WO2002071922A2 - Dispositif intra-uretral permettant de traiter ou de detecter differentes maladies et infections du systeme urinaire - Google Patents

Dispositif intra-uretral permettant de traiter ou de detecter differentes maladies et infections du systeme urinaire Download PDF

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Publication number
WO2002071922A2
WO2002071922A2 PCT/US2002/007322 US0207322W WO02071922A2 WO 2002071922 A2 WO2002071922 A2 WO 2002071922A2 US 0207322 W US0207322 W US 0207322W WO 02071922 A2 WO02071922 A2 WO 02071922A2
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WO
WIPO (PCT)
Prior art keywords
urethral
urethra
chemical compound
insertion element
urethral element
Prior art date
Application number
PCT/US2002/007322
Other languages
English (en)
Other versions
WO2002071922A3 (fr
Inventor
Robert A. Latour, Jr.
Brent Carman
Original Assignee
Clemson University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Clemson University filed Critical Clemson University
Priority to AU2002254167A priority Critical patent/AU2002254167A1/en
Publication of WO2002071922A2 publication Critical patent/WO2002071922A2/fr
Publication of WO2002071922A3 publication Critical patent/WO2002071922A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0004—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse
    • A61F2/0009—Closure means for urethra or rectum, i.e. anti-incontinence devices or support slings against pelvic prolapse placed in or outside the body opening close to the surface of the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2210/00—Anatomical parts of the body
    • A61M2210/10—Trunk
    • A61M2210/1078—Urinary tract
    • A61M2210/1089—Urethra

