AU2002322477A1 - Composite binding polypeptides - Google Patents

Composite binding polypeptides

Info

Publication number
AU2002322477A1
AU2002322477A1 AU2002322477A AU2002322477A AU2002322477A1 AU 2002322477 A1 AU2002322477 A1 AU 2002322477A1 AU 2002322477 A AU2002322477 A AU 2002322477A AU 2002322477 A AU2002322477 A AU 2002322477A AU 2002322477 A1 AU2002322477 A1 AU 2002322477A1
Authority
AU
Australia
Prior art keywords
binding polypeptides
composite binding
composite
polypeptides
binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002322477A
Inventor
Yen Choo
Mark Isalan
Michael Moore
Armin Sepp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gendaq Ltd
Original Assignee
Gendaq Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gendaq Ltd filed Critical Gendaq Ltd
Publication of AU2002322477A1 publication Critical patent/AU2002322477A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
AU2002322477A 2001-04-04 2002-04-04 Composite binding polypeptides Abandoned AU2002322477A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0108491A GB0108491D0 (en) 2001-04-04 2001-04-04 Engineering zinc fingers
GB0108491.2 2001-04-04
PCT/US2002/022272 WO2002099084A2 (en) 2001-04-04 2002-04-04 Composite binding polypeptides

Publications (1)

Publication Number Publication Date
AU2002322477A1 true AU2002322477A1 (en) 2002-12-16

Family

ID=9912259

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2002322477A Abandoned AU2002322477A1 (en) 2001-04-04 2002-04-04 Composite binding polypeptides

Country Status (3)

Country Link
AU (1) AU2002322477A1 (en)
GB (1) GB0108491D0 (en)
WO (1) WO2002099084A2 (en)

