WO2002088819A3 - Vorrichtung und verfahren zur optischen messung von chemischen und/oder biologischen proben - Google Patents

Vorrichtung und verfahren zur optischen messung von chemischen und/oder biologischen proben Download PDF

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Publication number
WO2002088819A3
WO2002088819A3 PCT/EP2002/004623 EP0204623W WO02088819A3 WO 2002088819 A3 WO2002088819 A3 WO 2002088819A3 EP 0204623 W EP0204623 W EP 0204623W WO 02088819 A3 WO02088819 A3 WO 02088819A3
Authority
WO
WIPO (PCT)
Prior art keywords
chemical
biological samples
sample
optical measurement
image field
Prior art date
Application number
PCT/EP2002/004623
Other languages
English (en)
French (fr)
Other versions
WO2002088819A2 (de
Inventor
Achim Kirsch
Roland Stange
Juergen Mueller
Original Assignee
Evotec Ag
Achim Kirsch
Roland Stange
Juergen Mueller
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Evotec Ag, Achim Kirsch, Roland Stange, Juergen Mueller filed Critical Evotec Ag
Priority to AU2002312858A priority Critical patent/AU2002312858A1/en
Priority to EP02738002A priority patent/EP1384104A2/de
Priority to US10/476,243 priority patent/US7474777B2/en
Publication of WO2002088819A2 publication Critical patent/WO2002088819A2/de
Publication of WO2002088819A3 publication Critical patent/WO2002088819A3/de

Links

Classifications

    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/18—Arrangements with more than one light path, e.g. for comparing two specimens
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G—PHYSICS
    • G02—OPTICS
    • G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
    • G02B21/00—Microscopes
    • G02B21/0096—Microscopes with photometer devices

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Optics & Photonics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)

Abstract

Eine optische Meßvorrichtung zur Messung chemischer und/oder biologischer Proben weist eine Beleuchtungseinrichtung (16) zur Beleuchtung der zu messenden Probe (20) auf. Ferner ist eine Optikeinrichtung (22) zur Abbildung eines Probenbereichs in einem Bildfeld (10) vorgesehen. Ein erster Teilbereich (12) des Bildfeldes wird von einem ersten Detektor (28) und ein zweiter Teilbereich (14) des Bildfeldes (10) wird von einem zweiten Detektor (34) erfasst. Es ist somit möglich, zwischen zwei Meßverfahren ohne Umschalten zu wechseln oder zwei Messungen an einer Probe gleichzeitig durchzuführen.
PCT/EP2002/004623 2001-04-28 2002-04-26 Vorrichtung und verfahren zur optischen messung von chemischen und/oder biologischen proben WO2002088819A2 (de)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2002312858A AU2002312858A1 (en) 2001-04-28 2002-04-26 Device and method for the optical measurement of chemical and/or biological samples
EP02738002A EP1384104A2 (de) 2001-04-28 2002-04-26 Vorrichtung und verfahren zur optischen messung von chemischen und/oder biologischen proben
US10/476,243 US7474777B2 (en) 2001-04-28 2002-04-26 Device and method for optical measurement of chemical and/or biological samples

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10121064A DE10121064A1 (de) 2001-04-28 2001-04-28 Vorrichtung und Verfahren zur optischen Messung von chemischen und/oder biologischen Proben
DE10121064.7 2001-04-28

Publications (2)

Publication Number Publication Date
WO2002088819A2 WO2002088819A2 (de) 2002-11-07
WO2002088819A3 true WO2002088819A3 (de) 2003-09-25

Family

ID=7683202

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/004623 WO2002088819A2 (de) 2001-04-28 2002-04-26 Vorrichtung und verfahren zur optischen messung von chemischen und/oder biologischen proben

Country Status (5)

Country Link
US (1) US7474777B2 (de)
EP (1) EP1384104A2 (de)
AU (1) AU2002312858A1 (de)
DE (1) DE10121064A1 (de)
WO (1) WO2002088819A2 (de)

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DE102004005878A1 (de) * 2004-02-05 2005-09-01 Rina-Netzwerk Rna Technologien Gmbh Verfahren zur Überwachung der Herstellung von Biomolekülkristallen
US7248360B2 (en) * 2004-04-02 2007-07-24 Ppd Biomarker Discovery Sciences, Llc Polychronic laser scanning system and method of use
US7276720B2 (en) * 2004-07-19 2007-10-02 Helicos Biosciences Corporation Apparatus and methods for analyzing samples
US20070070349A1 (en) * 2005-09-23 2007-03-29 Helicos Biosciences Corporation Optical train and method for TIRF single molecule detection and analysis
JP2007293210A (ja) * 2006-04-27 2007-11-08 Olympus Corp イメージング装置
ES2374686T3 (es) 2007-05-14 2012-02-21 Historx, Inc. Separación en compartimentos por caracterización de píxel usando agrupamiento de datos de imágenes.
CA2690633C (en) 2007-06-15 2015-08-04 Historx, Inc. Method and system for standardizing microscope instruments
GB2451442B (en) * 2007-07-30 2013-03-06 Lein Applied Diagnostics Ltd Optical measurement apparatus and method therefor
CA2604317C (en) * 2007-08-06 2017-02-28 Historx, Inc. Methods and system for validating sample images for quantitative immunoassays
CA2737116C (en) * 2008-09-16 2019-01-15 Historx, Inc. Reproducible quantification of biomarker expression
US9658222B2 (en) 2009-03-02 2017-05-23 Mbio Diagnostics, Inc. Planar waveguide based cartridges and associated methods for detecting target analyte
US8331751B2 (en) * 2009-03-02 2012-12-11 mBio Diagnositcs, Inc. Planar optical waveguide with core of low-index-of-refraction interrogation medium
US9212995B2 (en) 2009-03-02 2015-12-15 Mbio Diagnostics, Inc. System and method for detecting multiple molecules in one assay
DE102010015915A1 (de) * 2010-03-11 2011-09-15 Leica Microsystems Cms Gmbh Verfahren für einen beschleunigten Anregungswellenlängen-Scan bei einem Fluoreszenzmikroskop
DE102010035003B4 (de) * 2010-08-20 2015-08-06 PicoQuant GmbH. Unternehmen für optoelektronische Forschung und Entwicklung Räumlich und zeitlich hochauflösende Mikroskopie
JP6286863B2 (ja) * 2013-05-09 2018-03-07 ソニー株式会社 光学系、及びテラヘルツ放射顕微鏡