Definitions

  • an intraurethral device for use in a female urinary tract to treat or detect the presence or absence of a disorder or disease.
  • the intraurethral device comprises a urethral element having a distal end and a proximal end.
  • the shape of the distal end forms a generally concave surface that enables the urethral element to form a seal with the urethra when inserted therein. Such a seal can inhibit urinary leakage during detection and/or treatment.
  • the distal end of the urethral element is adapted to be inserted into a urethra and also contains a chemical compound capable of treating or detecting the presence or absence of a disorder or disease.
  • the chemical compound can generally vary depending on the type of disease or disorder, and whether it is desired to treat or detect such a disease or disorder.
  • doxorubicin can be used to treat various bladder infections.
  • a mycobacterium such as Bacillus Calmette-Guerin, can also be utilized for treatment of carcinoma located in the bladder.
  • antibiotics such as Amoxicillin (“Amoxil”) or trimethoprimsulfamethoxazole (“Bactrim DS”
  • hormones such as estrogen
  • anesthetic lidocaine such as astringents, such as silver nitrate
  • anti-inflammatory agents such as dimethyl sulfoxide (“DMSO”
  • medications such as indomethacin (“Indocin”); sodium pentosan-polysulfate (“Elmiron”); oxychorosens
  • the intraurethral device also contains a first insertion element and a second insertion element.
  • the first insertion element has an inner surface and an outer surface, wherein at least a portion of the first insertion element is operative communication with the urethral element.
  • the second insertion element has an inner surface and an outer surface, wherein the second insertion element defines a channel through which the proximal end of the urethral element is capable of being inserted.
  • the inner surface of the second insertion element is placed adjacent to the outer surface of the first insertion element such that the second insertion element is in operative communication with the first insertion element.
  • the first and second insertion elements are configured to insert the urethral element into the urethra.
  • the intraurethral device can also contain an enclosure that surrounds at least a portion of the urethral element.
  • the enclosure comprises a roll-out nipple.
  • a method for treating a disease or disorder.
  • the method comprises: a) providing an intraurethral device that comprises a urethral element having a distal end and a proximal end, the distal end of the urethral element being adapted to be inserted into a urethra, the distal end containing a chemical compound capable of treating or detecting the presence or absence of a disorder or disease; b) inserting said urethral element into the urethra so that the chemical compound is not substantially contaminated prior to insertion of the urethral element in the urethra; and c) allowing the chemical compound to be released from the urethral element into the urethra.
  • a method for detecting the presence or absence of a disease or disorder.
  • the method comprises a) providing an intraurethral device that comprises a urethral element having a distal end and a proximal end, the distal end of the urethral element being adapted to be inserted into a urethra, the distal end containing a chemical compound capable of treating or detecting the presence or absence of a disorder or disease; b) inserting the urethral element into the urethra so that the chemical compound is not substantially contaminated prior to insertion of the urethral element in the urethra; c) allowing the chemical compound to be released from the urethral element into the urethra; d) removing the urethral element from the urethra, and e) evaluation the chemical compound to determine whether a disease or disorder is present.
  • FIG. 1 illustrates one embodiment of an intraurethral device of the present invention
  • Fig. 2 illustrates one embodiment of the present invention, in which Fig. 2A shows the alignment of the intraurethral device with a urethra, Fig.
  • FIG. 2B shows the initial insertion of the urethral element into the urethra
  • Fig. 2C shows the partial withdrawal of the outer insertion element of the urethral element
  • Fig. 2D shows the complete withdrawal of both of the insertion elements
  • Fig. 3 illustrates the outer insertion element of one embodiment of an intraurethral device of the present invention, in which Fig. 3A is a front view of the outer insertion element, Fig. 3B is a side view of the outer insertion element; and Fig. 3C is a bottom view of the outer insertion element;
  • Fig. 4 illustrates the inner insertion element of one embodiment of an intraurethral device of the present invention, in which Fig. 4A is a front view of the inner insertion element, Fig. 4B is a side view of the inner insertion element; and Fig. 4C is a bottom view of the inner insertion element;
  • Fig. 5 illustrates one embodiment of an intraurethral device of the present invention, in which Fig. 5A shows a roll-out nipple in its rolled-up position and Fig. 5B shows the roll-out nipple in its unraveled position; and
  • Fig. 6 illustrates the urethral element of one embodiment of an intraurethral device of the present invention, in which Fig. 6A is a front view of the urethral element, Fig. 6B is a side view of the urethral element; and Fig. 6C is a top view of the urethral element.
  • the present invention is generally directed to an intraurethral device that can be used to detect and/or treat various diseases or disorders of the urinary system (e.g., urinary tract, bladder, kidneys, etc.).