Families Citing this family (213)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060054196A (en) * 2003-06-10 2006-05-22 주식회사 툴젠 Transducible dna-binding protein
KR20060039019A (en) 2003-08-08 2006-05-04 상가모 바이오사이언스 인코포레이티드 Methods and compositions for targeted cleavage and recombination
US20120196370A1 (en) 2010-12-03 2012-08-02 Fyodor Urnov Methods and compositions for targeted genomic deletion
US7888121B2 (en) 2003-08-08 2011-02-15 Sangamo Biosciences, Inc. Methods and compositions for targeted cleavage and recombination
AU2004274957B2 (en) 2003-09-19 2009-02-05 Sangamo Therapeutics, Inc. Engineered zinc finger proteins for regulation of gene expression
KR101213015B1 (en) 2003-11-05 2012-12-26 인터내셔널 인스티튜트 오브 캔서 이무놀로지 인코퍼레이티드 - hla-dr-binding antigen peptide derived from wt1
DE102005026163A1 (en) * 2004-08-24 2006-03-02 Dade Behring Marburg Gmbh Antibodies directed against the Marburg I polymorphism of Factor VII activating protease (FSAP), their production and use
US20060063231A1 (en) 2004-09-16 2006-03-23 Sangamo Biosciences, Inc. Compositions and methods for protein production
CA2615532C (en) 2005-07-26 2016-06-28 Sangamo Biosciences, Inc. Targeted integration and expression of exogenous nucleic acid sequences
DE602007005634D1 (en) 2006-05-25 2010-05-12 Sangamo Biosciences Inc VARIANT FOKI CREVICE HOLLAND DOMAINS
JP5551432B2 (en) * 2006-05-25 2014-07-16 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for gene inactivation
ZA200900787B (en) 2006-08-11 2010-05-26 Dow Agrosciences Llc Zinc finger nuclease-mediated homologous recombination
CA2667414C (en) * 2006-11-13 2015-12-29 Sangamo Biosciences, Inc. Methods and compositions for modification of the human glucocorticoid receptor locus
NZ576800A (en) 2006-12-14 2013-02-22 Dow Agrosciences Llc Optimized non-canonical zinc finger proteins
AU2008220031B2 (en) 2007-02-27 2013-06-13 International Institute Of Cancer Immunology, Inc. Method for activation of helper T cell and composition for use in the method
JP5400034B2 (en) 2007-04-26 2014-01-29 サンガモ バイオサイエンシーズ， インコーポレイテッド Targeted integration into the PPP1R12C locus
EP2568048A1 (en) 2007-06-29 2013-03-13 Pioneer Hi-Bred International, Inc. Methods for altering the genome of a monocot plant cell
CA2692453C (en) 2007-07-12 2018-01-09 Trevor Collingwood Methods and compositions for inactivating alpha 1,6 fucosyltransferase (fut8) gene expression
CA2937438C (en) 2007-09-27 2020-07-07 Dow Agrosciences Llc Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes
EP2188384B1 (en) 2007-09-27 2015-07-15 Sangamo BioSciences, Inc. Rapid in vivo identification of biologically active nucleases
US8563314B2 (en) 2007-09-27 2013-10-22 Sangamo Biosciences, Inc. Methods and compositions for modulating PD1
US11235026B2 (en) 2007-09-27 2022-02-01 Sangamo Therapeutics, Inc. Methods and compositions for modulating PD1
AU2008317354B2 (en) 2007-10-25 2014-04-10 Ospedale San Raffaele S.R.L. Methods and compositions for targeted integration
EP2281050B1 (en) 2008-04-14 2014-04-02 Sangamo BioSciences, Inc. Linear donor constructs for targeted integration
WO2009154686A1 (en) 2008-05-28 2009-12-23 Sangamo Biosciences, Inc. Compositions for linking dna-binding domains and cleavage domains
EP2130836B1 (en) * 2008-06-03 2013-02-13 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Means and methods for producing zinc fingers and concatemers thereof
CA2726768C (en) 2008-06-10 2016-09-06 Sangamo Biosciences, Inc. Methods and compositions for generation of bax- and bak-deficient cell lines
SG191561A1 (en) 2008-08-22 2013-07-31 Sangamo Biosciences Inc Methods and compositions for targeted single-stranded cleavage and targeted integration
WO2010053518A2 (en) 2008-10-29 2010-05-14 Sangamo Biosciences, Inc. Methods and compositions for inactivating glutamine synthetase gene expression
CN102625655B (en) 2008-12-04 2016-07-06 桑格摩生物科学股份有限公司 Zinc finger nuclease is used to carry out genome editor in rats
CA2747124C (en) 2008-12-17 2018-09-04 Dow Agrosciences Llc Targeted integration into the zp15 locus
US8551945B2 (en) 2009-02-04 2013-10-08 Sangamo Biosciences, Inc. Methods and compositions for treating neuropathies
AU2010226313B2 (en) 2009-03-20 2014-10-09 Sangamo Therapeutics, Inc. Modification of CXCR4 using engineered zinc finger proteins
US9834787B2 (en) 2009-04-09 2017-12-05 Sangamo Therapeutics, Inc. Targeted integration into stem cells
US8772008B2 (en) 2009-05-18 2014-07-08 Sangamo Biosciences, Inc. Methods and compositions for increasing nuclease activity
