WO2002076539A1 - Improvements in and relating to an injection device - Google Patents

Improvements in and relating to an injection device Download PDF

Info

Publication number
WO2002076539A1
WO2002076539A1 PCT/GB2002/001459 GB0201459W WO02076539A1 WO 2002076539 A1 WO2002076539 A1 WO 2002076539A1 GB 0201459 W GB0201459 W GB 0201459W WO 02076539 A1 WO02076539 A1 WO 02076539A1
Authority
WO
WIPO (PCT)
Prior art keywords
dose setting
cartridge
drive
piston
setting spindle
Prior art date
Application number
PCT/GB2002/001459
Other languages
French (fr)
Inventor
Christopher Nigel Langley
Robert Woolston
Original Assignee
Dca Design International Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BRPI0208013-3A priority Critical patent/BR0208013B1/en
Priority to CA2440018A priority patent/CA2440018C/en
Priority to HU0303427A priority patent/HU228440B1/en
Priority to US10/471,721 priority patent/US7794430B2/en
Priority to JP2002575049A priority patent/JP4480330B2/en
Priority to EP02708502A priority patent/EP1372767B1/en
Priority to DK02708502T priority patent/DK1372767T3/en
Priority to PL363974A priority patent/PL203748B1/en
Application filed by Dca Design International Limited filed Critical Dca Design International Limited
Priority to KR1020037012543A priority patent/KR100854465B1/en
Priority to AU2002242864A priority patent/AU2002242864B2/en
Priority to IL15760602A priority patent/IL157606A0/en
Priority to DE60217654T priority patent/DE60217654T2/en
Priority to MXPA03008682A priority patent/MXPA03008682A/en
Publication of WO2002076539A1 publication Critical patent/WO2002076539A1/en
Priority to HR20030774A priority patent/HRP20030774B1/en
Priority to HK04104748A priority patent/HK1061659A1/en
Priority to CY20071100508T priority patent/CY1106507T1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
    • A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
    • A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2414—Ampoule inserted into the ampoule holder from the side
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
    • A61M5/31541—Means preventing setting of a dose beyond the amount remaining in the cartridge
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
    • A61M5/3159—Dose expelling manners
    • A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir

Abstract

Injection devices are known for the self administration of medicament by patients in which the medicaments is typically contained within a cartridge located within the injection device. It is a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. Also, the injection device must be of a size that enables a piston or similar used to drive a cartridge bung within the cartridge to be moved both to a maximum dispense position within the cartridge and to be fully withdrawn from the cartridge to allow for replacement of the cartridge. A drive mechanism for an injection device is disclosed in which a piston (48) is successively moved along the first axis to drive a bung (20) into a medicament cartridge (18), a displacement mechanism comprising a dose setting spindle (30) is disposed along a second axis, the second axis being parallel to the first axis, transmission means connected between the dose setting spindle (30) and the piston (20), and displacement means to displace the dose setting spindle (30) with respect to the medicament cartridge (18), a movement of the displacement means in a first direction causing movement of the dose setting spindle (30) and the piston (20) in the first direction.

