WO2002064036A1 - Appareil et procede pour recueillir le sang residuel a partir du placenta - Google Patents

Appareil et procede pour recueillir le sang residuel a partir du placenta Download PDF

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Publication number
WO2002064036A1
WO2002064036A1 PCT/CN2001/000124 CN0100124W WO02064036A1 WO 2002064036 A1 WO2002064036 A1 WO 2002064036A1 CN 0100124 W CN0100124 W CN 0100124W WO 02064036 A1 WO02064036 A1 WO 02064036A1
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WO
WIPO (PCT)
Prior art keywords
placenta
bag
blood
catheter
port
Prior art date
Application number
PCT/CN2001/000124
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English (en)
Chinese (zh)
Inventor
Dao-Pei Lu
Yi-Lan Wang
Kai Sun
Original Assignee
Dao-Pei Lu
Yi-Lan Wang
Kai Sun
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dao-Pei Lu, Yi-Lan Wang, Kai Sun filed Critical Dao-Pei Lu
Priority to CNA018226264A priority Critical patent/CN1489448A/zh
Priority to PCT/CN2001/000124 priority patent/WO2002064036A1/fr
Publication of WO2002064036A1 publication Critical patent/WO2002064036A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/02—Blood transfusion apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/80—Suction pumps
    • A61M1/81—Piston pumps, e.g. syringes

Definitions

  • the invention belongs to the field of clinical umbilical-placental blood hematopoietic stem cell collection, and more particularly, is a method and a collecting device for collecting placental residual blood. Background technique
  • Hematopoietic stem cell transplantation of bone marrow and peripheral blood has become one of the major advances in the field of hematopoietic stem cell transplantation in the past 10 years. Especially in China, with the increase of single-child families, the proportion of bone marrow donors will decrease. Hematopoietic stem cell transplantation has its unique practical value and shows broad prospects for clinical application.
  • the number of hematopoietic cells in a single cord blood can basically meet the needs of children who undergo stem cell transplantation. However, for adolescents and adult patients who are heavier, the number of hematopoietic cells in a single cord blood has become a major limiting factor.
  • the umbilical cord blood transplantation that has been carried out basically remains in childhood.
  • a certain amount of fetal blood remaining in the placenta is an important supplement to umbilical cord blood, but there is still no satisfactory method for collecting placental residual blood.
  • the two-stage method of cord blood-placental blood collection proposed by Broxmeyer is generally used (see Shen Baijun Et al. "Basics of Human Cord Blood. Clinical", Tianjin Science and Technology Press, 1995, pp. 104-105), the first stage is to collect cord blood from the umbilical cord during the placenta delivery, and the second stage is to puncture multiple times with a syringe needle Placental surface veins are used to obtain the remaining blood in the placenta.
  • the umbilical artery is injected with saline through the catheter to flush the umbilical blood vessels and placenta, and the umbilical blood is collected from the umbilical vein.
  • This method maximizes Hematopoietic cells are collected, but the umbilical artery is thin and curved, making the intubation operation extremely time-consuming.
  • the placenta is delivered, the remaining blood in the placenta usually physiologically coagulates within five to ten minutes, especially at low temperatures. The success rate of placenta remaining blood is low; no clinical application has been reported.
  • the purpose of the present invention is to provide a method for collecting placental residual blood, which can be used to collect more placental residual blood to meet the needs of adolescents and adult patients who are heavier in weight.
  • Another object of the present invention is to provide a device for collecting placental residual blood, which can implement the above method and collect more placental residual blood to meet the needs of adolescents and adult patients who are heavier in weight.
  • the invention considers the physiological characteristics of the placenta in the uterus, and realizes a method capable of collecting more placenta remaining blood by simulating the environmental conditions of the placenta in the uterus.
