WO2003007913A3 - Nouveau procede d'administration orale d'un medicament - Google Patents

Nouveau procede d'administration orale d'un medicament Download PDF

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Publication number
WO2003007913A3
WO2003007913A3 PCT/US2002/023406 US0223406W WO03007913A3 WO 2003007913 A3 WO2003007913 A3 WO 2003007913A3 US 0223406 W US0223406 W US 0223406W WO 03007913 A3 WO03007913 A3 WO 03007913A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
mucoadhesive
drug
layer
reservoir
Prior art date
Application number
PCT/US2002/023406
Other languages
English (en)
Other versions
WO2003007913A2 (fr
Inventor
Samir Mitragotri
Zancong Shen
Original Assignee
Samir Mitragotri
Zancong Shen
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Samir Mitragotri, Zancong Shen filed Critical Samir Mitragotri
Priority to AU2002319653A priority Critical patent/AU2002319653A1/en
Publication of WO2003007913A2 publication Critical patent/WO2003007913A2/fr
Publication of WO2003007913A3 publication Critical patent/WO2003007913A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention se rapporte à un nouveau système de timbre adhérant aux muqueuses permettant l'administration d'un médicament et comportant une couche de support imperméable, un réservoir de médicament et une couche adhérant aux muqueuses. Après introduction dans le tractus gastro-intestinal, la couche adhérant aux muqueuses du timbre se colle à la paroi luménale, puis le réservoir libère le médicament de manière unidirectionnelle à travers la couche adhérant aux muqueuses en direction de la muqueuse intestinale. Ce système de timbre et le procédé d'administration de médicaments associés permettent avantageusement d'accroître la biodisponibilité de médicaments faiblement absorbés tels que des molécules polaires ou des protéines et des peptides bioactifs.
PCT/US2002/023406 2001-07-20 2002-07-18 Nouveau procede d'administration orale d'un medicament WO2003007913A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002319653A AU2002319653A1 (en) 2001-07-20 2002-07-18 Method for oral drug delivery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30705901P 2001-07-20 2001-07-20
US60/307,059 2001-07-20

Publications (2)

Publication Number Publication Date
WO2003007913A2 WO2003007913A2 (fr) 2003-01-30
WO2003007913A3 true WO2003007913A3 (fr) 2003-05-01

Family

ID=23188061

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/023406 WO2003007913A2 (fr) 2001-07-20 2002-07-18 Nouveau procede d'administration orale d'un medicament

Country Status (3)

