WO2002078462A1 - Procedes et produits permettant d'enlever le tartre des dents d'un animal domestique - Google Patents

Procedes et produits permettant d'enlever le tartre des dents d'un animal domestique Download PDF

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Publication number
WO2002078462A1
WO2002078462A1 PCT/EP2002/003512 EP0203512W WO02078462A1 WO 2002078462 A1 WO2002078462 A1 WO 2002078462A1 EP 0203512 W EP0203512 W EP 0203512W WO 02078462 A1 WO02078462 A1 WO 02078462A1
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WO
WIPO (PCT)
Prior art keywords
tartar
pet
product
agent
teeth
Prior art date
Application number
PCT/EP2002/003512
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English (en)
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WO2002078462B1 (fr
Inventor
John Russell-Maynard
Original Assignee
Societe Des Produits Nestle S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Societe Des Produits Nestle S.A. filed Critical Societe Des Produits Nestle S.A.
Priority to AU2002302478A priority Critical patent/AU2002302478A1/en
Publication of WO2002078462A1 publication Critical patent/WO2002078462A1/fr
Publication of WO2002078462B1 publication Critical patent/WO2002078462B1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
    • A61D5/00—Instruments for treating animals' teeth
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/25—Shaping or working-up of animal feeding-stuffs by extrusion
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/40—Feeding-stuffs specially adapted for particular animals for carnivorous animals, e.g. cats or dogs
    • A23K50/42—Dry feed