EP2449135B1 (en) 2009-06-30 2016-01-06 Sangamo BioSciences, Inc. Rapid screening of biologically active nucleases and isolation of nuclease-modified cells
CA2769262C (en) 2009-07-28 2019-04-30 Sangamo Biosciences, Inc. Methods and compositions for treating trinucleotide repeat disorders
CA2770312A1 (en) 2009-08-11 2011-02-17 Sangamo Biosciences, Inc. Organisms homozygous for targeted modification
AR078740A1 (en) 2009-10-22 2011-11-30 Dow Agrosciences Llc PROTEINS WITH ZINC FINGERS DESIGNED BY ENGINEERING THAT HAVE THE OBJECTIVE OF VEGETABLE GENES INCLUDED IN THE BIOSINTESIS OF FATTY ACIDS
US8956828B2 (en) 2009-11-10 2015-02-17 Sangamo Biosciences, Inc. Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases
CN102939383B (en) 2009-12-30 2015-04-29 先锋国际良种公司 Methods and compositions for targeted polynucleotide modification
US10260062B2 (en) 2010-01-22 2019-04-16 Sangamo Therapeutics, Inc. Targeted genomic alteration
DK2534173T3 (en) 2010-02-08 2019-10-14 Sangamo Therapeutics Inc Manipulated cleavage half-domains
JP2013518602A (en) 2010-02-09 2013-05-23 サンガモ バイオサイエンシーズ， インコーポレイテッド Targeted genome modification by partially single-stranded donor molecules
US9567573B2 (en) 2010-04-26 2017-02-14 Sangamo Biosciences, Inc. Genome editing of a Rosa locus using nucleases
EP3636766A1 (en) 2010-05-03 2020-04-15 Sangamo Therapeutics, Inc. Compositions for linking zinc finger modules
CN103025344B (en) 2010-05-17 2016-06-29 桑格摩生物科学股份有限公司 Novel DNA-associated proteins and application thereof
CA3157027A1 (en) 2010-07-21 2012-01-26 Sangamo Therapeutics, Inc. Methods and compositions for modification of a t-cell receptor gene
AU2011312562B2 (en) 2010-09-27 2014-10-09 Sangamo Therapeutics, Inc. Methods and compositions for inhibiting viral entry into cells
EA037547B1 (en) 2010-10-05 2021-04-12 Интернешнл Инститьют Оф Кэнсер Иммунолоджи, Инк. Method for activating helper t cells
CN103270046B (en) 2010-10-12 2016-05-11 费城儿童医院 The method and composition for the treatment of haemophilia B
WO2012094132A1 (en) 2011-01-05 2012-07-12 Sangamo Biosciences, Inc. Methods and compositions for gene correction
CA2825273A1 (en) 2011-01-20 2012-07-26 Oneday - Biotech And Pharma Ltd. Antioxidant, anti-inflammatory, anti-radiation, metal chelating compounds and uses thereof
CN103842511A (en) 2011-03-23 2014-06-04 先锋国际良种公司 Methods for producing a complex transgenic trait locus
JP6158170B2 (en) 2011-04-27 2017-07-12 アミリス， インコーポレイテッド Methods for genome modification
CN104080914A (en) 2011-06-21 2014-10-01 先锋国际良种公司 Methods and compositions for producing male sterile plants
WO2013012674A1 (en) 2011-07-15 2013-01-24 The General Hospital Corporation Methods of transcription activator like effector assembly
EP2737063B1 (en) 2011-07-25 2016-06-01 Sangamo BioSciences, Inc. Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (cftr) gene
KR102061557B1 (en) 2011-09-21 2020-01-03 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for refulation of transgene expression
CA3099582A1 (en) 2011-10-27 2013-05-02 Sangamo Biosciences, Inc. Methods and compositions for modification of the hprt locus
EP2780460B1 (en) 2011-11-16 2018-07-11 Sangamo Therapeutics, Inc. Modified dna-binding proteins and uses thereof
US8841260B2 (en) 2012-02-29 2014-09-23 Sangamo Biosciences, Inc. Methods and compositions for treating Huntington's Disease
AU2013256240B2 (en) 2012-05-02 2018-09-20 Corteva Agriscience Llc Targeted modification of malate dehydrogenase
CA2871524C (en) 2012-05-07 2021-07-27 Sangamo Biosciences, Inc. Methods and compositions for nuclease-mediated targeted integration of transgenes
US9890364B2 (en) 2012-05-29 2018-02-13 The General Hospital Corporation TAL-Tet1 fusion proteins and methods of use thereof
HUE051612T2 (en) 2012-07-11 2021-03-01 Sangamo Therapeutics Inc Methods and compositions for the treatment of lysosomal storage diseases
JP6329537B2 (en) 2012-07-11 2018-05-23 サンガモ セラピューティクス， インコーポレイテッド Methods and compositions for delivery of biological agents
US10648001B2 (en) 2012-07-11 2020-05-12 Sangamo Therapeutics, Inc. Method of treating mucopolysaccharidosis type I or II
EP2874641A4 (en) 2012-07-23 2016-10-12 Oneday Biotech And Pharma Ltd Glutathione-elevating compositions and uses thereof
EP2877194A4 (en) 2012-07-25 2016-03-16 Oneday Biotech And Pharma Ltd Compositions and methods for increasing carnitine level in muscle tissues
EP2890780B8 (en) 2012-08-29 2020-08-19 Sangamo Therapeutics, Inc. Methods and compositions for treatment of a genetic condition
