WO2002100420A3 - Compositions pharmaceutiques a base de zeolite contenant du zinc et de l'erythromycine, destinees au traitement de l'acne - Google Patents

Compositions pharmaceutiques a base de zeolite contenant du zinc et de l'erythromycine, destinees au traitement de l'acne Download PDF

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Publication number
WO2002100420A3
WO2002100420A3 PCT/EP2002/006275 EP0206275W WO02100420A3 WO 2002100420 A3 WO2002100420 A3 WO 2002100420A3 EP 0206275 W EP0206275 W EP 0206275W WO 02100420 A3 WO02100420 A3 WO 02100420A3
Authority
WO
WIPO (PCT)
Prior art keywords
zeolite
erythromycin
acne
treatment
pharmaceutical
Prior art date
Application number
PCT/EP2002/006275
Other languages
English (en)
Other versions
WO2002100420A2 (fr
Inventor
Gennaro Maurizio De
Guido Cerri
Carla Marcella Caramella
Maria Cristina Bonferoni
Original Assignee
Univ Napoli Federico Ii
Univ Pavia
Gennaro Maurizio De
Guido Cerri
Carla Marcella Caramella
Maria Cristina Bonferoni
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Napoli Federico Ii, Univ Pavia, Gennaro Maurizio De, Guido Cerri, Carla Marcella Caramella, Maria Cristina Bonferoni filed Critical Univ Napoli Federico Ii
Publication of WO2002100420A2 publication Critical patent/WO2002100420A2/fr
Publication of WO2002100420A3 publication Critical patent/WO2002100420A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/30—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/02—Medicinal preparations containing materials or reaction products thereof with undetermined constitution from inanimate materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/26—Aluminium; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A61K8/27—Zinc; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Birds (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne une composition pharmaceutique, destinée en particulier au traitement de l'acné. Cette composition comprend une association synergique d'érythromycine et un excipient à base de zéolite modifiée de manière à contenir du Zn. Cette association est formulée pour permettre une application topique sous forme de poudre, d'onguent ou de pâte. L'invention concerne également un procédé de préparation consistant à échanger en premier lieu les ions présents dans la zéolite naturelle extraite de roches avec du Na+ puis à échanger ensuite les ions sodium avec des ions Zn2+ ; à mélanger ensuite cette zéolite porteuse de zinc avec de l'érythromycine.
PCT/EP2002/006275 2001-06-08 2002-06-07 Compositions pharmaceutiques a base de zeolite contenant du zinc et de l'erythromycine, destinees au traitement de l'acne WO2002100420A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM01A000325 2001-06-08
IT2001RM000325A ITRM20010325A1 (it) 2001-06-08 2001-06-08 Composizioni farmaceutiche a base di zeoliti contenenti zinco ed eritromicina da impiegare nella terapia anti-acne.

Publications (2)

Publication Number Publication Date
WO2002100420A2 WO2002100420A2 (fr) 2002-12-19
WO2002100420A3 true WO2002100420A3 (fr) 2003-11-20

Family

ID=11455584

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/006275 WO2002100420A2 (fr) 2001-06-08 2002-06-07 Compositions pharmaceutiques a base de zeolite contenant du zinc et de l'erythromycine, destinees au traitement de l'acne

Country Status (2)

Country Link
IT (1) ITRM20010325A1 (fr)
WO (1) WO2002100420A2 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005020467A1 (de) * 2005-04-15 2006-10-19 Klinomed Institut für angewandte Nanotechnologie und Nanomedizin GmbH Mittel zur Therapie und Prophylaxe von Hauterkrankungen
ZA200607508B (en) 2005-09-10 2008-09-25 Gast Kevin Pharmaceutical composition
DE102005053090A1 (de) * 2005-11-04 2007-05-10 Hubert Danz Verwendung eines aktivierten Zeolithen als pharmazeutisches Mittel für die Reduzierung giftiger Stoffe
ITMI20071930A1 (it) 2007-10-05 2009-04-06 Sasol Italy S P A Composizioni farmaceutiche a base di zeoliti porose quali mezzi di rilascio di molecole farmacologicamente attive e relativo uso
WO2010018418A1 (fr) * 2008-08-12 2010-02-18 Novatech D.O.O. Formulation à base de clinoptilolite micronisée utilisée en tant qu’agent thérapeutique produisant un silicium extrêmement biodisponible
IT1401589B1 (it) * 2010-08-03 2013-07-26 Ecobase Gmbh Zeoliti ad azione neuroprotettiva.
CL2013003807A1 (es) * 2013-12-31 2014-07-11 Univ Santiago Chile Dispositivos de tubos pequeños de silicona que contienen nanopartículas y micropartículas de zeolitas como agentes de liberación prolongada y controlada, cargadas con 2-metoxiestradiol y suspendidas en un medio oleoso que también contiene 2-metoxiestradiol.
TW201705962A (zh) 2015-03-23 2017-02-16 生物製藥Ｘ公司 皮膚用四環素醫藥組成物
CN109545287B (zh) * 2018-12-14 2021-11-26 安徽大学 一种四黄祛痘复方的筛选方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261982A (en) * 1977-11-09 1981-04-14 The Procter & Gamble Company Therapeutic composition

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4261982A (en) * 1977-11-09 1981-04-14 The Procter & Gamble Company Therapeutic composition

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Derwent World Patents Index; AN 2000-678084, XP002220009, BELITSKII I.A. ET AL.: "Cosmetic composition" *
IZUMI Y., URABE K., ONAKA M.: "Zeolite, clay and heteropoly acid in organic reactions", KODANSHA LTD /VCH, TOKYO/WEINHEIM, XP002220008 *
LI Y ET AL: "Ammoxidation of ethane - V. Solid-state ion exchange to prepare cobalt zeolite catalysts", APPLIED CATALYSIS A: GENERAL, ELSEVIER SCIENCE, AMSTERDAM, NL, vol. 188, no. 1-2, 5 November 1999 (1999-11-05), pages 211 - 217, XP004271998, ISSN: 0926-860X *

Also Published As

Publication number Publication date
WO2002100420A2 (fr) 2002-12-19
ITRM20010325A1 (it) 2002-12-09
ITRM20010325A0 (it) 2001-06-08

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