Definitions

  • the present invention generally relates to dental hygiene. More specifically, the present invention relates to improving the dental hygiene of pets.
  • Periodontal disease is one of the most commonly treated diseases by veterinarians in the Unit d States.
  • Periodontal disease starts with the formation of a film of a soft amorphous material called plaque, consisting primarily of oral bacteria, bacterial byproducts and oral debris.
  • plaque consisting primarily of oral bacteria, bacterial byproducts and oral debris.
  • This film typically covers both the exposed tooth surface and the area lying under the gum line, the gingival cavity.
  • calcium and othei mineral salts this layer hardens and develops into tartar.
  • tartar is hard, it is also porous and adheres to the tooth surface. It appears to be progressively deposited in layers and provides a rough surface onto which more plaque is deposited. As tartar builds up, a broad range of microbes can attach.
  • the byproducts of metabolism from these bacteria cause inflammation of local tissues including those surrounding the gingival cavity. This ultimately leads to periodontal disease.
  • gingivitis characterized by inflammation of the gums. As periodontal disease progresses, gingivitis becomes periodontitis, with inflammation extending into the connective tissues surrounding the tooth. Through gingivitis and periodontitis, it is thought that harmful bacteria enter into the blood stream and ultimately lodge in the heart and other internal organs.
  • the present invention provides improved products and methods for maintaining or improving the dental hygiene of a pet. More specifically, the present invention provides improved methods and products for facilitating the removal of tartar from the teeth of a pet. To this end, in an embodiment, the present invention provides a product for facilitating the removal of tartar from the teeth of a pet.
  • a chewable product is provided that includes a therapeutically effective amount of a tartar softening agent selected from the group consisting of mild chelating agents, proteases, dextranases and weak acids and their salts. The salts may be inorganic or organic.
  • the chewable product is designed to remove tartar, at least in part, by an abrasive action.
  • the chewable product is in an elongate, generally rectangular shape.
  • the chewable product is in the shape of a bone.
  • the chewable product is in the shape of a biscuit.
  • the weak acid is selected from the group consisting of those acids that preferentially react with the anions contained in tartar, but not with the tooth structure.
  • the weak acid preferentially reacts with carbonate.
  • Examples include: carboxylic acids, polycarboxylic acids, salts of sulphates, salts of phosphates, sulphonic acids, sulfamic acids, amino acids, organic acids based on sulfur or phosphorous; organic and inorganic acids derived from phosphoric acid, organic acids derived from phosphinic acid, acidic polypeptides and proteins; organic or inorganic acids based on silicon, ammonium salts, salts of amines, amino containing compounds, salts of heterocyclic compounds containing nitrogen; inorganic substances derived form soil, clays, and other inorganic compounds that act as phosphate, carbonate or hydroxide scavengers; and salts complexes and derivatives of, and polymers containing all of these.
  • the mild chelating agent is one that preferentially binds calcium and magnesium.
  • examples of such agents include: carboxylates, polycarboxylates, polyamino organic compounds, amino-polysaccharides, sulphonic acids, sulfamic acids, amino acids, organic acids based on sulfur or phosphorous; organic and inorganic acids derived from phosphoric acid; organic acids derived from phosphinic acid; compounds containing quaternary ammonium or phosphonium moieties, including acidic polypeptides and proteins; organic or inorganic acids based on silicon, silicates and polysilicates; and salts, complexes and polymers containing any of the above.
  • the tartar softening agent is citric acid.
  • the tartar softening agent comprises approximately 0.2% to about 10.0 % by weight of the product.
  • a method of controlling tartar on the teeth of a pet comprises the steps of: contacting a pet's teeth with an agent that disrupts an inorganic layer of a tartar structure on the pet's teeth; and subjecting the teeth to an abrasive action.
  • the agent that disrupts an organic layer of the tartar structure on the pet's teeth is selected from a group that includes proteases and dextranases.
  • the agent is in the form of a liquid.
  • the agent is contained in a structure that provides the abrasive action. h an embodiment of the method, the abrasive action is created, at least in part, by brushing the pet's teeth.
  • the agent is selected from the group consisting of: organic acids and salts; chelating agents; proteases; dextranases and inorganic salts and acids.
  • the method includes the step of causing the pet to chew a product including the agent. In an embodiment of the method, the product is a bone.
  • a method of manufacturing a product for controlling tartar on a pet's teeth comprises the steps of preparing a chewable structure including an agent that is designed to disrupt the layers that define a tartar material located on a pet's tooth.
  • the product is constructed so as to have a bone shape.
  • a product for controlling the tartar on a pets' tooth comprises a chewable product including a continuous and a discontinuous phase and a tartar softening agent.
  • the invention provides a method of maintaining or improving the health of a pet by inhibiting the spread of pathogens, having oral origin, from the mouth of the pet to other areas of its body, the method comprising facilitating the removal of tartar from the pet's teeth.
  • the method may include the step of administering to the pet a tartar softening agent in an amount effective to soften tartar present on its teeth.
  • the step of administering the agent may be carried out repeatedly at intervals.
  • the said agent may be administered as a component of a structure that provides an abrasive action when contacted with the pet's teeth.
  • the method may therefore further includes the steps of providing a chewable structure wherein the agent is containable, including the agent in the chewable structure in a tartar softening effective amount when the structure is orally administered according to a predetermined regimen, and administering the structure containing the agent to a pet according to such regimen.