Description

Improvements in and Relating to an Injection Device
The present invention relates to improvements in an injection device, and in particular to improvements in aportable injection device for dispensing controlled quantities of amedicament.
Injection devices are known for the self administration of medicament by patients. For example, thosesuffemgfiOmώabetesιrayrequireregul -injections ofinsulin. Injection devices allowthe patient to select a dose and to administer that dose. It is known to automate this process so that a user need only press a button and the injection device will dispense a selected dose of medicament. This relieves the patient of the task of controlling the amount dispensed while manually expelling the medicament fromthe injection device. This canbe a particular problem for the elderly, the infirm, those suffering from vision difficulties and others suffering from diabetes related problems which impair their faculties.
The medicament is typically contained within a cartridge located within the injection device. The cartridge has a bung or piston at one end which is dri ven towards a second end of the cartridge to expel the medicament fromthe injection device. Itis a problem that injection devices should be small enough to fit into a jacket pocket or a hand bag without difficulty. At the same time, the injection device must be of a size that enables a piston or the like used to drive the cartridge bung within the cartridge to be moved both to amaximum dispense position within the cartridge and to be fully withdrawn fromthe cartridge to allow for replacement of the cartridge.
It is an advantage of the present invention that it provides a solution to these conflicting requirements.
According to a first aspect of the present invention, a drive mechanism for an injection device in which a piston is successively moved along a first axis in relation to afirst end of amedicament cartridge containing amedicament selectively to drive abung closing afirst end of the medicament cartridge into the medicament cartridge to expelmedicament through a delivery member located at asecond end of the medicament cartridge, in which the displacement mechanism comprises a dose setting spindle disposed along asecond axis, the second axis being parallel to the first axis, transmissionmeans connectedbetween the dose setting spindle and the piston, and displacement means to displace the dose setting spindle withrespect to the medicament cartridge, amovement of the displacement means in a first direction causing movement of the dose setting spindle and the piston in the first direction.
Preferably the drive mechanism further comprises adosedialmechanism connected to the dose setting spindle to control the movement of the dose setting spindle. More preferably, the dose setting spindle is connected to the dose dial mechanism by a spline.
Preferably, the piston comprises a sleeve member connected to the drive rack and apistonmember located concentrically within the sleeve member and extending outward fromthe sleeve member.
According to a second aspect of the present invention an injection device having amain housing incorporates a drive mechanism in accordance with the first aspect of the invention.
Preferably, the displacement means comprises a button located for displacement within ahousing of the injection device. More preferably, the dose dial mechanism is retained within the button.
Preferably, the injector device further comprises asecondary housing adapted for displacement with respect to the main housing, the secondary housing being provided with aweb for abutment with an abutment surface provided on the transmission means in order to allow the piston to be displaced along the first axis in a direction opposite the first direction
The invention will now be described, by ay of example only, with reference to the accompanying drawings in which: -
Figure 1 shows a side section of an injection device having a drive mechanism according to the present invention in which the injection device is closed and a medicament cartridge is full; Figure 2 shows a side section similar to Figure 1 with the injection device ready for use; Figure 3 shows a side section similar to Figure 1 with a dosage of medicament dialled; Figure 4 shows a side section similar to Figure 1 with the dosage delivered; Figure 5 shows a side section similar to Figure 1 with the injection device closed and the medicament cartridge half full;
Figure 6 shows a side section of the drive mechanism of Figure 1 with the medicament cartridge empty; and
Figure 7 shows a side s ection similar to Figure 1 with the drive mechanism fully withdrawn and a cartridge access cover removed.
Like reference numerals will be used to refer to like parts of the injection device.
Referring first to Figure 1 there maybe seen an injection device 2 in accordance with the present invention. The injection device 2 compiises amain housing 4, a secondary housing 6, adialdose mechanism 8, a drive mechanism 10, a button 12 and a cover 14. A needle unit 16 including a delivery member in the form a hollow needle is secured to a first end of the main housing 4. A medicament cartridge 18 having a first end and a second end may be stored in the main housing 4. In the illustrated embo di ent, the medicament cartridge 18 is located between the main housing 4 and the secondary housing 6. When the needle unit lόisinplace, the needle unit pierces a flexible membrane at the first end of the medicament cartridge 18. A displaceable bung 20 is located at the second end ofthe medicament cartridge 18. Thecover 14 is provided over the first end of the main housing 4 to protect the needle unit 16 from damage and auser from inadvertent pricking by the needle. The cover 14 also provides a discrete appearance to the injection device 2.
The secondary housing 6 is displaceable with respect to the main housing 4 to allow access by a user to the medicament cartridge 18. As can be seen, in the illustrated embodiment, the secondary housing 6 is slidably retractable within the mainhousing 4 (Figure 7) . The secondary housing 6 is provided with a web 7 extending inwardly ofthe secondary housing 6.
The button 12 is preferably in the form of a cup adapted for slidable movement within the main housing4. Themainhousing4andthe button 12arepreferablyprovidedwithacatch to releasably retain the button 12 inaclosedor 'off position. In the illustrated embodiment the main housing 4 has an opening 22 into which extend a finger 24 fromthe button 12 and a flexible tab or cap 26. The cap 26 and the finger 24 normally each extend part way through the opening 22. Pushing of the cap 26 pushes the finger 24 fromthe opening releases the button 12. When the pressure on the cap 26 ceases the cap 26 will revert to the previous position so as to allow the finger 24 to enter the opening 22 following depression ofthe button 12, The finger 24 maybe used to engage a lip 28 on the main housing 4 to retain the button 12 within the main housing 4.