  • an intraurethral device of the present invention can be easily inserted into a urethra in a clean and/or sterile manner.
  • the intraurethral device can deliver one or more chemical compounds to the urethra for treating one or more diseases or disorders of the urinary system.
  • the intraurethral device can contain one or more indicator materials that are designed to quickly signal the presence or absence of a certain disease or disorder in the urinary system.
  • a urethral element is typically utilized that can be removably inserted into a urethra.
  • any device known in the art that can be inserted into a urethra can be utilized in the present invention.
  • urethral plugs inserted into the urethra to physically inhibit urinary leakage can be used in the present invention.
  • a urethral element 60 is shown that includes a distal end 65 connected to a proximal end 64 by a tubular section 62.
  • the proximal end 64 is an external flange that is capable of substantially preventing over-insertion of the urethral element 60 and/or to aid in the removal of the urethral element 60.
  • the distal end 65 has a cup-shape that forms a generally concave surface 69. It should be understood, however, that the present invention is not limited to a cup-shaped urethral element and that any other shape capable of providing a generally concave surface can also be utilized. Further, it should also be understood that a generally concave surface is not required in all embodiments of the present invention.
  • the urethral element 60 can be made in a variety of ways.
  • the urethral element 60 can be made from a material that is generally biocompatible such that it is suitable . for contact with the urethra.
  • the urethral element 60 can be made from a biocompatible material that is also flexible. Although not required, flexible materials can sometimes allow the urethral element 60 to form a better seal with the walls of the urethra.
  • suitable flexible materials can include, but are not limited to, elastomeric polymers, such as polyurethane, silicone rubber, natural rubber, polyester, chloroprene, polybutadiene, combinations thereof, or any other elastomeric material suitable for urethral and urine contact.
  • elastomeric polymers such as polyurethane, silicone rubber, natural rubber, polyester, chloroprene, polybutadiene, combinations thereof, or any other elastomeric material suitable for urethral and urine contact.
  • elastomeric polymers such as polyurethane, silicone rubber, natural rubber, polyester, chloroprene, polybutadiene, combinations thereof, or any other elastomeric material suitable for urethral and urine contact.
  • silicone rubber such as medical grade silicone rubber commonly used in various medical devices.
  • any other elastomeric material can be used in the present invention.
  • the urethral element 60 need not be made from the same material(s).
  • the cup-shaped end 65, the tubular section 62, and the external flange 64 may all contain different material(s), if desired.
  • the cup-shaped end 65 can be made from a flexible elastomeric material, while the external flange 64 and the tubular section 62 can conversely be made from a less flexible or non-flexible material.
  • the component(s) of the urethral element 60 can also generally possess any desired dimension or shape. In general, a physician usually determines the precise size for use, after measuring the patient's urethra.
  • a urethral element 60 can be made into a variety of different shapes and sizes to better conform to different urethras.
  • the urethral element 60 can also conform to the size and shape of the urethra after insertion, there may be no need to custom make the urethral element.
  • the urethral element 60 can have a total length of between about 15 millimeters ("mm") to about 30 mm in length, and in one particular embodiment, the length can be about 25 mm.
  • the total length of the urethral element 60 is approximately equal to the combined values of the dimensions represented as "a”, "b", "c", and "d". These dimensions can generally be selected to have any value, depending on the desired shape and size of the urethral element.
  • the dimensions represented as "a”, “b", “c", and “d” are 5.0 mm, 3.0 mm, 15 mm, and 2 mm respectively.
  • the component(s) of the urethral element 60 can also have other varying dimensions.
  • the outer diameter of the tubular section 62 can be between about 2 mm to about 8 mm, and in one particular embodiment, about 4.0 mm.
  • the tubular section 62 can define a hollow channel 68 that extends through.the flange 64 to form a urethral element opening 67.
  • the inner diameter of the tubular section 62 can be between about 1 mm to about 7 mm, and in one particular embodiment, about 2.5 mm.
  • the width dimension "e" of the flange 64 can be between about 10 mm to about 40 mm, and in one particular embodiment, about 18 mm.
  • the thickness dimension "f" of the flange 64 can be between about 2 mm to about 8 mm, and in one particular embodiment, about 4.0 mm.
  • the outer edges 71 of the flange 64 can also be rounded, such as having a radius of curvature of about 2.0 mm.
  • the cup-shaped end 65 can also possess a variety of different dimensions. For example, in the illustrated embodiment, the cup- shaped end 65 has ah outer diameter "g" of between about 4 mm to about 16 mm, and in one particular embodiment, about 8.0 mm.
  • the cup-shaped end 65 also has an inner diameter "h" of between about 3 mm to about 15 mm, and in one particular embodiment, about 5.0 mm.
  • the cup-shaped end 65 can contain one or more rounded surfaces.
