CN107007834A - Tumor thermotherapy pill and its preparation facilities, preparation technology - Google Patents
Tumor thermotherapy pill and its preparation facilities, preparation technology Download PDFInfo
- Publication number
- CN107007834A CN107007834A CN201710325707.3A CN201710325707A CN107007834A CN 107007834 A CN107007834 A CN 107007834A CN 201710325707 A CN201710325707 A CN 201710325707A CN 107007834 A CN107007834 A CN 107007834A
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- Prior art keywords
- pill
- core drug
- fluid channel
- injection device
- micro
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0052—Thermotherapy; Hyperthermia; Magnetic induction; Induction heating therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2813—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
Abstract
The present invention relates to a kind of tumor thermotherapy pill and its preparation facilities, preparation technology, this tumor thermotherapy pill, including：Core drug；With the shell for being wrapped up core drug；Wherein described core drug is chance water exothermic reaction material；The core drug that the heat that this tumor thermotherapy pill kills tumour cell (tissue) is suitable to produce thermal response by chance water is provided; and heat release medicine (core drug) is wrapped up by inert material; it is easy to transport, preserve and inject; further; because the protection of parcel shell in the treatment injection process of this medicine; exothermic reaction will not occur immediately, so that the normal structure that injection device is passed through will not be damaged.
Description
Technical field
The present invention relates to medical device field, and in particular to a kind of tumor thermotherapy pill and its preparation facilities, preparation technology.
Background technology
Tumor thermotherapy is one of interventional therapy in addition to surgery excision, radiation and chemotherapy, although surgery excision, radiotherapy
It is considered as maximally effective treatment means with chemotherapy.But surgery excision can cause mutilation, radiotherapy then can be because of pair work with chemotherapy
Cause the injury to body and spirit with excessive, all these approach are all by the inevitably survival rate of reduction patient and life
Deposit quality.Therefore, there is minimally invasive, toxic side effect small and the knub thermotherapy of orientable treatment is attracted attention and applied.Tumour
Thermotherapy is the temperature that tumor tissues and its surrounding tissue are lifted by various heater meanses, when tumor tissues are heated to a constant temperature
When spending, it is possible to kill tumour cell.
Conventional tumor thermotherapy measure at present has microwave heating, radio frequency heating, focusing ultrasonic wave is heated, laser is very hot, heat
Medium is included in physical means (Li Dingjiu etc., hyperthermic oncology, the Zhengzhou such as heating：Publishing house of Zhengzhou University, 2003).Microwave due to
Penetration depth is shallow, can only make superficial heating, be used for superficial tumor.Although RF thermotherapeutic can heating deep tumour, water need to be used
Cold exhausted part, subcutaneous fat occurs to overheat and pain, causes rhabdion, operates also more difficult.Focusing ultrasonic wave thermotherapy penetration power is strong,
Deep tumor, but the limitation due to ultrasonic wave in itself can be treated, it is impossible to penetrate the tissue of gassiness, bone can not be passed through, therefore
It is very limited using scope.In summary, these knub thermotherapies have that temperature rise effect is limited, heated perimeter is difficult to fit
Shape temperature detecting precision is low, health tissues can suffer from that pyrolytic damage etc. is unfavorable, therefore can cause final target killing efficiency
Not high, there are the situations such as residual, transfer and recurrence in tumour cell.
Therefore, the heating tumor target tissue how oriented, tumor tissues are heated to effectively killing temperature and not damaged
Hinder normal structure, and this key issue there is no good solution so far, in addition, the heat treatment unit based on the above method
One common but complicated, and operation technique is complicated, and medical expense is very high.
The content of the invention
It is an object of the invention to provide a kind of tumor thermotherapy pill and its preparation facilities, preparation technology, traditional tumour is broken through
The limitation of thermotherapy method, the tumor thermotherapy pill of low cost is prepared using microflow control technique.
In order to solve the above-mentioned technical problem, the invention provides a kind of tumor thermotherapy pill, including：
Core drug；With
The shell that core drug is wrapped up；Wherein
The core drug is chance water exothermic reaction material.