  • the present invention provides a method for collecting placenta residual blood, which includes the following steps: a) Place the placenta that has just been delivered into a uterine simulation bag, the uterine simulation bag has a flexible bag body, and the temperature of the bag body is maintained at 30 ° C--45 ° C;
  • This collection method can simulate the environmental conditions of the placenta in the uterus, ensure blood circulation in the placenta, and collect more residual blood from the placenta.
  • the temperature of the bag body is maintained at 30. C—45. Between C, the placenta can be kept in the uterus at the same temperature as the body temperature, so that the blood in the placenta will not coagulate.
  • Aseptic collection The placenta is enclosed in the bag with the help of a uterine simulation bag, which is more exposed to the air than other placenta collection methods, and its aseptic conditions are more complete. Moreover, with the protection of the bag body, it is avoided to directly squeeze the placenta, which is also beneficial for aseptic collection.
  • the method for collecting placental residual blood of the present invention can be further developed:
  • the uterine simulation bag can be set as follows: the uterine simulation bag is a silent layer bag made of a flexible material; the flexible material is rubber, plastic or plastic. Further, an opening is formed on the outer layer of the double-layer bag, and the opening is reversibly sealed, such as plugging or clamping with a clip; or the opening edge of the uterine simulation bag is set as a closing structure.
  • the uterine simulation bag is also set up as follows: the opening side of the uterine simulation bag is provided with an extended closed edge or an openable structure, and the bag body is provided with an opening to facilitate the umbilical cord on the placenta when the placenta is inserted into the bag body. Stick out from it.
  • the temperature of the uterine simulation bag is filled with 30 in the interlayer of the double-layer bag.
  • the liquid is physiological saline or sterilized purified water.
  • the liquid can be injected in a variety of ways. This is known to those skilled in the art.
  • the present invention does not limit the method of liquid injection.
  • the extraction device connected to the catheter is a syringe.
  • the catheter connected between the syringe and the umbilical vein is provided with a three-way joint
  • the third port of the three-way joint is connected with a blood bag
  • the three-way joint is provided with a transfer switch;
  • a changeover switch will drain the placental blood drawn from the umbilical vein into the syringe into the iliac blood bag.
  • the transfer switch can be implemented in various ways.
  • a section of the transfer switch is a round pipe, and a plane formed by three ports of the vertical tee joint can be rotatably extended into the tee joint, and the wall of the round pipe There are at least two notches or holes.
  • the other section of the rotary switch is a handle. Turn the handle to change the alignment direction of the notches or holes on the wall of the circular tube, and connect two ports of the tee joint.
  • the extraction device connected to the duct may also be an air pump provided with an air inlet and an air outlet.
  • the air inlet of the air exhaust pump is provided with an air inlet check valve.
  • the air port is provided with an air outlet check valve, the air inlet is connected to a catheter connected to the umbilical vein, and a blood collection bag is connected to the air outlet. Because placenta usually solidifies in about 5-10 minutes after delivery, especially at low temperatures.
  • an extraction device was used to connect the iliac vein and iliac blood bag on the placenta through a catheter during the collection of placental blood. Therefore, it is ensured that the blood is aseptically collected into the blood collection bag containing anticoagulant within 5 minutes after the placenta is delivered.
  • the temperature of the bag body is preferably maintained at 36 °. C—42. Between C.
  • the temperature of the bag body is preferably 40 ° C.
  • the catheter inserted into the umbilical vein of the umbilical section of the placenta The catheter wall of the port is provided with at least one gap to form a split structure to prevent the port of the catheter from being blocked by the umbilical vein wall. It can also be set as follows: at least one opening is provided in the catheter wall near the port of the catheter inserted in the umbilical vein of the umbilical section of the placenta to prevent the port of the catheter from being blocked by the umbilical vein wall.
  • the catheter inserted into the umbilical vein of the umbilical section of the placenta is double-layered at the portion near the port or a section of the catheter from the portion near the port, and the outer layer of the catheter near the port is partially provided It is a thin wall, and an air inlet is provided on the outer layer of the catheter.
