WO2002067239A3 - Process for preparing intermediates of hiv protease inhibitors - Google Patents

Process for preparing intermediates of hiv protease inhibitors Download PDF

Info

Publication number
WO2002067239A3
WO2002067239A3 PCT/US2001/051428 US0151428W WO02067239A3 WO 2002067239 A3 WO2002067239 A3 WO 2002067239A3 US 0151428 W US0151428 W US 0151428W WO 02067239 A3 WO02067239 A3 WO 02067239A3
Authority
WO
WIPO (PCT)
Prior art keywords
protease inhibitors
hiv protease
preparing intermediates
intermediates
preparing
Prior art date
Application number
PCT/US2001/051428
Other languages
French (fr)
Other versions
WO2002067239A2 (en
Inventor
Roman Davis
Thomas Claiborne Lovelace
Original Assignee
Glaxo Group Ltd
Roman Davis
Thomas Claiborne Lovelace
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd, Roman Davis, Thomas Claiborne Lovelace filed Critical Glaxo Group Ltd
Priority to AU2002255473A priority Critical patent/AU2002255473A1/en
Priority to EP01271082A priority patent/EP1404680A2/en
Priority to JP2002566479A priority patent/JP2004519473A/en
Priority to US10/399,809 priority patent/US20040026230A1/en
Publication of WO2002067239A2 publication Critical patent/WO2002067239A2/en
Publication of WO2002067239A3 publication Critical patent/WO2002067239A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Abstract

The invention describes a method for effecting intramolecular cyclization reactions using light, in the absence of radical initiators, to provide useful polycyclic compounds.
PCT/US2001/051428 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors WO2002067239A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
AU2002255473A AU2002255473A1 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
EP01271082A EP1404680A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
JP2002566479A JP2004519473A (en) 2000-10-24 2001-10-22 Method for producing intermediate of HIV protease inhibitor
US10/399,809 US20040026230A1 (en) 2001-10-22 2001-10-22 Process for preparing intermediates of hiv protease inhibitors

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24282200P 2000-10-24 2000-10-24
US60/242,822 2000-10-24

Publications (2)

Publication Number Publication Date
WO2002067239A2 WO2002067239A2 (en) 2002-08-29
WO2002067239A3 true WO2002067239A3 (en) 2004-01-08

Family

ID=22916319

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/US2001/051428 WO2002067239A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors
PCT/US2001/046116 WO2002060905A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/US2001/046116 WO2002060905A2 (en) 2000-10-24 2001-10-22 Process for preparing intermediates of hiv protease inhibitors

Country Status (4)

Country Link
EP (1) EP1404680A2 (en)
JP (1) JP2004519473A (en)
AU (1) AU2002255473A1 (en)
WO (2) WO2002067239A2 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005533821A (en) * 2002-06-27 2005-11-10 スミスクライン ビーチャム コーポレーション Preparation of stereoisomers of (3α, 3α / β, 6α / β) hexahydrofuro [2,3-b] furan-3-ol
KR101429300B1 (en) 2006-03-29 2014-08-11 길리애드 사이언시즈, 인코포레이티드 Process for preparation of hiv protease inhibitors
DE602007012365D1 (en) 2006-11-09 2011-03-17 Little Island Co Cork PROCESS FOR PREPARING HEXAHYDROFUROA2,3-BÜFURAN-3-OL
CN103864813B (en) * 2012-12-18 2017-02-22 上海迪赛诺化学制药有限公司 Synthetic methods of hexahydrofuro[2,3-b]furan-3-ol and enantiomer thereof
CN107607635B (en) * 2017-08-15 2020-07-31 东北制药集团股份有限公司 Method for detecting content of propiolic alcohol in levophosphamide salt by adopting headspace gas chromatography
JP2023504546A (en) 2019-12-06 2023-02-03 バーテックス ファーマシューティカルズ インコーポレイテッド Substituted Tetrahydrofurans as Modulators of Sodium Channels
AR126073A1 (en) 2021-06-04 2023-09-06 Vertex Pharma N-(HYDROXYALKYL(HETERO)ARYL)TETRAHYDROFURAN CARBOXAMIDES AS SODIUM CHANNEL MODULATORS

