WO2002099084A3 - Composite binding polypeptides - Google Patents

Composite binding polypeptides Download PDF

Info

Publication number
WO2002099084A3
WO2002099084A3 PCT/US2002/022272 US0222272W WO02099084A3 WO 2002099084 A3 WO2002099084 A3 WO 2002099084A3 US 0222272 W US0222272 W US 0222272W WO 02099084 A3 WO02099084 A3 WO 02099084A3
Authority
WO
WIPO (PCT)
Prior art keywords
binding polypeptides
composite binding
polypeptides
composite
constructed
Prior art date
Application number
PCT/US2002/022272
Other languages
French (fr)
Other versions
WO2002099084A2 (en
WO2002099084A9 (en
Inventor
Michael Moore
Armin Sepp
Mark Isalan
Yen Choo
Original Assignee
Gendaq Ltd
Michael Moore
Armin Sepp
Mark Isalan
Yen Choo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gendaq Ltd, Michael Moore, Armin Sepp, Mark Isalan, Yen Choo filed Critical Gendaq Ltd
Priority to AU2002322477A priority Critical patent/AU2002322477A1/en
Priority to US10/474,282 priority patent/US20040197892A1/en
Publication of WO2002099084A2 publication Critical patent/WO2002099084A2/en
Publication of WO2002099084A3 publication Critical patent/WO2002099084A3/en
Publication of WO2002099084A9 publication Critical patent/WO2002099084A9/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Disclosed herein are polypeptides with novel DNA binding specificities, constructed from combinations of zinc fingers, and methods for their preparation and use.
PCT/US2002/022272 2001-04-04 2002-04-04 Composite binding polypeptides WO2002099084A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002322477A AU2002322477A1 (en) 2001-04-04 2002-04-04 Composite binding polypeptides
US10/474,282 US20040197892A1 (en) 2001-04-04 2002-04-04 Composition binding polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0108491.2 2001-04-04
GB0108491A GB0108491D0 (en) 2001-04-04 2001-04-04 Engineering zinc fingers

Publications (3)

Publication Number Publication Date
WO2002099084A2 WO2002099084A2 (en) 2002-12-12
WO2002099084A3 true WO2002099084A3 (en) 2003-10-23
WO2002099084A9 WO2002099084A9 (en) 2004-12-16

Family

ID=9912259

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/022272 WO2002099084A2 (en) 2001-04-04 2002-04-04 Composite binding polypeptides

Country Status (3)

Country Link
AU (1) AU2002322477A1 (en)
GB (1) GB0108491D0 (en)
WO (1) WO2002099084A2 (en)