Country Link
US (1) US20030017195A1 (fr)
AU (1) AU2002319653A1 (fr)
WO (1) WO2003007913A2 (fr)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10332160A1 (de) 2003-07-15 2005-02-03 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Peptid- oder Protein-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004036437A1 (de) 2004-07-27 2006-03-23 Röhm GmbH & Co. KG Multipartikuläre Arzneiform für wenig lösliche Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
DE102004059792A1 (de) * 2004-12-10 2006-06-14 Röhm GmbH & Co. KG Multipartikuläre Arzneiform, enthaltend mucoadhaesiv formulierte Nukleinsäure-Wirkstoffe, sowie ein Verfahren zur Herstellung der Arzneiform
EP1991210A1 (fr) * 2006-02-15 2008-11-19 Intec Pharma Ltd. Système de gastro-rétention pour dé livrer des macromolécules
GB0704718D0 (en) * 2007-03-12 2007-04-18 Prendergast Patrick T Compounds and methods for preventing and treating mucositis
US20080286344A1 (en) * 2007-05-16 2008-11-20 Olivia Darmuzey Solid form
WO2008140461A1 (fr) * 2007-05-16 2008-11-20 Fmc Corporation Forme solide
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
EA020466B1 (ru) 2007-06-04 2014-11-28 Синерджи Фармасьютикалз Инк. Агонисты гуанилатциклазы, пригодные для лечения желудочно-кишечных нарушений, воспаления, рака и других заболеваний
CA2726917C (fr) 2008-06-04 2018-06-26 Synergy Pharmaceuticals Inc. Agonistes de guanylate cyclase utile dans le traitement de troubles gastro-intestinaux, d'une inflammation, d'un cancer et d'autres troubles
CA2730603C (fr) 2008-07-16 2019-09-24 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase utiles dans le traitement des affections gastro-intestinales, de l'inflammation gastro-intestinale, du cancer gastro-intestinal et d'autres affections
US7825719B2 (en) * 2008-12-29 2010-11-02 Advanced Energy Industries, Inc. System and method for wideband phase-adjustable common excitation
EP2419085A4 (fr) * 2009-04-14 2013-04-24 Univ California Dispositifs améliorés pour médicaments à usage oral et formulations médicamenteuses
US20110142889A1 (en) * 2009-12-16 2011-06-16 Nod Pharmaceuticals, Inc. Compositions and methods for oral drug delivery
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
EP2861220A2 (fr) * 2012-06-14 2015-04-22 Entrega, Inc. Dispositifs mucoadhésifs pour l'administration d'agents actifs
US20140234212A1 (en) * 2013-02-21 2014-08-21 Massachusetts Institute Of Technology Targeted Buccal Delivery of Agents
WO2014131024A2 (fr) 2013-02-25 2014-08-28 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et applications associées
CA2905435A1 (fr) 2013-03-15 2014-09-25 Synergy Pharmaceuticals Inc. Compositions utiles pour le traitement de troubles gastro-intestinaux
EP2970384A1 (fr) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonistes de la guanylate cyclase et leurs utilisations
WO2015026552A2 (fr) * 2013-08-23 2015-02-26 Entrega, Inc. Dispositifs mucoadhésifs permettant l'administration d'agents actifs
CA2926691A1 (fr) 2013-10-10 2015-04-16 Synergy Pharmaceuticals, Inc. Agonistes de guanylate cyclase utiles pour le traitement de troubles induits par les opioides
RU2688136C1 (ru) 2013-12-06 2019-05-20 Интервет Интернэшнл Б.В. Композиция для пероральной доставки биоактивных агентов
MX359973B (es) * 2014-04-01 2018-10-05 Univ Mexico Nac Autonoma Sistema farmacéutico para la administración oral de sustancias terapéuticas sensibles.
US10570169B2 (en) 2014-05-22 2020-02-25 Ionis Pharmaceuticals, Inc. Conjugated antisense compounds and their use
DK3006045T3 (en) 2014-10-07 2017-07-17 Cyprumed Gmbh Pharmaceutical formulations for oral administration of peptide or protein drugs
DE102014119576A1 (de) 2014-12-23 2016-06-23 Ernst-Moritz-Arndt-Universität Greifswald Pharmazeutische Arzneimittelform zur Applikation auf Schleimhäuten
EP3316873B1 (fr) * 2015-06-30 2021-04-28 Entrega Inc. Dispositif d'administration orale de principes actifs
AU2016335287A1 (en) 2015-10-07 2018-04-12 Cyprumed Gmbh Pharmaceutical formulations for the oral delivery of peptide drugs
CA3009814A1 (fr) 2016-01-11 2017-07-20 Synergy Pharmaceuticals, Inc. Formulations et methodes pour traiter la rectocolite hemorragique
CA3015172A1 (fr) 2016-02-18 2017-08-24 Privo Technologies, Inc. Systeme et methode d'administration d'agent therapeutique a base de microparticules a deux etages
GB2554444B (en) * 2016-09-28 2021-10-13 Biome Oxford Ltd A device for sampling gastro-intestinal material
WO2018065634A1 (fr) 2016-10-07 2018-04-12 Cyprumed Gmbh Compositions pharmaceutiques pour l'administration par voie nasale de médicaments de type peptide ou protéine
WO2018151849A1 (fr) 2017-02-17 2018-08-23 Privo Technologies, Inc. Dispositif et méthode d'administration d'agents thérapeutiques multicouche à base de particules
US10478403B1 (en) 2017-05-03 2019-11-19 Privo Technologies, Inc. Intraoperative topically-applied non-implantable rapid release patch
US20210087250A1 (en) 2018-04-06 2021-03-25 Cyprumed Gmbh Pharmaceutical compositions for the transmucosal delivery of therapeutic peptides and proteins
JP2023516887A (ja) * 2020-01-31 2023-04-21 シデリス，アンダース・ウィリアム・ジェイムズ 薬物送達デバイス

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028141A1 (fr) * 1995-03-13 1996-09-19 Reckitt & Colman Products Limited Ameliorations concernant des compositions organiques
EP0873750A1 (fr) * 1997-04-23 1998-10-28 Permatec Technologie Ag Comprimés bioadhésifs
WO2000032172A1 (fr) * 1998-11-27 2000-06-08 Kanji Takada Preparation orale servant a diffuser un medicament du tube digestif

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4764379A (en) * 1987-08-24 1988-08-16 Alza Corporation Transdermal drug delivery device with dual permeation enhancers
US5446070A (en) * 1991-02-27 1995-08-29 Nover Pharmaceuticals, Inc. Compositions and methods for topical administration of pharmaceutically active agents
US5639469A (en) * 1994-06-15 1997-06-17 Minnesota Mining And Manufacturing Company Transmucosal delivery system

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996028141A1 (fr) * 1995-03-13 1996-09-19 Reckitt & Colman Products Limited Ameliorations concernant des compositions organiques
EP0873750A1 (fr) * 1997-04-23 1998-10-28 Permatec Technologie Ag Comprimés bioadhésifs
WO2000032172A1 (fr) * 1998-11-27 2000-06-08 Kanji Takada Preparation orale servant a diffuser un medicament du tube digestif

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
SHEN ZANCONG ET AL: "Intestinal patches for oral drug delivery.", PHARMACEUTICAL RESEARCH. UNITED STATES APR 2002, vol. 19, no. 4, April 2002 (2002-04-01), pages 391 - 395, XP008013240, ISSN: 0724-8741 *

Also Published As

Publication number Publication date
AU2002319653A1 (en) 2003-03-03
WO2003007913A2 (fr) 2003-01-30
US20030017195A1 (en) 2003-01-23

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