AU2013312538B2 (en) 2012-09-07 2019-01-24 Corteva Agriscience Llc FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
UA118090C2 (en) 2012-09-07 2018-11-26 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Fad2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks
UA119135C2 (en) 2012-09-07 2019-05-10 ДАУ АГРОСАЙЄНСІЗ ЕлЕлСі Engineered transgene integration platform (etip) for gene targeting and trait stacking
ES2824024T3 (en) 2012-10-10 2021-05-11 Sangamo Therapeutics Inc T cell modifying compounds and uses thereof
EP2906602B1 (en) 2012-10-12 2019-01-16 The General Hospital Corporation Transcription activator-like effector (tale) - lysine-specific demethylase 1 (lsd1) fusion proteins
US9255250B2 (en) 2012-12-05 2016-02-09 Sangamo Bioscience, Inc. Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene
JP2016500268A (en) 2012-12-13 2016-01-12 ダウ アグロサイエンシィズ エルエルシー Precise gene targeting for specific loci in maize
CN110195040A (en) 2012-12-17 2019-09-03 大塚制药株式会社 The activation method of helper T lymphocyte
EP2954042B1 (en) 2013-02-07 2017-12-06 The General Hospital Corporation Tale transcriptional activators
JP6491113B2 (en) 2013-02-25 2019-03-27 サンガモ セラピューティクス， インコーポレイテッド Methods and compositions for enhancing nuclease-mediated gene disruption
US9937207B2 (en) 2013-03-21 2018-04-10 Sangamo Therapeutics, Inc. Targeted disruption of T cell receptor genes using talens
UA121197C2 (en) 2013-04-05 2020-04-27 Доу Агросайенсіс Ллс Methods and compositions for integration of an exogenous sequence within the genome of plants
CA2910427C (en) 2013-05-10 2024-02-20 Sangamo Biosciences, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
JP2016521975A (en) 2013-05-15 2016-07-28 サンガモ バイオサイエンシーズ， インコーポレイテッド Methods and compositions for the treatment of genetic conditions
CA3131284C (en) 2013-08-28 2023-09-19 David Paschon Compositions for linking dna-binding domains and cleavage domains
EP3057432B1 (en) 2013-10-17 2018-11-21 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells
ES2881473T3 (en) 2013-10-17 2021-11-29 Sangamo Therapeutics Inc Delivery methods and compositions for nuclease-mediated genetic engineering of the genome
UA120502C2 (en) 2013-11-04 2019-12-26 Дау Агросайєнсиз Елелсі Optimal maize loci
RU2019128647A (en) 2013-11-04 2019-11-05 ДАУ АГРОСАЙЕНСИЗ ЭлЭлСи OPTIMUM LOCUS CORN
JP6634022B2 (en) 2013-11-04 2020-01-22 ダウ アグロサイエンシィズ エルエルシー Optimal soybean loci
EP3066202B1 (en) 2013-11-04 2021-03-03 Dow AgroSciences LLC Optimal soybean loci
CA2929179A1 (en) 2013-11-11 2015-05-14 Sangamo Biosciences, Inc. Htt genetic repressor, viral vector, and uses thereof
HUE044540T2 (en) 2013-11-13 2019-10-28 Childrens Medical Center Nuclease-mediated regulation of gene expression
EP3757116A1 (en) 2013-12-09 2020-12-30 Sangamo Therapeutics, Inc. Methods and compositions for genome engineering
WO2015095804A1 (en) 2013-12-19 2015-06-25 Amyris, Inc. Methods for genomic integration
AU2015218576B2 (en) 2014-02-24 2020-02-27 Sangamo Therapeutics, Inc. Methods and compositions for nuclease-mediated targeted integration
EP3929279A1 (en) 2014-03-18 2021-12-29 Sangamo Therapeutics, Inc. Methods and compositions for regulation of zinc finger protein expression
WO2015164748A1 (en) 2014-04-24 2015-10-29 Sangamo Biosciences, Inc. Engineered transcription activator like effector (tale) proteins
KR102380324B1 (en) 2014-05-08 2022-03-30 상가모 테라퓨틱스, 인코포레이티드 Methods and compositions for treating huntington's disease
CA2947622A1 (en) 2014-05-13 2015-11-19 Sangamo Biosciences, Inc. Genome editing methods and compositions for prevention or treatment of a disease
WO2015188065A1 (en) 2014-06-05 2015-12-10 Sangamo Biosciences, Inc. Methods and compositions for nuclease design
CA2954201A1 (en) 2014-07-08 2016-01-14 Vib Vzw Means and methods to increase plant yield
MX2017000555A (en) 2014-07-14 2017-08-10 Univ Washington State Nanos knock-out that ablates germline cells.
US11278572B2 (en) 2014-07-18 2022-03-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Reducing CXCR4 expression and/or function to enhance engraftment of hematopoietic stem cells
WO2016014794A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells
WO2016014837A1 (en) 2014-07-25 2016-01-28 Sangamo Biosciences, Inc. Gene editing for hiv gene therapy
WO2016019144A2 (en) 2014-07-30 2016-02-04 Sangamo Biosciences, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
ES2886012T3 (en) 2014-09-16 2021-12-16 Sangamo Therapeutics Inc Methods and compositions for nuclease-mediated genome engineering and correction in hematopoietic stem cells