  • the gas is filled into the interlayer of the catheter wall from the air inlet, the local thin wall swells to form a gas sacral, which tightly combines the outer layer of the catheter with the umbilical vein.
  • the inner layer of the catheter is not excessively compressed.
  • the catheter is very easy to slide in the umbilical vein at the base of the placenta.
  • a double-layered catheter is inserted into the confluence of the umbilical vein at the base of the placenta, and then the gas is filled with gas.
  • the purpose of fixing the catheter and blocking the umbilical artery blood flow is achieved, and the placental base
  • the umbilical vein confluence often collapses due to negative pressure suction blood collection, blocking the venous blood return, and setting the catheter before the urinary catheter is stent-like or openings in the front section of the catheter, which significantly improves the phenomenon of venous blood return obstruction. .
  • the invention also provides a collection device for placenta residual blood, which is provided with: a uterine simulation bag, the uterine simulation bag is a flexible bag body, and the temperature of the bag body is maintained at 30. C- -45. Between C
  • the extraction device is connected with a catheter which can be inserted into the umbilical vein of the umbilical cord section of the placenta.
  • the collecting device of the present invention can be further developed:
  • the uterine simulation bag in the acquisition device of the present invention may be set as follows:
  • the uterine simulation bag is a double-layer bag made of a flexible material. Further, the flexible material is rubber, plastic or plastic.
  • the double-layer bag has an opening on the outer layer, and is reversibly sealed on the opening, such as a plug, Or clamp it with a clip.
  • the interlayer of the double-layer bag body is filled with 30 ° C- -45. C of liquid.
  • the liquid is physiological saline or purified water after disinfection.
  • the uterine simulation bag in the acquisition device of the present invention may also be set as follows:
  • the opening edge of the uterine simulation bag is set as a closing structure.
  • the opening edge of the uterine simulation bag is provided with an extended closing edge or an openable structure, and the bag body is further provided with an opening from which the umbilical cord on the placenta protrudes when the placenta is inserted into the bag body.
  • the extraction device may be a syringe, and a tee joint is provided on a catheter connected between the syringe and the umbilical vein, and a blood collection bag is connected to a third port of the tee joint,
  • the three-way joint is provided with a changeover switch for controlling the conduction of the port; a section of the changeover switch is set as a round pipe, and a plane formed by three ports of the vertical three-way joint rotatably extends into the three-way joint, and the wall of the round pipe
  • the extraction device may also be an air pump provided with an air inlet and an air outlet.
  • the air inlet of the air exhaust pump is provided with an air inlet check valve, and the air outlet is provided with an air outlet.
  • the inlet valve is connected to a catheter connected to the umbilical vein, and a blood collection bag is connected to the outlet.
  • At least one notch is provided in the catheter wall of the port of the umbilical vein inserted into the umbilical vein section of the placenta to form a split structure to prevent the port of the catheter from being blocked by the wall of the umbilical vein.
  • At least one opening is provided on a catheter wall of the umbilical vein of the umbilical vein inserted into the umbilical cross section of the placenta to prevent the port of the catheter from being blocked by the umbilical vein wall.
  • the catheter inserted into the umbilical vein of the umbilical cord section of the placenta is double-layered at the portion near the port or a section of the catheter from the portion near the port, and the outer layer of the catheter is provided with an inlet.
  • the air outlet, the outer layer of the duct close to the port is partially thin-walled and guided from the air inlet.
  • FIG. 1 is a flowchart of a method for collecting placental residual blood according to the present invention
  • Figure 2 is a schematic diagram of a section of the umbilical cord
  • FIG. 3 is a first schematic structural diagram of a placenta residual blood collection device according to the present invention.
  • FIG. 4 is a schematic diagram of a second structure of a placenta residual blood collection device according to the present invention.
  • FIG. 5 is a schematic diagram of a first structure of a uterine simulation bag of a placenta residual blood collection device according to the present invention.
  • FIG. 6 is a schematic diagram of a second structure of a uterine simulation bag of the placenta residual blood collection device of the present invention.
