WO2003003984A8 - Novel proteins and nucleic acids encoding same - Google Patents

Novel proteins and nucleic acids encoding same Download PDF

Info

Publication number
WO2003003984A8
WO2003003984A8 PCT/US2002/021268 US0221268W WO03003984A8 WO 2003003984 A8 WO2003003984 A8 WO 2003003984A8 US 0221268 W US0221268 W US 0221268W WO 03003984 A8 WO03003984 A8 WO 03003984A8
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acids
acids encoding
encoding same
novel proteins
proteins
Prior art date
Application number
PCT/US2002/021268
Other languages
French (fr)
Other versions
WO2003003984A2 (en
WO2003003984A9 (en
Inventor
Elma R Fernandes
Corine A M Vernet
Richard A Shimkets
David W Anderson
Muralidhara Padigaru
Ferenc L Boldog
Li Li
Suresh G Shenoy
Stacie J Casman
Luca Rastelli
John P Ii Alsobrook
Catherine E Burgess
William M Grosse
Vladimir Y Gusev
Weizhen Ji
Denise M Lepley
Xiaohong Liu
Amanda J Mezick
Meera Patturajan
Lei Shen
Steven K Spaderna
Kimberly A Spytek
Edward S Szekeres Jr
Raymond J Taupier Jr
Velizar T Tchernev
Bryan D Zerhusen
Edward Z Voss
Original Assignee
Curagen Corp
Elma R Fernandes
Corine A M Vernet
Richard A Shimkets
David W Anderson
Muralidhara Padigaru
Ferenc L Boldog
Li Li
Suresh G Shenoy
Stacie J Casman
Luca Rastelli
John P Ii Alsobrook
Catherine E Burgess
William M Grosse
Vladimir Y Gusev
Weizhen Ji
Denise M Lepley
Xiaohong Liu
Amanda J Mezick
Meera Patturajan
Lei Shen
Steven K Spaderna
Kimberly A Spytek
Edward S Szekeres Jr
Raymond J Taupier Jr
Velizar T Tchernev
Bryan D Zerhusen
Edward Z Voss
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/966,546 external-priority patent/US20020168716A1/en
Application filed by Curagen Corp, Elma R Fernandes, Corine A M Vernet, Richard A Shimkets, David W Anderson, Muralidhara Padigaru, Ferenc L Boldog, Li Li, Suresh G Shenoy, Stacie J Casman, Luca Rastelli, John P Ii Alsobrook, Catherine E Burgess, William M Grosse, Vladimir Y Gusev, Weizhen Ji, Denise M Lepley, Xiaohong Liu, Amanda J Mezick, Meera Patturajan, Lei Shen, Steven K Spaderna, Kimberly A Spytek, Edward S Szekeres Jr, Raymond J Taupier Jr, Velizar T Tchernev, Bryan D Zerhusen, Edward Z Voss filed Critical Curagen Corp
Priority to AU2002327198A priority Critical patent/AU2002327198A1/en
Publication of WO2003003984A2 publication Critical patent/WO2003003984A2/en
Publication of WO2003003984A9 publication Critical patent/WO2003003984A9/en
Publication of WO2003003984A8 publication Critical patent/WO2003003984A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/US2002/021268 2001-07-05 2002-07-03 Novel proteins and nucleic acids encoding same WO2003003984A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002327198A AU2002327198A1 (en) 2001-07-05 2002-07-03 Novel proteins and nucleic acids encoding same

Applications Claiming Priority (22)