The dose dialmechanism8 is locatedin the button 12. When the button 12 is in the fully depressed position, the dial dose mechanism 8 is obscured from view. On release ofthe button 12, the dial dose mechanism 8 is exposed for manipulation by a user to set a required dosage.
A dose setting spindle 30 is connected at a first end by a spline 32 to the dose dial mechanism 8. The dose setting spindle 30 is provided with athreadedportion. A counter rod34 extends from a second end ofthe dose setting spindle 30. A radially extending flange 38 is also provided at a second end ofthe dose setting spindle 30. In the closed position the radially extending flange 38 abuts an abutment surface 40 provided in the main housing 4.
The main housing 4 is also provided with a first set of counter contacts 42. When the injection device 2 is in a 'ready' position, counter contacts 36 on the counter rod 34 many or match up with the first set of counter contacts 42 in the main housing 4:
A drive means is provided carried fromthe dose setting spindle 30. The drive means comprises a drive rack 44 in the form of a member having a threaded bore. The drive rack44 is carried from the thread ofthe dose setting spindle 30 such that rotation ofthe dose setting spindle 30 causes the drive rack 44 to precess along the dose setting spindle 30. The drive rack 44 is connected to a piston 46. In a fully withdrawn position, the drive rack 44 is located on the dose setting spindle 30 adjacent the dose dial mechanism 8. The piston 46 comprises a piston member 48 located concentrically within a sleeve member 50 and extending outward from the sleeve member 50, such that in use, the sleeve member 50 passes outside ofthe medicament cartridge 18 and the piston member 48 passes within the medicament cartridge 18 to abut and drive the displaceable medicament cartridge bung 20. As can be seen the piston 46 and the medicament cartridge 18 are disposed along a first axis.
In the fully withdrawnposition, the rearmost surface ofthe piston 46 may abut an inner surface of the button 12.
To operate the injection device 2 a user first releases the button 12 in the manner described to cause the button 12 to move to the 'ready' position (Figure 2) . The dose dial mechanism 8 can now be operatedto rotate the dose setting spindle 30. This has the effect of causing the drive rack 44 to precess along the dose setting spindle 30 by a given distance (Figure 3). This distance corresponds to the displacement ofthe cartridge bung 20 required to dispense arequiredamount of medicament. The counter contacts 36,42 can be used to measure rotation of he dose setting spindle 30 which in turn gives an accurate guide as to how far the drive rack 44 has moved. The dial dose mechanismincluding the dose setting spindle 30 and the drive rack 44 are disposed along a second axis. The second axis is disposed parallel to the first axis.
The button 12 is then depressed driving the piston member 48 into the displaceable bung 20 ofthe medicament cartridge 18 until the radially extending flange 38 ofthe dose setting spindle 30 again abuts the abutment surface 40 ofthe main housing 4. In this position, the finger 24 ofthe button 12 will once again extend through the opening 22 in the main housing 4 (Figure 4).
On the next use ofthe injection device 2, the pistonmember 48 is at least partially withdrawn from the medicament cartridge 18 since the piston 46 together with the piston member 48 is drawn with the button 12 away from the first end ofthe main housing 4. A new dose is set, precessing the drive rack 44 further along the dose setting spindle 30 prior to depression ofthe button 12. As the process is repeated the drive rack 44 precesses yet further along the dose setting spindle 30 (Figure 5).
This process maybe repeated until the medicament cartridge 18 is empty, the medicament cartridge 18 contains insufficient medicament to deliver the dialled dose or some other condition is met. For example, the dri ve rack 44 may abut the radially extending flange 38 on the dos e setting spindle 30 and precess no further, the dose setting spindle 30 being of a suitable length such that the drive rack 44 will abut the radially extending flange 38 when the displaceable bung 20 can travel no further within the medicament cartridge 18 (Figure 6).
The piston member 48 may then be withdrawn to allow replacement ofthe medicament caitridge 18. In the illustrated embodiment, this occurs in the following manner. A user displaces the secondary housing away fromthe first end ofthe main housing 4 along a third axis . The third axis is substantially parallel to the first axis andthesecondaxis. As the secondary housing 6 is moved, the web 7 abuts with an abutment surface 45 provided for this purpose on the drive rack 44. Further movement ofthe secondary housing 6 moves the drive rack 44, together with the piston 46 along the first axis away from the first end ofthe main housing 4, thereby removing the piston 46 from within the medicament cartridge 18. Thus, when the secondary housing has been fully displaced as shown in Figure 7, the piston 46 has been withdrawn fromthe medicament cartridge 18 and the user is free to remove the medicament cartridge 18 and replace the medicament caitridge 18 as required.
The inj ection device 2 described has among its advantages that it is relatively simple to assemble andhas relatively few moving parts. The counter contacts 36,42 allowthe angular position ofthe dose setting spindle 30 to be determined, thus allowing for calculation ofthe precise location ofthe pistonmember 48. Further, since the dose dial mechanism 8 is hidden untilrelease ofthe button 12, the dial dose mechanism 8 cannot be tampered with while the button 12 is depressed.
Also, in comparison with known pen type injectors in which the piston and a drive means for successively displacing the piston are located along a single axis amore compact design of pen type injector is provided for in the present invention.
The relative arrangement ofthe drive mechanism and the medicament cartridge means that the main housing provides arelatively large flat face where arelatively large dose display, such as aliquid crystal display may be located. This in turn enables the dose^display to use relatively large figures or other characters. This is an advantage for those with impaired vision.