Further, the chance water exothermic reaction material includes：Inorganic alkaline compound, organic basic compound, inorganic acid
Property compound, organic acidity compound, the one or more of alkali metal or alkali metal compound；
Constituting the material of the shell includes：Inorganic oil, organic oil, inorganic polymer or organic polymer polymerization
The one or more of thing.
Another aspect, present invention also offers a kind of pill preparation facilities.
The pill preparation facilities includes：
Micro-fluidic chip for preparing parcel pill, and
Core drug injection device, the sheathing material injection device being connected with the micro-fluidic chip；Wherein
The output end connection solidification equipment of the micro-fluidic chip, and will consolidate into the shell of the parcel pill of solidification equipment
Change.
Further, the micro-fluidic chip includes：The first fluid channel being connected with core drug injection device, with shell
The second fluid channel that Material injection device is connected, and the end of the first fluid channel connects the side of the second fluid channel for an injection nozzle
Wall；And
An air knife for being used to cut off solution is additionally provided with the side wall of second fluid channel and positioned at injection nozzle rear end, one is micro-
Type air pump connects the air knife；Wherein
The sheathing material injection device is pushed into outer shell solution and entered in the second fluid channel, and stops at injection nozzle, and
Injection nozzle is wrapped up；Core drug is pushed into outer shell solution by core drug injection device by the first fluid channel, injection nozzle
Afterwards, the sheathing material injection device is persistently pushed into outer shell solution, and has wrapped up core drug by air-flow cut-out at air knife
Outer shell solution.
Further, the solidification equipment is to be heating and curing or ultraviolet curing equipment, and
Medicine receiving flask is also associated with positioned at the output end of the solidification equipment.
Further, the pill preparation facilities also includes processor module, i.e.,
The control end of the processor respectively with core drug injection device, sheathing material injection device, and miniature gas
Pump, solidification equipment are connected.
Further, the parcel pill is tumor thermotherapy pill；Wherein
The core drug is high concentration NaOH solution；And
The outer shell solution is uv photosensitivity curing materials.
The third aspect, present invention also offers a kind of pill preparation technology, including：
After by outer shell solution, core drug is wrapped up, solidified.
Further, the pill preparation technology is realized by pill preparation facilities, i.e.,
The pill preparation facilities includes：
Micro-fluidic chip for preparing parcel pill, and
Core drug injection device, the sheathing material injection device being connected with the micro-fluidic chip；Wherein
The output end connection solidification equipment of the micro-fluidic chip, and will consolidate into the shell of the parcel pill of solidification equipment
Change.
Further, the micro-fluidic chip includes：The first fluid channel being connected with core drug injection device, with shell
The second fluid channel that Material injection device is connected, and the end of the first fluid channel connects the side of the second fluid channel for an injection nozzle
Wall；And
An air knife for being used to cut off solution is additionally provided with the side wall of second fluid channel and positioned at injection nozzle rear end, one is micro-
Type air pump connects the air knife；Wherein
The sheathing material injection device is pushed into outer shell solution and entered in the second fluid channel, and stops at injection nozzle, and
Injection nozzle is wrapped up；Core drug is pushed into outer shell solution by core drug injection device by the first fluid channel, injection nozzle
Afterwards, the sheathing material injection device is persistently pushed into outer shell solution, and has wrapped up core drug by air-flow cut-out at air knife
Outer shell solution.
Beneficial effects of the present invention are as follows：The heat that this tumor thermotherapy pill kills tumour cell (tissue) is suitable to by chance water
The core drug for producing thermal response is provided, and heat release medicine (core drug) wraps up by inert material, it is easy to transport, preserve and
Injection, further, because the protection of parcel shell, exothermic reaction will not occur immediately in the treatment injection process of this medicine,
So as to which the normal structure that injection device is passed through will not be damaged.
Brief description of the drawings
The present invention is further described with reference to the accompanying drawings and examples.
Fig. 1 is the configuration diagram of the tumor thermotherapy pill of the present invention；
Fig. 2 is the structural representation of the pill preparation facilities of the present invention.
In figure：Core drug 1, shell 2, outer shell solution 2a, micro-fluidic chip 3, the first fluid channel 301, injection nozzle 301a,
Second fluid channel 302, air knife 303, gap 4.
