WO2002083185A1 - Method of gene transfer via vascular system or ureter - Google Patents

Method of gene transfer via vascular system or ureter Download PDF

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Publication number
WO2002083185A1
WO2002083185A1 PCT/JP2002/002770 JP0202770W WO02083185A1 WO 2002083185 A1 WO2002083185 A1 WO 2002083185A1 JP 0202770 W JP0202770 W JP 0202770W WO 02083185 A1 WO02083185 A1 WO 02083185A1
Authority
WO
WIPO (PCT)
Prior art keywords
gene
ureter
vascular system
transplanted kidney
gene transfer
Prior art date
Application number
PCT/JP2002/002770
Other languages
French (fr)
Japanese (ja)
Inventor
Shiro Takahara
Enyu Imai
Yoshitaka Isaka
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to JP2002580986A priority Critical patent/JP4310108B2/en
Priority to US10/474,142 priority patent/US8263756B2/en
Publication of WO2002083185A1 publication Critical patent/WO2002083185A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1833—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0075—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the delivery route, e.g. oral, subcutaneous
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Transplantation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

It is intended to provide a method of transferring a gene via vascular system or ureter. In a preferred embodiment, an aqueous solution containing an expression vector having a desired gene is injected ex vivo via the vascular system of a desired organ or ureter and thus the desired gene is transferred into the injected region. This method is particularly useful in an ex vivo gene therapy wherein hepatocyte growth factor (HGF) gene is transferred into a transplanted kidney by using the electroporation method. By using this method, it is possible to make HGF to continuously exert its effect not on the organs in the whole body but exclusively on the transplanted kidney. Thus, it is a safe and effective therapy of protecting the take of the transplanted kidney.
PCT/JP2002/002770 2001-04-06 2002-03-22 Method of gene transfer via vascular system or ureter WO2002083185A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2002580986A JP4310108B2 (en) 2001-04-06 2002-03-22 Methods for introducing genes via the vascular system or ureter
US10/474,142 US8263756B2 (en) 2001-04-06 2002-03-22 Method of gene transfer via vascular system or ureter

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001-109051 2001-04-06
JP2001109051 2001-04-06

Publications (1)

Publication Number Publication Date
WO2002083185A1 true WO2002083185A1 (en) 2002-10-24

Family

ID=18961069

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/002770 WO2002083185A1 (en) 2001-04-06 2002-03-22 Method of gene transfer via vascular system or ureter

Country Status (3)

Country Link
US (1) US8263756B2 (en)
JP (1) JP4310108B2 (en)
WO (1) WO2002083185A1 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1588718A1 (en) 2004-03-31 2005-10-26 AnGes MG, Inc. Gene therapy of hepatocyte growth factor to enhance muscular and cutaneous flap survival
JP2019116511A (en) * 2012-02-22 2019-07-18 有限会社エッグクリエーション Sirtuin inducer, tissue repair agent, hepatocyte growth factor inducer, tissue homeostasis maintenance agent and tlr4 agonist which comprise hyaluronic acid fragment as active ingredient

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8361976B2 (en) 2004-07-09 2013-01-29 University Of Massachusetts Therapeutic alteration of transplantable tissues through in situ or ex vivo exposure to RNA interference molecules
ES2263382B1 (en) * 2005-05-16 2007-11-16 Fundacion Para La Investigacion Biomedica Del Hospital Gregorio Marañon ARTIFICIAL MATRIX OF ENDOTHELIZED FIBRINE GEL SUPERPRODUCTOR OF PROANGIOGEN FACTORS.

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0462549A1 (en) * 1990-06-19 1991-12-27 NAKAMURA, Toshikazu Process of preparing a therapeutic agent for renal diseases
FR2717500A1 (en) * 1994-03-17 1995-09-22 Pasteur Institut Use of recombinant vector encoding specific protein to transform kidney cells
WO1996030535A1 (en) * 1995-03-30 1996-10-03 Beth Israel Deaconess Medical Center, Inc. Gene transfer into the kidney
WO2000022095A2 (en) * 1998-10-15 2000-04-20 Children's Medical Center Corporation Method and apparatus for direct in vivo gene transfer by electrotransfection
WO2002000264A1 (en) * 2000-06-27 2002-01-03 Dnavec Research Inc. Virus vector for transferring gene into renal cells

