WO2003004518A3 - Cortistatin analogs capable of binding selectively to growth hormone secretagogue receptors - Google Patents

Cortistatin analogs capable of binding selectively to growth hormone secretagogue receptors Download PDF

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Publication number
WO2003004518A3
WO2003004518A3 PCT/EP2002/006777 EP0206777W WO03004518A3 WO 2003004518 A3 WO2003004518 A3 WO 2003004518A3 EP 0206777 W EP0206777 W EP 0206777W WO 03004518 A3 WO03004518 A3 WO 03004518A3
Authority
WO
WIPO (PCT)
Prior art keywords
growth hormone
hormone secretagogue
binding selectively
analogs capable
secretagogue receptors
Prior art date
Application number
PCT/EP2002/006777
Other languages
French (fr)
Other versions
WO2003004518A2 (en
Inventor
Romano Deghenghi
Original Assignee
Ardana Bioscience Ltd
Romano Deghenghi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ardana Bioscience Ltd, Romano Deghenghi filed Critical Ardana Bioscience Ltd
Priority to AU2002314182A priority Critical patent/AU2002314182A1/en
Publication of WO2003004518A2 publication Critical patent/WO2003004518A2/en
Publication of WO2003004518A3 publication Critical patent/WO2003004518A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/083—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being octreotide or a somatostatin-receptor-binding peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Optics & Photonics (AREA)
  • Public Health (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Endocrinology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

The peptides of formula (I): Pro-Cys-Xaa-D-Trp-Lys-Xbb-Cys-Lys-NH2, and their derivatives with metal chelating agents are useful in the treatment of tumours and acromegaly, and to reduce the appetite.
PCT/EP2002/006777 2001-07-06 2002-06-19 Cortistatin analogs capable of binding selectively to growth hormone secretagogue receptors WO2003004518A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002314182A AU2002314182A1 (en) 2001-07-06 2002-06-19 Cortistatin analogs capable of binding selectively to growth hormone secretagogue receptors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT2001MI001445A ITMI20011445A1 (en) 2001-07-06 2001-07-06 ANALOGUES OF CORTISTANTINA CAPABLE OF BINDING SELECTIVELY TO THE RECEPTORS OF SECRETAGOGUES OF GROWTH HORMONE
ITMI01A001445 2001-07-06

Publications (2)

Publication Number Publication Date
WO2003004518A2 WO2003004518A2 (en) 2003-01-16
WO2003004518A3 true WO2003004518A3 (en) 2003-04-10

Family

ID=11448017

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006777 WO2003004518A2 (en) 2001-07-06 2002-06-19 Cortistatin analogs capable of binding selectively to growth hormone secretagogue receptors

Country Status (3)

Country Link
AU (1) AU2002314182A1 (en)
IT (1) ITMI20011445A1 (en)
WO (1) WO2003004518A2 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7476653B2 (en) 2003-06-18 2009-01-13 Tranzyme Pharma, Inc. Macrocyclic modulators of the ghrelin receptor
CU23558A1 (en) 2006-02-28 2010-07-20 Ct Ingenieria Genetica Biotech COMPOUNDS ANALOG TO THE PEPTIDIC SECRETAGOGS OF THE GROWTH HORMONE
EP2118080B1 (en) 2007-02-09 2016-08-31 Ocera Therapeutics, Inc. Macrocyclic ghrelin receptor modulators and methods of using the same
EP2334686B1 (en) 2008-08-28 2019-02-27 President and Fellows of Harvard College Cortistatin analogues and syntheses therof
EP2493910A1 (en) 2009-10-30 2012-09-05 Tranzyme Pharma, Inc. Macrocyclic ghrelin receptor antagonists and inverse agonists and methods of using the same
MY180383A (en) 2013-12-24 2020-11-28 Harvard College Cortistatin analogues and syntheses and uses thereof
EP3294298A4 (en) 2015-05-08 2018-10-17 President and Fellows of Harvard College Cortistatin analogues, syntheses, and uses thereof
EP3316889A4 (en) 2015-07-01 2018-11-14 President and Fellows of Harvard College Cortistatin analogues and syntheses and uses thereof

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; January 2001 (2001-01-01), DEGHENGHI R ET AL: "Cortistatin, but not somatostatin, binds to growth hormone secretagogue (GHS) receptors of human pituitary gland.", XP002224725, Database accession no. PREV200100128359 *
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, vol. 24, no. 1, January 2001 (2001-01-01), pages RC1 - RC3, ISSN: 0391-4097 *
PAPOTTI MAURO ET AL: "Growth hormone secretagogue binding sites in peripheral human tissues.", JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, vol. 85, no. 10, October 2000 (2000-10-01), pages 3803 - 3807, XP002224724, ISSN: 0021-972X *
SPIER AVRON D ET AL: "Cortistatin: A member of the somatostatin neuropeptide family with distinct physiological functions.", BRAIN RESEARCH REVIEWS, vol. 33, no. 2-3, September 2000 (2000-09-01), pages 228 - 241, XP002224723, ISSN: 0165-0173 *

Also Published As

Publication number Publication date
AU2002314182A1 (en) 2003-01-21
ITMI20011445A1 (en) 2003-01-06
WO2003004518A2 (en) 2003-01-16
ITMI20011445A0 (en) 2001-07-06

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