  • the cup-shaped end 65 contains a rounded surface 77, which has a radius of curvature of about 5.0 mm.
  • the urethral element 60 can also contain rounded surfaces 73 and 75, which have a radius of curvature of about 2.5 mm and about 4.0 mm, respectively. In one embodiment, these rounded surfaces can minimize tissue irritation within the urethra.
  • doxorubicin can be used to treat various bladder infections.
  • a mycobacterium such as Bacillus Calmette-Guerin, can also be utilized for treatment of carcinoma located in the bladder.
  • other chemical compounds that can be utilized for disease and/or disorder treatment include, but are not limited to, antibiotics, such as Amoxicillin
  • Amoxil or trimethoprimsulfamethoxazole
  • hormones such as estrogen
  • anesthetic lidocaine such as silver nitrate
  • anti-inflammatory agents such as dimethyl sulfoxide (“DMSO”
  • medications such as indomethacin ("Indocin”); sodium pentosan- polysulfate (“Elmiron”); oxychorosens (“Clorpactin”), natruim chromogulcate
  • steroids such as Lyisonlone
  • quinolones such as "Cipro” and "Levaquin”
  • steroids such as Cincinnati, Calif., quinolones, such as "Cipro” and “Levaquin”
  • steroids such as Cincinnati, Calif., quinolones, such as "Cipro” and “Levaquin”; and the like.
  • a chemical compound for treating various diseases and disorders can be applied to the urethral element 60 in a variety of ways.
  • the compound(s) can be contained within the cavity formed by the cup- shaped end 65 of the urethral element 60.
  • an enclosure such as a roll-out nipple 80
  • a roll-out nipple 80 can be utilized to cover the urethral element 60 prior to its insertion into the urethra.
  • the nipple 80 can ensure that the compound(s) are only applied upon insertion into the urethra and that the urethral element 60 is applied in a relatively clean and/or sterile manner.
  • the nipple 80 can be made from any of a variety of materials, such as various plastics or rubber materials. If desired, certain adhesives (e.g., starch) may also be utilized to ensure that the nipple 80 remains enclosed at its tip prior to use of the intraurethral device.
  • the treatment compounds can be also be applied to the urethral element 60 in various other ways.
  • the chemical compound(s) can be coated onto the outer surface of the urethral element 60, such as to the outer surface of the cup-shaped end 65 or the tubular section 62.
  • the chemical compound(s) can be incorporated into the polymer used to form the urethral element 60.
  • the chemical compound when incorporated into the polymer, can be configured to controllably release from the urethral element 60 as it remains within the urethra. It should be understood that the present invention is not limited to any particular method or device for applying the chemical treatment compound(s) to the urethra, and that other methods and devices are also contemplated by the present invention.
  • the intraurethral device of the present invention is also capable of detecting the presence of such diseases and disorders.
  • an indicator strip (not shown) can be disposed around the inner surface of the cup- shaped end 65 of the urethral element 60. It should be understood, however, that the indicator strip may be disposed on any portion of the urethral element 60, so long as the materials on the strip are capable of being placed into communication with the bodily fluids of the patient.
  • the indicator strip may contain one or a plurality of indicator materials that are well known in the art for detecting such urinary diseases or disorders.
  • the indicator material(s) can turn one color upon the detection of a certain chemical, and remain the same, or turn another color, in the absence of the chemical.
  • the indicator material(s) may also detect the severity of a problem, such as by turning a darker color if the detected disorder or disease is more severe.
  • the indicator strip can contain one or more known materials that are capable of detecting certain chemicals, such as ketones, proteins, red blood cells, white blood cells, glucose, nitrates, hemoccult, calcium, oxalates, blood urea nitrogen, and the like. When detected, these chemicals, among others, can provide a clinical sign to a medical professional or user of a variety of possible disorders and diseases.
  • the indicator strip can also contain other indicator materials as well, such as a material capable of measuring pH.
  • the urethral element 60 is first inserted into a urethra so that the indicator materials(s) can be placed into communication with urine and other fluids within the urethra. If a selected disease or disorder is present (or absent), the indicator(s) may then react (e.g., change color) to indicate the presence of such disease or disorder. As such, when the urethral element 60 is withdrawn, a user or medical professional can easily determine whether such disease or infection is present within the patient's urinary system. Besides utilizing an indicator strip, it should be understood that indicator material(s) may also be directly applied to the urethral element 60, if desired.
  • the urethral element 60 which contains various materials for disease treatment and/or detection, can be .inserted into a urethra in a variety of ways.
  • a user or medical professional may directly and manually insert the urethral element 60 into the urethra.
  • the urethral element 60 can be inserted into the urethra with the assistance of one or more insertion devices. Such insertion devices can inhibit contamination of the chemical compound of the urethral element 60 prior to insertion into the urethra.