Families Citing this family (207)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060054196A (en) * 2003-06-10 2006-05-22 주식회사 툴젠 Transducible dna-binding protein
WO2005014791A2 (en) 2003-08-08 2005-02-17 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
EP1678315B1 (en) 2003-09-19 2011-08-03 Sangamo BioSciences, Inc. Engineered zinc finger proteins for regulation of gene expression
CN100513563C (en) 2003-11-05 2009-07-15 株式会社国际癌症免疫研究所 Wt1-origin HLA-DR-binding antigen peptide
DE102005026163A1 (en) * 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Antibodies directed against the Marburg I polymorphism of Factor VII activating protease (FSAP), their production and use
CA2579677A1 (en) 2004-09-16 2006-03-30 Sangamo Biosciences, Inc. Compositions and methods for protein production
CN101273141B (en) 2005-07-26 2013-03-27 桑格摩生物科学股份有限公司 Targeted integration and expression of exogenous nucleic acid sequences
EP2019839B1 (en) 2006-05-25 2011-12-07 Sangamo BioSciences, Inc. Methods and compositions for gene inactivation
DE602007005634D1 (en) 2006-05-25 2010-05-12 Sangamo Biosciences Inc VARIANT FOKI CREVICE HOLLAND DOMAINS
AU2007284748B2 (en) 2006-08-11 2013-05-16 Corteva Agriscience Llc Zinc finger nuclease-mediated homologous recombination
US9217026B2 (en) 2006-11-13 2015-12-22 Sangamo Biosciences, Inc. Method of inactivating a glucocorticoid receptor gene in an isolated cell
MX2009006303A (en) 2006-12-14 2009-10-21 Dow Agrosciences Llc Optimized non-canonical zinc finger proteins.
AU2008220031B2 (en) 2007-02-27 2013-06-13 International Institute Of Cancer Immunology, Inc. Method for activation of helper T cell and composition for use in the method
DE602008003684D1 (en) 2007-04-26 2011-01-05 Sangamo Biosciences Inc TARGETED INTEGRATION IN THE PPP1R12C POSITION
EP2568048A1 (en) 2007-06-29 2013-03-13 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
JP5770471B2 (en) 2007-07-12 2015-08-26 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for inactivating α-1,6-fucosyltransferase (FUT8) gene expression
US8399218B2 (en) 2007-09-27 2013-03-19 Dow Agrosciences, Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
CN101883863B (en) 2007-09-27 2018-01-23 桑格摩生物科学股份有限公司 The rapid in vivo identification of biologically active nucleases
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
CA2703045C (en) 2007-10-25 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for targeted integration
JP2011518555A (en) 2008-04-14 2011-06-30 サンガモ バイオサイエンシーズ， インコーポレイテッド Linear donor constructs for targeted integration
CA2725773C (en) 2008-05-28 2017-12-05 Sangamo Biosciences, Inc. Compositions for linking dna-binding domains and cleavage domains
EP2130836B1 (en) * 2008-06-03 2013-02-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Means and methods for producing zinc fingers and concatemers thereof
AU2009258117B2 (en) 2008-06-10 2014-10-09 Sangamo Therapeutics, Inc. Methods and compositions for generation of Bax- and Bak-deficient cell lines
KR101759586B1 (en) 2008-08-22 2017-07-19 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for targeted single-stranded cleavage and targeted integration
US8153399B2 (en) 2008-10-29 2012-04-10 Sangamo Biosciences, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
CA2745031C (en) 2008-12-04 2018-08-14 Sangamo Biosciences, Inc. Genome editing in rats using zinc-finger nucleases
BRPI0922641B1 (en) 2008-12-17 2021-10-26 Dow Agrosciences Llc METHOD OF INTEGRATION OF ONE OR MORE EXOGENOUS NUCLEIC ACID SEQUENCES INTO THE GENOME OF A PLANT CELL
EP2393506B1 (en) 2009-02-04 2018-03-28 Sangamo Therapeutics, Inc. Methods and compositions for treating neuropathies
EP2408921B1 (en) 2009-03-20 2017-04-19 Sangamo BioSciences, Inc. Modification of cxcr4 using engineered zinc finger proteins
WO2010117464A1 (en) 2009-04-09 2010-10-14 Sangamo Biosciences, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
CA2765488C (en) 2009-06-30 2018-01-02 Sangamo Biosciences, Inc. Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
EP2461819A4 (en) 2009-07-28 2013-07-31 Sangamo Biosciences Inc Methods and compositions for treating trinucleotide repeat disorders