  • FIG. 7 is a sectional view of a catheter of a placenta residual blood collection device of the present invention.
  • FIG. 8 is an inhalation state of a first structure of a tee joint of a placenta residual blood collection device of the present invention
  • FIG. 9 is a state of discharge of a first structure of a tee joint of a placenta residual blood collection device of the present invention.
  • FIG. 11 is a suction state of the two structures of the tee joint of the placenta residual blood collection device of the present invention.
  • FIG. 13 is a closed state of the second structure of the tee joint of the placenta residual blood collection device of the present invention
  • FIG. 14 is a schematic structural diagram of an air pump as an extraction device of the placenta residual blood collection device of the present invention.
  • the method for collecting placenta remaining blood is a method for further collecting blood remaining inside the placenta after the collection of conventional cord blood.
  • the operation should be performed under sterile conditions, and during the operation, it can be sterilized by conventional disinfection methods, such as ethylene oxide sterilization and disinfection.
  • the distal end of the umbilical cord is clamped with sterile hemostatic forceps.
  • the placenta is delivered, the remaining blood of the placenta is collected.
  • the method includes the following steps:
  • the uterine simulation bag 1 has a flexible bag body, and the temperature of the bag body is controlled at 30. C—45. C; wherein, the uterine simulation bag 1 may be a double-layer bag made of a flexible material.
  • the flexible material may be a material such as rubber, plastic, or plastic.
  • a polyvinyl chloride plastic used for preparing a blood collection bag may be selected.
  • the temperature of the uterine simulation bag is filled with 30 in the interlayer of the double bag. C-45. C's liquid remains.
  • the outer layer 12 of the double-layer bag has an opening, and a plug 16 is plugged into the opening.
  • a liquid 14 of a certain temperature is injected from the opening 16 of the outer layer 12 to keep the uterine simulation bag 1 at a certain temperature.
  • the liquid may be physiological saline or pure water after disinfection, as shown in FIG. 5.
  • the opening edge of the uterine simulation bag is set as a closing structure.
  • the closing structure preferably has elasticity.
  • the closing structure closes the placenta in the bag body and isolates it from the outside world to make the aseptic condition more perfect. This can also be done:
  • the opening 13 of the uterine simulation bag is provided with an extended closed edge 131 or an openable structure.
  • the openable structure is provided with a convex edge 132 on the inner wall of one side of the opening, corresponding to one side.
  • a groove 133 is provided on the inner wall, and the convex edge 132 can be snapped into or pulled out from the groove 133 so as to be opened.
  • the bag body is also provided with an opening 15 so that when the placenta is inserted into the bag body, the umbilical cord on the placenta protrudes therefrom. With this structure, the placenta is enclosed in the bag body and isolated from the outside world, so that the aseptic conditions are more perfect.
  • the extraction device may be connected to the blood collection bag through a catheter, and the blood is repeatedly extracted from the placenta through a one-way switching channel, and discharged into the blood collection bag.
  • the extraction device 3 connected to the catheter may be a syringe, as shown in FIG. 3.
  • the catheter 2 connected between the syringe and the umbilical vein V is provided with a three-way joint 5, the third port 55 of the three-way joint 5 is connected to a blood collection bag 4, and the three-way joint 5 is provided with a transfer switch;
  • the change-over switch 52 on the connector 5 discharges the placental blood drawn from the umbilical vein V into the syringe into the blood collection bag 4.
  • the 52-section of the transfer switch is a round pipe, and a plane formed by three ports of the vertical tee joint rotatably extends into the tee joint 5.
  • the wall of the round pipe is provided with at least two notches or holes to rotate.
  • the other part of the switch is the handle 56. Turn the handle to change the alignment of the notches or holes on the wall of the tube, and connect two ports of the tee joint.
  • the present invention provides two embodiments for illustration. 8 to FIG. 13, wherein FIG. 8 to FIG. 10 are the first structure. 8 is an inhalation state of a first structure of a tee joint of a placental residual blood collection device of the present invention; FIG.