US10889834B2 (en) 2014-12-15 2021-01-12 Sangamo Therapeutics, Inc. Methods and compositions for enhancing targeted transgene integration
US20180002379A1 (en) 2015-01-21 2018-01-04 Sangamo Therapeutics, Inc. Methods and compositions for identification of highly specific nucleases
EP3277823B1 (en) 2015-04-03 2023-09-13 Dana-Farber Cancer Institute, Inc. Composition and methods of genome editing of b-cells
US10179918B2 (en) 2015-05-07 2019-01-15 Sangamo Therapeutics, Inc. Methods and compositions for increasing transgene activity
KR20170141217A (en) 2015-05-12 2017-12-22 상가모 테라퓨틱스, 인코포레이티드 Nuclease-mediated regulation of gene expression
US9957501B2 (en) 2015-06-18 2018-05-01 Sangamo Therapeutics, Inc. Nuclease-mediated regulation of gene expression
US10450585B2 (en) 2015-07-13 2019-10-22 Sangamo Therapeutics, Inc. Delivery methods and compositions for nuclease-mediated genome engineering
CN108025034B (en) * 2015-07-15 2022-09-30 新加坡科技研究局 Regulation of hepatitis b virus replication
DK3331355T3 (en) 2015-08-06 2024-07-08 Univ Missouri Porcine reproductive and respiratory syndrome virus (prrsv)-resistant porcine and cells having modified cd163 genes
CA2998500A1 (en) 2015-09-23 2017-03-30 Sangamo Therapeutics, Inc. Htt repressors and uses thereof
CA3004349A1 (en) 2015-11-23 2017-06-01 Sangamo Therapeutics, Inc. Methods and compositions for engineering immunity
NZ743429A (en) 2015-12-18 2022-02-25 Sangamo Therapeutics Inc Targeted disruption of the mhc cell receptor
JP7128741B2 (en) 2015-12-18 2022-08-31 サンガモ セラピューティクス， インコーポレイテッド Targeted disruption of T-cell receptors
BR112018014288A2 (en) 2016-01-15 2018-12-18 Univ Minnesota methods and compositions for the treatment of neurological disease
EP3411056A4 (en) 2016-02-02 2019-10-02 Sangamo Therapeutics, Inc. Compositions for linking dna-binding domains and cleavage domains
EP3417061B1 (en) 2016-02-18 2022-10-26 The Regents of the University of California Methods and compositions for gene editing in stem cells
JP2019515654A (en) 2016-03-16 2019-06-13 ザ ジェイ． デヴィッド グラッドストーン インスティテューツ Methods and compositions for treating obesity and / or diabetes, and methods and compositions for identifying candidate treatment agents
EP3433362B1 (en) 2016-03-23 2021-05-05 Dana-Farber Cancer Institute, Inc. Methods for enhancing the efficiency of gene editing
US11293033B2 (en) 2016-05-18 2022-04-05 Amyris, Inc. Compositions and methods for genomic integration of nucleic acids into exogenous landing pads
MA45670A (en) 2016-07-13 2019-05-22 Vertex Pharma PROCESSES, COMPOSITIONS AND KITS TO INCREASE GENOME EDITING EFFICIENCY
EP3838287A3 (en) 2016-07-27 2021-07-28 Case Western Reserve University Compounds and methods of promoting myelination
EP3497213B1 (en) 2016-08-09 2023-10-18 Vib Vzw Cellulose synthase inhibitors and mutant plants
IL264639B2 (en) 2016-08-24 2024-01-01 Sangamo Therapeutics Inc Regulation of globulin gene expression using engineered zinc finger nucleases
SG10201913948PA (en) 2016-08-24 2020-03-30 Sangamo Therapeutics Inc Engineered target specific nucleases
US10960085B2 (en) 2016-09-07 2021-03-30 Sangamo Therapeutics, Inc. Modulation of liver genes
WO2018067697A1 (en) 2016-10-04 2018-04-12 Precision Biosciences, Inc. Co-stimulatory domains for use in genetically-modified cells
US11219695B2 (en) 2016-10-20 2022-01-11 Sangamo Therapeutics, Inc. Methods and compositions for the treatment of Fabry disease
AU2017347928A1 (en) 2016-10-31 2019-05-09 Sangamo Therapeutics, Inc. Gene correction of scid-related genes in hematopoietic stem and progenitor cells
CA3043635A1 (en) 2016-12-01 2018-06-07 Sangamo Therapeutics, Inc. Tau modulators and methods and compositions for delivery thereof
JP7416406B2 (en) 2016-12-08 2024-01-17 ケース ウェスタン リザーブ ユニバーシティ Methods and compositions for increasing functional myelin production
AU2017378431A1 (en) 2016-12-14 2019-06-20 Ligandal, Inc. Compositions and methods for nucleic acid and/or protein payload delivery
WO2018195418A1 (en) 2017-04-20 2018-10-25 Oregon Health & Science University Human gene correction
US11655275B2 (en) 2017-05-03 2023-05-23 Sangamo Therapeutics, Inc. Methods and compositions for modification of a cystic fibrosis transmembrane conductance regulator (CFTR) gene
EP3634493A1 (en) 2017-05-08 2020-04-15 Precision BioSciences, Inc. Nucleic acid molecules encoding an engineered antigen receptor and an inhibitory nucleic acid molecule and methods of use thereof
US11512287B2 (en) 2017-06-16 2022-11-29 Sangamo Therapeutics, Inc. Targeted disruption of T cell and/or HLA receptors