CA2770312A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
EP2491127B1 (en) 2009-10-22 2017-09-20 Dow AgroSciences LLC Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
WO2011082310A2 (en) 2009-12-30 2011-07-07 Pioneer Hi-Bred International, Inc. Methods and compositions for targeted polynucleotide modification
CA2787494C (en) 2010-01-22 2019-09-17 Dow Agrosciences Llc Targeted genomic alteration
AU2011213242B2 (en) 2010-02-08 2015-01-29 Sangamo Therapeutics, Inc. Engineered cleavage half-domains
WO2011100058A1 (en) 2010-02-09 2011-08-18 Sangamo Biosciences, Inc. Targeted genomic modification with partially single-stranded donor molecules
BR112012027532A2 (en) 2010-04-26 2020-10-13 Sangamo Biosciences, Inc. genome editing of a pink locus using zinc finger nucleases.
PL2566972T3 (en) 2010-05-03 2020-06-29 Sangamo Therapeutics, Inc. Compositions for linking zinc finger modules
WO2011146121A1 (en) 2010-05-17 2011-11-24 Sangamo Biosciences, Inc. Novel dna-binding proteins and uses thereof
CA2993567C (en) 2010-07-21 2022-06-28 Sangamo Biosciences, Inc. Methods and compositions for modification of a t-cell receptor gene
US9566352B2 (en) 2010-09-27 2017-02-14 Sangamo Biosciences, Inc. Methods and compositions for inhibiting viral entry into cells
AU2011313327B2 (en) 2010-10-05 2015-10-22 International Institute Of Cancer Immunology, Inc. Method for activating helper T cell
ES2562421T3 (en) 2010-10-12 2016-03-04 The Children's Hospital Of Philadelphia Methods and compositions to treat hemophilia B
WO2012094132A1 (en) 2011-01-05 2012-07-12 Sangamo Biosciences, Inc. Methods and compositions for gene correction
IN2013MN01582A (en) 2011-01-20 2015-06-12 Oneday Biotech And Pharma Ltd
BR112013024337A2 (en) 2011-03-23 2017-09-26 Du Pont complex transgenic trace locus in a plant, plant or seed, method for producing in a plant a complex transgenic trace locus and expression construct
BR112013025567B1 (en) 2011-04-27 2021-09-21 Amyris, Inc METHODS FOR GENOMIC MODIFICATION
MX2013015174A (en) 2011-06-21 2014-09-22 Pioneer Hi Bred Int Methods and compositions for producing male sterile plants.
WO2013012674A1 (en) 2011-07-15 2013-01-24 The General Hospital Corporation Methods of transcription activator like effector assembly
EP2737063B1 (en) 2011-07-25 2016-06-01 Sangamo BioSciences, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
AU2012312260B2 (en) 2011-09-21 2017-08-31 Sangamo Therapeutics, Inc. Methods and compositions for regulation of transgene expression
CA3099582A1 (en) 2011-10-27 2013-05-02 Sangamo Biosciences, Inc. Methods and compositions for modification of the hprt locus
JP6144691B2 (en) 2011-11-16 2017-06-07 サンガモ セラピューティクス， インコーポレイテッド Modified DNA binding proteins and uses thereof
BR112014021104B1 (en) 2012-02-29 2023-03-28 Sangamo Biosciences, Inc NON-NATURALLY OCCURRING FUSION PROTEIN COMPRISING AN MANIPULATED ZINC FINGER DNA-BINDING DOMAIN WHICH BINDS TO AN HTT GENE, ITS USE, IN VITRO METHOD OF MODIFYING THE EXPRESSION OF AN HTT GENE IN A CELL, AND METHOD OF GENERATION OF A MODEL SYSTEM FOR THE STUDY OF HUNTINGTON'S DISEASE
NZ701060A (en) 2012-05-02 2016-10-28 Sangamo Biosciences Inc Targeted modification of malate dehydrogenase
RU2650819C2 (en) 2012-05-07 2018-04-17 Сангамо Терапьютикс, Инк. Methods and compositions for nuclease-mediated targeting of transgenes
US9890364B2 (en) 2012-05-29 2018-02-13 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
JP6329537B2 (en) 2012-07-11 2018-05-23 サンガモ セラピューティクス， インコーポレイテッド Methods and compositions for delivery of biological agents
WO2014011237A1 (en) 2012-07-11 2014-01-16 Sangamo Biosciences, Inc. Methods and compositions for the treatment of lysosomal storage diseases
CA2879019A1 (en) 2012-07-23 2014-01-30 Oneday - Biotech And Pharma Ltd. Glutathione-elevating compositions and uses thereof
EP2877194A4 (en) 2012-07-25 2016-03-16 Oneday Biotech And Pharma Ltd Compositions and methods for increasing carnitine level in muscle tissues
KR102218562B1 (en) 2012-08-29 2021-02-19 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for treatment of a genetic condition
