WO2002094850A3 - Haplotypes of the gnrh2 gene - Google Patents

Haplotypes of the gnrh2 gene Download PDF

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Publication number
WO2002094850A3
WO2002094850A3 PCT/US2001/050630 US0150630W WO02094850A3 WO 2002094850 A3 WO2002094850 A3 WO 2002094850A3 US 0150630 W US0150630 W US 0150630W WO 02094850 A3 WO02094850 A3 WO 02094850A3
Authority
WO
WIPO (PCT)
Prior art keywords
gnrh2
gene
haplotypes
disclosed
haplotyping
Prior art date
Application number
PCT/US2001/050630
Other languages
French (fr)
Other versions
WO2002094850A2 (en
Inventor
Amy Duda
Stefanie E Kliem
Krishnan Nandabalan
Elizabeth Ann Sausker
Original Assignee
Genaissance Pharmaceuticals
Amy Duda
Stefanie E Kliem
Krishnan Nandabalan
Elizabeth Ann Sausker
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaissance Pharmaceuticals, Amy Duda, Stefanie E Kliem, Krishnan Nandabalan, Elizabeth Ann Sausker filed Critical Genaissance Pharmaceuticals
Priority to AU2002258375A priority Critical patent/AU2002258375A1/en
Publication of WO2002094850A2 publication Critical patent/WO2002094850A2/en
Publication of WO2002094850A3 publication Critical patent/WO2002094850A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel genetic variants of the Gonadotropin-Releasing Hormone 2 (GNRH2) gene are described. Various genotypes, haplotypes, and haplotype pairs that exist in the general United States population are disclosed for the GNRH2 gene. Compositions and methods for haplotyping and/or genotyping the GNRH2 gene in an individual are also disclosed. Polynucleotides defined by the haplotypes disclosed herein are also described.
PCT/US2001/050630 2000-05-18 2001-11-01 Haplotypes of the gnrh2 gene WO2002094850A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002258375A AU2002258375A1 (en) 2000-05-18 2001-11-01 Haplotypes of the gnrh2 gene

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20518700P 2000-05-18 2000-05-18
US01/16353 2001-05-18

Publications (2)

Publication Number Publication Date
WO2002094850A2 WO2002094850A2 (en) 2002-11-28
WO2002094850A3 true WO2002094850A3 (en) 2003-09-25

Family

ID=22761163

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/016353 WO2001087910A2 (en) 2000-05-18 2001-05-18 Haplotypes of the gnrh2 gene
PCT/US2001/050630 WO2002094850A2 (en) 2000-05-18 2001-11-01 Haplotypes of the gnrh2 gene

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2001/016353 WO2001087910A2 (en) 2000-05-18 2001-05-18 Haplotypes of the gnrh2 gene

Country Status (2)

Country Link
AU (2) AU6474101A (en)
WO (2) WO2001087910A2 (en)

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE SNP [online] NATIONAL LIBRARY OF MEDICINE, NIH (BETHESDA, MD, USA); 2 September 2000 (2000-09-02), XP002968340, retrieved from (ss#) 1166130 accession no. NCBI Database accession no. (rs#) 676749 *
WHITE ET AL.: "Second gene for gonadotropin-releasing hormone in humans", PROC. NATL. ACAD. SCI. USA, vol. 95, January 1998 (1998-01-01), pages 305 - 309, XP000882990 *

Also Published As

Publication number Publication date
AU2002258375A1 (en) 2002-12-03
WO2001087910A2 (en) 2001-11-22
WO2002094850A2 (en) 2002-11-28
AU6474101A (en) 2001-11-26

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