WO2002066021A3 - Inhibitoren der protein kinase d und der protein kinase 2 als mittel zur hemmung von tumorzellen und zur stimulierung der angiogehese - Google Patents

Inhibitoren der protein kinase d und der protein kinase 2 als mittel zur hemmung von tumorzellen und zur stimulierung der angiogehese Download PDF

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Publication number
WO2002066021A3
WO2002066021A3 PCT/DE2002/000652 DE0200652W WO02066021A3 WO 2002066021 A3 WO2002066021 A3 WO 2002066021A3 DE 0200652 W DE0200652 W DE 0200652W WO 02066021 A3 WO02066021 A3 WO 02066021A3
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WO
WIPO (PCT)
Prior art keywords
inhibitors
protein kinase
agents
angiogenesis
tumour cells
Prior art date
Application number
PCT/DE2002/000652
Other languages
English (en)
French (fr)
Other versions
WO2002066021A2 (de
Inventor
Robert Preissner
Wolfgang Dubiell
Andrean Goede
Cornelius Froemmel
Original Assignee
Universitaetsklinikum Charite
Robert Preissner
Wolfgang Dubiell
Andrean Goede
Cornelius Froemmel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Universitaetsklinikum Charite, Robert Preissner, Wolfgang Dubiell, Andrean Goede, Cornelius Froemmel filed Critical Universitaetsklinikum Charite
Priority to AU2002252950A priority Critical patent/AU2002252950A1/en
Priority to DE10290562T priority patent/DE10290562D2/de
Publication of WO2002066021A2 publication Critical patent/WO2002066021A2/de
Publication of WO2002066021A3 publication Critical patent/WO2002066021A3/de

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/121—Ketones acyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Die Erfindung bezieht sich auf neue Mittel zur Beeinflussung des Tumorwachstums oder der Angiogenese. Als wirksame Mittel zur Hemmung des Tumorwachstums, der Tumorangiogenese und Metastasierung werden Inhibitoren der Protein Kinase D und der Protein Kinase 2, die mit dem COP9 Signalosom assoziiert sind (Zielkomplex), eingesetzt. Aktivatoren der Zielkomplex-assoziierten Kinasen dienen zur Aktivierung der Angiogenese. Die erfindungsgemässe Verwendung von Inhibitoren der Zielkomplex-assoziierten Kinasen liegt in der Auslösung von Apoptose in Tumorzellen sowie in der Hemmung der Tumorangiogenese und Metastasierung. Die Aktivatoren bewirken eine Förderung der Neubildung von Gefässen.
PCT/DE2002/000652 2001-02-22 2002-02-21 Inhibitoren der protein kinase d und der protein kinase 2 als mittel zur hemmung von tumorzellen und zur stimulierung der angiogehese WO2002066021A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2002252950A AU2002252950A1 (en) 2001-02-22 2002-02-21 Protein kinase d inhibitors and protein kinase 2 inhibitors as agents for inhibiting tumour cells and for stimulating angiogenesis
DE10290562T DE10290562D2 (de) 2001-02-22 2002-02-21 Zielkomplex als Mittel zur Hemmung von Tumorzellen und zur Stimulierung der Angiogenese

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10109883.9 2001-02-22
DE10109883 2001-02-22
DE10117266 2001-03-30
DE10117266.4 2001-03-30

Publications (2)

Publication Number Publication Date
WO2002066021A2 WO2002066021A2 (de) 2002-08-29
WO2002066021A3 true WO2002066021A3 (de) 2002-10-31

Family

ID=26008653

Family Applications (2)

Application Number Title Priority Date Filing Date
PCT/DE2002/000652 WO2002066021A2 (de) 2001-02-22 2002-02-21 Inhibitoren der protein kinase d und der protein kinase 2 als mittel zur hemmung von tumorzellen und zur stimulierung der angiogehese
PCT/DE2002/000653 WO2002066027A1 (de) 2001-02-22 2002-02-21 Mittel zur hemmung von tumorzellen

Family Applications After (1)

Application Number Title Priority Date Filing Date
PCT/DE2002/000653 WO2002066027A1 (de) 2001-02-22 2002-02-21 Mittel zur hemmung von tumorzellen

Country Status (3)

