WO2000010673A8 - Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids - Google Patents

Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids

Info

Publication number
WO2000010673A8
WO2000010673A8 PCT/IL1999/000459 IL9900459W WO0010673A8 WO 2000010673 A8 WO2000010673 A8 WO 2000010673A8 IL 9900459 W IL9900459 W IL 9900459W WO 0010673 A8 WO0010673 A8 WO 0010673A8
Authority
WO
WIPO (PCT)
Prior art keywords
blood
surface exposure
anionic
anionic phospholipids
biological fluids
Prior art date
Application number
PCT/IL1999/000459
Other languages
French (fr)
Other versions
WO2000010673A1 (en
Inventor
Ilan Ziv
Anat Shirvan
Original Assignee
Nst Neurosurvival Technologies
Ilan Ziv
Anat Shirvan
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL12590898A external-priority patent/IL125908A/en
Priority claimed from IL13126699A external-priority patent/IL131266A0/en
Application filed by Nst Neurosurvival Technologies, Ilan Ziv, Anat Shirvan filed Critical Nst Neurosurvival Technologies
Priority to AU53849/99A priority Critical patent/AU5384999A/en
Publication of WO2000010673A1 publication Critical patent/WO2000010673A1/en
Publication of WO2000010673A8 publication Critical patent/WO2000010673A8/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721—Lipocortins

Abstract

An affinity filter and method of using same, effective in capturing and thereby removing particles characterized by surface exposure of anionic phospholipids present in a biological fluid, particularly blood or blood-derived products. Examples of other biological fluids include semen, cerebrospinal fluid, urine and mucous. The affinity filter includes a body formed with an inlet and an outlet, including a solid support and an anionic-phospholipid binding compound linked to the solid support. The positively charged anionic-phospholipid binding compound serves for specifically binding the particles characterized by surface exposure of anionic phospholipids and thereby removing the particles from the biological fluid, and particularly from blood or blood-derived products, for example in order to prepare the blood or blood-derived product for transfusion into a subject.
PCT/IL1999/000459 1998-08-24 1999-08-23 Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids WO2000010673A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU53849/99A AU5384999A (en) 1998-08-24 1999-08-23 Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
IL125908 1998-08-24
IL12590898A IL125908A (en) 1998-08-24 1998-08-24 Peptides and pharmaceutical compositions comprising same
US20071598A 1998-11-27 1998-11-27
US09/200,715 1998-11-27
IL131266 1999-08-05
IL13126699A IL131266A0 (en) 1999-08-05 1999-08-05 Peptides and pharmaceutical compositions comprising same

Publications (2)

Publication Number Publication Date
WO2000010673A1 WO2000010673A1 (en) 2000-03-02
WO2000010673A8 true WO2000010673A8 (en) 2000-07-27

Family

ID=27271883

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL1999/000459 WO2000010673A1 (en) 1998-08-24 1999-08-23 Apparatus and method for capturing particles with surface exposure of anionic phospholipids from biological fluids

Country Status (2)

Country Link
AU (1) AU5384999A (en)
WO (1) WO2000010673A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL131266A0 (en) 1999-08-05 2001-01-28 N S T Neurosurvival Technologi Peptides and pharmaceutical compositions comprising same
AU2001237805A1 (en) * 2000-02-08 2001-08-20 Acspurt B.V. Material and method for immobilization of bioactive species
US7635680B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaceuticals, Inc. Attenuation of reperfusion injury
US7645739B2 (en) 2001-02-21 2010-01-12 Alavita Pharmaceuticals, Inc. Modified annexin compositions and methods of using same
US7635676B2 (en) 2001-02-21 2009-12-22 Alavita Pharmaccuticals, Inc. Modified annexin proteins and methods for their use in organ transplantation
ATE359807T1 (en) 2001-02-21 2007-05-15 Surromed Inc MODIFIED ANNEXIN PROTEINS AND PREVENTION AND TREATMENT OF THROMBOSIS
FR2841557B1 (en) * 2002-07-01 2005-12-09 Commissariat Energie Atomique PEPTIDES HAVING AFFINITY FOR PHOSPHOLIPID AND USES
US7511016B2 (en) 2004-07-07 2009-03-31 Mosamedix B.V. Annexins, derivatives thereof, and annexin-cys variants, as well as therapeutic and diagnostic uses thereof

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3701433A (en) * 1970-11-10 1972-10-31 Pall Corp Filter for use in the filtration of blood
US4350594A (en) * 1980-04-16 1982-09-21 Kuraray Co., Ltd. Blood purification using plural ultrafiltration stages
US4572724A (en) * 1984-04-12 1986-02-25 Pall Corporation Blood filter
US5362406A (en) * 1990-07-27 1994-11-08 Pall Corporation Leucocyte depleting filter device and method of use
CA2127605A1 (en) * 1993-12-23 1995-06-24 Peter J. Degen Affinity separation method
NZ283171A (en) * 1994-04-11 1998-02-26 Nexins Research Bv Detecting or quantifying apoptotic cells in a sample
EP0765166B1 (en) * 1994-06-16 2003-05-21 Neorx Corporation Radiolabeled annexin-galactose conjugates
US5630946A (en) * 1995-02-15 1997-05-20 Pall Corporation Method for processing a biological fluid including leukocyte removal in an extracorporeal circuit

Also Published As

Publication number Publication date
WO2000010673A1 (en) 2000-03-02
AU5384999A (en) 2000-03-14

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