  • the invention extends also to the use of a tartar softening agent in a method of inhibiting the spread of pathogens having oral origin from the mouth of a pet animal to other areas of its body, the method comprising administering to a pet a tartar softening agent in a tartar-softening effective amount, thereby facilitating the removal of tartar from the pet's teeth.
  • the invention provides further for the use of a tartar softening agent in the manufacture of a product comprising a chewable structure wherein the agent is included in a tartar softening effective amount when administered to a pet according to a predetermined regimen.
  • the regimen may include administering the product as part of a meal, or as a supplement to the pet's diet. When administered as a supplement, the product is preferably provided as a treat.
  • the invention provides generally for a method of maintaining or improving the condition of a pet, the method including the step of improving or maintaining the oral health of the pet. The oral health of the pet may be thus maintained or improved by the step of maintaining or improving the dental health of the pet. This method may include the step of facilitating the removal of tartar from the pet's teeth. Tartar removal may be achieved by orally administering to the pet a tartar softening agent in a tartar softening effective amount.
  • An advantage of the present invention is to provide an improved product for providing dental hygiene to a pet. Moreover, an advantage of the present invention is to provide an improved method for providing dental hygiene to a pet.
  • an advantage of the present invention is to provide an improved product that facilitates the removal of tartar from the teeth of a pet.
  • Another advantage of the present invention is to provide an improved method for removing tartar from the teeth of a mammal.
  • an advantage of the present invention is to provide an improved method for cleaning the teeth of a pet.
  • Yet another advantage is to provide a method for assisting in maintaining and improving the general health and condition of a pet. Additional features and advantages of the present invention will be described in and apparent from the detailed description of the presently preferred embodiments and the figures.
  • Figure 1 illustrates a cross-sectional view of a mouth of a pet.
  • Figure 2 illustrates schematically dog tartar as seen under a scanning electron microscope.
  • Figure 3 illustrates an embodiment of a product for enhancing the dental hygiene of a pet.
  • the present invention provides improved products and methods for providing dental hygiene to a pet. More specifically, the present invention is directed to products and method for enhancing the removal of tartar from the teeth of a pet.
  • the invention further provides a method of maintaining or improving the health of a pet by inhibiting the spread of pathogens, having oral origin, from the mouth of the pet to other areas of its body, such as its vital organs. Through facilitating the removal of tartar from the pet's teeth, the accumulation, propagation and spread of such pathogens is inhibited. This is expected to have a beneficial effect on the general or overall health and condition of the pet.
  • the method may include the step of administering to the pet a tartar softening agent in an amount effective to soften tartar present on its teeth.
  • the step of administering the agent may be carried out repeatedly at intervals accordmg to a predetermined regimen. For example, the agent may be administered daily and as a component of a structure that provides an abrasive action when contacted with the pet's teeth. An embodiment of such a structure will be described in greater detail below.
  • the tartar softening agent of the invention may be used in the manufacture of a product having a chewable structure and where the agent is included in a tartar- softening effective amount when the product is admmistered to a pet according to a predetermined regimen.
  • the regimen may include administering the product as part of a meal, or as a supplement to the pet's diet. When administered as a supplement, the product is preferably provided as a treat.
  • the agent may be included by mixing it in with the remaining ingredients for producing the chewable structure. This method is appropriate where the structure is to be extruded. If the structure is of a porous nature, the tartar-softening agent may be infiltrated or impregnated into the product matrix. Alternatively, it may be sprayed, dusted or coated on, according to techniques well known in the art.
  • FIG. 1 a cross-sectional view of the mouth 10 of a pet is illustrated.
  • the portion of mouth 10 illustrated includes the cheek 12 and buccal cavity 14.
  • Located within the mouth 10 are the gums 16 and teeth 18.
  • the area between the gums and teeth is the gingival cavity 20.
  • tartar can accumulate on the surface 22 of the teeth 18 of a pet.
  • tartar build-up in the gingival cavity 20 can be especially detrimental.
  • FIG 2 a schematic cross-sectional view of an electron microscope view of tartar 24 is illustrated.
  • the inventors have found, through electron microscope studies on dog tartar, that tartar 24 has an unusual structure. It comprises a number of layers. Illustrated in Figure 2 are four representative layers, 26, 28, 30, and 32.
  • Layers 26 and 30 are layers comprised of inorganic material such as calcium salts and complexes incorporating carbonate and phosphate anions. These are typically the thickest layers of the tartar 24 and comprise primarily porous, inorganic material. This porous material includes holes typical of oral bacteria.
  • Underneath each of the inorganic layers 26 and 30 are layers 28 and 32 composed of proteinaceous organic material.
  • the inventors have surprisingly found that it is possible to soften tartar 24 by disrupting either of the inorganic layers 26 and 30 and/or proteinaceous organic layers 28 and 32. Accordingly, in an embodiment pursuant to the present invention, the inorganic layers 26 and 30 are subjected to a composition that disintegrates, or at least disrupts, the inorganic layers and turns them into a soft mucus similar to the proteinaceous mass. For example, Applicants have surprisingly discovered that when placed in a 3% solution of citric acid that pet tartar disintegrates and turns into a soft mucus-like proteinaceous organic mass.