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHIN-KANG SHA ET AL.: "Radical Cyclization of alpha-Iodo Enones by Photoinduced Electron Transfer Reaction", CHEM. COMMUN., 1998, pages 397 - 8, XP002214198 *
COSSY J ET AL: "An Approach to the Skeleton of Eriolanin", TETRAHEDRON LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 36, no. 12, 20 March 1995 (1995-03-20), pages 2067 - 2070, XP004028406, ISSN: 0040-4039 *
DULCÈRE, J.-P. ET AL.: "New Triethylamine induced Carbocycliation of beta-Bromopropargyl Ethers in the Pyrimidinedione Series", SYNLETT, 1995, pages 705 - 6, XP002214199 *
JANINE COSSY ET AL.: "Formation of Radicals by Irradiation of Alkyl Halides in the Presence of Triethylamine", TETRAHEDRON LETTERS, ELEVIER SCIENCE PUBLISHERS, AMSTERDAN, NL, vol. 35, no. 44, 1994, pages 8161 - 2, XP002214197 *

Also Published As

Publication number Publication date
JP2004519473A (en) 2004-07-02
AU2002255473A1 (en) 2002-09-04
WO2002067239A2 (en) 2002-08-29
WO2002060905A2 (en) 2002-08-08
EP1404680A2 (en) 2004-04-07

Similar Documents

Publication Publication Date Title
AU2002355718A1 (en) Laser spectral engineering for lithographic process
WO2004052850A3 (en) Methods and compounds producing dipeptidyl peptidase iv inhibitors and intermediates thereof
MY140593A (en) 2-oxo-1-pyrrolidine derivatives, process for preparing them and their uses
WO2003012100A3 (en) Method for the production of nucleic acids consisting of stochastically combined parts of source nucleic acids
WO2001077360A3 (en) Methods for ansamitocin production
WO2002067239A3 (en) Process for preparing intermediates of hiv protease inhibitors
AU6578400A (en) Novel method for preparing benzoperhydroisoindole compounds
HK1094575A1 (en) A process for the preparation of phenyltetrazole derivatives
AU2001272433A1 (en) Method for producing transition metal compounds and their use for the polymerization of olefins
WO2003024974A3 (en) Process for preparing protease inhibitor intermediates
HK1051558A1 (en) Method for the enzymatic resolution of the racemates of aminomethyl-aryl-cyclohexanol derivatives.
IL156331A0 (en) A process for the preparation of paclitaxel
AU2001250429A1 (en) Method for producing 2-alkyl-3-chlorophenols
WO2004011449A3 (en) Method for the production of phenylalanine derivatives
AU2002356488A1 (en) A method of alignment by using interferometry
WO2004018466A3 (en) A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
DK1444244T3 (en) Process for the preparation of desclarithromycin, as well as intermediates
WO2004096828A3 (en) Novel method and intermediates for the preparation of 19-nor-steroid compounds
AU6584601A (en) Method for producing indols
AU2002253800A1 (en) Process for preparing intermediates of hiv protease inhibitors
WO2004037170A3 (en) Process for making spirolactone compounds
MXPA03004534A (en) Novel compounds for use as hiv protease inhibitors.
AU2001294268A1 (en) Process for intramolecular radical cyclization
AU5925498A (en) Processes for producing 3-cyanopyridine from 2-methyl-1,5-pentanediamine
WO2002020490A3 (en) Process to produce halo-4-phenoxyquinolines

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PH PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
XX Miscellaneous:

Free format text: THE RECEIVING OFFICE HAS INFORMED THE IB THAT INTERNATIONAL APPLIC. PCT/US2001/046116 HAS BEEN ERRONEOUSLY ASSIGNED AN INTERNAT. FILING DATE AND IS VACATED AND REPLACED BY THIS INT. APPLICATION. THE NOTICE WAS RECEIVED BY THE IB IN TIME TO PREVENT THE INTERNATIONAL PUBLICATION, HOWEVER, DUE TO A CLERICAL ERROR, THE APPLICATION PCT/US2001/046116 WAS NEVERTHELESS PUBLISHED ON 20020808.

WWE Wipo information: entry into national phase

Ref document number: 2002566479

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 10399809

Country of ref document: US

WWE Wipo information: entry into national phase

Ref document number: 2001271082

Country of ref document: EP

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWP Wipo information: published in national office

Ref document number: 2001271082

Country of ref document: EP

WWW Wipo information: withdrawn in national office

Ref document number: 2001271082

Country of ref document: EP