WO2002101232A3 - Proteine interagissant avec bace - Google Patents

Proteine interagissant avec bace Download PDF

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Publication number
WO2002101232A3
WO2002101232A3 PCT/EP2002/006667 EP0206667W WO02101232A3 WO 2002101232 A3 WO2002101232 A3 WO 2002101232A3 EP 0206667 W EP0206667 W EP 0206667W WO 02101232 A3 WO02101232 A3 WO 02101232A3
Authority
WO
WIPO (PCT)
Prior art keywords
disease
bace
alzheimer
proteins
interacting proteins
Prior art date
Application number
PCT/EP2002/006667
Other languages
English (en)
Other versions
WO2002101232A2 (fr
Inventor
Els Marjaux
Diana Ines Dominguez-Tinland
Wim Annaert
Strooper Bart De
Original Assignee
Vlaams Interuniv Inst Biotech
Els Marjaux
Diana Ines Dominguez-Tinland
Wim Annaert
Strooper Bart De
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech, Els Marjaux, Diana Ines Dominguez-Tinland, Wim Annaert, Strooper Bart De filed Critical Vlaams Interuniv Inst Biotech
Priority to AU2002345051A priority Critical patent/AU2002345051A1/en
Publication of WO2002101232A2 publication Critical patent/WO2002101232A2/fr
Publication of WO2002101232A3 publication Critical patent/WO2002101232A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention se rapporte au domaine de la maladie d'Alzheimer. Elle concerne l'identification, l'isolement et le séquençage de différents gènes codant pour des protéines qui interagissent avec la b-sécrétase (BACE). Ces protéines interagissant avec BACE pourraient être impliquées dans les mécanismes conduisant au développement de la maladie d'Alzheimer. Les acides nucléiques et protéines comprenant ces protéines interagissant avec BACE, ou dérivées de celles-ci, sont utiles pour le dépistage et le diagnostic de la maladie d'Alzheimer, pour l'identification et la mise au point d'agents thérapeutiques permettant de traiter la maladie d'Alzheimer, et pour la production de lignées cellulaires et d'animaux transgéniques pouvant servir de modèles pour la maladie d'Alzheimer.
PCT/EP2002/006667 2001-06-12 2002-06-07 Proteine interagissant avec bace WO2002101232A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002345051A AU2002345051A1 (en) 2001-06-12 2002-06-07 Bace interacting proteins

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01202228.1 2001-06-12
EP01202228 2001-06-12

Publications (2)

Publication Number Publication Date
WO2002101232A2 WO2002101232A2 (fr) 2002-12-19
WO2002101232A3 true WO2002101232A3 (fr) 2003-12-31

Family

ID=8180458

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006667 WO2002101232A2 (fr) 2001-06-12 2002-06-07 Proteine interagissant avec bace

Country Status (2)

Country Link
AU (1) AU2002345051A1 (fr)
WO (1) WO2002101232A2 (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2941230B1 (fr) * 2009-01-19 2011-03-18 Centre Nat Rech Scient Polypeptides d'adressage specifique a des cellules-cibles d'otx2
WO2019094608A1 (fr) 2017-11-08 2019-05-16 Denali Therapeutics Inc. Anticorps anti-bace1 et leurs procédés d'utilisation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010354A2 (fr) * 2000-08-01 2002-02-07 Institut De Recherche Cliniques De Montreal (Ircm) Secretase/sheddase avec activite d'asp-ase sur l'enzyme de clivage app du site beta (bace asp2, memepsine 2)

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002010354A2 (fr) * 2000-08-01 2002-02-07 Institut De Recherche Cliniques De Montreal (Ircm) Secretase/sheddase avec activite d'asp-ase sur l'enzyme de clivage app du site beta (bace asp2, memepsine 2)

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
ABBENANTE G ET AL: "Inhibitors of beta-amyloid formation based on the beta-secretase cleavage site.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 268, no. 1, 5 February 2000 (2000-02-05), pages 133 - 135, XP001122396, ISSN: 0006-291X *
DATABASE SWALL [online] 1 May 1999 (1999-05-01), ROWEN: "Large prolin-rich BAT3", XP002230520, retrieved from EBI Database accession no. Q9Z1R2 *
SKOVRONSKY D M ET AL: "beta-Secretase revealed: starting gate for race to novel therapies for Alzheimer's disease", TRENDS IN PHARMACOLOGICAL SCIENCES, ELSEVIER TRENDS JOURNAL, CAMBRIDGE, GB, vol. 21, no. 5, May 2000 (2000-05-01), pages 161 - 163, XP004198178, ISSN: 0165-6147 *

Also Published As

Publication number Publication date
AU2002345051A1 (en) 2002-12-23
WO2002101232A2 (fr) 2002-12-19

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