CN105264067B (en) 2012-09-07 2020-11-10 美国陶氏益农公司 FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
UA118090C2 (en) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
UA119135C2 (en) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Engineered transgene integration platform (etip) for gene targeting and trait stacking
AU2013329186B2 (en) 2012-10-10 2019-02-14 Sangamo Therapeutics, Inc. T cell modifying compounds and uses thereof
EP2906602B1 (en) 2012-10-12 2019-01-16 The General Hospital Corporation Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
JP2016500254A (en) 2012-12-05 2016-01-12 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for the regulation of metabolic diseases
MX2015007574A (en) 2012-12-13 2015-10-22 Dow Agrosciences Llc Precision gene targeting to a particular locus in maize.
SG10201705028WA (en) 2012-12-17 2017-07-28 Otsuka Pharma Co Ltd Method for activating helper t cell
WO2014124284A1 (en) 2013-02-07 2014-08-14 The General Hospital Corporation Tale transcriptional activators
EP2958996B1 (en) 2013-02-25 2019-10-16 Sangamo Therapeutics, Inc. Methods and compositions for enhancing nuclease-mediated gene disruption
CA2906970C (en) 2013-03-21 2021-05-18 Ospedale San Raffaele Srl Targeted disruption of t cell receptor genes using engineered zinc finger protein nucleases
CN105263312A (en) 2013-04-05 2016-01-20 美国陶氏益农公司 Methods and compositions for integration of an exogenous sequence within the genome of plants
US10604771B2 (en) 2013-05-10 2020-03-31 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
CN105683376A (en) 2013-05-15 2016-06-15 桑格摩生物科学股份有限公司 Methods and compositions for treatment of a genetic condition
JP6588438B2 (en) 2013-08-28 2019-10-09 サンガモ セラピューティクス， インコーポレイテッド Composition for linking a DNA binding domain and a cleavage domain
CN110713995B (en) 2013-10-17 2023-08-01 桑格摩生物科学股份有限公司 Delivery methods and compositions for nuclease-mediated genome engineering
US10117899B2 (en) 2013-10-17 2018-11-06 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
MX360318B (en) 2013-11-04 2018-10-29 Dow Agrosciences Llc Optimal maize loci.
US10233465B2 (en) 2013-11-04 2019-03-19 Dow Agrosciences Llc Optimal soybean loci
BR102014027438B1 (en) 2013-11-04 2022-09-27 Dow Agrosciences Llc RECOMBINANT NUCLEIC ACID MOLECULE AND PRODUCTION METHOD OF A TRANSGENIC PLANT CELL
US9909131B2 (en) 2013-11-04 2018-03-06 Dow Agrosciences Llc Optimal soybean loci
NZ719477A (en) 2013-11-11 2022-05-27 Sangamo Therapeutics Inc Methods and compositions for treating huntington’s disease
SI3068881T1 (en) 2013-11-13 2019-05-31 Children's Medical Center Corporation Nuclease-mediated regulation of gene expression
ES2813367T3 (en) 2013-12-09 2021-03-23 Sangamo Therapeutics Inc Methods and compositions for genomic engineering
EP3083958B1 (en) 2013-12-19 2019-04-17 Amyris, Inc. Methods for genomic integration
US10370680B2 (en) 2014-02-24 2019-08-06 Sangamo Therapeutics, Inc. Method of treating factor IX deficiency using nuclease-mediated targeted integration
AU2015231353B2 (en) 2014-03-18 2020-11-05 Sangamo Therapeutics, Inc. Methods and compositions for regulation of zinc finger protein expression
US9522936B2 (en) 2014-04-24 2016-12-20 Sangamo Biosciences, Inc. Engineered transcription activator like effector (TALE) proteins
CN106413760B (en) 2014-05-08 2020-01-14 桑格摩生物科学股份有限公司 Methods and compositions for treating huntington's disease
EP3142707A4 (en) 2014-05-13 2018-02-21 Sangamo Therapeutics, Inc. Methods and compositions for prevention or treatment of a disease
WO2015188056A1 (en) 2014-06-05 2015-12-10 Sangamo Biosciences, Inc. Methods and compositions for nuclease design
WO2016005449A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
PT3169778T (en) 2014-07-14 2024-01-29 Univ Washington State Nanos knock-out that ablates germline cells
US11278572B2 (en) 2014-07-18 2022-03-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
US9757420B2 (en) 2014-07-25 2017-09-12 Sangamo Therapeutics, Inc. Gene editing for HIV gene therapy