JP2020529834A (en) 2017-06-30 2020-10-15 プレシジョン バイオサイエンシズ，インク． Genetically modified T cells containing modified introns of the T cell receptor alpha gene
SG11202002728VA (en) 2017-10-03 2020-04-29 Juno Therapeutics Inc Hpv-specific binding molecules
EP3692057B9 (en) 2017-10-03 2023-10-04 Precision BioSciences, Inc. Modified epidermal growth factor receptor peptides for use in genetically-modified cells
EP3704238B1 (en) 2017-11-01 2024-01-03 Precision Biosciences, Inc. Engineered nucleases that target human and canine factor viii genes as a treatment for hemophilia a
US11661611B2 (en) 2017-11-09 2023-05-30 Sangamo Therapeutics, Inc. Genetic modification of cytokine inducible SH2-containing protein (CISH) gene
MX2020005561A (en) 2017-12-01 2020-10-12 Encoded Therapeutics Inc Engineered dna binding proteins.
WO2019143675A1 (en) 2018-01-17 2019-07-25 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
KR20200110687A (en) 2018-01-17 2020-09-24 버텍스 파마슈티칼스 인코포레이티드 Quinoxalinone compounds, compositions, methods and kits for increasing genome editing efficiency
WO2019143678A1 (en) 2018-01-17 2019-07-25 Vertex Pharmaceuticals Incorporated Dna-pk inhibitors
JP7275152B2 (en) 2018-02-08 2023-05-17 サンガモ セラピューティクス， インコーポレイテッド Engineered target-specific nucleases
AU2019247199A1 (en) 2018-04-05 2020-10-15 Editas Medicine, Inc. T cells expressing a recombinant receptor, related polynucleotides and methods
MA52656A (en) 2018-04-05 2021-02-17 Editas Medicine Inc PROCESSES FOR THE PRODUCTION OF CELLS EXPRESSING A RECOMBINANT RECEIVER AND ASSOCIATED COMPOSITIONS
EP3781587A4 (en) 2018-04-18 2022-03-30 Sangamo Therapeutics, Inc. Zinc finger protein compositions for modulation of huntingtin (htt)
US11690921B2 (en) 2018-05-18 2023-07-04 Sangamo Therapeutics, Inc. Delivery of target specific nucleases
EP3841204A4 (en) 2018-08-23 2022-05-18 Sangamo Therapeutics, Inc. Engineered target specific base editors
JP2022500052A (en) 2018-09-18 2022-01-04 サンガモ セラピューティクス， インコーポレイテッド Programmed cell death 1 (PD1) specific nuclease
EP3898661A1 (en) 2018-12-21 2021-10-27 Precision BioSciences, Inc. Genetic modification of the hydroxyacid oxidase 1 gene for treatment of primary hyperoxaluria
FI3908568T3 (en) 2019-01-11 2024-09-13 Acuitas Therapeutics Inc Lipids for lipid nanoparticle delivery of active agents
US11857641B2 (en) 2019-02-06 2024-01-02 Sangamo Therapeutics, Inc. Method for the treatment of mucopolysaccharidosis type I
WO2020163856A1 (en) 2019-02-10 2020-08-13 The J. David Gladstone Institutes, A Testamentary Trust Established Under The Will Of J. David Gladstone Modified mitochondrion and methods of use thereof
KR20210146986A (en) 2019-04-02 2021-12-06 상가모 테라퓨틱스, 인코포레이티드 Methods of treating beta-thalassemia
CA3135799A1 (en) 2019-04-03 2020-10-08 Precision Biosciences, Inc. Genetically-modified immune cells comprising a microrna-adapted shrna (shrnamir)
CA3136265A1 (en) 2019-04-05 2020-10-08 Precision Biosciences, Inc. Methods of preparing populations of genetically-modified immune cells
CN113766921A (en) 2019-04-23 2021-12-07 桑格摩生物治疗股份有限公司 Regulator for chromosome 9 open reading frame 72 gene expression and its use
JP2022531577A (en) 2019-05-01 2022-07-07 ジュノー セラピューティクス インコーポレイテッド Cells expressing chimeric receptors from the modified CD247 locus, related polynucleotides, and methods.
KR20220016475A (en) 2019-05-01 2022-02-09 주노 쎄러퓨티크스 인코퍼레이티드 Cells, Associated Polynucleotides and Methods Expressing Recombinant Receptors at the Modified TFTFR2 Locus
WO2021016608A1 (en) 2019-07-25 2021-01-28 Precision Biosciences, Inc. Compositions and methods for sequential stacking of nucleic acid sequences into a genomic locus
US20220273720A1 (en) 2019-08-20 2022-09-01 Precision Biosciences, Inc. Lymphodepletion dosing regimens for cellular immunotherapies
WO2021035170A1 (en) 2019-08-21 2021-02-25 Precision Biosciences, Inc. Compositions and methods for tcr reprogramming using fusion proteins
US20230002459A1 (en) 2019-10-02 2023-01-05 Sangamo Therapeutics, Inc. Zinc Finger Protein Transcription Factors for Treatment of Prion Disease
CN114466867A (en) 2019-10-02 2022-05-10 桑格摩生物治疗股份有限公司 Zinc finger protein transcription factor for inhibiting alpha-synuclein expression
WO2021087305A1 (en) 2019-10-30 2021-05-06 Precision Biosciences, Inc. Cd20 chimeric antigen receptors and methods of use for immunotherapy
TW202132565A (en) 2019-11-01 2021-09-01 美商聖加莫治療股份有限公司 Gin recombinase variants
WO2021113543A1 (en) 2019-12-06 2021-06-10 Precision Biosciences, Inc. Methods for cancer immunotherapy, using lymphodepletion regimens and cd19, cd20 or bcma allogeneic car t cells
