WO2003000418A3 - Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system - Google Patents

Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system Download PDF

Info

Publication number
WO2003000418A3
WO2003000418A3 PCT/US2002/019935 US0219935W WO03000418A3 WO 2003000418 A3 WO2003000418 A3 WO 2003000418A3 US 0219935 W US0219935 W US 0219935W WO 03000418 A3 WO03000418 A3 WO 03000418A3
Authority
WO
WIPO (PCT)
Prior art keywords
microfluidic system
interface port
fluid interface
virtual wall
system including
Prior art date
Application number
PCT/US2002/019935
Other languages
French (fr)
Other versions
WO2003000418A2 (en
Inventor
Sebastian Boehm
John Gilbert
Original Assignee
Coventor Inc
Sebastian Boehm
John Gilbert
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/027,516 external-priority patent/US20020197733A1/en
Priority claimed from US10/029,108 external-priority patent/US6808683B2/en
Priority claimed from US10/027,484 external-priority patent/US20030015425A1/en
Priority claimed from US10/027,171 external-priority patent/US7041257B2/en
Priority claimed from US10/028,852 external-priority patent/US7179423B2/en
Priority claimed from US10/027,922 external-priority patent/US20030077570A1/en
Priority to EP02737579A priority Critical patent/EP1412729A4/en
Priority to CA002451753A priority patent/CA2451753A1/en
Application filed by Coventor Inc, Sebastian Boehm, John Gilbert filed Critical Coventor Inc
Priority to JP2003507051A priority patent/JP2005514187A/en
Priority to AU2002310501A priority patent/AU2002310501A1/en
Publication of WO2003000418A2 publication Critical patent/WO2003000418A2/en
Publication of WO2003000418A3 publication Critical patent/WO2003000418A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0268—Drop counters; Drop formers using pulse dispensing or spraying, eg. inkjet type, piezo actuated ejection of droplets from capillaries
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D57/00—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C
    • B01D57/02—Separation, other than separation of solids, not fully covered by a single other group or subclass, e.g. B03C by electrophoresis
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0241—Drop counters; Drop formers
    • B01L3/0244—Drop counters; Drop formers using pins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44743—Introducing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44782—Apparatus specially adapted therefor of a plurality of samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44756—Apparatus specially adapted therefor
    • G01N27/44791—Microapparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00364—Pipettes
    • B01J2219/00371—Pipettes comprising electrodes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00783—Laminate assemblies, i.e. the reactor comprising a stack of plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00831—Glass
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00819—Materials of construction
    • B01J2219/00837—Materials of construction comprising coatings other than catalytically active coatings
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00851—Additional features
    • B01J2219/00869—Microreactors placed in parallel, on the same or on different supports
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00905—Separation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/143—Quality control, feedback systems
    • B01L2200/147—Employing temperature sensors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/089—Virtual walls for guiding liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0415—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic
    • B01L2400/0421—Moving fluids with specific forces or mechanical means specific forces electrical forces, e.g. electrokinetic electrophoretic flow
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N2035/1027—General features of the devices
    • G01N2035/1034—Transferring microquantities of liquid
    • G01N2035/1037—Using surface tension, e.g. pins or wires
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Electrochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Clinical Laboratory Science (AREA)
  • Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Environmental & Geological Engineering (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Jet Pumps And Other Pumps (AREA)

Abstract

A fluid interface port in a microfluidic system and a method of forming the fluid interface port is provided. The fluid interface port comprises an opening formed in the side wall of a microchannel sized and dimensioned to form a virtual wall when the microchannel is filled with a first liquid. The fluid interface port is utilized to fill the microchannel with a first liquid, to introduce a second liquid into the first liquid and to eject fluid from the microchannel.
PCT/US2002/019935 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system WO2003000418A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002310501A AU2002310501A1 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
JP2003507051A JP2005514187A (en) 2001-06-20 2002-06-20 Microfluidic system including virtual wall fluidic interconnect ports for interconnecting fluids with microfluidic systems
EP02737579A EP1412729A4 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
CA002451753A CA2451753A1 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US29951501P 2001-06-20 2001-06-20
US60/299,515 2001-06-20
US10/027,516 US20020197733A1 (en) 2001-06-20 2001-12-21 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US10/027,922 US20030077570A1 (en) 2001-09-20 2001-12-21 Small molecule substrate based enzyme activity assays
US10/027,922 2001-12-21
US10/027,516 2001-12-21
US10/027,484 2001-12-21
US10/028,852 US7179423B2 (en) 2001-06-20 2001-12-21 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US10/027,171 US7041257B2 (en) 2001-09-25 2001-12-21 Microfabricated two-pin liquid sample dispensing system
US10/029,108 2001-12-21
US10/027,484 US20030015425A1 (en) 2001-06-20 2001-12-21 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
US10/029,108 US6808683B2 (en) 2001-09-25 2001-12-21 Droplet dispensing system
US10/028,852 2001-12-21
US10/027,171 2001-12-21