  • a product in an embodiment, includes an agent that is designed to disintegrate, or at least soften, the inorganic layers 26 and 30 of the tartar 24.
  • the agent can be supplied in a variety of types of products.
  • the product 40 includes an active agent that will dissolve or soften the inorganic layers of tartar.
  • active agents can be utilized.
  • the active agent can include an organic acid or salt, a mild chelating agent, proteases, dextranases or weak inorganic acids and salts.
  • a preferred organic acid is citric acid.
  • Preferred chelating agents include those that preferentially bind calcium and magnesium, e.g. EDTA, cyclodextrans, chitosan and derivatives.
  • active agents include inorganic or organic agents that can react with or solubilise anionic components of the tartar - especially carbonates and phosphates - but not react with the tooth surface. These may include: sulphonic and sulfamic acids, organic acids based on sulfur or phosphorous, organic and inorganic acids derived from phosphoric acid, organic acids derived from phosphinic acid, compounds containing quaternary ammonium or phosphonium moieties; amino acids, including acidic polypeptides and proteins; organic or inorganic acids based on silicon, silicates and polysilicates, as well as salts and complexes of, and polymers containing the above.
  • the active agent should be included in the product so that it comprises approximately 0.2 % to about 10 % by weight.
  • the body portion 42 of the product 40 can comprise a variety of different substrates.
  • An example of a product that can be utilized is set forth in U.S. Patent Application Serial No. 60/280,064 entitled.
  • a body 42 having a continuous and discontinuous phase is provided.
  • the continuous and discontinuous phases provide a number of advantages in that it facilitates a cleaning action. When this cleaning action is coupled with the active agent of the present invention, Applicants believe that synergistic results are provided.
  • Figure 3 illustrates a bone shaped embodiment of the product 40 of the present invention
  • a variety of products can be utilized to deliver and facilitate the removal of tartar.
  • Such products include shaped products such as biscuits and other chew products as well as mouthwashes, drinks, toothpastes or tooth gels, toothbrushes impregnated with the agent, and the like.
  • a mixture of dry ingredients was prepared by adding to a Sovemeca Mixer (Sovemeca Ltd, Vermand , France). These ingredients were mixed intimately before being fed to a long barrel twin screw Clextral extruder. Applying SME of about 320J/J, with the simultaneous addition of 1 part glycerol to 3 of the powdered ingredient mix, the total mixture was heated to a plastic state. Without raising the internal pressure above 2 atmospheres, the plastic mixture was released through a die to form a strip about 12 mm thick and transferred on a belt heated to about 50°C to a cutting station, where a rotary cutter was employed to divide the extruded stream into blocky, rectangular bodies of dimensions about 125mm x 52mm x 12mm. These were allowed to cool gradually to 18°C before being hermetically packaged for later addition to a pet meal.
  • Example No. 2 To demonstrate the effectiveness of the product of this invention as exemplified in example 1, 3 g of the product was thinly shaved with a razor blade and placed in ajar together with 15ml of water. It was designated “Product IT.” A second jar was filled with 15ml of water and designated “Water Control.” Two extracted dogs' teeth (Premolar 4) were selected for testing. Each of these teeth had an equivalent heavy coverage of tartar. One tooth was placed into each jar. The jar was then sealed and left undisturbed for 3 hours. The teeth were removed and gently washed with water and air dried.
  • each member of a group (designated "NewProd") of 12 beagle dogs was individually fed one of the products made pursuant to example 1 above, in addition to a diet of a canned commercial petfood.
  • the product of example 1 constituted approximately 25% of the dog's total diet by weight.
  • a second group (designated "Control") of 12 beagle dogs was simultaneously fed on only the canned commercial pet food. At the end of the period, both groups were assessed for the accumulation of tartar on their teeth.
  • a third group of dogs was defined and, instead of being fed the product of the present invention, this group (designated "Biscuit") were fed commercial dog biscuits in an equivalent quantity (i.e. at -25% of diet by weight).
  • an oral examination had been conducted on each dog prior to selecting it for the trial. Dogs with known or observed dental/oral problems (e.g. severe periodontal disease, excessive number of missing teeth etc) were not included.
  • Dogs were blocked for assignment to the diets on the basis of this chew score, age and sex. Diets were assigned randomly within blocks. The dogs were confined indoors to eat. For the groups receiving the Example 1 product and the comparative commercial dog biscuit, these was given in a bowl, 4 hours after the main meal, in the morning. The bowl was removed 1 hour after and the amount of treats not eaten was scored and measured.
  • a complete dental assessment was performed on all dogs on the first day of the test period to determine their existing tartar scores. On day 21, the examination was repeated. On each occasion the dogs were sedated for a brief period of time (several minutes) to enable their tartar scores to be determined.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Veterinary Medicine (AREA)
  • Birds (AREA)
  • Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Fodder In General (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention porte sur des produits et des procédés permettant de maintenir ou d'améliorer l'hygiène dentaire d'un animal domestique. Le produit renferme une quantité efficace d'un agent ramollissant le tartre. L'agent peut être contenu dans une structure à mâcher pouvant être administrée à un animal domestique comme récompense ou comme partie intégrante d'un repas.
PCT/EP2002/003512 2001-03-30 2002-03-25 Procedes et produits permettant d'enlever le tartre des dents d'un animal domestique WO2002078462A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002302478A AU2002302478A1 (en) 2001-03-30 2002-03-25 Methods and products for removing tartar from the teeth of a pet