Application Number Priority Date Filing Date Title
US30316801P 2001-07-05 2001-07-05
US30324101P 2001-07-05 2001-07-05
US60/303,168 2001-07-05
US60/303,241 2001-07-05
US09/966,546 US20020168716A1 (en) 1999-04-09 2001-09-26 Novel amino acid sequences for human microfibril glycoprotein 4-like polypeptides
US09/966,545 2001-09-26
US09/966,546 2001-09-26
US09/965,212 US20030003462A1 (en) 1999-04-09 2001-09-26 Novel human interleukin-like proteins and polynucleotides encoding them
US09/965,212 2001-09-26
US09/966,545 US20020172999A1 (en) 1999-04-09 2001-09-26 Novel KIAA1061-like cell adhesion molecule-like proteins and polynucleotides encoding them
US36906502P 2002-04-01 2002-04-01
US36899602P 2002-04-01 2002-04-01
US60/369,065 2002-04-01
US60/368,996 2002-04-01
US37873002P 2002-05-08 2002-05-08
US60/378,730 2002-05-08
US38432702P 2002-05-30 2002-05-30
US60/384,327 2002-05-30
US38681602P 2002-06-07 2002-06-07
US60/386,816 2002-06-07
US17437202A 2002-06-17 2002-06-17
US10/174,372 2002-06-17

Publications (3)

Publication Number Publication Date
WO2003003984A2 WO2003003984A2 (en) 2003-01-16
WO2003003984A9 WO2003003984A9 (en) 2009-05-22
WO2003003984A8 true WO2003003984A8 (en) 2009-08-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/021268 WO2003003984A2 (en) 2001-07-05 2002-07-03 Novel proteins and nucleic acids encoding same

Country Status (1)

Country Link
WO (1) WO2003003984A2 (en)