Claims

1 A drive mechanism for aninjection device in which apisto is successivelymoved along afirst axis inrelationto afirst end of amedicament cartridge containing amedicament selectively to drive a bung closing a first end ofthe medicament cartridge into the medicament caitridge to expel medicament through a delivery member located at a second end ofthe medicament caitridge, in which the displacement mechanism comprises a dose setting spindle disposed along asecond axis, the second axis being parallel to the first axis, transmissionmeans connected between the dose setting spindle and the piston, and displacement means to displace the dose setting spindle with respect to the medicament cartridge, a movement ofthe displacement means in a first direction causing movement ofthe dose setting spindle and the piston in the first direction.
2 A drive mechanismf r an injection device according to claim 1 , characteris ed in that the drive mechanism further comprises a dose dial mechanism connected to the dose setting spindle to control rotational movement ofthe dose setting spindle.
3 A drive mechanismfbr aninjection device according to claim2, characterised in that the dose setting spindle is connected to the dose dial mechanism by a spline.
4 A drive mechanismfor an injection device according to any previous claim, characterised in that the transmission means comprises a drive rack.
5 A drive mechanismfor aninjection device accordingto anyprevious claim, characterised in that the piston comprises a sleeve member connected to the drive rack and a piston member located concentrically within the sleeve member and extending outward fromthe sleeve member.
6 Adrivemechanismforaninjectiondeviceaccordingto anyprevious claim, characterised in that the dose setting spindle is provided with counter contacts.
7 Aninjection device havmgamainhousing incorporating adrivemechanismaccording to any previous claim.
8 An injection device according to claim 7, characterised in that the displacement means comprises a button located for displacement within a housing ofthe injection device.
9 An injection device according to claim 8 , characterised in that the dose dial mechanismis retained within the button.
10 Aninjection device according to any of claims 7 to 9 in which the injector device further comprises a secondary housing adapted for displacement with respect to the main housing, is characterised in that the secondary housing is provided with a web for abutment with an abutment suiface provided on the transmissionmeans in order to allow the piston to be displaced along the first axis in a direction opposite the first direction.
PCT/GB2002/001459 2001-03-27 2002-03-26 Improvements in and relating to an injection device WO2002076539A1 (en)

