WO2002079460A3 - Crystals of ketopantoate hydroxymethyl transferase - Google Patents

Crystals of ketopantoate hydroxymethyl transferase Download PDF

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Publication number
WO2002079460A3
WO2002079460A3 PCT/GB2002/001405 GB0201405W WO02079460A3 WO 2002079460 A3 WO2002079460 A3 WO 2002079460A3 GB 0201405 W GB0201405 W GB 0201405W WO 02079460 A3 WO02079460 A3 WO 02079460A3
Authority
WO
WIPO (PCT)
Prior art keywords
crystals
hydroxymethyl transferase
ketopantoate
ketopantoate hydroxymethyl
crystal
Prior art date
Application number
PCT/GB2002/001405
Other languages
French (fr)
Other versions
WO2002079460A2 (en
Inventor
Tom Leon Blundell
Christopher Abell
Tsuyoshi Inoue
Delft Frank Von
Original Assignee
Astex Technology Ltd
Tom Leon Blundell
Christopher Abell
Tsuyoshi Inoue
Delft Frank Von
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astex Technology Ltd, Tom Leon Blundell, Christopher Abell, Tsuyoshi Inoue, Delft Frank Von filed Critical Astex Technology Ltd
Priority to EP02720121A priority Critical patent/EP1373482A2/en
Priority to AU2002251191A priority patent/AU2002251191A1/en
Publication of WO2002079460A2 publication Critical patent/WO2002079460A2/en
Publication of WO2002079460A3 publication Critical patent/WO2002079460A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1003—Transferases (2.) transferring one-carbon groups (2.1)
    • C12N9/1014—Hydroxymethyl-, formyl-transferases (2.1.2)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention provides a crystal of ketopantoate hydroxymethyltransferase (KPHMT). The crystal may be characterised by the three dimensional atomic coordinates of Table 1. The invention also provides the use of such crystals and the Table of coordinates in computer modelling applications, for example in drug discovery.
PCT/GB2002/001405 2001-03-30 2002-04-02 Crystals of ketopantoate hydroxymethyl transferase WO2002079460A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP02720121A EP1373482A2 (en) 2001-03-30 2002-04-02 Crystals of ketopantoate hydroxymethyltransferase
AU2002251191A AU2002251191A1 (en) 2001-03-30 2002-04-02 Crystals of ketopantoate hydroxymethyl transferase

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/820,745 US20040053385A1 (en) 2001-03-30 2001-03-30 Crystal structure
US09/820,745 2001-03-30

Publications (2)

Publication Number Publication Date
WO2002079460A2 WO2002079460A2 (en) 2002-10-10
WO2002079460A3 true WO2002079460A3 (en) 2003-04-24

Family

ID=25231610

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001405 WO2002079460A2 (en) 2001-03-30 2002-04-02 Crystals of ketopantoate hydroxymethyl transferase

Country Status (4)

Country Link
US (1) US20040053385A1 (en)
EP (1) EP1373482A2 (en)
AU (1) AU2002251191A1 (en)
WO (1) WO2002079460A2 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108456701B (en) * 2018-03-23 2020-10-16 精晶药业股份有限公司 Preparation method of D-pantoic acid lactone

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BREE DE ET AL: "Preparation and characterization of the recombinant selenomethionine analogue of insulin-like growth factor-I", PROTEIN EXPRESSION AND PURIFICATION, vol. 13, no. 3, August 1998 (1998-08-01), pages 319 - 325, XP002221193, ISSN: 1046-5928 *
JONES ET AL: "Cloning and sequencing of the Escherichia coli panB gene, which encodes ketopantoate hydroxymethyltransferase, and overexpression of the enzyme", JOURNAL OF BACTERIOLOGY, vol. 175, no. 7, 1 April 1993 (1993-04-01), pages 2125 - 2130, XP002092390, ISSN: 0021-9193 *
KURTOV ET AL: "The Aspergillus nidulans panB gene encodes ketopantoate hydroxymethyltransferase, required for biosynthesis of pantothenate and coenzyme A", MOLECULAR AND GENERAL GENETICS, vol. 262, no. 1, August 1999 (1999-08-01), pages 115 - 120, XP002226714, ISSN: 0026-8925 *

Also Published As

Publication number Publication date
AU2002251191A1 (en) 2002-10-15
EP1373482A2 (en) 2004-01-02
WO2002079460A2 (en) 2002-10-10
US20040053385A1 (en) 2004-03-18

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