Families Citing this family (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1622634A2 (en) * 2002-04-01 2006-02-08 Curagen Corporation Therapeutic polypeptides, nucleic acids encoding same, and methods of use
KR101438983B1 (en) 2003-11-06 2014-09-05 시애틀 지네틱스, 인크. Monomethylvaline compounds capable of conjugation to ligands
EP1753463A2 (en) 2004-06-01 2007-02-21 Genentech, Inc. Antibody drug conjugates and methods
RU2412947C2 (en) 2004-09-23 2011-02-27 Дженентек, Инк. Antibodies, constructed on cysteine basis and their conjugates
US20100111856A1 (en) 2004-09-23 2010-05-06 Herman Gill Zirconium-radiolabeled, cysteine engineered antibody conjugates
EP2475391B1 (en) 2009-09-09 2018-09-12 Centrose, LLC Extracellular targeted drug conjugates
WO2011130598A1 (en) 2010-04-15 2011-10-20 Spirogen Limited Pyrrolobenzodiazepines and conjugates thereof
CN114246952A (en) 2010-06-08 2022-03-29 基因泰克公司 Cysteine engineered antibodies and conjugates
CN103313990B (en) 2010-11-17 2016-07-20 基因泰克公司 Alanyl maytansinol antibody coupling matter
MX2013013054A (en) 2011-05-12 2014-02-20 Genentech Inc Multiple reaction monitoring lc-ms/ms method to detect therapeutic antibodies in animal samples using framework signature peptides.
DK2750713T3 (en) 2011-10-14 2015-12-21 Medimmune Ltd PYRROLOBENZODIAZEPINS AND CONJUGATES THEREOF
WO2013130093A1 (en) 2012-03-02 2013-09-06 Genentech, Inc. Biomarkers for treatment with anti-tubulin chemotherapeutic compounds
PT2906253T (en) 2012-10-12 2018-11-05 Medimmune Ltd Pyrrolobenzodiazepine - anti-psma antibody conjugates
US9931414B2 (en) 2012-10-12 2018-04-03 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
RS53818B1 (en) 2012-10-12 2015-06-30 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
WO2014057119A1 (en) 2012-10-12 2014-04-17 Adc Therapeutics Sàrl Pyrrolobenzodiazepine-antibody conjugates
US10695433B2 (en) 2012-10-12 2020-06-30 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
EP2906251B1 (en) 2012-10-12 2017-09-27 ADC Therapeutics SA Pyrrolobenzodiazepine-anti-cd22 antibody conjugates
US10736903B2 (en) 2012-10-12 2020-08-11 Medimmune Limited Pyrrolobenzodiazepine-anti-PSMA antibody conjugates
JP6527466B2 (en) 2012-12-21 2019-06-05 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Asymmetric pyrrolobenzodiazepine dimers for use in the treatment of proliferative and autoimmune diseases
WO2014096368A1 (en) 2012-12-21 2014-06-26 Spirogen Sàrl Pyrrolobenzodiazepines and conjugates thereof
JP6340019B2 (en) 2013-03-13 2018-06-06 メドイミューン・リミテッドＭｅｄＩｍｍｕｎｅ Ｌｉｍｉｔｅｄ Pyrrolobenzodiazepine and its conjugates
EA027910B1 (en) 2013-03-13 2017-09-29 Медимьюн Лимитед Pyrrolobenzodiazepines and conjugates thereof
BR112015023333A8 (en) 2013-03-13 2018-04-17 Medimmune Ltd pyrrolbenzodiazepines and conjugates thereof
EA201690195A1 (en) 2013-08-12 2016-05-31 Дженентек, Инк. ANTIBODY CONJUGATE CONNECTIONS ON THE BASIS OF DIMER 1- (HLORMETHYL) -2,3-DIGYDRO-1H-BENZO [E] INDOL AND METHODS OF APPLICATION AND TREATMENT
WO2015052532A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
WO2015052535A1 (en) 2013-10-11 2015-04-16 Spirogen Sàrl Pyrrolobenzodiazepine-antibody conjugates
GB201317982D0 (en) 2013-10-11 2013-11-27 Spirogen Sarl Pyrrolobenzodiazepines and conjugates thereof
EP3054985B1 (en) 2013-10-11 2018-12-26 Medimmune Limited Pyrrolobenzodiazepine-antibody conjugates
MX2016007578A (en) 2013-12-16 2016-10-03 Genentech Inc 1-(chloromethyl)-2,3-dihydro-1h-benzo[e]indole dimer antibody-drug conjugate compounds, and methods of use and treatment.
CN107106700B (en) 2013-12-16 2020-10-30 基因泰克公司 Peptidomimetic compounds and antibody-drug conjugates thereof
RU2689388C1 (en) 2013-12-16 2019-05-28 Дженентек, Инк. Peptidomimetic compounds and their conjugates of antibodies with drugs
CN106687141A (en) 2014-09-10 2017-05-17 麦迪穆有限责任公司 Pyrrolobenzodiazepines and conjugates thereof
EP3388449A3 (en) 2014-09-12 2018-10-24 F. Hoffmann-La Roche AG Cysteine engineered antibodies and conjugates