Embodiment
In conjunction with the accompanying drawings, the present invention is further explained in detail.These accompanying drawings are simplified schematic diagram, only with
Illustration illustrates the basic structure of the present invention, therefore it only shows the composition relevant with the present invention.
Embodiment 1
As shown in figure 1, the invention provides a kind of tumor thermotherapy pill, including：Core drug 1；Enter with by core drug 1
The shell of row parcel；Wherein described core drug 1 is chance water exothermic reaction material.
Specifically, the chance water exothermic reaction material includes：Inorganic alkaline compound, organic basic compound, inorganic acid
Property compound, organic acidity compound, the one or more of alkali metal or alkali metal compound；And constitute the thing of the shell
Matter includes：Inorganic oil, organic oil, the one or more of inorganic polymer or organic high molecular polymer.
The average diameter range of the core drug 1 and parcel shell is such as, but not limited between 1nm-5mm, its shape
For spherical, bar shaped or random property.
The effect of the core drug 1 is release heat, and the effect treated as needed controls volume, the quality of medication amount
And composition, the effect of parcel shell is time and speed that control core medicine 1 reacts, therapeutic effect control bag as needed
Wrap up in the volume, quality and composition of shell.
The control method of the core drug 1 and parcel enclosure volume, quality and composition is to be based on microflow control technique, is passed through
Complicated microchannel, micro-valve and drive control is realized, specifically as described in embodiment 1 or embodiment 2.
Embodiment 2
The present invention prepares the pill (i.e. tumor thermotherapy pill) of low cost using microflow control technique, by core drug
1 and the accurate control of the parcel quality of shell, volume and composition, obtain that killing-efficiency is high, harmless to perienchyma, be easy to transport
Tumor thermotherapy pill that is defeated, preserving and operate.
As shown in Fig. 2 present invention also offers a kind of pill preparation facilities, including：
Micro-fluidic chip 3 for preparing parcel pill, and
Core drug injection device, the sheathing material injection device being connected with the micro-fluidic chip 3；Wherein
The output end connection solidification equipment of the micro-fluidic chip 3, and the shell of the parcel pill of solidification equipment will be entered
Solidification.
The micro-fluidic chip 3 includes：The first fluid channel 301 being connected with core drug injection device, with outer shell material
The second fluid channel 302 that material injection device is connected, and the end of the first fluid channel 301 is micro- for an injection nozzle 301a connections second
The side wall of runner 302；And one is additionally provided with for cutting on the side wall of second fluid channel 302 and positioned at injection nozzle 301a rear ends
The air knife 303 of disconnected solution a, micro air pump connects the air knife 303；Wherein described sheathing material injection device is pushed into outer shell solution
2a enters in the second fluid channel 302, and stops at injection nozzle 301a, and injection nozzle 301a is wrapped up；Core drug injection dress
Put after by the first fluid channel 301, injection nozzle 301a, core drug 1 is pushed into outer shell solution 2a, the sheathing material note
Injection device is persistently pushed into outer shell solution 2a, and cuts off the outer shell solution for having wrapped up core drug 1 by air-flow at air knife 303
2a；After severance, the air knife 303 is stopped, and again passes through one section of outer shell solution 2a for having wrapped up core drug 1 rear heavy
Multiple said process, because air knife 303 is spaced work, and outer shell solution 2a is split according to the core drug 1 of parcel, and
Isolated between the outer shell solution 2a split by the gap 4 of formation.
This described solidification equipment is to be heating and curing or ultraviolet curing equipment, and positioned at the output end of the solidification equipment
It is also associated with medicine receiving flask.
The pill preparation facilities also includes processor module, i.e., the control end of described processor is noted with core drug respectively
Injection device, sheathing material injection device, and micro air pump, solidification equipment are connected.
The core drug injection device, sheathing material injection device are using the high accuracy injection for being suitable to regulation and control injection volume
Device, such as, but not limited to high-precision syringe pump.
The parcel pill is tumor thermotherapy pill；Wherein described core drug 1 is high concentration NaOH solution or NaOH
Powder；And the outer shell solution 2a is that uv photosensitivity curing materials, i.e., ultraviolet photosensitive raw material, and two kinds of compositions will not occur
Chemical reaction.