  • FIG. 9 is an exhaust state of a first structure of a tee joint of a placental residual blood collection device of the present invention
  • FIG. 10 is a closed state of a first structure of a tee joint of a placenta residual blood collection device of the present invention.
  • the three The through joint is provided with a housing 51, and three ports 511, 512, and 513 are connected to the housing.
  • a changeover switch 52 is provided in the housing, and the changeover switch is provided with three openings 521, 522, and 523.
  • the changeover switch 52 can be rotated in the housing by turning the handle 56 connected to the changeover switch to change the alignment relationship between the opening on the changeover switch and the port on the housing to achieve the placenta drawn from the umbilical vein V into the syringe Blood is drained into the blood collection bag 4.
  • the opening 521 is aligned with the port 511, and the opening 523 is aligned with the port 513, so that the port 511 of the tee communicates with the port 513, the port 512 and the ports 511 and 513 are cut off, and placental blood can flow in from the port 513 511, Placental blood is drawn into the syringe. As shown in FIG.
  • the opening 522 is aligned with the port 511, and the opening 521 is aligned with the port 512, so that the port 511 of the tee is in communication with the port 512, the port 513 and ports 511 and 512 are cut off, and placental blood can flow from the port 511 512, Placental blood is drained from the syringe.
  • each opening of the transfer switch is not aligned with any port on the housing, and the three-way joint is in a cut-off state.
  • 11 to 13 show a second structure of the three-way joint. 11 is an inhalation state of the second structure of the tee joint of the placental residual blood collection device of the present invention; FIG.
  • FIG. 12 is an exhaust state of the second structure of the tee joint of the placental residual blood collection device of the present invention
  • FIG. 13 is a closed state of the second structure of the tee joint of the placenta residual blood collection device of the present invention.
  • the tee joint is provided with a housing 51, and three ports 511, 512, and 513 are connected to the housing.
  • a changeover switch 52 is provided in the casing, and the changeover switch is provided with two openings 521 and 522.
  • the switch 56 can be rotated in the housing by turning the handle 56 connected to the switch to change the alignment relationship between the opening on the switch and the port on the housing, so as to achieve the Placental blood is drained into the blood collection bag 4.
  • Port 512 of the three-way connector is connected to a syringe
  • port 511 is connected to a blood collection bag
  • port 513 is connected to a catheter for extracting placental blood from the umbilical vein.
  • the opening 521 is aligned with the port 512
  • the opening 522 is aligned with the port 513, so that the port 512 of the tee is in communication with the port 513, the port 511 and ports 512 and 513 are cut off, and placental blood can flow in from the port 513 512, inhaled Placental blood to the syringe.
  • the opening 522 is aligned with the port 512, and the opening 521 is aligned with the port 511, so that the port 511 of the tee is in communication with the port 512, the port 513 and ports 511 and 512 are cut off, and placental blood can flow from the port 512 511.
  • the placental blood is discharged from the syringe to the blood collection bag.
  • each opening of the transfer switch is not aligned with any port on the housing, and the three-way joint is in a cut-off state.
  • the temperature of the uterine simulation bag is controlled between 30 ° C and 45 ° C, and the temperature of the bag body is preferably maintained at 36 ° C. C-42. Between C, the optimal bag temperature is 40 ° C. C, can be controlled by the temperature of the liquid filled in the bag sandwich.
  • the bag body intermittently extruding the placenta through the uterine simulation bag is an extrusion that simulates the uterine contraction tension, which is helpful for the collection of placental blood.
  • the catheter wall of the port 26 of the umbilical vein inserted into the umbilical vein section of the placenta is provided with at least one gap 23 to form a split structure to prevent the port of the catheter from being blocked by the umbilical vein wall.
  • At least one opening 22 is provided on the catheter wall near the end of the catheter in the umbilical vein inserted into the umbilical section of the placenta to prevent the port of the catheter from being blocked by the umbilical vein wall.