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US4283112A (en) * 1979-04-24 1981-08-11 Venable Thomas C Telescope guiding system
DE3328821A1 (de) * 1983-08-10 1985-02-28 Fa. Carl Zeiss, 7920 Heidenheim Autofokus fuer mikroskope
GB2181538A (en) * 1985-10-08 1987-04-23 Mehdi Vaez Iravani SAW detector and PC microscope
US4844617A (en) * 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
JPH06174433A (ja) * 1992-12-04 1994-06-24 Tokyo Koku Keiki Kk 微小円筒形部品寸法測定システム
US5508844A (en) * 1994-09-01 1996-04-16 Blake, Sr.; Roger A. Telescope tracker
EP0782027A2 (de) * 1988-07-13 1997-07-02 Optiscan Pty Ltd Konfokales Rastermikroskop
US5659642A (en) * 1992-10-23 1997-08-19 Optiscan Pty. Ltd. Confocal microscope and endoscope
JPH10307252A (ja) * 1997-05-07 1998-11-17 Hitachi Denshi Ltd 自動合焦点光学式テレビカメラ顕微鏡

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JPS5913206A (ja) * 1982-07-15 1984-01-24 Hitachi Denshi Ltd 合焦制御装置
US5635402A (en) * 1992-03-05 1997-06-03 Alfano; Robert R. Technique for determining whether a cell is malignant as opposed to non-malignant using extrinsic fluorescence spectroscopy
US5384455A (en) * 1993-04-12 1995-01-24 Environmental Research Institute Of Michigan Measurement-diverse speckle imaging
DE4330347C2 (de) * 1993-09-08 1998-04-09 Leica Lasertechnik Verwendung einer Vorrichtung zur Selektion und Detektion mindestens zweier Spektralbereiche eines Lichtstrahls
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JP3404134B2 (ja) * 1994-06-21 2003-05-06 株式会社ニュークリエイション 検査装置
US5813987A (en) * 1995-08-01 1998-09-29 Medispectra, Inc. Spectral volume microprobe for analysis of materials
WO1997043611A1 (en) * 1996-05-16 1997-11-20 Affymetrix, Inc. Systems and methods for detection of labeled materials
US6084670A (en) * 1997-03-11 2000-07-04 Nihon Kohden Corporation Particle analyzer and composite lens formed by integrally joining plural lens elements of different focal points
DE19728966C2 (de) * 1997-03-25 1999-03-18 Optomed Optomedical Systems Gmbh Bildgebendes Spektrometer
DE19748211A1 (de) * 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
DE19919092A1 (de) * 1999-04-27 2000-11-02 Zeiss Carl Jena Gmbh Anordnung zur optischen Auswertung eines Gegenstandsarrays
DE19936999C2 (de) * 1999-08-02 2002-03-14 Jena Optronik Gmbh Anordnung zum Erfassen der Fluoreszenzstrahlung von matrixförmigen Probenträgern

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283112A (en) * 1979-04-24 1981-08-11 Venable Thomas C Telescope guiding system
DE3328821A1 (de) * 1983-08-10 1985-02-28 Fa. Carl Zeiss, 7920 Heidenheim Autofokus fuer mikroskope
GB2181538A (en) * 1985-10-08 1987-04-23 Mehdi Vaez Iravani SAW detector and PC microscope
US4844617A (en) * 1988-01-20 1989-07-04 Tencor Instruments Confocal measuring microscope with automatic focusing
EP0782027A2 (de) * 1988-07-13 1997-07-02 Optiscan Pty Ltd Konfokales Rastermikroskop
US5659642A (en) * 1992-10-23 1997-08-19 Optiscan Pty. Ltd. Confocal microscope and endoscope
JPH06174433A (ja) * 1992-12-04 1994-06-24 Tokyo Koku Keiki Kk 微小円筒形部品寸法測定システム
US5508844A (en) * 1994-09-01 1996-04-16 Blake, Sr.; Roger A. Telescope tracker
JPH10307252A (ja) * 1997-05-07 1998-11-17 Hitachi Denshi Ltd 自動合焦点光学式テレビカメラ顕微鏡

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
PATENT ABSTRACTS OF JAPAN vol. 018, no. 505 (P - 1803) 21 September 1994 (1994-09-21) *
PATENT ABSTRACTS OF JAPAN vol. 1999, no. 02 26 February 1999 (1999-02-26) *
See also references of EP1384104A2 *

Also Published As

Publication number Publication date
EP1384104A2 (de) 2004-01-28
DE10121064A1 (de) 2002-10-31
US20040257576A1 (en) 2004-12-23
AU2002312858A1 (en) 2002-11-11
WO2002088819A2 (de) 2002-11-07
US7474777B2 (en) 2009-01-06

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