WO2003004066A1 - Gene therapeutics - Google Patents

Gene therapeutics Download PDF

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Publication number
WO2003004066A1
WO2003004066A1 PCT/JP2002/006772 JP0206772W WO03004066A1 WO 2003004066 A1 WO2003004066 A1 WO 2003004066A1 JP 0206772 W JP0206772 W JP 0206772W WO 03004066 A1 WO03004066 A1 WO 03004066A1
Authority
WO
WIPO (PCT)
Prior art keywords
polypeptide
gene therapeutics
amino acid
acid sequence
activity
Prior art date
Application number
PCT/JP2002/006772
Other languages
French (fr)
Japanese (ja)
Inventor
Keiji Tanaka
Hideto Chono
Mio Morishita
Haruko Konishi
Mitsuhiro Ueno
Kiyozo Asada
Ikunoshin Kato
Original Assignee
Takara Bio Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takara Bio Inc. filed Critical Takara Bio Inc.
Publication of WO2003004066A1 publication Critical patent/WO2003004066A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Molecular Biology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Drugs containing a gene encoding a polypeptide which has the amino acid sequence of a polypeptide having a cell adhesion activity and the amino acid sequence of a polypeptide having a fibroblast growth factor activity.
PCT/JP2002/006772 2001-07-05 2002-07-04 Gene therapeutics WO2003004066A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-204300 2001-07-05
JP2001204300A JP2005052001A (en) 2001-07-05 2001-07-05 Gene therapeutic agent

Publications (1)

Publication Number Publication Date
WO2003004066A1 true WO2003004066A1 (en) 2003-01-16

Family

ID=19040794

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/006772 WO2003004066A1 (en) 2001-07-05 2002-07-04 Gene therapeutics

Country Status (2)

Country Link
JP (1) JP2005052001A (en)
WO (1) WO2003004066A1 (en)

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
US5049658A (en) * 1988-01-05 1991-09-17 Takara Shuzo Co., Ltd. Polypeptide with cell-spreading activity
JPH03232898A (en) * 1990-02-05 1991-10-16 Takara Shuzo Co Ltd Functional polypeptide
JPH03284700A (en) * 1990-03-30 1991-12-16 Takara Shuzo Co Ltd Functional polypeptide
US5302701A (en) * 1991-10-14 1994-04-12 Takara Shuzo Co., Ltd. Polypeptide having human fibronectin-like cell adhesive activity
WO1995003831A1 (en) * 1993-08-02 1995-02-09 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates
WO1997018318A1 (en) * 1995-11-13 1997-05-22 Takara Shuzo Co., Ltd. Method for gene introduction into target cells by retrovirus
JPH1029952A (en) * 1996-07-16 1998-02-03 Takara Shuzo Co Ltd Composition for controlling human immunodeficiency virus infection and controlling thereby
WO1999040945A2 (en) * 1998-02-11 1999-08-19 The Regents Of The University Of California Combination of a nucleic acid and a vasoactive agent for enhanced gene delivery
WO1999055861A2 (en) * 1998-04-28 1999-11-04 Eisai Co., Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
WO2000001836A1 (en) * 1998-07-01 2000-01-13 Takara Shuzo Co., Ltd. Gene transfer methods

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5026839A (en) * 1985-12-17 1991-06-25 Synergen, Inc DNA encoding a basic fibroblast growth factor
US5049658A (en) * 1988-01-05 1991-09-17 Takara Shuzo Co., Ltd. Polypeptide with cell-spreading activity
JPH03232898A (en) * 1990-02-05 1991-10-16 Takara Shuzo Co Ltd Functional polypeptide
JPH03284700A (en) * 1990-03-30 1991-12-16 Takara Shuzo Co Ltd Functional polypeptide
US5302701A (en) * 1991-10-14 1994-04-12 Takara Shuzo Co., Ltd. Polypeptide having human fibronectin-like cell adhesive activity
WO1995003831A1 (en) * 1993-08-02 1995-02-09 Prizm Pharmaceuticals, Inc. Monogenous preparations of cytotoxic conjugates
WO1997018318A1 (en) * 1995-11-13 1997-05-22 Takara Shuzo Co., Ltd. Method for gene introduction into target cells by retrovirus
JPH1029952A (en) * 1996-07-16 1998-02-03 Takara Shuzo Co Ltd Composition for controlling human immunodeficiency virus infection and controlling thereby
WO1999040945A2 (en) * 1998-02-11 1999-08-19 The Regents Of The University Of California Combination of a nucleic acid and a vasoactive agent for enhanced gene delivery
WO1999055861A2 (en) * 1998-04-28 1999-11-04 Eisai Co., Ltd. Fibroblast growth factor mutein compositions and methods of use therefor
WO2000001836A1 (en) * 1998-07-01 2000-01-13 Takara Shuzo Co., Ltd. Gene transfer methods

Also Published As

Publication number Publication date
JP2005052001A (en) 2005-03-03

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