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27999801P 2001-03-30 2001-03-30
US60/279,998 2001-03-30

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WO2002078462A1 true WO2002078462A1 (fr) 2002-10-10
WO2002078462B1 WO2002078462B1 (fr) 2003-03-20

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AU (1) AU2002302478A1 (fr)
WO (1) WO2002078462A1 (fr)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012100991A1 (fr) 2011-01-24 2012-08-02 Basf Se Compositions améliorant la santé buccale
US9661830B2 (en) 2012-04-17 2017-05-30 Big Heart Pet, Inc. Appetizing and dentally efficacious animal chews
US9737053B2 (en) 2012-04-17 2017-08-22 Big Heart Pet, Inc. Methods for making appetizing and dentally efficacious animal chews

Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2054742A (en) * 1931-09-03 1936-09-15 Internat Scient Products Co Preparation for the teeth and the mouth
US3535420A (en) * 1967-12-11 1970-10-20 Procter & Gamble Oral compositions for calculus retardation
US3701830A (en) * 1971-02-26 1972-10-31 Monsanto Co Method for improving oral health and hygiene in dogs and cats
US3956479A (en) * 1966-09-13 1976-05-11 Colgate-Palmolive Company Pharmaceutical composition containing novel quaternary ammonium compounds
US4364925A (en) * 1974-12-18 1982-12-21 Fisher Stanton E Unitized animal food system product
US4806340A (en) * 1985-09-13 1989-02-21 Colgate-Palmolive Company Anticalculus oral composition
EP0305282A1 (fr) * 1987-08-24 1989-03-01 University Of South Alabama Inhibition de la déposition du tartre par des peptides polyanioniques hydrophobes et leurs dérivés
CH676200A5 (en) * 1988-12-13 1990-12-28 Yair Dr Schiftan Reducing dental plaque formation in cats and dogs - with chewable substrate impregnated with dental or oral treatment agent
US4992420A (en) * 1987-02-26 1991-02-12 Nestec S.A. Dental anti-plaque and anti-caries agent
FR2651433A1 (fr) * 1989-09-07 1991-03-08 Dana Dominique Complexe enzymatique a activite sur le tartre et la carie dentaire.
US5094870A (en) * 1989-05-30 1992-03-10 Nabisco Brands, Inc. Canine biscuits containing an inorganic pyrophosphate
US5100651A (en) * 1986-12-05 1992-03-31 Danielle Boyer Health product, in particular for the caring of the teeth of dogs
US5114704A (en) * 1989-05-30 1992-05-19 Nabisco Brands, Inc. Raw hide having a coating containing an inorganic pyrophosphate
EP0512599A2 (fr) * 1991-05-09 1992-11-11 Unilever N.V. Contrôle du dépôt de tartre à l'aide de composés polyhydroxy phosphorylés
US5328682A (en) * 1990-10-25 1994-07-12 Boots Company Plc Mouthwash
FR2719996A1 (fr) * 1994-05-18 1995-11-24 Balis Jean Francois Poudre dentifrice antitartre.
EP0909536A2 (fr) * 1997-10-14 1999-04-21 Société des Produits Nestlé S.A. Produit alimentaire pour animaux domestiques destiné à l'hygiène des animaux domestiques
US5904928A (en) * 1996-04-19 1999-05-18 Societe A Responsabilite Limitee Antitartar composition and its use in food supplements for animals
WO2001052667A2 (fr) * 2000-01-18 2001-07-26 Societe Des Produits Nestle S.A. Compositions d'aliment pour animaux domestiques permettant de traiter des animaux domestiques contre des especes helicobacter