  • the portion of the catheter 1 inserted into the umbilical vein of the umbilical section of the placenta near the port 26 or a section of the catheter from the portion near the port 26 is set as a double layer 241, 242 near the port 26
  • the outer layer 241 of the duct 2 is partially set as a thin wall 243.
  • the outer layer 241 of the duct 2 is provided with an air inlet 21, and an air inlet check valve is provided at the air inlet 21. As shown in the figure, it may be an elastomer.
  • the center of the elastic body is provided with a vent hole 211, the vent hole is wedge-shaped, the outer end becomes larger, the inner end becomes smaller, and the inner end is closed and abutted; when inflated, the tip port of the air needle or the injection tip port of the syringe passes from the vent
  • the air hole 211 is squeezed in, inflated into the interlayer, and the thin wall 243 is bulged. While maintaining the high pressure in the interlayer, the air needle or syringe is pulled out. At this time, the gas does not leak out, and the thin wall 243 remains bulged. status.
  • Example 2 of a method for collecting placenta residual blood
  • FIG. 4 is a schematic diagram of a second structure of the placenta residual blood collection device of the present invention.
  • the steps of this embodiment and the collection method of the above embodiment are basically the same, except that the structure of the bag body of the uterine simulation bag and the structure of the extraction device are different. At the same time, the tee joint is eliminated, and the blood collection bag is directly connected. On the air pump as a suction device.
  • the uterine simulation bag 1 has a flexible bag body, and the temperature of the bag body is controlled at 30. C—45. Between C; wherein, the uterine simulation bag 1 may be a Han-layer bag made of a flexible material, with an inner layer of 11 and an outer layer of 12.
  • the flexible material may be a material such as rubber, plastic, or plastic.
  • a polyvinyl chloride plastic used for preparing a blood collection bag may be selected.
  • the temperature of the uterine simulation bag is maintained by providing a heating device 16 or a heating device in the interlayer of the silent bag, such as an electric heating wire 16, or other methods known to those skilled in the art.
  • the extraction device 3 connected to the duct is an air pump provided with an air inlet 32 and an air outlet 33, and the air inlet 32 of the air exhaust pump is provided with an air inlet check valve 321
  • the air outlet 33 is provided with an air outlet check valve 331, the air inlet 32 is connected to one end 25 of the catheter 2 connected to the umbilical vein, and the air outlet 33 is connected to the blood collection bag 4.
  • the air pump is provided with a pump body 31, and a piston 34 is provided in the pump body.
  • a push rod 35 is connected to the piston 34, and the push rod 35 extends from an end of the pump body opposite to the air inlet and the air outlet.
  • a collection device for placenta residual blood is provided with:
  • a uterine simulation bag which is a flexible bag body, which is provided with a temperature control device; an extraction device, which is connected with a catheter that can be inserted into the umbilical vein of the umbilical cord section of the placenta.
  • the uterine simulation bag 1 may be a Han bag made of a flexible material.
  • the flexible material may be a material such as rubber, plastic, or plastic, such as a polyvinyl chloride plastic used for preparing a blood collection bag.
  • the temperature control device of the uterine simulation bag can be a liquid maintained at a certain temperature in the interlayer of the silent bag body and the double-layer bag body, that is, the temperature of the uterine simulation bag is filled with the interlayer of the double-layer bag.
  • An opening is formed on the outer layer 12 of the double-layer bag, and a plug 16 is plugged on the opening.
  • a liquid 14 of a certain temperature is injected from the opening 16 of the outer layer 12 to keep the uterine simulation bag 1 at a certain temperature.
  • the liquid may be physiological saline or sterilized pure water, as shown in FIG. 5.
  • the other end 25 of the catheter 1 is connected to an extraction device 3, and the placental blood is withdrawn from the umbilical vein V by the extraction device 3;
  • the opening edge of the uterine simulation bag is set as a closing structure.
  • the closing structure preferably has elasticity.
