WO2002064776A3 - Signal transduction proteins 15b3, 15b3-1 and 15b3-2, and related dna sequences - Google Patents

Signal transduction proteins 15b3, 15b3-1 and 15b3-2, and related dna sequences Download PDF

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Publication number
WO2002064776A3
WO2002064776A3 PCT/EP2002/001562 EP0201562W WO02064776A3 WO 2002064776 A3 WO2002064776 A3 WO 2002064776A3 EP 0201562 W EP0201562 W EP 0201562W WO 02064776 A3 WO02064776 A3 WO 02064776A3
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WO
WIPO (PCT)
Prior art keywords
dna sequences
signal transduction
transduction proteins
gene products
related dna
Prior art date
Application number
PCT/EP2002/001562
Other languages
German (de)
French (fr)
Other versions
WO2002064776A2 (en
Inventor
Armin Schneider
Achim Fischer
Bettina Klausner
Moritz Rossner
Birgitta Kammandel
Rebecca Widenmeyer
Bernhard Goetz
Gisela Eisenhardt
Stephanie Jomana Naim
Dieter Newrzella
Original Assignee
Axaron Bioscience Ag
Armin Schneider
Achim Fischer
Bettina Klausner
Moritz Rossner
Birgitta Kammandel
Rebecca Widenmeyer
Bernhard Goetz
Gisela Eisenhardt
Stephanie Jomana Naim
Dieter Newrzella
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Axaron Bioscience Ag, Armin Schneider, Achim Fischer, Bettina Klausner, Moritz Rossner, Birgitta Kammandel, Rebecca Widenmeyer, Bernhard Goetz, Gisela Eisenhardt, Stephanie Jomana Naim, Dieter Newrzella filed Critical Axaron Bioscience Ag
Priority to AU2002250943A priority Critical patent/AU2002250943A1/en
Publication of WO2002064776A2 publication Critical patent/WO2002064776A2/en
Publication of WO2002064776A3 publication Critical patent/WO2002064776A3/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Psychiatry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

The invention relates to DNA sequences, expression vectors containing the inventive DNA sequences, host cells, gene products of the cited DNA sequences coding for signal transduction proteins, and other derivatives of the cited objects of the invention. Said DNA sequences and gene products either have a protective action, i.e. impart a certain resistance to apoplexy, or they cause an increase in ischaemic damage. The invention also relates to the use of the inventive DNA sequences or the signal transduction proteins expressed by said DNA sequences as pharmaceuticals, and to the non-therapeutic uses of the inventive DNA sequences or gene products.
PCT/EP2002/001562 2001-02-14 2002-02-14 Signal transduction proteins 15b3, 15b3-1 and 15b3-2, and related dna sequences WO2002064776A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2002250943A AU2002250943A1 (en) 2001-02-14 2002-02-14 Signal transduction proteins 15b3, 15b3-1 and 15b3-2, and related dna sequences

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10106835.2 2001-02-14
DE10106835A DE10106835A1 (en) 2001-02-14 2001-02-14 Signal transduction proteins 15B3, 15B3-1 and 15B3-2 and underlying DNA sequences

Publications (2)

Publication Number Publication Date
WO2002064776A2 WO2002064776A2 (en) 2002-08-22
WO2002064776A3 true WO2002064776A3 (en) 2003-08-21

Family

ID=7674010

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/001562 WO2002064776A2 (en) 2001-02-14 2002-02-14 Signal transduction proteins 15b3, 15b3-1 and 15b3-2, and related dna sequences

Country Status (3)

Country Link
AU (1) AU2002250943A1 (en)
DE (1) DE10106835A1 (en)
WO (1) WO2002064776A2 (en)