US9816074B2 (en) 2014-07-25 2017-11-14 Sangamo Therapeutics, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
US9616090B2 (en) 2014-07-30 2017-04-11 Sangamo Biosciences, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
WO2016044416A1 (en) 2014-09-16 2016-03-24 Sangamo Biosciences, Inc. Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
WO2016118726A2 (en) 2015-01-21 2016-07-28 Sangamo Biosciences, Inc. Methods and compositions for identification of highly specific nucleases
ES2959608T3 (en) 2015-04-03 2024-02-27 Dana Farber Cancer Inst Inc Composition and editing methods of the B cell genome
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
CA2984013A1 (en) 2015-05-12 2016-11-17 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
EP3322297A4 (en) 2015-07-13 2019-04-17 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
SG10201913958QA (en) * 2015-07-15 2020-03-30 Agency Science Tech & Res Modulation of hepatitis b virus replication
EP3331355B1 (en) 2015-08-06 2024-04-03 The Curators of the University of Missouri Porcine reproductive and respiratory syndrome virus (prrsv)-resistant porcine and cells having modified cd163 genes
JP6853257B2 (en) 2015-09-23 2021-03-31 サンガモ セラピューティクス， インコーポレイテッド HTT repressor and its use
AU2016361350B2 (en) 2015-11-23 2023-04-06 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
BR112018012235A2 (en) 2015-12-18 2018-12-04 Sangamo Therapeutics Inc targeted mhc cell receptor disruption
AU2016369490C1 (en) 2015-12-18 2021-12-23 Sangamo Therapeutics, Inc. Targeted disruption of the T cell receptor
AU2017207818B2 (en) 2016-01-15 2024-03-28 Regents Of The University Of Minnesota Methods and compositions for the treatment of neurologic disease
EP3769775A3 (en) 2016-02-02 2021-03-17 Sangamo Therapeutics, Inc. Compositions for linking dna-binding domains and cleavage domains
US20190249172A1 (en) 2016-02-18 2019-08-15 The Regents Of The University Of California Methods and compositions for gene editing in stem cells
WO2017161043A1 (en) 2016-03-16 2017-09-21 The J. David Gladstone Institutes Methods and compositions for treating obesity and/or diabetes and for identifying candidate treatment agents
AU2017238512B2 (en) 2016-03-23 2022-12-08 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
EP4219731A3 (en) 2016-05-18 2023-08-09 Amyris, Inc. Compositions and methods for genomic integration of nucleic acids into exogenous landing pads
EP3484870B1 (en) 2016-07-13 2022-11-16 Vertex Pharmaceuticals Incorporated Methods, compositions and kits for increasing genome editing efficiency
JP7325104B2 (en) 2016-07-27 2023-08-14 ケース ウェスタン リザーブ ユニバーシティ Compounds and methods for promoting myelination
US11193136B2 (en) 2016-08-09 2021-12-07 Vib Vzw Cellulose synthase inhibitors and mutant plants
KR102455249B1 (en) 2016-08-24 2022-10-17 상가모 테라퓨틱스, 인코포레이티드 Engineered target specific nuclease
CN110325635B (en) 2016-08-24 2023-12-26 桑格摩生物治疗股份有限公司 Regulation of gene expression using engineered nucleases
JP7256739B2 (en) 2016-09-07 2023-04-12 サンガモ セラピューティクス， インコーポレイテッド Modulation of liver genes
CA3039014A1 (en) 2016-10-04 2018-04-12 Precision Biosciences, Inc. Co-stimulatory domains for use in genetically-modified cells
MX2019004487A (en) 2016-10-20 2020-02-07 Sangamo Therapeutics Inc Methods and compositions for the treatment of fabry disease.
US11020492B2 (en) 2016-10-31 2021-06-01 Sangamo Therapeutics, Inc. Gene correction of SCID-related genes in hematopoietic stem and progenitor cells
KR20190085529A (en) 2016-12-01 2019-07-18 상가모 테라퓨틱스, 인코포레이티드 Tau modulators and methods and compositions for their delivery
ES2968892T3 (en) 2016-12-08 2024-05-14 Univ Case Western Reserve Methods and compositions to increase the production of functional myelin
JP7317706B2 (en) 2016-12-14 2023-07-31 リガンダル インコーポレイテッド Methods and compositions for nucleic acid and protein payload delivery
BR112019021993A2 (en) 2017-04-20 2020-05-12 Oregon Health & Science University HUMAN GENE CORRECTION
EP3619322A4 (en) 2017-05-03 2021-06-30 Sangamo Therapeutics, Inc. Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (cftr) gene