Priority Applications (16)

Application Number Priority Date Filing Date Title
KR1020037012543A KR100854465B1 (en) 2001-03-27 2002-03-26 driving mechanism for an injection device
CA2440018A CA2440018C (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device
AU2002242864A AU2002242864B2 (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device
JP2002575049A JP4480330B2 (en) 2001-03-27 2002-03-26 Improvements to and related to infusion devices
EP02708502A EP1372767B1 (en) 2001-03-27 2002-03-26 Drive mechanism for an injection device
DK02708502T DK1372767T3 (en) 2001-03-27 2002-03-26 Improvement of and related to an injection device
PL363974A PL203748B1 (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device
BRPI0208013-3A BR0208013B1 (en) 2001-03-27 2002-03-26 drive mechanism for an injection device.
HU0303427A HU228440B1 (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device
US10/471,721 US7794430B2 (en) 2001-03-27 2002-03-26 Injection device
IL15760602A IL157606A0 (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device
DE60217654T DE60217654T2 (en) 2001-03-27 2002-03-26 Drive mechanism for an injection device
MXPA03008682A MXPA03008682A (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device.
HR20030774A HRP20030774B1 (en) 2001-03-27 2003-09-25 Improvements in and relating to an injection device
HK04104748A HK1061659A1 (en) 2001-03-27 2004-07-02 Drive mechanism for an injection device
CY20071100508T CY1106507T1 (en) 2001-03-27 2007-04-12 MECHANISM-GUIDE FOR INJECTION ARRANGEMENT

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0107608.2 2001-03-27
GBGB0107608.2A GB0107608D0 (en) 2001-03-27 2001-03-27 Improvements in and relating to an injection device

Publications (1)

Publication Number Publication Date
WO2002076539A1 true WO2002076539A1 (en) 2002-10-03

Family

ID=9911633

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB2002/001459 WO2002076539A1 (en) 2001-03-27 2002-03-26 Improvements in and relating to an injection device

Country Status (23)

Country Link
US (1) US7794430B2 (en)
EP (1) EP1372767B1 (en)
JP (2) JP4480330B2 (en)
KR (1) KR100854465B1 (en)
CN (1) CN1247273C (en)
AU (1) AU2002242864B2 (en)
BR (1) BR0208013B1 (en)
CA (1) CA2440018C (en)
CY (1) CY1106507T1 (en)
DE (1) DE60217654T2 (en)
DK (1) DK1372767T3 (en)
ES (1) ES2279861T3 (en)
GB (1) GB0107608D0 (en)
HK (1) HK1061659A1 (en)
HR (1) HRP20030774B1 (en)
HU (1) HU228440B1 (en)
IL (1) IL157606A0 (en)
MX (1) MXPA03008682A (en)
PL (1) PL203748B1 (en)
PT (1) PT1372767E (en)
RU (1) RU2289430C2 (en)
WO (1) WO2002076539A1 (en)
ZA (1) ZA200306652B (en)

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WO2009049885A1 (en) * 2007-10-17 2009-04-23 Haselmeier Gmbh Injection device with reset of the piston rod caused by cartridge exchange
WO2009097934A1 (en) * 2008-02-05 2009-08-13 Shl Group Ab Injection device with pre-activation means
EP2682142A1 (en) * 2012-07-06 2014-01-08 Sanofi-Aventis Deutschland GmbH Autoinjector
WO2014166888A1 (en) * 2013-04-10 2014-10-16 Sanofi Injection device
US9592337B2 (en) 2010-12-22 2017-03-14 Alcon Research, Ltd. Device for at least one of injection or aspiration
WO2016198540A3 (en) * 2015-06-11 2017-04-20 Novo Nordisk A/S Drug delivery device with extended protective cap
US10512731B2 (en) 2013-07-17 2019-12-24 Sanofi Drug delivery device

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KR101136115B1 (en) * 2004-02-18 2012-04-17 아레스 트레이딩 에스.아. Hand-held electronically controlled injection device for injecting liquid medications
BRPI0614025A2 (en) 2005-01-24 2012-12-25 Antares Pharma Inc jet injectors
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