  • insertion devices can also facilitate self-insertion of the urethral element 60 by a user.
  • FIGs. 1 , 3A-3C, and 4A-4C for example, one embodiment of an intraurethral device 10 that utilizes a urethral element 60 in conjunction with an outer insertion element 20 and an inner insertion element 40 is illustrated.
  • the outer insertion element contains an inner body portion 24 that is attached at one end to an outer body portion 26.
  • the outer insertion element 20 also contains an elongated element 22 (e.g., shaft) that is attached at one end to the inner body portion 24.
  • any of a variety of attachment mechanisms such as adhesives, can be utilized in attaching the portions of the outer insertion element 20.
  • the outer insertion element 20 can also be formed as one integral portion. .
  • the portion(s) of the outer insertion element 20 can be formed to have a variety of different shapes and/or sizes.
  • the elongated element 22, the inner body portion 24, and the outer body portion 26 have a cylindrical, tube-like shape. These portions may be solid or define a hollow channel.
  • the outer body portion 26 defines a cylindrical, tube-like channel 27 for placement of the inner body portion 24 therein.
  • the diameter of the elongated element 22, the inner body portion 24, and the outer body portion 26 can generally vary.
  • the outer diameter "i" of the inner body portion 24 can be about 6.9 mm
  • the outer diameter "k” of the outer body portion 26 can be about 16.0 mm
  • the inner diameter "I” of the outer body portion 26 can be about 12.1 mm
  • m of the shaft 22 can be about 2.0 mm.
  • the length of one or more portions of the outer insertion element 20 can also be selectively varied as desired.
  • the length "n" of the entire insertion element 20 can be about 100 mm.
  • the length of the elongated element 22 is about
  • the length of the outer body portion 26 (including the flanges 28) can be about 86.0 mm and the length of the hollow channel 27 defined by the outer body portion 26 can be about 35.0 mm.
  • an additional inner insertion element 40 is utilized in operative communication with the outer insertion element 20 to facilitate insertion of the urethral element 60 into a urethra.
  • the inner insertion element 40 can also help to maintain the sterility and/or cleanliness of the urethral element 60 prior to its insertion into a urethra.
  • FIG. 4A-4C one embodiment of an inner insertion element 40 that can be used in the present invention is illustrated. As shown, the inner insertion element 40 contains a first body portion 44 attached to a second body portion 46.
  • the outer cylindrical surface of the second body portion 46 is attached to the inner cylindrical surface of the first body portion 46.
  • any of a variety of attachment mechanisms e.g., adhesives, etc.
  • the inner insertion element 40 can also be formed as one integral portion.
  • the portion(s) of the inner insertion element 40 can generally be formed to have a variety of different shapes and/or sizes. For example, in one embodiment, as shown in Figs. 4A-4C, the first body portion 44 and the second body portion 46 have a cylindrical, tube-like shape.
  • both the first and second body portions 44 and 46 define cylindrical, tube-like channels for placement of the inner insertion element 20 therein, as will be described in more detail below.
  • the diameter of the first body portion 44 and the second body portion 46 can generally vary. In one embodiment, for instance, the outer diameter "o" of the first body portion 44 can be about 12.0 mm, the inner diameter "p" of the first body portion
  • the outer diameter "q" of the second body portion 46 can be about 9.1 mm
  • the inner diameter "r" of the second body portion 46 can be about 8.1 mm.
  • the length of one or more portions of the inner insertion element 40 can also be selectively varied as desired.
  • the length "s" of the entire insertion element 40 can be about 50 mm.
  • the length of the first body portion 44 is about 47 mm
  • the length of the second body portion 46 is about 8 mm
  • the portion 46 extends beyond the portion 44 by approximately 3 mm.
  • the portion(s) of the insertion elements 20 and 40 can be made any of a variety of materials, such as rigid and/or semi-rigid materials.
  • the insertion elements 20 and 40 can contain plastic materials, such as polyolefins, polyamides, polycarbonates, etc; paper materials, such as cardboard; and the like.
  • the insertion elements 20 and 40 can contain a semi-rigid rubber material, such as polyurethane. It should be understood, however, that the insertion elements 20 and 40 need not be made from the same material.
  • the components of a single insertion element can also be made from different materials if desired.
  • a nipple 80 can be utilized to at least partially enclose the urethral element 60 prior to its insertion into the urethra.
  • the nipple 80 can be attached to the second body portion 46 of the inner insertion element 40 in such a manner that the nipple 80 substantially covers the urethral element 60 prior to its insertion in a urethra.
  • the nipple 80 can be sealed to the inner insertion element 40 according to any sealing method known in the art.
  • still other devices can be utilized to enhance the ability of the urethral element 60 to remain relatively sterile and/or clean prior to and/or during insertion.
  • some or all of the intraurethral device 10 can be enclosed with an additional sterile bag (not shown).
  • the components described above can be assembled to form the intraurethral device according to the process illustrated in Fig. 1. Such assembly can be performed by a user, a medical professional, or during manufacture of the device.