CN115210251A (en) 2020-01-22 2022-10-18 桑格摩生物治疗股份有限公司 Zinc finger protein transcription factor for repressing TAU expression
WO2021158915A1 (en) 2020-02-06 2021-08-12 Precision Biosciences, Inc. Recombinant adeno-associated virus compositions and methods for producing and using the same
CN115697044A (en) 2020-03-31 2023-02-03 艾洛生物系统有限公司 Regulation of endogenous mogroside pathway genes in watermelon and other cucurbitaceae
CN115715203A (en) 2020-05-06 2023-02-24 塞勒克提斯公司 Methods of genetically modifying cells to deliver therapeutic proteins
CA3177093A1 (en) 2020-05-06 2021-11-11 Cellectis S.A. Methods for targeted insertion of exogenous sequences in cellular genomes
US20230183664A1 (en) 2020-05-11 2023-06-15 Precision Biosciences, Inc. Self-limiting viral vectors encoding nucleases
CN115835873A (en) 2020-05-13 2023-03-21 朱诺治疗学股份有限公司 Method for generating donor batch cells expressing recombinant receptor
WO2021260186A1 (en) 2020-06-26 2021-12-30 Juno Therapeutics Gmbh Engineered t cells conditionally expressing a recombinant receptor, related polynucleotides and methods
EP4182297A1 (en) 2020-07-16 2023-05-24 Acuitas Therapeutics, Inc. Cationic lipids for use in lipid nanoparticles
EP4192875A1 (en) 2020-08-10 2023-06-14 Precision BioSciences, Inc. Antibodies and fragments specific for b-cell maturation antigen and uses thereof
US20220064596A1 (en) 2020-08-25 2022-03-03 Kite Pharma, Inc. T cells with improved functionality
JP2023542705A (en) 2020-09-25 2023-10-11 サンガモ セラピューティクス， インコーポレイテッド Zinc finger fusion proteins for nucleobase editing
IL301795A (en) 2020-10-02 2023-05-01 Sangamo Therapeutics Inc Novel zinc finger protein transcription factors for repressing alpha-synuclein expression
WO2022076547A1 (en) 2020-10-07 2022-04-14 Precision Biosciences, Inc. Lipid nanoparticle compositions
EP4232461A1 (en) 2020-10-23 2023-08-30 ELO Life Systems, Inc. Methods for producing vanilla plants with improved flavor and agronomic production
US20230398148A1 (en) 2020-11-04 2023-12-14 Juno Therapeutics, Inc. Cells expressing a chimeric receptor from a modified invariant cd3 immunoglobulin superfamily chain locus and related polynucleotides and methods
MX2023005665A (en) 2020-11-16 2023-08-01 Pig Improvement Co Uk Ltd Influenza a-resistant animals having edited anp32 genes.
WO2022165111A1 (en) 2021-01-28 2022-08-04 Precision Biosciences, Inc. Modulation of tgf beta signaling in genetically-modified eukaryotic cells
US20240141311A1 (en) 2021-04-22 2024-05-02 North Carolina State University Compositions and methods for generating male sterile plants
WO2023064872A1 (en) 2021-10-14 2023-04-20 Precision Biosciences, Inc. Combinations of anti-bcma car t cells and gamma secretase inhibitors
WO2023070003A1 (en) 2021-10-19 2023-04-27 Precision Biosciences, Inc. Gene editing methods for treating alpha-1 antitrypsin (aat) deficiency
WO2023081900A1 (en) 2021-11-08 2023-05-11 Juno Therapeutics, Inc. Engineered t cells expressing a recombinant t cell receptor (tcr) and related systems and methods
WO2023091910A1 (en) 2021-11-16 2023-05-25 Precision Biosciences, Inc. Methods for cancer immunotherapy
WO2023105244A1 (en) 2021-12-10 2023-06-15 Pig Improvement Company Uk Limited Editing tmprss2/4 for disease resistance in livestock
IL313486A (en) 2021-12-16 2024-08-01 Acuitas Therapeutics Inc Lipids for use in lipid nanoparticle formulations
CN118591626A (en) 2021-12-22 2024-09-03 桑格摩生物治疗股份有限公司 Novel zinc finger fusion proteins for nucleobase editing
WO2023131616A1 (en) 2022-01-05 2023-07-13 Vib Vzw Means and methods to increase abiotic stress tolerance in plants
WO2023131637A1 (en) 2022-01-06 2023-07-13 Vib Vzw Improved silage grasses
WO2023144199A1 (en) 2022-01-26 2023-08-03 Vib Vzw Plants having reduced levels of bitter taste metabolites
WO2024013514A2 (en) 2022-07-15 2024-01-18 Pig Improvement Company Uk Limited Gene edited livestock animals having coronavirus resistance
WO2024100604A1 (en) 2022-11-09 2024-05-16 Juno Therapeutics Gmbh Methods for manufacturing engineered immune cells
WO2024161021A1 (en) 2023-02-03 2024-08-08 Juno Therapeutics Gmbh Methods for non-viral manufacturing of engineered immune cells
WO2024206821A1 (en) 2023-03-31 2024-10-03 Briacell Therapeutics Corp. Methods for enhancing the immunogenicity of cellular vaccines
WO2024216118A1 (en) 2023-04-14 2024-10-17 Precision Biosciences, Inc. Muscle-specific expression cassettes
WO2024216116A1 (en) 2023-04-14 2024-10-17 Precision Biosciences, Inc. Muscle-specific expression cassettes