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH11103858A (en) * 1997-10-01 1999-04-20 Tr Tec Kk Dna transfer by electroporation
US6593130B1 (en) * 1999-04-16 2003-07-15 The Regents Of The University Of California Method and apparatus for ex vivo and in vivo cellular electroporation of gene protein or drug therapy
MXPA01011137A (en) 1999-05-03 2003-07-14 Uab Research Foundation Noninvasive genetic immunization, expression products therefrom, and uses thereof.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0462549A1 (en) * 1990-06-19 1991-12-27 NAKAMURA, Toshikazu Process of preparing a therapeutic agent for renal diseases
FR2717500A1 (en) * 1994-03-17 1995-09-22 Pasteur Institut Use of recombinant vector encoding specific protein to transform kidney cells
WO1996030535A1 (en) * 1995-03-30 1996-10-03 Beth Israel Deaconess Medical Center, Inc. Gene transfer into the kidney
WO2000022095A2 (en) * 1998-10-15 2000-04-20 Children's Medical Center Corporation Method and apparatus for direct in vivo gene transfer by electrotransfection
WO2002000264A1 (en) * 2000-06-27 2002-01-03 Dnavec Research Inc. Virus vector for transferring gene into renal cells

Non-Patent Citations (22)

* Cited by examiner, † Cited by third party
Title
DATABASE MEDLINE [online] DAI C. ET AL.: "Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice", accession no. STN Database accession no. 21663895 *
DATABASE MEDLINE [online] IMAI E. ET AL.: "Gene electrotransfer: Potential for gene therapy of renal diseases", accession no. STN Database accession no. 21830998 *
DATABASE MEDLINE [online] IMAI E. ET AL.: "Gene therapy for kidney disease", accession no. STN Database accession no. 20516053 *
DATABASE MEDLINE [online] TSUJIE M. ET AL.: "Gene transfer targeting interstitial fibroblasts by the artificial viral envelope-type hemagglutinating virus of Japan liposome method", accession no. STN Database accession no. 20253278 *
ENYU IMAI ET AL.: "Jin eno idenshi donyu to idenshi chiryo", IGAKU NO AYUMI, vol. 193, no. 1, 1 April 2000 (2000-04-01), pages 87 - 90, XP002954951 *
ENYU IMAI ET AL.: "Jin shikkan no idenshi chiryo ha dokomade kano ka", KIDNEY AND DIALYSIS, vol. 49, no. 6, 2000, pages 1021 - 1024, XP002954950 *
ENYU IMAI ET AL.: "Jin shikkan no idenshi chiryo no kanosei to sono genjo", JOURNAL OF OSAKA SOCIETY FOR DIALYSIS THERAPY, vol. 18, no. 2, 2000, pages 193 - 197, XP002954948 *
ENYU IMAI ET AL.: "Jin shikkan oyobi jin ishoku (post genome iryo no tenbo: soron)", NIHON RINSHO, vol. 59, no. 1, 1 January 2001 (2001-01-01), pages 65 - 71, XP002954949 *
EXPERT OPINION ON INVESTIGATIONAL DRUGS, vol. 9, no. 5, 17 May 2000 (2000-05-17), pages 1029 - 1039 *
HARUTO AZUMA ET AL.: "Hepatocyte growth factor (HGF) no mansei kyozetsu hanno (rat ishoku jin) ni taisuru chiryo koka", THE JAPANESE JOURNAL OF UROLOGY, vol. 90, no. 2, 8 February 1999 (1999-02-08), (THE 87TH ANNUAL MEETING OF THE JAPANESE UROLOGICAL ASSOCIATION, ABSTRACT NO. 0-163), pages 150, XP002954955 *
HARUTO AZUMA ET AL.: "Hepatocyte growth factor (HGF) no mansei kyuozetsu hannu (rat ishoku jin) ni taisuru chiryo koka", THE JAPANESE JOURNAL OF UROLOGY, vol. 92, no. 2, 20 February 2001 (2001-02-20), (THE 89TH ANNUAL MEETING OF THE JAPANESE UROLOGICAL ASSOCIATION, ABSTRACT NO. MP-17), pages 184, XP002954956 *
HIROYUKI NAKAMURA ET AL.: "Electroporation ho o mochiita Egr-1 DNA enzyme donyu ni yoru jinkanshitsu shogai shinten no yokusei", TJE JAPANESE SOCIETY OF NEPHROLOGY, 22 March 2001 (2001-03-22), XP002954959, Retrieved from the Internet <URL:http://endai.umin.ac.jp/cgi-open-bin/hanyou/lookup/detail.cgi?oarm=a00018-00010&cond='A00018-00010-10097'&&> [retrieved on 20020409] *
HIROYUKI NAKAMURA ET AL.: "Electroporation ho o mochiita Egr-1 DNA enzyme donyu ni yoru jinkansitsu shogai shinten no yokusei", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 43, no. 3, 25 April 2001 (2001-04-25), (DAI 44 KAI (HEISEI 13 NENDO 2001) THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. 0-142), pages 189 *
J. AM. SOC. NEPHROL., vol. 13, no. 2, 17 May 2002 (2002-05-17), pages 411 - 422 *
KIDNEY INTERNATIONAL, vol. 57, no. 5, 17 May 2002 (2002-05-17), pages 1973 - 1980 *
KIDNEY INTERNATIONAL, vol. 61, no. SUPPL. 1, 17 May 2002 (2002-05-17), pages 37 - 41 *
MARUYAMA H. ET AL.: "Kidney-targeted maked DNA transfer by retrograde renal vein injection in rats", HUMAN GENE THERAPY, vol. 13, no. 3, 10 February 2002 (2002-02-10), pages 455 - 468, XP002955053 *
MICHIKO TSUJIE ET AL.: "Electroporation ho o mochiita jin shikyutai eno idenshi donyu ho no kaihatsu", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 42, no. 3, 25 April 2000 (2000-04-25), (THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. 0-256), pages 198, XP002954954 *
SHINYA MIZUNO ET AL.: "Ishoku igaku ni okeru HGF no yakuwari", IGAKU NO AYUMI, vol. 196, no. 13, 31 March 2001 (2001-03-31), pages 905 - 912, XP002954953 *
TSUJIE M. ET AL.: "Electroporation-mediated gene transfer that targets glomeruli", J. AM. SOC. NEPHROL., vol. 12, 2001, pages 949 - 954, XP002954952 *
YOSHITAKA ISAKA ET AL.: "Ishoku jin no choki seichaku o mezashita idenshi chiryo", THE JAPANESE JOURNAL OF NEPHROLOGY, vol. 43, no. 3, 25 April 2001 (2001-04-25), (DAI 44 KAI (HEISEI 13 NENDO 2001) THE JAPANESE SOCIETY OF NEPHROLOGY GAKUJUTSU SOKAI SHOROKUSHU, ABSTRACT NO. W-5-4), pages 164, XP002954957 *
YOSHITAKA ISAKA ET AL.: "Ishoku jin no choki seichaku o mezashita idenshi chiryo", THE JAPANESE SOCIETY OF NEPHROLOGY, 22 March 2001 (2001-03-22), XP002954958, Retrieved from the Internet <URL:http://endai.umin.ac.jp/cgi-open-bin/hanyou/lookup/detail.cgi?parm=a00018-00010&cond='A00018-00010-20035'&&> [retrieved on 20020409] *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1588718A1 (en) 2004-03-31 2005-10-26 AnGes MG, Inc. Gene therapy of hepatocyte growth factor to enhance muscular and cutaneous flap survival
US7790692B2 (en) 2004-03-31 2010-09-07 Anges Mg Inc. Hepatocyte growth factor nucleic acid sequence to enhance musculocutaneous flap survival
JP2019116511A (en) * 2012-02-22 2019-07-18 有限会社エッグクリエーション Sirtuin inducer, tissue repair agent, hepatocyte growth factor inducer, tissue homeostasis maintenance agent and tlr4 agonist which comprise hyaluronic acid fragment as active ingredient

Also Published As

Publication number Publication date
JPWO2002083185A1 (en) 2004-08-05
US20040175370A1 (en) 2004-09-09
JP4310108B2 (en) 2009-08-05
US8263756B2 (en) 2012-09-11

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