  • the inner insertion element 40 can initially be placed into operative communication with the outer insertion element 20 by positioning the inner cylindrical surface of the first body portion 44 over the outer cylindrical surface of the inner body portion 24 such that the inner insertion element 40 fits between the flanges 28 of the outer insertion element 20. (See Figs. 3A-3C). As a result, the inner insertion element 40 can slide along the entire length of the inner body portion 24.
  • the inner insertion element 40 is moved along the length of the inner body portion 24 of the outer insertion element 20 such that at least a portion of the elongated element 22 extends beyond the inner insertion element 40.
  • the urethral element opening 67 of the urethral element 60 is then placed over the portion of the elongated element 22 that extends beyond the inner insertion element 40.
  • the urethral element 60 can generally be connected to the elongated element 22 utilizing any desired method.
  • the inner insertion element 40 is then moved in the direction of the urethral element 60 while the outer insertion element 20 is held in place or moved away from the urethral element 60.
  • the flange 64 folds into a U-shape, such as shown in Fig. 2A. Due to the friction between the surface of the flexible flange 64 and the inner surface of the inner insertion element 40, the flange 64 remains in its folded state.
  • the inner insertion element 40 containing the folded flange 64 is further moved until the second body portion 46 is placed in contact with the cup-shaped end 65 of the urethral element. At this point, the intraurethral device 10 is assembled and ready for use.
  • FIGs. 2A-2D one method for inserting the urethral element 60 of the intraurethral device 10 shown in Fig. 1 into a urethra is illustrated.
  • a user or medical professional grasps the intraurethral device in an outwardly extended position and aligns the roll-out nipple 80 and urethral element 60 with a urethra opening.
  • the outer insertion element 20 is moved toward the urethra, as indicated by the directional arrow of Fig. 2B.
  • the downward motion of the outer insertion element 20 causes the elongated element 22 and the urethral element 60 to be inserted into the urethra.
  • the downward motion of the outer insertion element 20 causes the roll-out nipple 80 to unravel, such that the urethral element 60 does not generally come into contact with a non-sterile surface, and thus, does not drag substantial amounts of bacteria, fungi, or other pathogenic microorganisms into the urethra, prior to and/or during insertion.
  • the outer body portion 26 contains two flanges 28.
  • the flanges 28 come into contact with the urethra wall, thereby inhibiting any further downward movement of the outer insertion element 20. In this manner, over-insertion of the urethral plug can be substantially prevented.
  • the inner insertion element 40 is then moved upward, as indicated by the directional arrow shown in Fig. 2C. In some instances, it may also be desired to simultaneously hold the outer insertion element 20 in place while moving the inner insertion element 40 away from the urethra.
  • the upward motion of the inner insertion element 40 causes the urethral plug 60 to be released from the elongated element 22, thereby unrolling the flange 64 of the urethral element 60 from its U-shaped position into a flat position, such as shown in Fig. 2C. Because the unrolled flange 64 has a width greater than the width of the urethra opening, it can inhibit over- insertion of the urethral element 60 therein.
  • the insertion elements 20 and 40 can then be completely removed.
  • a user can withdraw the elongated element 22 by pulling the insertion element 20 in an outwardly direction, as indicated by the directional arrow depicted in Fig. 2D.
  • the outside of the urethral element 60 can also be also coated with a lubricant, such as VASELINE or K-Y JELLY, prior to insertion into the urethra in order to protect sensitive urethral tissue.
  • the urethral element 60 which is now positioned within the urethra, can deliver one or more chemical compounds for treating various diseases or infections, or can detect the presence of such diseases or chemicals.
  • the urethral element 60 can be removed in a variety of ways. In most instances, the urethral element 60 can be removed without the aid of a medical professional. In particular, removal can normally be accomplished manually or by voluntary urinary exertion. Moreover, although not necessary, a variety of other mechanisms can also be utilized to facilitate the removal of the urethral element 60.
  • the urethral element 60 can include a removal device (not shown), such as a string, filament, cord, tether, and the like, to facilitate manual removal of the urethral element 60.
  • a removal device can generally allow the patient to facilitate manual plug removal as desired, by manually exerting pressure on the device. Additionally, should expulsion not occur when the urethral element 60 is released from its intraurethral location, a removal device can also allow the patient to completely remove the urethral element 60. It should be understood that a removal device may be secured to the urethral element 60 by any suitable method known in the art, as long as adequate strength is present to facilitate manual removal of the urethral element 60 by applying a force to the removal device.
  • the removal device may be molded as a unitary structure with the urethral element 60.