Also Published As

Publication number Publication date
WO2002099084A9 (en) 2004-12-16
GB0108491D0 (en) 2001-05-23
WO2002099084A2 (en) 2002-12-12
WO2002099084A3 (en) 2003-10-23

Similar Documents

Publication Publication Date Title
AU2002322477A1 (en) Composite binding polypeptides
AU2002247826A1 (en) Specific binding members
AU2003275473A1 (en) Phenolic binding peptides
GB2374086B (en) Composite sliding material
AU2001273994A1 (en) Armor-plating composite
IL202255A0 (en) Binding domain-immunoglobulin fusion proteins
GB2381493B (en) Composite materials
AU2002241899A1 (en) Tip39 polypeptides
AU2001288220A1 (en) Hyperglycosylated polypeptides
AU2003285892A1 (en) Bace binding peptides and uses thereof
GB2378995B (en) Composite materials
AU2002351469A1 (en) Acrp30-like polynucleotides, polypeptides, and antibodies
AU2002218199A1 (en) Truncated phosphodiesterase-7 polypeptides
AU2002258746A1 (en) Outer membrane associated polypeptides
GB0119446D0 (en) Binding proteins
AU2002244920A1 (en) Hcv-binding polypeptides
AU2002321224A1 (en) Composite elements
AU2002303790A1 (en) Composite
AUPR251401A0 (en) Binding
AUPR354801A0 (en) Binding
AU2002328853A1 (en) Carcinoma-related peptides
AU2002228311A1 (en) Composite material structure
AU2002321613A1 (en) Composite material structure
AU2002307711A1 (en) Anti-obesity polypeptides
AU2002225532A1 (en) Silver-dispersing polypeptides

Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase