WO2002083174A1 - Method of administering substance to left ventricle - Google Patents

Method of administering substance to left ventricle Download PDF

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Publication number
WO2002083174A1
WO2002083174A1 PCT/JP2002/003534 JP0203534W WO02083174A1 WO 2002083174 A1 WO2002083174 A1 WO 2002083174A1 JP 0203534 W JP0203534 W JP 0203534W WO 02083174 A1 WO02083174 A1 WO 02083174A1
Authority
WO
WIPO (PCT)
Prior art keywords
left ventricle
substance
administering
administering substance
function
Prior art date
Application number
PCT/JP2002/003534
Other languages
French (fr)
Japanese (ja)
Inventor
Atsushi Nishimura
Nobuyuki Koyama
Toshifumi Watanabe
Original Assignee
Takeda Chemical Industries, Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries, Ltd. filed Critical Takeda Chemical Industries, Ltd.
Publication of WO2002083174A1 publication Critical patent/WO2002083174A1/en

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5082—Supracellular entities, e.g. tissue, organisms
    • G01N33/5088—Supracellular entities, e.g. tissue, organisms of vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

By administering a substance into the left ventricle while substantially narrowing nonhuman mammalian aorta, the substance can be conveniently and efficiently administered to the mammal specifically to the heart. Thus, this administration method is usable in clarifying the function of a gene having an unknown function, screening a candidate compound for a drug, evaluating a drug effect and so on.
PCT/JP2002/003534 2001-04-10 2002-04-09 Method of administering substance to left ventricle WO2002083174A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001110990 2001-04-10
JP2001-110990 2001-04-10
JP2002009142 2002-01-17
JP2002-009142 2002-01-17

Publications (1)

Publication Number Publication Date
WO2002083174A1 true WO2002083174A1 (en) 2002-10-24

Family

ID=26613345

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/003534 WO2002083174A1 (en) 2001-04-10 2002-04-09 Method of administering substance to left ventricle

Country Status (1)

Country Link
WO (1) WO2002083174A1 (en)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0970289A (en) * 1995-06-27 1997-03-18 Takeda Chem Ind Ltd Human crf2 recepter protein, its production and use
WO1999046277A1 (en) * 1998-03-09 1999-09-16 Smithkline Beecham Corporation HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USE

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0970289A (en) * 1995-06-27 1997-03-18 Takeda Chem Ind Ltd Human crf2 recepter protein, its production and use
WO1999046277A1 (en) * 1998-03-09 1999-09-16 Smithkline Beecham Corporation HUMAN EDG-1c POLYNUCLEOTIDES AND POLYPEPTIDES AND METHODS OF USE

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
HARADA K. ET AL.: "Angiotensin II type 1A receptor knockout mice display less left ventricular remodeling and improved survival after myocardial infarction", CIRCULATION, vol. 100, 1999, pages 2093 - 2099, XP002952983 *
JEYASEELAN R. ET AL.: "A novel cardiac-restricted target for doxorubicin. CARP, a nuclear modulator of gene expression in cardiac progenitor cells and cardiomyocytes", J. BIOL. CHEM., vol. 272, no. 36, 1997, pages 22800 - 22808, XP002952981 *
KUWAHARA K. ET AL.: "Involvement of cardiotrophin-1 in cardiac myocyte-nonmyocyte interactions during hypertrophy of rat cardiac myocytes in vitro", CIRCULATION, vol. 100, 1999, pages 1116 - 1124, XP002952980 *
MCVEY M.J. ET AL.: "Cardiovascular pharmacology of the adenosine A1/A2-receptor agonist AMP 579: Coronary hemodynamic and cardioprotective effects in the canine myocardium", J. CARDIOVASC. PHARMACOL., vol. 33, no. 5, 1999, pages 703 - 710, XP002952984 *
MIYAMOTO M.I. ET AL.: "Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure", PROC. NATL. ACAD. SCI. USA, vol. 97, no. 2, 2000, pages 793 - 798, XP002952979 *
MOCHIZUKI S. ET AL.: "Na+/Ca++ exchanger and myocardial ischemia/reperfusion", JPN. HEART J., vol. 39, 1998, pages 707 - 714, XP002952985 *
SHINMURA K. ET AL.: "Catheter-delivered in vivo gene transfer into rat myocardium using the fusigenic liposomal mediated method", JPN. HEART J., vol. 41, 2000, pages 633 - 647, XP002952978 *
ZOU Y. ET AL.: "CARP, a cardiac ankyrin repeat protein, is downstream in the Nkx2-5 homeobox gene pathway", DEVELOPMENT, vol. 124, 1997, pages 793 - 804, XP002952982 *

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