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Abstract

L'invention a pour objet un dispositif intra-urétral utilisé dans le tractus urinaire féminin. Ce dispositif comporte un élément urétral contenant un composé chimique capable de traiter ou de déceler la présence ou l'absence d'un trouble ou d'une maladie. Selon un mode de réalisation, ledit dispositif contient également des éléments d'insertion externes et internes qui sont en communication fonctionnelle avec l'élément urétral de manière à faciliter l'insertion de ce dernier dans l'urètre pratiquement sans contaminer le composé chimique avant l'insertion.
PCT/US2002/007322 2001-03-13 2002-03-12 Dispositif intra-uretral permettant de traiter ou de detecter differentes maladies et infections du systeme urinaire WO2002071922A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002254167A AU2002254167A1 (en) 2001-03-13 2002-03-12 Intraurethral device for treating or detecting various diseases or infections of the urinary system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27538901P 2001-03-13 2001-03-13
US60/275,389 2001-03-13

Publications (2)

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WO2002071922A2 true WO2002071922A2 (fr) 2002-09-19
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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6899703B2 (en) 2001-03-13 2005-05-31 Clemson University Intraurethral device for treating or detecting various diseases or infections of the urinary system
US7847552B2 (en) 2007-01-10 2010-12-07 General Electric Company Exclusion of compromised PET data during simultaneous PET-MR acquisition

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110066137A1 (en) * 2007-12-18 2011-03-17 Osel, Inc. Applicator for applying powder formulations and uses thereof
BR112014003044B1 (pt) * 2011-08-29 2020-10-13 Coloplast A/S. kit de cateter
CN106345045A (zh) * 2016-10-18 2017-01-25 福建美菰林生物科技有限公司 一种阴道给药器

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117569A (en) * 1959-05-21 1964-01-14 Aurthur H Griep Indicator instrument
US5910316A (en) * 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5916176A (en) * 1994-08-25 1999-06-29 Caillouette; James C. Estrogen or estradiol need determination by vaginal or urethral acidity determination
US5954688A (en) * 1997-08-26 1999-09-21 Queen's University At Kingston Everting toroid device for delivering a drug into a body cavity

