WO2002101086A3 - Complete mitochondrial genome sequences as a diagnostic tool for the health sciences - Google Patents

Complete mitochondrial genome sequences as a diagnostic tool for the health sciences Download PDF

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Publication number
WO2002101086A3
WO2002101086A3 PCT/CA2002/000848 CA0200848W WO02101086A3 WO 2002101086 A3 WO2002101086 A3 WO 2002101086A3 CA 0200848 W CA0200848 W CA 0200848W WO 02101086 A3 WO02101086 A3 WO 02101086A3
Authority
WO
WIPO (PCT)
Prior art keywords
mitochondrial genome
mutations
diagnostic tool
genome sequences
health sciences
Prior art date
Application number
PCT/CA2002/000848
Other languages
French (fr)
Other versions
WO2002101086A2 (en
Inventor
Mark Birch-Machin
Gabriel D Dakubo
Ryan Parr
Robert Thayer
Alioune Ngom
Ng John Th
Original Assignee
1304854 Ontario Ltd
Mark Birch-Machin
Gabriel D Dakubo
Ryan Parr
Robert Thayer
Alioune Ngom
Ng John Th
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 1304854 Ontario Ltd, Mark Birch-Machin, Gabriel D Dakubo, Ryan Parr, Robert Thayer, Alioune Ngom, Ng John Th filed Critical 1304854 Ontario Ltd
Priority to JP2003503836A priority Critical patent/JP2005506057A/en
Priority to CA002450403A priority patent/CA2450403A1/en
Priority to EP02737683A priority patent/EP1397508A2/en
Publication of WO2002101086A2 publication Critical patent/WO2002101086A2/en
Priority to US10/732,374 priority patent/US20050026167A1/en
Publication of WO2002101086A3 publication Critical patent/WO2002101086A3/en
Priority to PCT/CA2004/002124 priority patent/WO2005056573A1/en
Priority to US11/339,751 priority patent/US20070190534A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)

Abstract

The examination of mutations in the entire mitochondrial genome is used as a diagnostic system for diseases such as prostate cancer, and non melanoma skin cancer. Characteristic mutations and rearrangements including, point mutations (transitions, transversions), deletions, inversions, duplications, recombinations, insertions or combinations thereof in the mitochondrial genome are used as early indicators of prostate cancer, and non melanoma skin cancer. Moreover, the 4977bp, or 'common deletion' as well as other associated mutations and/or deletions are used as a measure of aging.
PCT/CA2002/000848 2001-06-11 2002-06-10 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences WO2002101086A2 (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
JP2003503836A JP2005506057A (en) 2001-06-11 2002-06-10 Whole mitochondrial genome sequence as a diagnostic tool for health science
CA002450403A CA2450403A1 (en) 2001-06-11 2002-06-10 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
EP02737683A EP1397508A2 (en) 2001-06-11 2002-06-10 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US10/732,374 US20050026167A1 (en) 2001-06-11 2003-12-11 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
PCT/CA2004/002124 WO2005056573A1 (en) 2002-06-10 2004-12-13 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US11/339,751 US20070190534A1 (en) 2001-06-11 2006-01-26 Mitochondrial sites and genes associated with prostate cancer

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29734001P 2001-06-11 2001-06-11
US60/297,340 2001-06-11
CA002450004A CA2450004A1 (en) 2001-06-11 2003-12-18 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US10/732,374 Continuation-In-Part US20050026167A1 (en) 2001-06-11 2003-12-11 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences

Publications (2)

Publication Number Publication Date
WO2002101086A2 WO2002101086A2 (en) 2002-12-19
WO2002101086A3 true WO2002101086A3 (en) 2003-12-11

Family

ID=34808883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2002/000848 WO2002101086A2 (en) 2001-06-11 2002-06-10 Complete mitochondrial genome sequences as a diagnostic tool for the health sciences

Country Status (4)

