WO2002094344A3 - Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids - Google Patents

Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids Download PDF

Info

Publication number
WO2002094344A3
WO2002094344A3 PCT/GB2002/002371 GB0202371W WO02094344A3 WO 2002094344 A3 WO2002094344 A3 WO 2002094344A3 GB 0202371 W GB0202371 W GB 0202371W WO 02094344 A3 WO02094344 A3 WO 02094344A3
Authority
WO
WIPO (PCT)
Prior art keywords
ibp
removal
binding proteins
biological fluids
insulin binding
Prior art date
Application number
PCT/GB2002/002371
Other languages
French (fr)
Other versions
WO2002094344A2 (en
Inventor
Arezki Mahiout
Werner Kleophas
Stephan Martin
Original Assignee
Allied Therapeutics Ltd
Arezki Mahiout
Werner Kleophas
Stephan Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allied Therapeutics Ltd, Arezki Mahiout, Werner Kleophas, Stephan Martin filed Critical Allied Therapeutics Ltd
Priority to EP02771679A priority Critical patent/EP1423176A2/en
Priority to AU2002307869A priority patent/AU2002307869A1/en
Publication of WO2002094344A2 publication Critical patent/WO2002094344A2/en
Publication of WO2002094344A3 publication Critical patent/WO2002094344A3/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B01D15/3828—Ligand exchange chromatography, e.g. complexation, chelation or metal interaction chromatography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/16—Blood plasma; Blood serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/34—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration
    • A61M1/3472—Filtering material out of the blood by passing it through a membrane, i.e. hemofiltration or diafiltration with treatment of the filtrate
    • A61M1/3486—Biological, chemical treatment, e.g. chemical precipitation; treatment by absorbents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28016—Particle form
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
    • B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
    • B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
    • B01J20/3244—Non-macromolecular compounds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J45/00—Ion-exchange in which a complex or a chelate is formed; Use of material as complex or chelate forming ion-exchangers; Treatment of material for improving the complex or chelate forming ion-exchange properties
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Anesthesiology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)

Abstract

A method for removing an insulin binding protein (IBP) from a biological fluid which comprises contacting the biological fluid with an affinity agent capable of forming a complex with said IBP and separating complexed IBP from said biological fluid.
PCT/GB2002/002371 2001-05-21 2002-05-21 Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids WO2002094344A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02771679A EP1423176A2 (en) 2001-05-21 2002-05-21 Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids
AU2002307869A AU2002307869A1 (en) 2001-05-21 2002-05-21 Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0112363.7A GB0112363D0 (en) 2001-05-21 2001-05-21 Method and apparatus for treating biological fluids
GB0112363.7 2001-05-21

Publications (2)

Publication Number Publication Date
WO2002094344A2 WO2002094344A2 (en) 2002-11-28
WO2002094344A3 true WO2002094344A3 (en) 2003-03-13

Family

ID=9915025

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/002371 WO2002094344A2 (en) 2001-05-21 2002-05-21 Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids

Country Status (4)

Country Link
EP (1) EP1423176A2 (en)
AU (1) AU2002307869A1 (en)
GB (1) GB0112363D0 (en)
WO (1) WO2002094344A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4773354B2 (en) * 2004-08-18 2011-09-14 株式会社カネカ Peptides and adsorbents capable of binding to insulin-binding proteins
AU2013204469B2 (en) * 2008-12-19 2015-04-09 Baxalta GmbH Systems and methods for obtaining immunoglobulin from blood
US20100158893A1 (en) 2008-12-19 2010-06-24 Baxter International Inc. Systems and methods for obtaining immunoglobulin from blood
WO2010080494A1 (en) * 2008-12-19 2010-07-15 Tercica, Inc. Methods for identifying degradation products in a polypeptide sample

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1562546A (en) * 1976-06-22 1980-03-12 Mitsui Toatsu Chemicals Removing specific factors from blood
EP0132534A2 (en) * 1983-06-01 1985-02-13 Kanegafuchi Chemical Industry Co., Ltd. Device for the extracorporeal treatment of body fluids
DD221367A5 (en) * 1982-08-12 1985-04-24 Diamond Shamrock Corp PROCESS FOR PREPARING A BIOSPECIFIC POLYMER