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4539234A (en) 1981-05-27 1985-09-03 Unitika Ltd. Urethral catheter capable of preventing urinary tract infection and process for producing the same
DK162185C (da) 1987-09-15 1998-02-23 Linda Jonasson Indretning til hindring af ufrivillig afgang af urin
WO1990004431A1 (fr) 1988-10-20 1990-05-03 Chen Fusen H Dispositif pour l'incontinence
US5306226A (en) 1989-02-09 1994-04-26 Salama Fouad A Urinary control with inflatable seal and method of using same
IL89297A0 (en) 1989-02-15 1989-09-10 Technion Res & Dev Foundation Auxilary intra-urethral magnetic valve for persons suffering from urinary incontinence
US5007897A (en) 1989-05-30 1991-04-16 Kalb Irvin M Drug delivery catheter
US5670111A (en) 1990-01-10 1997-09-23 Rochester Medical Corporation Method of shaping structures with an overcoat layer including female urinary catheter
US5114398A (en) 1990-02-27 1992-05-19 Medical Engineering Corporation Female incontinence control device with mechanically operable valve
US5090424A (en) 1990-12-31 1992-02-25 Uromed Corporation Conformable urethral plug
US5479945A (en) * 1990-12-31 1996-01-02 Uromed Corporation Method and a removable device which can be used for the self-administered treatment of urinary tract infections or other disorders
US5724994A (en) 1990-12-31 1998-03-10 Uromed Corporation Fluidly expandable urethral plug assembly which receives fluid from an external source and method for controlling urinary incontinence
US5140999A (en) 1991-09-30 1992-08-25 Primed International Corp. Urinary incontinence valve device
US5476434A (en) 1992-05-27 1995-12-19 Kalb; Irvin M. Female incontinence device including electronic sensors
BE1007071A3 (nl) * 1993-04-28 1995-03-07 Philips Electronics Nv Optische versterker.
US5788687A (en) 1994-02-01 1998-08-04 Caphco, Inc Compositions and devices for controlled release of active ingredients
US5554147A (en) 1994-02-01 1996-09-10 Caphco, Inc. Compositions and devices for controlled release of active ingredients
US5671755A (en) 1994-06-29 1997-09-30 Uromed Corporation Assembly and method for controlling urinary incontinence in humans
US5624395A (en) 1995-02-23 1997-04-29 Cv Dynamics, Inc. Urinary catheter having palpitatable valve and balloon and method for making same
US5813974A (en) 1995-12-19 1998-09-29 Dolade Guardia; Jose Manuel Device for women suffering from incontinence
US5906575A (en) 1996-04-25 1999-05-25 Rochester Medical Corporation Urethral urine retention device
US5959014A (en) 1996-05-07 1999-09-28 Emory University Water-stabilized organosilane compounds and methods for using the same
US5749826A (en) 1996-11-06 1998-05-12 Faulkner; James W. Urinary incontinence control device
US5887593A (en) 1997-01-28 1999-03-30 Levius; Dezso K. Urinary incontinence device
CA2285591A1 (fr) 1997-04-03 1998-10-08 Point Biomedical Corporation Systeme intravesical de liberation de medicaments
US5954869A (en) 1997-05-07 1999-09-21 Bioshield Technologies, Inc. Water-stabilized organosilane compounds and methods for using the same
US5806527A (en) 1997-06-04 1998-09-15 Borodulin; German Urethral plug with means for protection against infection
US5989179A (en) * 1997-07-07 1999-11-23 Hk Medical Technologies Incorporated Bladder control device housing and method
US5871016A (en) 1997-10-08 1999-02-16 Hk Medical Technologies Incorporated Bladder control device retainer and method
US6142928A (en) 1998-12-21 2000-11-07 Kimberly-Clark Worldwide, Inc. Urinary incontinence device and a method of making the same
US6090098A (en) 1998-12-21 2000-07-18 Kimberly-Clark Worldwide, Inc. Method for alleviating female urinary incontinence
US6090038A (en) 1998-12-21 2000-07-18 Kimberly-Clark Worldwide, Inc. Expandable dome-shaped urinary incontinence device and a method of making the same
US6171230B1 (en) 1999-03-04 2001-01-09 Canox International Ltd. Female incontinence catheter
US6440060B1 (en) 2000-03-08 2002-08-27 Clemson University Intra-urethral device for incontinence and method for making and using the same
US6558312B2 (en) 2001-03-13 2003-05-06 Clemson University Intraurethral device for incontinence
WO2002071922A2 (fr) 2001-03-13 2002-09-19 Clemson University Dispositif intra-uretral permettant de traiter ou de detecter differentes maladies et infections du systeme urinaire
US7267670B2 (en) * 2001-08-30 2007-09-11 Mulholland S Grant Reinforced urethral suppository

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117569A (en) * 1959-05-21 1964-01-14 Aurthur H Griep Indicator instrument
US5910316A (en) * 1992-08-24 1999-06-08 The United States Of America, As Represented By The Department Of Health And Human Services Use of nitric oxide-releasing agents to treat impotency
US5916176A (en) * 1994-08-25 1999-06-29 Caillouette; James C. Estrogen or estradiol need determination by vaginal or urethral acidity determination
US5954688A (en) * 1997-08-26 1999-09-21 Queen's University At Kingston Everting toroid device for delivering a drug into a body cavity

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6899703B2 (en) 2001-03-13 2005-05-31 Clemson University Intraurethral device for treating or detecting various diseases or infections of the urinary system
US7847552B2 (en) 2007-01-10 2010-12-07 General Electric Company Exclusion of compromised PET data during simultaneous PET-MR acquisition

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WO2002071922A3 (fr) 2003-02-27
US20020156458A1 (en) 2002-10-24
AU2002254167A1 (en) 2002-09-24
US6899703B2 (en) 2005-05-31

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