This pill preparation facilities is cleverly by core drug injection device, sheathing material injection device, the first fluid channel
301st, the second fluid channel 302 and injection nozzle 301a and air knife 303 are combined, and are realized inexpensive quickly by parcel core medicine
The outer shell solution 2a of thing 1 carries out segmentation cut-out, and the channel interval sent into each other by air knife, enables subsequent cure device
Independent parcel pill is enough produced, is not in inter-adhesive phenomenon, is particularly suitable for medicine volume production.
Embodiment 3
On the basis of embodiment 2, the invention provides a kind of pill preparation technology, including：
After by outer shell solution 2a, core drug 1 is wrapped up, solidified.
The pill preparation technology realizes that is, described pill preparation facilities includes by pill preparation facilities：For preparing
The micro-fluidic chip 3 of pill is wrapped up, and the core drug injection device, the sheathing material that are connected with the micro-fluidic chip 3 are injected
Device；The output end connection solidification equipment of wherein described micro-fluidic chip 3, and the shell of the parcel pill of solidification equipment will be entered
Solidification.
The micro-fluidic chip 3 includes：The first fluid channel 301 being connected with core drug injection device, with outer shell material
The second fluid channel 302 that material injection device is connected, and the end of the first fluid channel 301 is micro- for an injection nozzle 301a connections second
The side wall of runner 302；And one is additionally provided with for cutting on the side wall of second fluid channel 302 and positioned at injection nozzle 301a rear ends
The air knife 303 of disconnected solution a, micro air pump connects the air knife 303；Wherein described sheathing material injection device is pushed into outer shell solution
2a enters in the second fluid channel 302, and stops at injection nozzle 301a, and injection nozzle 301a is wrapped up；Core drug injection dress
Put after by the first fluid channel 301, injection nozzle 301a, core drug 1 is pushed into outer shell solution 2a, the sheathing material note
Injection device is persistently pushed into outer shell solution 2a, and cuts off the outer shell solution for having wrapped up core drug 1 by air-flow at air knife 303
2a。
So that the core drug 1 is high concentration NaOH solution as an example, in pill preparation technology of the present invention, micro-fluidic chip 3
For its core component, the core drug 1 and ultraviolet photosensitive curing compounds being stored in corresponding injection device are in external force syringe pump
Under driving, into micro-fluidic chip 3 and form by ultraviolet photosensitive curing compounds wrap up NaOH solution particle (or drop),
Solidification is reacted under the irradiation of ultraviolet light in solidification equipment, so as to form the solid particle that kernel is NaOH solution, its NaOH
The volume and quality of solution, the volume and quality for wrapping up shell depend on the flow velocity and its velocity ratio of two syringe pumps.
Flow velocity selected by the syringe of NaOH solution is perfused with for 1uL/min, the syringe institute of ultraviolet photosensitive raw material is perfused with
It is 5uL/min to select flow velocity, and the external diameter of obtained tumor thermotherapy pill is 30um, and the external diameter of its part of core drug 1 is 20um, shape
Shape is spherical.Above-mentioned flow velocity will be adjusted and be adjusted to 2uL/min and 10uL/min, the external diameter of obtained tumor thermotherapy pill is
45um, the external diameter of its part of core drug 1 is 30um, is shaped as spherical, it was demonstrated that the size of core drug 1 and parcel shell is big
Small controllable, both diameter proportion sizes are controllable.
Using the above-mentioned desirable embodiment according to the present invention as enlightenment, by above-mentioned description, relevant staff is complete
Various changes and amendments can be carried out without departing from the scope of the technological thought of the present invention' entirely.The technology of this invention
Property scope is not limited to the content on specification, it is necessary to its technical scope is determined according to right.
Claims (10)
1. a kind of tumor thermotherapy pill, it is characterised in that including：
Core drug；With
The shell that core drug is wrapped up；Wherein
The core drug is chance water exothermic reaction material.
2. tumor thermotherapy pill according to claim 1, it is characterised in that
The chance water exothermic reaction material includes：Inorganic alkaline compound, organic basic compound, inorganic acidic compound, have
The one or more of machine acid compound, alkali metal or alkali metal compound；
Constituting the material of the shell includes：Inorganic oil, organic oil, inorganic polymer or organic high molecular polymer
It is one or more of.
