date
AU2002322584A1 (en) 2003-03-03
WO2003008562A2 (en) 2003-01-30

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