Patent Citations (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2054742A (en) * 1931-09-03 1936-09-15 Internat Scient Products Co Preparation for the teeth and the mouth
US3956479A (en) * 1966-09-13 1976-05-11 Colgate-Palmolive Company Pharmaceutical composition containing novel quaternary ammonium compounds
US3535420A (en) * 1967-12-11 1970-10-20 Procter & Gamble Oral compositions for calculus retardation
US3701830A (en) * 1971-02-26 1972-10-31 Monsanto Co Method for improving oral health and hygiene in dogs and cats
US4364925A (en) * 1974-12-18 1982-12-21 Fisher Stanton E Unitized animal food system product
US4806340A (en) * 1985-09-13 1989-02-21 Colgate-Palmolive Company Anticalculus oral composition
US5100651A (en) * 1986-12-05 1992-03-31 Danielle Boyer Health product, in particular for the caring of the teeth of dogs
US4992420A (en) * 1987-02-26 1991-02-12 Nestec S.A. Dental anti-plaque and anti-caries agent
EP0305282A1 (fr) * 1987-08-24 1989-03-01 University Of South Alabama Inhibition de la déposition du tartre par des peptides polyanioniques hydrophobes et leurs dérivés
CH676200A5 (en) * 1988-12-13 1990-12-28 Yair Dr Schiftan Reducing dental plaque formation in cats and dogs - with chewable substrate impregnated with dental or oral treatment agent
US5094870A (en) * 1989-05-30 1992-03-10 Nabisco Brands, Inc. Canine biscuits containing an inorganic pyrophosphate
US5114704A (en) * 1989-05-30 1992-05-19 Nabisco Brands, Inc. Raw hide having a coating containing an inorganic pyrophosphate
FR2651433A1 (fr) * 1989-09-07 1991-03-08 Dana Dominique Complexe enzymatique a activite sur le tartre et la carie dentaire.
US5328682A (en) * 1990-10-25 1994-07-12 Boots Company Plc Mouthwash
EP0512599A2 (fr) * 1991-05-09 1992-11-11 Unilever N.V. Contrôle du dépôt de tartre à l'aide de composés polyhydroxy phosphorylés
FR2719996A1 (fr) * 1994-05-18 1995-11-24 Balis Jean Francois Poudre dentifrice antitartre.
US5904928A (en) * 1996-04-19 1999-05-18 Societe A Responsabilite Limitee Antitartar composition and its use in food supplements for animals
EP0909536A2 (fr) * 1997-10-14 1999-04-21 Société des Produits Nestlé S.A. Produit alimentaire pour animaux domestiques destiné à l'hygiène des animaux domestiques
WO2001052667A2 (fr) * 2000-01-18 2001-07-26 Societe Des Produits Nestle S.A. Compositions d'aliment pour animaux domestiques permettant de traiter des animaux domestiques contre des especes helicobacter

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Title
CHIEW S Y ET AL: "Assessment of ultrasonic debridement of calculus-associated periodontally-involved root surfaces by the limulus amoebocyte lysate assay. An in vitro study.", JOURNAL OF CLINICAL PERIODONTOLOGY. DENMARK APR 1991, vol. 18, no. 4, April 1991 (1991-04-01), pages 240 - 244, XP001098322, ISSN: 0303-6979 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012100991A1 (fr) 2011-01-24 2012-08-02 Basf Se Compositions améliorant la santé buccale
EP3424516A1 (fr) 2011-01-24 2019-01-09 Basf Se Compositions améliorant la santé buccale
US9661830B2 (en) 2012-04-17 2017-05-30 Big Heart Pet, Inc. Appetizing and dentally efficacious animal chews
US9737053B2 (en) 2012-04-17 2017-08-22 Big Heart Pet, Inc. Methods for making appetizing and dentally efficacious animal chews
US10631555B2 (en) 2012-04-17 2020-04-28 Big Heart Pet, Inc. Methods for making appetizing and dentally efficacious animal chews

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WO2002078462B1 (fr) 2003-03-20

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