Country Link
AU (1) AU2002252950A1 (de)
DE (4) DE10207881A1 (de)
WO (2) WO2002066021A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10147088A1 (de) * 2001-09-25 2003-04-17 Medinnova Ges Med Innovationen Verwendung von Wirksubstanzen zur Prophylaxe und/oder Therapie von Erkrankungen, die mit Zellwachstumsstörungen einhergehen und Testsystem zum Auffinden solcher Wirksubstanzen
ES2245612B1 (es) * 2004-06-29 2007-08-16 Universidad De Barcelona Nuevo uso terapeutico del formoterol.
ITFI20050031A1 (it) * 2005-02-21 2006-08-22 Stefan Coccoloni Una composizione farmaceutica atta a prevenire l'invecchiamento e l'insorgere di malattie vascolari,neoplastiche,cutanee e dell'apparato pilifero
GB0625270D0 (en) * 2006-12-19 2007-01-31 Univ Leicester Angiogenesis
US9095606B1 (en) 2010-11-13 2015-08-04 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis
US9066974B1 (en) 2010-11-13 2015-06-30 Sirbal Ltd. Molecular and herbal combinations for treating psoriasis

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9003057D0 (sv) * 1990-09-26 1990-09-26 Astra Ab New process
US5135954A (en) * 1991-05-24 1992-08-04 The Regents Of The University Of California Use of formoterol for treatment of tissue injury

Non-Patent Citations (9)

* Cited by examiner, † Cited by third party
Title
DELMAS D ET AL: "RESVERATROL, AN EFFICIENT INHIB ITOR OF HUMAN COLORECTAL CANCER CELL PROLIFERATION", BIOLOGY OF THE CELL, ELSEVIER, PARIS, FR, vol. 2, no. 92, April 2000 (2000-04-01), pages 163, XP001069130, ISSN: 0248-4900 *
HSIEH TZE-CHEN ET AL: "Differential effects on growth, cell cycle arrest, and induction of apoptosis by resveratrol in human prostate cancer cell lines", EXPERIMENTAL CELL RESEARCH, SAN DIEGO, CA, US, vol. 249, no. 1, 25 May 1999 (1999-05-25), pages 109 - 115, XP002192994, ISSN: 0014-4827 *
KHAR A ET AL: "Antitumor activity of curcumin is mediated through the induction of apoptosis in AK-5 tumor cells", FEBS LETTERS, ELSEVIER SCIENCE PUBLISHERS, AMSTERDAM, NL, vol. 445, no. 1, 19 February 1999 (1999-02-19), pages 165 - 168, XP004259868, ISSN: 0014-5793 *
MEHTA K ET AL: "ANTIPROLIFERATIVE EFFECT OF CURCUMIN (DIFERULOYLMETHANE) AGAINST HUMAN BREAST TUMOR CELL LINES", ANTI-CANCER DRUGS, OXFORD, GB, vol. 8, June 1997 (1997-06-01), pages 470 - 481, XP000933933, ISSN: 0959-4973 *
MEISHIANG ET AL: "Cancer Chemopreventive Activity of Resveratrol, a natural product Derived from grapes", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 275, 10 January 1997 (1997-01-10), pages 218 - 220, XP002124508, ISSN: 0036-8075 *
STEELE V E ET AL: "CANCER CHEMOPREVENTION DRUG DEVELOPMENT STRATEGIES FOR RESVERATROL", PHARMACEUTICAL BIOLOGY, SWETS AND ZEITLINGER, LISSE,, NL, vol. 36, no. SUPPL, 1998, pages 62 - 68, XP000910995, ISSN: 1388-0209 *
UENO N T ET AL: "GROWTH SUPPRESSION OF LOW HER-2/NEU-EXPRESSING BREAST CANCER CELL LINE MDA-MB-435 BY TYROSINE KINASE INHIBITOR EMODIN", ONCOLOGY REPORTS, NATIONAL HELLENIC RESEARCH FOUNDATION, ATHENS, GR, vol. 3, no. 3, 1 May 1996 (1996-05-01), pages 509 - 511, XP000672384, ISSN: 1021-335X *
XIONG Y P ET AL: "MOLECULAR TARGETS OF RESVERATROL ON HUMAN COLON CANCER CELL LINES", PROCEEDINGS OF THE ANNUAL MEETING OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, NEW YORK, NY, US, vol. 55, no. 40, March 1999 (1999-03-01), pages 55, XP001063169, ISSN: 0197-016X *
ZHANG L ET AL: "SENSITIZATION OF HER-2/NEU-OVEREXPRESSING NON-SMALL CELL LUNG CANCER CELLS TO CHEMOTHERAPEUTIC DRUGS BY TYROSINE KINASE INHIBITOR EMODIN", ONCOGENE, BASINGSTOKE, HANTS, GB, vol. 12, no. 3, 1 February 1996 (1996-02-01), pages 571 - 576, XP000672224, ISSN: 0950-9232 *

Also Published As

Publication number Publication date
WO2002066027A1 (de) 2002-08-29
DE10207881A1 (de) 2003-02-13
DE10207882A1 (de) 2003-02-27
DE10290562D2 (de) 2004-04-29
AU2002252950A1 (en) 2002-09-04
WO2002066021A2 (de) 2002-08-29
DE10290563D2 (de) 2004-04-29

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