WO2002069883A3 - Cathecin derivatives as leukocyte elastase inhibitors for treating inflammatory disorders - Google Patents

Cathecin derivatives as leukocyte elastase inhibitors for treating inflammatory disorders Download PDF

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Publication number
WO2002069883A3
WO2002069883A3 PCT/IB2002/001877 IB0201877W WO02069883A3 WO 2002069883 A3 WO2002069883 A3 WO 2002069883A3 IB 0201877 W IB0201877 W IB 0201877W WO 02069883 A3 WO02069883 A3 WO 02069883A3
Authority
WO
WIPO (PCT)
Prior art keywords
inflammatory disorders
cathecin
derivatives
leukocyte elastase
treating inflammatory
Prior art date
Application number
PCT/IB2002/001877
Other languages
French (fr)
Other versions
WO2002069883A2 (en
Inventor
Spiridione Garbisa
Original Assignee
Univ Padova
Spiridione Garbisa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Padova, Spiridione Garbisa filed Critical Univ Padova
Publication of WO2002069883A2 publication Critical patent/WO2002069883A2/en
Publication of WO2002069883A3 publication Critical patent/WO2002069883A3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/12—Mucolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)

Abstract

The present invention is directed to a method for treatment of inflammatory disorders by inhibiting leukocyte elastase in a host in need thereof. The method includes the step of administering an effective amount of catechin, such as epigallocatechin-3-gallate or epigallocatechin, in pure form or in a pharmaceutically acceptable carrier. The catechin can be administered orally, topically, by injection, or by inhalation.
PCT/IB2002/001877 2001-02-06 2002-02-06 Cathecin derivatives as leukocyte elastase inhibitors for treating inflammatory disorders WO2002069883A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26684401P 2001-02-06 2001-02-06
US60/266,844 2001-02-06

Publications (2)

Publication Number Publication Date
WO2002069883A2 WO2002069883A2 (en) 2002-09-12
WO2002069883A3 true WO2002069883A3 (en) 2004-07-29

Family

ID=23016216

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2002/001877 WO2002069883A2 (en) 2001-02-06 2002-02-06 Cathecin derivatives as leukocyte elastase inhibitors for treating inflammatory disorders

Country Status (1)

Country Link
WO (1) WO2002069883A2 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2615444A1 (en) * 2005-07-15 2007-01-25 Donald J. Baker Compositions and methods for treating and preventing inflammatory and/or degenerative processes in humans and other animals
CN112724258A (en) * 2019-10-29 2021-04-30 深圳市第二人民医院 Composite polypeptide molecule for targeted killing of cancer cells and preparation method thereof
IT202000007816A1 (en) * 2020-04-14 2021-10-14 Adamas Biotech S R L CORONAVIRUS INHIBITOR MEDICAL DEVICE

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376653A (en) * 1991-12-30 1994-12-27 Sterling Winthrop Inc. 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors
EP0742012A2 (en) * 1995-05-10 1996-11-13 Kureha Chemical Industry Co., Ltd. Pharmaceutical composition containing substance inhibiting HSP47 production
GB2306231A (en) * 1995-10-13 1997-04-30 Sharp Kk Patterned optical polarising element
US5922756A (en) * 1998-02-14 1999-07-13 Chan; Marion Man-Ying Method of inhibiting nitric oxide synthase
WO2000074662A2 (en) * 1999-06-07 2000-12-14 University Of Sheffield Arthritis treatment

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376653A (en) * 1991-12-30 1994-12-27 Sterling Winthrop Inc. 2-saccharinylmethyl heterocyclic carboxylates useful as proteolytic enzyme inhibitors
EP0742012A2 (en) * 1995-05-10 1996-11-13 Kureha Chemical Industry Co., Ltd. Pharmaceutical composition containing substance inhibiting HSP47 production
GB2306231A (en) * 1995-10-13 1997-04-30 Sharp Kk Patterned optical polarising element
US5922756A (en) * 1998-02-14 1999-07-13 Chan; Marion Man-Ying Method of inhibiting nitric oxide synthase
WO2000074662A2 (en) * 1999-06-07 2000-12-14 University Of Sheffield Arthritis treatment

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DEMEULE M ET AL: "Matrix metalloproteinase inhibition by green tea catechins", BIOCHIMICA ET BIOPHYSICA ACTA. PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY, ELSEVIER, AMSTERDAM,, NL, vol. 1478, no. 1, 16 March 2000 (2000-03-16), pages 51 - 60, XP004278911, ISSN: 0167-4838 *

Also Published As

Publication number Publication date
WO2002069883A2 (en) 2002-09-12

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