EP3634493A1 (en) 2017-05-08 2020-04-15 Precision BioSciences, Inc. Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
WO2019005957A1 (en) 2017-06-30 2019-01-03 Precision Biosciences, Inc. Genetically-modified t cells comprising a modified intron in the t cell receptor alpha gene
WO2019070541A1 (en) 2017-10-03 2019-04-11 Juno Therapeutics, Inc. Hpv-specific binding molecules
EP3692057B9 (en) 2017-10-03 2023-10-04 Precision BioSciences, Inc. Modified epidermal growth factor receptor peptides for use in genetically-modified cells
WO2019089913A1 (en) 2017-11-01 2019-05-09 Precision Biosciences, Inc. Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
KR20200079539A (en) 2017-11-09 2020-07-03 상가모 테라퓨틱스, 인코포레이티드 Genetic modification of cytokine-inducible SH2-containing protein (CISH) gene
EP3740479A1 (en) 2018-01-17 2020-11-25 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
CN111757876B (en) 2018-01-17 2024-03-22 沃泰克斯药物股份有限公司 DNA-PK inhibitors
EA202091707A1 (en) 2018-01-17 2020-12-02 Вертекс Фармасьютикалз Инкорпорейтед QUINOXALINE COMPOUNDS, COMPOSITIONS, METHODS AND KITS FOR INCREASING THE EFFICIENCY OF GENOME EDITING
AU2019218118A1 (en) 2018-02-08 2020-08-13 Sangamo Therapeutics, Inc. Engineered target specific nucleases
RU2020135966A (en) 2018-04-05 2022-05-06 Джуно Терапьютикс, Инк. METHODS FOR PRODUCING CELLS EXPRESSING A RECOMBINANT RECEPTOR AND RELATED COMPOSITIONS
MA52207A (en) 2018-04-05 2021-02-17 Editas Medicine Inc RECOMBINANT-EXPRESSING T-LYMPHOCYTES, POLYNUCLEOTIDES AND RELATED PROCESSES
JP7332622B2 (en) 2018-04-18 2023-08-23 サンガモ セラピューティクス， インコーポレイテッド Zinc finger protein compositions for regulation of huntingtin (HTT)
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
KR20210049124A (en) 2018-08-23 2021-05-04 상가모 테라퓨틱스, 인코포레이티드 Engineered target specific base editor
CN113015741A (en) 2018-09-18 2021-06-22 桑格摩生物治疗股份有限公司 Programmed cell death 1(PD1) specific nucleases
EP3898661A1 (en) 2018-12-21 2021-10-27 Precision BioSciences, Inc. Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
JP2022517783A (en) 2019-01-11 2022-03-10 アクイタス セラピューティクス インコーポレイテッド Lipids for Activator Lipid Nanoparticle Delivery Lipids
JP2022519410A (en) 2019-02-06 2022-03-24 サンガモ セラピューティクス， インコーポレイテッド Methods for the treatment of mucopolysaccharidosis type I
WO2020163856A1 (en) 2019-02-10 2020-08-13 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Modified mitochondrion and methods of use thereof
MA55531A (en) 2019-04-02 2022-02-09 Sangamo Therapeutics Inc METHODS FOR THE TREATMENT OF BETA-THALASSEMIA
CN113993999B (en) 2019-04-03 2022-11-22 精密生物科学公司 Genetically modified immune cells comprising microRNA-adapted shRNA (shRNAmiR)
WO2020206231A1 (en) 2019-04-05 2020-10-08 Precision Biosciences, Inc. Methods of preparing populations of genetically-modified immune cells
TW202104249A (en) 2019-04-23 2021-02-01 美商聖加莫治療股份有限公司 Modulators of chromosome 9 open reading frame 72 gene expression and uses thereof
WO2020223571A1 (en) 2019-05-01 2020-11-05 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified cd247 locus, related polynucleotides and methods
CN114025788A (en) 2019-05-01 2022-02-08 朱诺治疗学股份有限公司 Cells expressing recombinant receptors from modified TGFBR2 loci, related polynucleotides and methods
WO2021016608A1 (en) 2019-07-25 2021-01-28 Precision Biosciences, Inc. Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
CA3148179A1 (en) 2019-08-20 2021-02-25 Bruce J. Mccreedy Jr. Lymphodepletion dosing regimens for cellular immunotherapies
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20230002459A1 (en) 2019-10-02 2023-01-05 Sangamo Therapeutics, Inc. Zinc Finger Protein Transcription Factors for Treatment of Prion Disease
CN114466867A (en) 2019-10-02 2022-05-10 桑格摩生物治疗股份有限公司 Zinc finger protein transcription factor for inhibiting alpha-synuclein expression
US20220411479A1 (en) 2019-10-30 2022-12-29 Precision Biosciences, Inc. Cd20 chimeric antigen receptors and methods of use for immunotherapy
TW202132565A (en) 2019-11-01 2021-09-01 美商聖加莫治療股份有限公司 Gin recombinase variants
US20230036065A1 (en) 2019-12-06 2023-02-02 Precision Biosciences, Inc. Methods for cancer immunotherapy