Publications (2)

Publication Number Publication Date
WO2003000418A2 WO2003000418A2 (en) 2003-01-03
WO2003000418A3 true WO2003000418A3 (en) 2003-03-13

Family

ID=27567731

Family Applications (3)

Application Number Title Priority Date Filing Date
PCT/US2002/019934 WO2003000417A2 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
PCT/US2002/019932 WO2003000416A2 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
PCT/US2002/019935 WO2003000418A2 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system

Family Applications Before (2)

Application Number Title Priority Date Filing Date
PCT/US2002/019934 WO2003000417A2 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
PCT/US2002/019932 WO2003000416A2 (en) 2001-06-20 2002-06-20 Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system

Country Status (5)

Country Link
EP (1) EP1412729A4 (en)
JP (1) JP2005514187A (en)
AU (3) AU2002326314A1 (en)
CA (1) CA2451753A1 (en)
WO (3) WO2003000417A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles
US8986966B2 (en) 2002-09-27 2015-03-24 The General Hospital Corporation Microfluidic device for cell separation and uses thereof

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6696022B1 (en) 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US8329118B2 (en) * 2004-09-02 2012-12-11 Honeywell International Inc. Method and apparatus for determining one or more operating parameters for a microfluidic circuit
US6913697B2 (en) 2001-02-14 2005-07-05 Science & Technology Corporation @ Unm Nanostructured separation and analysis devices for biological membranes
WO2003066191A1 (en) 2002-02-04 2003-08-14 Colorado School Of Mines Laminar flow-based separations of colloidal and cellular particles
JP2005272295A (en) * 2004-02-26 2005-10-06 Dowa Mining Co Ltd Tetragonal barium titanate particles, method for manufacturing the same and ceramic capacitor
US20070196820A1 (en) 2005-04-05 2007-08-23 Ravi Kapur Devices and methods for enrichment and alteration of cells and other particles
FR2884437B1 (en) * 2005-04-19 2007-07-20 Commissariat Energie Atomique MICROFLUIDIC DEVICE AND METHOD FOR THE TRANSFER OF MATERIAL BETWEEN TWO IMMISCIBLE PHASES.
JP2009501938A (en) * 2005-07-18 2009-01-22 ユー．エス． ジェノミクス， インコーポレイテッド Microfluidic method and microfluidic device for sample preparation and analysis
US9878326B2 (en) 2007-09-26 2018-01-30 Colorado School Of Mines Fiber-focused diode-bar optical trapping for microfluidic manipulation
US8119976B2 (en) 2007-07-03 2012-02-21 Colorado School Of Mines Optical-based cell deformability
US9487812B2 (en) 2012-02-17 2016-11-08 Colorado School Of Mines Optical alignment deformation spectroscopy
US9885644B2 (en) 2006-01-10 2018-02-06 Colorado School Of Mines Dynamic viscoelasticity as a rapid single-cell biomarker
WO2007122850A1 (en) 2006-03-29 2007-11-01 Konica Minolta Medical & Graphic, Inc. Method of reaction in microchip channel and analyzer
US8999636B2 (en) 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
JP5016683B2 (en) * 2007-01-17 2012-09-05 アジレント・テクノロジーズ・インク Microfluidic chip having side openings for fluid introduction
ATE496695T1 (en) 2007-06-25 2011-02-15 Ibidi Gmbh SAMPLE CHAMBER
EP2017006A1 (en) * 2007-07-20 2009-01-21 Koninklijke Philips Electronics N.V. Microfluidic methods and systems for use in detecting analytes
US10722250B2 (en) 2007-09-04 2020-07-28 Colorado School Of Mines Magnetic-field driven colloidal microbots, methods for forming and using the same
WO2010014233A1 (en) * 2008-08-01 2010-02-04 President And Fellows Of Harvard College Systems and methods for bubble and/or foam inhibition
US8361716B2 (en) 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
EP2416163A4 (en) 2009-03-30 2014-07-02 Konica Minolta Opto Inc Microchip
SE534488C2 (en) * 2010-02-22 2011-09-06 Lunavation Ab A system for electrokinetic flow technology
CN103998144A (en) * 2011-10-28 2014-08-20 惠普发展公司，有限责任合伙企业 Parallel addressing method
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9341639B2 (en) 2013-07-26 2016-05-17 Industrial Technology Research Institute Apparatus for microfluid detection
CA2938161A1 (en) 2014-02-01 2015-08-06 Ezmems Ltd. Chip device for monitoring and regulating fluid flow, and methods of manufacture thereof
US11033898B2 (en) 2014-02-01 2021-06-15 Ezmems Ltd. Fluidic microelectromechanical sensors/devices and fabrication methods thereof
JP6868036B2 (en) * 2016-04-14 2021-05-12 ヒューレット−パッカード デベロップメント カンパニー エル．ピー．Ｈｅｗｌｅｔｔ‐Ｐａｃｋａｒｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏｍｐａｎｙ， Ｌ．Ｐ． Microfluidic device with capillary chamber
JP6919181B2 (en) * 2016-11-29 2021-08-18 株式会社リコー Droplet dispensing device, droplet dispensing method, and manufacturing method of adherend
CN107007834A (en) * 2017-05-10 2017-08-04 苏州万化集成生物科技有限公司 Tumor thermotherapy pill and its preparation facilities, preparation technology
CN110831682A (en) 2017-05-11 2020-02-21 Emd密理博公司 Method for maintaining narrow residence time distribution in continuous flow systems
EP3621715A4 (en) * 2017-05-11 2021-01-27 EMD Millipore Corporation Mechanical method of maintaining narrow residence time distributions in continuous flow systems
WO2022181554A1 (en) * 2021-02-25 2022-09-01 キヤノン株式会社 Microchannel device and method for manufacturing same
CN114113290A (en) * 2021-12-31 2022-03-01 杭州汇健科技有限公司 Biological sample lipid mass spectrometry detection kit, method and application