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037210A1 (en) * 1997-02-21 1998-08-27 KANTON ZÜRICH vertreten durch DIE ERZIEHUNGSDIREKTION Immunological detection of prions
WO1999014328A2 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001004311A1 (en) * 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001022920A2 (en) * 1999-09-29 2001-04-05 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
WO2001055326A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
EP1130094A2 (en) * 1999-07-08 2001-09-05 Helix Research Institute Primers for synthesizing full length cDNA clones and their use
WO2001068848A2 (en) * 2000-03-01 2001-09-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001090304A2 (en) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001093983A1 (en) * 2000-06-02 2001-12-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002000690A2 (en) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2002008288A2 (en) * 2000-07-20 2002-01-31 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998037210A1 (en) * 1997-02-21 1998-08-27 KANTON ZÜRICH vertreten durch DIE ERZIEHUNGSDIREKTION Immunological detection of prions
WO1999014328A2 (en) * 1997-09-17 1999-03-25 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001004311A1 (en) * 1999-07-07 2001-01-18 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
EP1130094A2 (en) * 1999-07-08 2001-09-05 Helix Research Institute Primers for synthesizing full length cDNA clones and their use
EP1074617A2 (en) * 1999-07-29 2001-02-07 Helix Research Institute Primers for synthesising full-length cDNA and their use
WO2001022920A2 (en) * 1999-09-29 2001-04-05 Human Genome Sciences, Inc. Colon and colon cancer associated polynucleotides and polypeptides
WO2001055326A2 (en) * 2000-01-31 2001-08-02 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001068848A2 (en) * 2000-03-01 2001-09-20 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001090304A2 (en) * 2000-05-19 2001-11-29 Human Genome Sciences, Inc. Nucleic acids, proteins, and antibodies
WO2001093983A1 (en) * 2000-06-02 2001-12-13 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2002000690A2 (en) * 2000-06-23 2002-01-03 Genentech, Inc. Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
WO2002008288A2 (en) * 2000-07-20 2002-01-31 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same

Non-Patent Citations (11)

* Cited by examiner, † Cited by third party
Title
DATABASE EPOP [online] 1 March 2002 (2002-03-01), BAKER K.P. ET AL.: "Secreted and transmembrane polypeptides and nucleic acids encoding the same", XP002214593, Database accession no. AX376345 *
DATABASE EPOP [online] 13 February 2002 (2002-02-13), BAKER K.P. ET AL.: "Secreted and transmembrane polypeptides and nucleic acids encoding the same", XP002214597, Database accession no. AX358871 *
DATABASE EPOP [online] 15 February 2002 (2002-02-15), BAKER K.P. ET AL.: "Secreted and transmembrane polypeptides and nucleic acids encoding the same", XP002214596, Database accession no. AX362364 *
DATABASE GSP [online] 16 May 2002 (2002-05-16), BAKER K.P.: "Human PRO247 protein sequence SEQ ID NO:40", XP002214595, Database accession no. ABB84836 *
DATABASE GSP [online] 24 April 2001 (2001-04-24), ASHKENAZI A.J. ET AL.: "Human PRO247 protein", XP002214589, Database accession no. AAB80254 *
DATABASE GSP [online] 24 May 2002 (2002-05-24), BIRSE C.E. ET AL.: "Human polypeptide SEQ ID NO:2312", XP002214598, Database accession no. ABB89936 *
DATABASE GSP [online] 26 June 2001 (2001-06-26), OTA T. ET AL.: "Human protein sequence SEQ ID NO:14536", XP002214592, Database accession no. AAB94199 *
DATABASE GSP [online] 3 September 2001 (2001-09-03), RUBEN S.M. ET AL.: "Human colon cancer antigen protein SEQ ID NO:6177", XP002214590, Database accession no. AAG75413 *
DATABASE GSP [online] 4 December 2001 (2001-12-04), ROSEN C.A. ET AL.: "Human secreted protein SEQ ID NO:418", XP002214594, Database accession no. AAU20426 *
DATABASE GSP [online] 6 November 2001 (2001-11-06), OTA T. ET AL.: "Human polypeptide SEQ ID NO:3764", XP002214591, Database accession no. AAM93765 *
NAGASE T ET AL: "PREDICTION OF THE CODING SEQUENCES OF UNIDENTIFIED HUMAN GENES. XVI THE COMPLETE SEQUENCES OF 150 NEW CDNA CLONES FROM BRAIN WHICH CODE FOR LARGE PROTEINS IN VITRO", DNA RESEARCH, vol. 7, 2000, pages 65 - 73, XP000949814, ISSN: 1340-2838 *

Also Published As

Publication number Publication date
WO2002064776A2 (en) 2002-08-22
AU2002250943A1 (en) 2002-08-28
DE10106835A1 (en) 2002-09-05

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