BR112022014160A2 (en) 2020-01-22 2022-09-13 Sangamo Therapeutics Inc ZINC FINGER PROTEIN TRANSCRIPTION FACTORS TO SUPPRESS TAU EXPRESSION
WO2021158915A1 (en) 2020-02-06 2021-08-12 Precision Biosciences, Inc. Recombinant adeno-associated virus compositions and methods for producing and using the same
WO2021202513A1 (en) 2020-03-31 2021-10-07 Elo Life Systems Modulation of endogenous mogroside pathway genes in watermelon and other cucurbits
AU2021269103A1 (en) 2020-05-06 2022-12-15 Cellectis S.A. Methods to genetically modify cells for delivery of therapeutic proteins
US20230212613A1 (en) 2020-05-06 2023-07-06 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
WO2021231259A1 (en) 2020-05-11 2021-11-18 Precision Biosciences, Inc. Self-limiting viral vectors encoding nucleases
CN115835873A (en) 2020-05-13 2023-03-21 朱诺治疗学股份有限公司 Method for generating donor batch cells expressing recombinant receptor
KR20230042283A (en) 2020-06-26 2023-03-28 주노 테라퓨틱스 게엠베하 Engineered T cells conditionally expressing recombinant receptors, related polynucleotides and methods
EP4182297A1 (en) 2020-07-16 2023-05-24 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
EP4192875A1 (en) 2020-08-10 2023-06-14 Precision BioSciences, Inc. Antibodies and fragments specific for b-cell maturation antigen and uses thereof
EP4204545A2 (en) 2020-08-25 2023-07-05 Kite Pharma, Inc. T cells with improved functionality
KR20230074519A (en) 2020-09-25 2023-05-30 상가모 테라퓨틱스, 인코포레이티드 Zinc finger fusion proteins for nucleobase editing
TW202229320A (en) 2020-10-02 2022-08-01 美商聖加莫治療股份有限公司 Novel zinc finger protein transcription factors for repressing alpha-synuclein expression
US20230365995A1 (en) 2020-10-07 2023-11-16 Precision Biosciences, Inc. Lipid nanoparticle compositions
MX2023004761A (en) 2020-10-23 2023-07-17 Elo Life Systems Inc Methods for producing vanilla plants with improved flavor and agronomic production.
CN116802203A (en) 2020-11-04 2023-09-22 朱诺治疗学股份有限公司 Cells expressing chimeric receptors from modified constant CD3 immunoglobulin superfamily chain loci, related polynucleotides and methods
WO2022101641A1 (en) 2020-11-16 2022-05-19 Pig Improvement Company Uk Limited Influenza a-resistant animals having edited anp32 genes
EP4284823A1 (en) 2021-01-28 2023-12-06 Precision BioSciences, Inc. Modulation of tgf beta signaling in genetically-modified eukaryotic cells
WO2022226316A1 (en) 2021-04-22 2022-10-27 Precision Biosciences, Inc. Compositions and methods for generating male sterile plants
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
AU2022371430A1 (en) 2021-10-19 2024-05-30 Precision Biosciences, Inc. Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
WO2023091910A1 (en) 2021-11-16 2023-05-25 Precision Biosciences, Inc. Methods for cancer immunotherapy
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
WO2023122722A1 (en) 2021-12-22 2023-06-29 Sangamo Therapeutics, Inc. Novel zinc finger fusion proteins for nucleobase editing
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEERLI ET AL.: "Positive and negative regulation of endogenous genes by designed transcription factors", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 4, 15 February 2000 (2000-02-15), pages 1495 - 1500, XP001050653 *
BOWERS ET AL.: "A folding transition and novel zinc finger accessory domain in the transcription factor ADR1", NATURE STRUCTURAL BIOLOGY, vol. 6, no. 5, May 1999 (1999-05-01), pages 478 - 485, XP002966751 *
CHEONG ET AL.: "STF1 is a novel TGACG-binding factor with a zinc finger motif and a bZIP domain which heterodimerizes with GBF proteins", THE PLANT JOURNAL, vol. 15, no. 2, 1998, pages 199 - 209, XP002966749 *
CHOO ET AL.: "In vivo repression by a site-specific DNA-binding protein designed against an oncogenic sequence", NATURE, vol. 372, 15 December 1994 (1994-12-15), pages 642 - 645, XP000986225 *
HE ET AL.: "Cloning and characterization of a novel zinc finger transcriptional repressor", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 274, no. 21, 21 May 1999 (1999-05-21), pages 14678 - 14684, XP002966750 *