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004547A1 (en) * 1994-08-01 1996-02-15 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US6042709A (en) * 1996-06-28 2000-03-28 Caliper Technologies Corp. Microfluidic sampling system and methods
US6068751A (en) * 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US6150119A (en) * 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5958202A (en) * 1992-09-14 1999-09-28 Perseptive Biosystems, Inc. Capillary electrophoresis enzyme immunoassay
WO1997047390A1 (en) * 1996-06-14 1997-12-18 University Of Washington Absorption-enhanced differential extraction device
US6090251A (en) * 1997-06-06 2000-07-18 Caliper Technologies, Inc. Microfabricated structures for facilitating fluid introduction into microfluidic devices
US6001231A (en) * 1997-07-15 1999-12-14 Caliper Technologies Corp. Methods and systems for monitoring and controlling fluid flow rates in microfluidic systems
US6284113B1 (en) * 1997-09-19 2001-09-04 Aclara Biosciences, Inc. Apparatus and method for transferring liquids
JP2001518624A (en) * 1997-09-26 2001-10-16 ユニバーシティ・オブ・ワシントン Simultaneous particle separation and chemical reactions
US6143152A (en) * 1997-11-07 2000-11-07 The Regents Of The University Of California Microfabricated capillary array electrophoresis device and method
US6110332A (en) * 1998-10-26 2000-08-29 The Regents Of The University Of California T-load microchannel array and fabrication method
GB9907249D0 (en) * 1999-03-29 1999-05-26 Cole Polytechnique Fudurale De Chemical assay apparatus
US6271038B1 (en) * 1999-12-15 2001-08-07 Glaxo Wellcome Inc. Methods for high throughout determination and ranking of formulations and solubility
CA2399398A1 (en) * 2000-02-11 2001-08-16 Aclara Biosciences, Inc. Microfluid device with sample injector and method of use
US6290909B1 (en) * 2000-04-13 2001-09-18 Sandia Corporation Sample injector for high pressure liquid chromatography