CN106714844B (en) 2014-09-12 2022-08-05 基因泰克公司 Anthracycline disulfide intermediates, antibody-drug conjugates and methods
GB201416112D0 (en) 2014-09-12 2014-10-29 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
EP3235820A1 (en) 2014-09-17 2017-10-25 Genentech, Inc. Pyrrolobenzodiazepines and antibody disulfide conjugates thereof
JP6878287B2 (en) 2014-11-25 2021-05-26 アーデーセー セラピューティクス ソシエテ アノニム Pyrrolobenzodiazepine-antibody conjugate
CA2969689A1 (en) 2014-12-03 2016-06-09 Genentech, Inc. Quaternary amine compounds and antibody-drug conjugates thereof
GB201506402D0 (en) 2015-04-15 2015-05-27 Berkel Patricius H C Van And Howard Philip W Site-specific antibody-drug conjugates
GB201506411D0 (en) 2015-04-15 2015-05-27 Bergenbio As Humanized anti-axl antibodies
MA43345A (en) 2015-10-02 2018-08-08 Hoffmann La Roche PYRROLOBENZODIAZEPINE ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
MA43354A (en) 2015-10-16 2018-08-22 Genentech Inc CONJUGATE DRUG CONJUGATES WITH CLOUDY DISULPHIDE
MA45326A (en) 2015-10-20 2018-08-29 Genentech Inc CALICHEAMICIN-ANTIBODY-DRUG CONJUGATES AND METHODS OF USE
GB201601431D0 (en) 2016-01-26 2016-03-09 Medimmune Ltd Pyrrolobenzodiazepines
GB201602356D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
GB201602359D0 (en) 2016-02-10 2016-03-23 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
EP4273551A3 (en) 2016-03-25 2024-01-17 F. Hoffmann-La Roche AG Multiplexed total antibody and antibody-conjugated drug quantification assay
GB201607478D0 (en) 2016-04-29 2016-06-15 Medimmune Ltd Pyrrolobenzodiazepine Conjugates
JP2019522633A (en) 2016-05-20 2019-08-15 ジェネンテック， インコーポレイテッド PROTAC antibody conjugates and methods of use
US20170370906A1 (en) 2016-05-27 2017-12-28 Genentech, Inc. Bioanalytical analysis of site-specific antibody drug conjugates
EP3464280B1 (en) 2016-06-06 2021-10-06 F. Hoffmann-La Roche AG Silvestrol antibody-drug conjugates and methods of use
CN109689111B (en) 2016-08-11 2024-04-05 基因泰克公司 Pyrrolobenzodiazepine prodrugs and antibody conjugates thereof
EP3522933B1 (en) 2016-10-05 2021-12-15 F. Hoffmann-La Roche AG Methods for preparing antibody drug conjugates
GB201617466D0 (en) 2016-10-14 2016-11-30 Medimmune Ltd Pyrrolobenzodiazepine conjugates
GB201702031D0 (en) 2017-02-08 2017-03-22 Medlmmune Ltd Pyrrolobenzodiazepine-antibody conjugates
CA3047683C (en) 2017-02-08 2020-03-10 Adc Therapeutics Sa Pyrrolobenzodiazepine-antibody conjugates
DK3612537T3 (en) 2017-04-18 2022-08-08 Medimmune Ltd PYRROLOBENZODIAZEPIN CONJUGATES
PL3612234T3 (en) 2017-04-20 2024-09-02 Adc Therapeutics Sa Combination therapy with an anti-axl antibody-drug conjugate
BR112019026564A2 (en) 2017-06-14 2020-06-30 Adc Therapeutics Sa dosing regimens for administration of an anti-cd19 adc
CN111065638B (en) 2017-08-18 2021-04-09 麦迪穆有限责任公司 Pyrrolobenzodiazepine conjugates
US10301319B2 (en) 2017-09-20 2019-05-28 Ph Pharma Co., Ltd. Thailanstatin analogs
GB201803342D0 (en) 2018-03-01 2018-04-18 Medimmune Ltd Methods
GB201806022D0 (en) 2018-04-12 2018-05-30 Medimmune Ltd Pyrrolobenzodiazepines and conjugates thereof
GB201814281D0 (en) 2018-09-03 2018-10-17 Femtogenix Ltd Cytotoxic agents
CN113056287A (en) 2018-10-24 2021-06-29 豪夫迈·罗氏有限公司 Conjugated chemical degradation inducers and methods of use
CN113227119A (en) 2018-12-10 2021-08-06 基因泰克公司 Photocrosslinked peptides for site-specific conjugation to Fc-containing proteins
GB201901197D0 (en) 2019-01-29 2019-03-20 Femtogenix Ltd G-A Crosslinking cytotoxic agents
GB2597532A (en) 2020-07-28 2022-02-02 Femtogenix Ltd Cytotoxic compounds
WO2024138128A2 (en) 2022-12-23 2024-06-27 Genentech, Inc. Cereblon degrader conjugates, and uses thereof
WO2024220546A2 (en) 2023-04-17 2024-10-24 Peak Bio, Inc. Antibodies and antibody-drug conjugates and methods of use and synthetic processes and intermediates

Also Published As

Publication number Publication date
WO2003003984A2 (en) 2003-01-16
WO2003003984A9 (en) 2009-05-22

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