Also Published As

Publication number Publication date
WO2002099084A2 (en) 2002-12-12
WO2002099084A9 (en) 2004-12-16
GB0108491D0 (en) 2001-05-23
AU2002322477A1 (en) 2002-12-16

Similar Documents

Publication Publication Date Title
WO2002099084A3 (en) Composite binding polypeptides
WO2005047314A3 (en) Fgf-beta binding and supported peptides
WO2004048399A3 (en) Skin or hair binding peptides
EP1623011A4 (en) IL-23p40 SPECIFIC IMMUNOGLOBULIN DERIVED PROTEINS, COMPOSITIONS, METHODS AND USES
AU2002314825A1 (en) Anti-p40 immunoglobulin derived proteins, compositions, methods and uses
EP1578930A4 (en) Cngh0004 polypeptides, antibodies, compositions, methods and uses
WO2005081873A9 (en) Il-13 mutein proteins, antibodies, compositions, methods and uses
AU2002359495A1 (en) Anti-tnf antibodies, compositions, methods and uses
AU2003304180A1 (en) Growth arrest specific gene 6 peptides, antibodies, compositions, methods and uses
AU2003225976A1 (en) Anti-tnf antibodies, compositions, methods and uses
WO2004003149A8 (en) Cngh0005 polypeptides, antibodies, compositions, methods and uses
AU2002365269A1 (en) Mut-il-18 or mut-il-18r proteins, antibodies, compositions, methods and uses
AU2001248178A1 (en) Chlamydia transmembrane protein as antigen, corresponding dna fragments and uses thereof
AU2000277350A1 (en) Labeled peptides, and processes and intermediates useful for their preparation
AU2003205605A1 (en) Conformation-specific, protein kinase binding peptides and related methods and products
WO2003057712A3 (en) Humanized lactoferrin and uses thereof
AU2003220557A1 (en) Multiple sclerosis-related immunoglobulin derived proteins, compositions, methods and uses
GB0217548D0 (en) Four human zinc-finger-containing proteins:MDZ3.MDZ4,MDZ7 and MDZ12
WO2004033694A3 (en) Promoter to il-18bp, its preparation and use
WO2003099863A3 (en) Resistin binding proteins, their preparation and use
IL151980A0 (en) Resistin binding proteins, their preparation and use
EP1501870A4 (en) Rsv proteins, antibodies, compositions, methods and uses
AU2001229517A1 (en) Human polynucleotides, polypeptides, and antibodies
AU2003218432A1 (en) Diabetes-related immunoglobulin derived proteins, compositions, methods and uses
AU2002353462A1 (en) Zinc finger proteins, polynucleotides encoding same and antibodies thereto

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 10474282

Country of ref document: US

122 Ep: pct application non-entry in european phase
COP Corrected version of pamphlet

Free format text: PAGES 1/6-6/6, DRAWINGS, REPLACED BY NEW PAGES 1/5-5/5

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP