WO2002099431A3 - Verwendung von cytosolischer nadp-abhängiger isocitrat-dehydrogenase in körperflüssigkeiten und stuhl zum nachweis einer malignen erkrankung sowie ein testkit hierzu - Google Patents

Verwendung von cytosolischer nadp-abhängiger isocitrat-dehydrogenase in körperflüssigkeiten und stuhl zum nachweis einer malignen erkrankung sowie ein testkit hierzu Download PDF

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Publication number
WO2002099431A3
WO2002099431A3 PCT/DE2002/002020 DE0202020W WO02099431A3 WO 2002099431 A3 WO2002099431 A3 WO 2002099431A3 DE 0202020 W DE0202020 W DE 0202020W WO 02099431 A3 WO02099431 A3 WO 02099431A3
Authority
WO
WIPO (PCT)
Prior art keywords
malign
illness
test kit
stools
identifying
Prior art date
Application number
PCT/DE2002/002020
Other languages
English (en)
French (fr)
Other versions
WO2002099431A2 (de
Inventor
Erich Eigenbrodt
Sybille Mazurek
Original Assignee
Schebo Biotech Ag
Erich Eigenbrodt
Sybille Mazurek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schebo Biotech Ag, Erich Eigenbrodt, Sybille Mazurek filed Critical Schebo Biotech Ag
Priority to DE10292477T priority Critical patent/DE10292477D2/de
Priority to EP02745117A priority patent/EP1395827A2/de
Publication of WO2002099431A2 publication Critical patent/WO2002099431A2/de
Publication of WO2002099431A3 publication Critical patent/WO2002099431A3/de

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • G01N2333/904—Oxidoreductases (1.) acting on CHOH groups as donors, e.g. glucose oxidase, lactate dehydrogenase (1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/91—Transferases (2.)
    • G01N2333/912—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • G01N2333/91205—Phosphotransferases in general
    • G01N2333/9121—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases
    • G01N2333/91215—Phosphotransferases in general with an alcohol group as acceptor (2.7.1), e.g. general tyrosine, serine or threonine kinases with a definite EC number (2.7.1.-)

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Die vorliegende Erfindung betrifft Verfahren zum Nachweis einer malignen Erkrankung in Menschen oder Tieren sowie einen Testkit zur Durchführung des erfindungsgemässen Verfahrens und schliesslich die Verwendung des Testkits zum selektiven Nachweis von cytosolischer NADP-abhängiger Isocitrat-Dehydrogenase in menschlichen oder tierischen Körperflüssigkeiten sowie in Stuhl und zur Bestimmung des Ausmasses der malignen Erkrankung sowie zur Bestimmung eines Behandlungsschemas.
PCT/DE2002/002020 2001-06-01 2002-06-01 Verwendung von cytosolischer nadp-abhängiger isocitrat-dehydrogenase in körperflüssigkeiten und stuhl zum nachweis einer malignen erkrankung sowie ein testkit hierzu WO2002099431A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE10292477T DE10292477D2 (de) 2001-06-01 2002-06-01 Verwendung von cytosolischer NADP-abhängiger Isocitrat-Dehydrogenase in Körperflüssigkeiten und Stuhl zum Nachweis einer malignen Erkrankung sowie ein Testkit hierzu
EP02745117A EP1395827A2 (de) 2001-06-01 2002-06-01 Verwendung von cytosolischer nadp-abhängiger isocitrat-dehydrogenase in körperflüssigkeiten und stuhl zum nachweis einer malignen erkrankung sowie ein testkit hierzu

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10126762 2001-06-01
DE10126763.0 2001-06-01
DE10126762.2 2001-06-01
DE10126763 2001-06-01

Publications (2)

Publication Number Publication Date
WO2002099431A2 WO2002099431A2 (de) 2002-12-12
WO2002099431A3 true WO2002099431A3 (de) 2003-02-20

Family

ID=26009452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/002020 WO2002099431A2 (de) 2001-06-01 2002-06-01 Verwendung von cytosolischer nadp-abhängiger isocitrat-dehydrogenase in körperflüssigkeiten und stuhl zum nachweis einer malignen erkrankung sowie ein testkit hierzu

Country Status (3)

Country Link
EP (1) EP1395827A2 (de)
DE (1) DE10292477D2 (de)
WO (1) WO2002099431A2 (de)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952177A (en) * 1997-12-03 1999-09-14 Incyte Pharmaceuticals, Inc. Human cytosolic isocitrate dehydrogenase

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5952177A (en) * 1997-12-03 1999-09-14 Incyte Pharmaceuticals, Inc. Human cytosolic isocitrate dehydrogenase

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
MAZUREK, S. E TAL: "Tumor M2-PK and glutaminolytic enzymes in the metabolic shift of tumor cells", ANTICANCER RESEARCH, no. 20, 2000, pages 5151 - 5154, XP009000350 *
MAZUREK, S. ET AL: "Energy metabolism in the involuting mamary gland", IN VIVO, vol. 13, no. 6, November 1999 (1999-11-01), Athens, greece, pages 467 - 477, XP009000352 *
MENACHE, R. ET AL: "Enzymes and isoenzymes in different body tissue and fluids in bening and malignant gynecological tumors", ISRAEL JOURNAL OF MEDICAL SCIENCES, vol. 13, no. 8, August 1977 (1977-08-01), pages 848 - 851, XP009000353 *
SHARMA, A. ET AL: "Isocitric dehydrogenase of the cerebrospinal fluid in brain tumours and meningitis", INDIAN JOURNAL OF MEDICAL RESEARCH, vol. 72, no. 3, 1980, pages 458 - 460, XP009000351 *

Also Published As

Publication number Publication date
EP1395827A2 (de) 2004-03-10
WO2002099431A2 (de) 2002-12-12
DE10292477D2 (de) 2004-04-29

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