Country Link
EP (1) EP1397508A2 (en)
JP (1) JP2005506057A (en)
CA (2) CA2450403A1 (en)
WO (1) WO2002101086A2 (en)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0200817D0 (en) * 2002-03-15 2002-03-15 Ulf Gyllensten Method and kit for detection of mutations in mitochondrial DNA
EP1694695A4 (en) * 2003-12-11 2007-10-31 1304854 Ontario Ltd Complete mitochondrial genome sequences as a diagnostic tool for the health sciences
US20130022979A1 (en) 2005-04-18 2013-01-24 Genesis Genomics Inc. 3.4kb MITOCHONDRIAL DNA DELETION FOR USE IN THE DETECTION OF CANCER
KR101363032B1 (en) * 2005-04-18 2014-02-13 미토믹스 인크. Mitochondrial mutations and rearrangements as a diagnostic tool for the detection of sun exposure, prostate cancer and other cancers
CN101874119B (en) * 2007-09-26 2015-01-28 米托米克斯公司 3.4 kb mitochondrial DNA deletion for use in the detection of cancer
CN101883864B (en) * 2007-11-09 2014-02-12 米托米克斯公司 Mitochondrial DNA deletion between about residues 12317-16254 for use in detection of cancer
WO2009117811A1 (en) * 2008-03-28 2009-10-01 Genesis Genomics Inc. Aberrant mitochondrial dna, associated fusion transcripts and hybridization probes therefor
EP2411522B1 (en) * 2009-03-27 2017-09-06 MDNA Life Sciences Inc. Aberrant mitochondrial dna, associated fusion transcripts and translation products and hybridization probes therefor
WO2014038622A1 (en) * 2012-09-05 2014-03-13 国立大学法人大阪大学 Biomarker for autoimmune diseases
MY184106A (en) * 2013-02-06 2021-03-18 Malaysian Palm Oil Board Treatment of dna damage and mitochondrial dysfunction using palm fruit juice
US20210246503A1 (en) * 2018-06-11 2021-08-12 The Broad Institute, Inc. Lineage tracing using mitochondrial genome mutations and single cell genomics

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068923A2 (en) * 2000-03-15 2001-09-20 The Johns Hopkins University Mitochondrial dosimeter

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001068923A2 (en) * 2000-03-15 2001-09-20 The Johns Hopkins University Mitochondrial dosimeter

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
BURGART L J ET AL: "SOMATIC MITOCHONDRIAL MUTATION IN GASTRIC CANCER", AMERICAN JOURNAL OF PATHOLOGY, PHILADELPHIA, PA, US, vol. 147, October 1995 (1995-10-01), pages 1105 - 1111, XP000863263, ISSN: 0002-9440 *
CORTOPASSI G ET AL: "MODELLING THE EFFECTS OF AGE-RELATED MTDNA MUTATION ACCUMULATION;COMPLEX 1 DEFICIENCY, SUPEROXIDE AND CELL DEATH", BIOCHIMICA ET BIOPHYSICA ACTA, AMSTERDAM, NL, vol. 1271, 24 May 1995 (1995-05-24), pages 171 - 176, XP000944048, ISSN: 0006-3002 *
ESHAGHIAN ALEX ET AL: "Alterations of mitochondrial DNA in aging skin and in non-melanoma skin cancers.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 43, March 2002 (2002-03-01), 93rd Annual Meeting of the American Association for Cancer Research;San Francisco, California, USA; April 06-10, 2002, March, 2002, pages 304 - 305, XP001153120, ISSN: 0197-016X *
FLISS MAKIKO S ET AL: "Facile detection of mitochondrial DNA mutations in tumors and bodily fluids.", SCIENCE (WASHINGTON D C), vol. 287, no. 5460, 17 March 2000 (2000-03-17), pages 2017 - 2019, XP002244376, ISSN: 0036-8075 *
JERONIMO C ET AL: "Mitochondrial mutations in early stage prostate cancer and bodily fluids.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 63, XP001153112, ISSN: 0197-016X *
JESSIE BENJAMIN C ET AL: "Accumulation of mitochondrial DNA deletions in the aging prostate.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 862 - 863, XP001153110, ISSN: 0197-016X *
JESSIE BENJAMIN C ET AL: "Accumulation of mitochondrial DNA deletions in the malignant prostate of patients of different ages.", EXPERIMENTAL GERONTOLOGY, vol. 37, no. 1, December 2001 (2001-12-01), pages 169 - 174, XP002244377, ISSN: 0531-5565 *
PARRELLA PAOLA ET AL: "Detection of mitochondrial DNA mutations in primary breast cancer and fine-needle aspirates.", CANCER RESEARCH, vol. 61, no. 20, 15 October 2001 (2001-10-15), pages 7623 - 7626, XP002244378, ISSN: 0008-5472 *
PENTA JS ET AL.: "Mitochondrial DNA in human malignancy", REVIEWS IN MUTATION RESEARCH, vol. 488, 2001, pages 119 - 133, XP002244375 *
PETROS JOHN ANTHONY ET AL: "Mitochondrial DNA point mutations are common in prostate cancer and enhance malignant phenotype.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 517, XP001153111, ISSN: 0197-016X *
THAYER ROBERT ET AL: "Mitochondrial DNA mutations and/or deletions in prostate cancers.", PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH ANNUAL, vol. 42, March 2001 (2001-03-01), 92nd Annual Meeting of the American Association for Cancer Research;New Orleans, LA, USA; March 24-28, 2001, March, 2001, pages 532 - 533, XP001153105, ISSN: 0197-016X *

Also Published As

Publication number Publication date
JP2005506057A (en) 2005-03-03
CA2450403A1 (en) 2002-12-19
WO2002101086A2 (en) 2002-12-19
EP1397508A2 (en) 2004-03-17
CA2450004A1 (en) 2005-06-18

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