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996004547A1 (en) * 1994-08-01 1996-02-15 Lockheed Martin Energy Systems, Inc. Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
US5858195A (en) * 1994-08-01 1999-01-12 Lockheed Martin Energy Research Corporation Apparatus and method for performing microfluidic manipulations for chemical analysis and synthesis
US6068751A (en) * 1995-12-18 2000-05-30 Neukermans; Armand P. Microfluidic valve and integrated microfluidic system
US5779868A (en) * 1996-06-28 1998-07-14 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US5880071A (en) * 1996-06-28 1999-03-09 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US6080295A (en) * 1996-06-28 2000-06-27 Caliper Technologies Corporation Electropipettor and compensation means for electrophoretic bias
US6042709A (en) * 1996-06-28 2000-03-28 Caliper Technologies Corp. Microfluidic sampling system and methods
US5800690A (en) * 1996-07-03 1998-09-01 Caliper Technologies Corporation Variable control of electroosmotic and/or electrophoretic forces within a fluid-containing structure via electrical forces
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5957579A (en) * 1997-10-09 1999-09-28 Caliper Technologies Corp. Microfluidic systems incorporating varied channel dimensions
US6186660B1 (en) * 1997-10-09 2001-02-13 Caliper Technologies Corp. Microfluidic systems incorporating varied channel dimensions
US6274089B1 (en) * 1998-06-08 2001-08-14 Caliper Technologies Corp. Microfluidic devices, systems and methods for performing integrated reactions and separations
US6150119A (en) * 1999-01-19 2000-11-21 Caliper Technologies Corp. Optimized high-throughput analytical system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP1412729A4 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8986966B2 (en) 2002-09-27 2015-03-24 The General Hospital Corporation Microfluidic device for cell separation and uses thereof
US8921102B2 (en) 2005-07-29 2014-12-30 Gpb Scientific, Llc Devices and methods for enrichment and alteration of circulating tumor cells and other particles

Also Published As

Publication number Publication date
AU2002310500A1 (en) 2003-01-08
CA2451753A1 (en) 2003-01-03
WO2003000417A3 (en) 2003-02-27
JP2005514187A (en) 2005-05-19
WO2003000416A3 (en) 2003-12-04
EP1412729A2 (en) 2004-04-28
EP1412729A4 (en) 2005-03-09
AU2002310501A1 (en) 2003-01-08
AU2002326314A1 (en) 2003-01-08
WO2003000417A2 (en) 2003-01-03
WO2003000418A2 (en) 2003-01-03
WO2003000416A2 (en) 2003-01-03

Similar Documents

Publication Publication Date Title
WO2003000416A3 (en) Microfluidic system including a virtual wall fluid interface port for interfacing fluids with the microfluidic system
CA2533107A1 (en) Mixing in microfluidic devices
WO2004077125A3 (en) Improvements in and relating to fluid filled devices
WO2006071726A3 (en) Vial for filling a syringe
WO2004108060A8 (en) Reconstitution device and method of use
EP1378461A3 (en) Flexible pouch having system for mixing two components
WO2003016196A3 (en) High throughput dispensing of fluids
WO2004096113A3 (en) Container with valve assembly for filling and dispensing substances, and apparatus and method for filling
AU2003210387A1 (en) Microfluid system
WO2001078893A3 (en) Fluidic impedances in microfluidic system
WO2003088733A8 (en) Microfluidic system including a bubble valve for regulating fluid through a microchannel
WO2005042067A3 (en) Wet/dry automatic injector assembly
WO2008008392A3 (en) Connect/disconnect coupling for a container
WO2005022058A3 (en) Portable water cooler with bagged fluids
AU2003217111A1 (en) Fluid transfer assembly
EP2556855A3 (en) Method and device for the iontophoretic delivery of a drug
WO2003082369A3 (en) A multi-compartment syringe
WO2002049956A3 (en) Dispensing valve assembly for liquid
CA2282437A1 (en) A container closure with a frangible seal and a connector for a fluid transfer device
WO2005058743A3 (en) Container and one-way valve assembly for storing and dispensing substances, and related method
WO2007014366A3 (en) Collapsible bag for dispensing liquids and method
CN107287111A (en) A kind of device and method for digital pcr
WO2007075433A3 (en) Beverage systems
EP2273179A3 (en) A valve for closing a container, container and a system and method for filling a container
EP0247425A3 (en) Flush device

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2451753

Country of ref document: CA

WWE Wipo information: entry into national phase

Ref document number: 2003507051

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2002737579

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2002737579

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642