WO2002074898A3 - Gradient block temperature control device - Google Patents

Gradient block temperature control device Download PDF

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Publication number
WO2002074898A3
WO2002074898A3 PCT/IB2002/001828 IB0201828W WO02074898A3 WO 2002074898 A3 WO2002074898 A3 WO 2002074898A3 IB 0201828 W IB0201828 W IB 0201828W WO 02074898 A3 WO02074898 A3 WO 02074898A3
Authority
WO
WIPO (PCT)
Prior art keywords
top plate
gradient
control unit
gradient block
temperature
Prior art date
Application number
PCT/IB2002/001828
Other languages
French (fr)
Other versions
WO2002074898A2 (en
Inventor
Michael Hodges
Original Assignee
Techne Cambridge Ltd
Michael Hodges
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Techne Cambridge Ltd, Michael Hodges filed Critical Techne Cambridge Ltd
Publication of WO2002074898A2 publication Critical patent/WO2002074898A2/en
Publication of WO2002074898A3 publication Critical patent/WO2002074898A3/en

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/54—Heating or cooling apparatus; Heat insulating devices using spatial temperature gradients
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Control Of Temperature (AREA)

Abstract

This invention relates to a temperature control apparatus for generating and maintaining a differential temperature gradient across a block that may be used, for example, to conduct biological reactions. According to one embodiment of the present invention, a gradient block includes a top plate and a data storage device. The data storage device is adapted to be connected to a control unit and stores data related to the calibration of the gradient block. According to another embodiment of the present invention, an apparatus for generating a temperature gradient across a gradient block includes a gradient block and a control unit for controlling the temperature of the thermoelectric devices. The control unit includes a top plate, and at least four pairs of thermoelectric devices in thermal contact with the top plate, the pairs of thermoelectric devices being capable of independently transferring heat with the top plate and dividing the top plate into at least four heat transfer zones. The control unit contains a microprocessor capable of storing data.
PCT/IB2002/001828 2001-03-16 2002-03-18 Gradient block temperature control device WO2002074898A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27657901P 2001-03-16 2001-03-16
US60/276,579 2001-03-16

Publications (2)

Publication Number Publication Date
WO2002074898A2 WO2002074898A2 (en) 2002-09-26
WO2002074898A3 true WO2002074898A3 (en) 2003-10-02

Family

ID=23057204

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/001828 WO2002074898A2 (en) 2001-03-16 2002-03-18 Gradient block temperature control device

Country Status (1)

Country Link
WO (1) WO2002074898A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE04752947T1 (en) * 2003-05-23 2006-11-16 Bio-Rad Laboratories, Inc., Hercules LOCALIZED TEMPERATURE CONTROL FOR ROOM ARRANGEMENTS OF REACTION MEDIA
CL2008003007A1 (en) * 2007-10-12 2009-10-02 Bigtec Private Ltd A microchip with layers of low temperature firing ceramics (ltcc) forming a reaction chamber, conductive rings that surround the reaction chamber and a heater that supplies heat to the rings, the microchip manufacturing method and a micro polymerase chain reaction (pcr) device.

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5690893A (en) * 1994-06-10 1997-11-25 Hitachi, Ltd. Analyzer having sensor with memory device
WO1998020975A1 (en) * 1996-11-08 1998-05-22 Eppendorf-Netheler-Hinz Gmbh Temperature-regulating block with temperature-regulating devices
US5779981A (en) * 1993-10-20 1998-07-14 Stratagene Thermal cycler including a temperature gradient block
DE19736470A1 (en) * 1997-08-21 1999-03-04 Ulrich Prof Dr Med Schenck Data processing-compatible sample carrier and method for analyzing samples

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5779981A (en) * 1993-10-20 1998-07-14 Stratagene Thermal cycler including a temperature gradient block
US5690893A (en) * 1994-06-10 1997-11-25 Hitachi, Ltd. Analyzer having sensor with memory device
WO1998020975A1 (en) * 1996-11-08 1998-05-22 Eppendorf-Netheler-Hinz Gmbh Temperature-regulating block with temperature-regulating devices
DE19736470A1 (en) * 1997-08-21 1999-03-04 Ulrich Prof Dr Med Schenck Data processing-compatible sample carrier and method for analyzing samples

Also Published As

Publication number Publication date
WO2002074898A2 (en) 2002-09-26

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