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5344832A (en) 1990-01-10 1994-09-06 The Board Of Supervisors Of Louisiana University And Agricultural And Mechanical College Method for the long term reduction of body fat stores, insulin resistance, hyperinsulinemia and hyperglycemia in vertebrates
US5126324A (en) 1990-06-07 1992-06-30 Genentech, Inc. Method of enhancing growth in patients using combination therapy
US5714432A (en) 1992-12-28 1998-02-03 Kabushiki Kaisha Riken Exhaust gas cleaner comprising supported silver or silver oxide particles
GB9302462D0 (en) 1993-12-01 1993-12-01 Semple Keith Motor cycle centre-stand lock
IL118474A (en) 1995-06-01 2001-08-08 Sankyo Co Benzimidazole derivatives and pharmaceutical compositions containing the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1562546A (en) * 1976-06-22 1980-03-12 Mitsui Toatsu Chemicals Removing specific factors from blood
DD221367A5 (en) * 1982-08-12 1985-04-24 Diamond Shamrock Corp PROCESS FOR PREPARING A BIOSPECIFIC POLYMER
EP0132534A2 (en) * 1983-06-01 1985-02-13 Kanegafuchi Chemical Industry Co., Ltd. Device for the extracorporeal treatment of body fluids

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
YAMANAKA YOSHITAKA ET AL: "Inhibition of insulin receptor activation by insulin-like growth factor binding proteins.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 272, no. 49, 5 December 1997 (1997-12-05), pages 30729 - 30734, XP002223807, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
GB0112363D0 (en) 2001-07-11
EP1423176A2 (en) 2004-06-02
WO2002094344A2 (en) 2002-11-28
AU2002307869A1 (en) 2002-12-03

Similar Documents

Publication Publication Date Title
WO2002016412A3 (en) Binding polypeptides for b lymphocyte stimulator protein (blys)
EP1293783A3 (en) Apparatus and method for handling biological sample containers
AU2001239912A1 (en) Method and apparatus for handling diverse body fluids
AU2003235627A1 (en) Method and device for the analysis of body fluids
AU2002360522A1 (en) An apparatus for fluid transport and related method thereof
EP1130397A3 (en) Equipment for determination of an analyte from a sample
AU2002254321A1 (en) Method and apparatus for the automated generation of nucleic acid ligands
AU2002308583A1 (en) Apparatus and methods for capturing particulate material within blood vessels
AU2002219487A1 (en) Apparatus and method for propelling fluids
EP1457218A4 (en) Automatic apparatus for blood dialysis and priming method using the apparatus
AU2002243587A1 (en) Microfluidic apparatus for performing gel protein extractions and methods for using the apparatus
HUP0402276A3 (en) Method for detecting analyte(s) using magnetic colloidal particles
AU2001252807A1 (en) Method and apparatus for collecting and transporting liquids, specifically blood
WO2006045103A3 (en) Device and method for removing heavy metals from contaminated samples with membranes comprising purified metallothionein
WO2004103939A3 (en) Assay method and apparatus
AU2002309765A1 (en) Method and apparatus for surgically restoring coronary blood vessels
WO2002094344A3 (en) Method and apparatus for removal of insulin binding proteins (ibp) from biological fluids
AU2002327040A1 (en) Filtration device and system for biological fluids and a method for filtering
AU2003206347A1 (en) Separating method and an apparatus performing such a method
AU2002347859A1 (en) System, method, and apparatus for submitting genetic samples and receiving genetic testing results anonymously
WO2000010673A8 (en) Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids
HUP0401953A2 (en) Biotin derivatives
AU2002367565A1 (en) Method and apparatus for filtering and adsorbing biological and chemical agents
AU2002365084A1 (en) Method and reagent for the detection of proteins and peptides
EP1681571B8 (en) Apparatus and method for handling fluids for analysis

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ OM PH PL PT RO RU SD SE SG SI SK SL TJ TM TN TR TT TZ UA UG US UZ VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

WWE Wipo information: entry into national phase

Ref document number: 2002771679

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2002771679

Country of ref document: EP

NENP Non-entry into the national phase

Ref country code: JP

WWW Wipo information: withdrawn in national office

Country of ref document: JP

WWW Wipo information: withdrawn in national office

Ref document number: 2002771679

Country of ref document: EP