3. a kind of pill preparation facilities, it is characterised in that including：
Micro-fluidic chip for preparing parcel pill, and
Core drug injection device, the sheathing material injection device being connected with the micro-fluidic chip；Wherein
The output end connection solidification equipment of the micro-fluidic chip, and the shell solidification of the parcel pill of solidification equipment will be entered.
4. pill preparation facilities according to claim 3, it is characterised in that
The micro-fluidic chip includes：The first fluid channel being connected with core drug injection device, injects with sheathing material and fills
The second fluid channel being connected is put, and the end of the first fluid channel connects the side wall of the second fluid channel for an injection nozzle；And
An air knife for being used to cut off solution, a miniature gas are additionally provided with the side wall of second fluid channel and positioned at injection nozzle rear end
Pump connects the air knife；Wherein
The sheathing material injection device is pushed into outer shell solution and entered in the second fluid channel, and stops at injection nozzle, and will note
Nozzle is wrapped up；After core drug is pushed into outer shell solution by core drug injection device by the first fluid channel, injection nozzle, institute
State sheathing material injection device and be persistently pushed into outer shell solution, and cut off the shell for having wrapped up core drug by air-flow at air knife
Solution.
5. pill preparation facilities according to claim 4, it is characterised in that
The solidification equipment is to be heating and curing or ultraviolet curing equipment, and
Medicine receiving flask is also associated with positioned at the output end of the solidification equipment.
6. pill preparation facilities according to claim 5, it is characterised in that
The pill preparation facilities also includes processor module, i.e.,
The control end of the processor respectively with core drug injection device, sheathing material injection device, it is and micro air pump, solid
Makeup puts connected.
7. pill preparation facilities according to claim 6, it is characterised in that
The parcel pill is tumor thermotherapy pill；Wherein
The core drug is high concentration NaOH solution；And
The outer shell solution is uv photosensitivity curing materials.
8. a kind of pill preparation technology, it is characterised in that including：
After by outer shell solution, core drug is wrapped up, solidified.
9. pill preparation technology according to claim 8, it is characterised in that
The pill preparation technology realized by pill preparation facilities, i.e.,
The pill preparation facilities includes：
Micro-fluidic chip for preparing parcel pill, and
Core drug injection device, the sheathing material injection device being connected with the micro-fluidic chip；Wherein
The output end connection solidification equipment of the micro-fluidic chip, and the shell solidification of the parcel pill of solidification equipment will be entered.
10. pill preparation technology according to claim 9, it is characterised in that
The micro-fluidic chip includes：The first fluid channel being connected with core drug injection device, injects with sheathing material and fills
The second fluid channel being connected is put, and the end of the first fluid channel connects the side wall of the second fluid channel for an injection nozzle；And
An air knife for being used to cut off solution, a miniature gas are additionally provided with the side wall of second fluid channel and positioned at injection nozzle rear end
Pump connects the air knife；Wherein
The sheathing material injection device is pushed into outer shell solution and entered in the second fluid channel, and stops at injection nozzle, and will note
Nozzle is wrapped up；After core drug is pushed into outer shell solution by core drug injection device by the first fluid channel, injection nozzle, institute
State sheathing material injection device and be persistently pushed into outer shell solution, and cut off the shell for having wrapped up core drug by air-flow at air knife
Solution.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710325707.3A CN107007834A (en) | 2017-05-10 | 2017-05-10 | Tumor thermotherapy pill and its preparation facilities, preparation technology |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710325707.3A CN107007834A (en) | 2017-05-10 | 2017-05-10 | Tumor thermotherapy pill and its preparation facilities, preparation technology |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN107007834A true CN107007834A (en) | 2017-08-04 |
Family
ID=59448814
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| CN201710325707.3A Pending CN107007834A (en) | 2017-05-10 | 2017-05-10 | Tumor thermotherapy pill and its preparation facilities, preparation technology |
Country Status (1)
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111565847A (en) * | 2018-01-15 | 2020-08-21 | 罗伯特·博世有限公司 | Microfluidic device and method for operating the same |
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