  • the opening 13 of the uterine simulation bag is provided with an extended closed edge 131 or an openable structure, and the openable structure is provided with a convex edge 132 on the inner wall of one side of the opening.
  • a groove 133 is provided on the inner wall of the corresponding side, and the convex edge 132 can be snapped into or removed from the groove 133 to achieve unsealing.
  • the bag body is also provided with an opening 15 so that when the placenta is inserted into the bag body, the umbilical cord on the placenta protrudes from it. With this structure, the placenta is enclosed in the bag body and isolated from the outside world. Make the aseptic conditions more perfect.
  • the extraction device may be connected to the blood collection bag through a catheter.
  • the extraction device 3 connected to the catheter may be a syringe, as shown in FIG. 3.
  • the catheter 2 connected between the syringe and the umbilical vein V is provided with a three-way joint 5.
  • the third port 55 of the three-way joint 5 is connected with a blood collection bag 4, and the three-way joint 5 is provided with a transfer switch.
  • the changeover switch 52 on the through connector 5 discharges the placental blood drawn from the umbilical vein V into the syringe into the blood collection bag 4.
  • the section of the changeover switch 52 is a round pipe, and a plane formed by three ports of the vertical tee joint rotatably extends into the tee joint 5.
  • the wall of the round pipe is provided with at least two notches or holes to rotate.
  • the other part of the switch is the handle 56. Turn the handle to change the alignment of the notches or holes on the wall of the tube, and connect two ports of the tee joint.
  • the present invention provides two embodiments for illustration. 8 to FIG. 13, wherein FIG. 8 to FIG. 10 are the first structure. 8 is an inhalation state of a first structure of a tee joint of a placental residual blood collection device of the present invention; FIG. 9 is an exhaust state of a first structure of a tee joint of a placental residual blood collection device of the present invention; FIG.
  • the tee joint is provided with a housing 51, and three ports 511, 512, and 513 are connected to the housing.
  • a changeover switch 52 is provided in the housing, and the changeover switch is provided with three openings 521, 522, and 523.
  • the changeover switch 52 can be rotated in the housing by turning the handle 56 connected to the changeover switch to change the alignment relationship between the opening on the changeover switch and the port on the housing to achieve the placenta drawn from the umbilical vein V into the syringe. Blood is drained into the blood collection bag 4.
  • the opening 521 is aligned with the port 511
  • the opening 523 is aligned with the port 513, so that the port 511 of the tee communicates with the port 513, the port 512 and the ports 511 and 513 are cut off, and placental blood can flow in from the port 513 511. Placental blood is drawn into the syringe. As shown in FIG.
  • the opening 522 is aligned with the port 511, and the opening 521 is aligned with the port 512, so that the port 511 of the tee is in communication with the port 512, the port 513 and ports 511 and 512 are both cut off, and placental blood can flow from the port 511 512, Placental blood is drained from the syringe.
  • each opening of the transfer switch is misaligned with any port on the housing, and the tee joint is in a cut-off state.
  • 11 to 13 show a second structure of the three-way joint. 11 is an inhalation state of the second structure of the tee joint of the placental residual blood collection device of the present invention; FIG.
  • FIG. 12 is an exhaust state of the second structure of the tee joint of the placental residual blood collection device of the present invention
  • FIG. 13 is a closed state of the second structure of the tee joint of the placenta residual blood collection device of the present invention.
  • the three-way joint is provided with a housing 51, and three ports 511, 512, and 513 are connected to the housing.
  • a changeover switch 52 is provided in the casing, and the changeover switch is provided with two openings 521 and 522. By turning the handle 56 connected to the transfer switch, the transfer switch 52 can be rotated in the housing, and the alignment relationship between the opening on the transfer switch and the port on the housing can be changed, so as to achieve the Placental blood is drained into the blood collection bag 4.
  • Port 512 of the three-way connector is connected to a syringe
  • port 511 is connected to a blood collection bag
  • port 513 is connected to a catheter for extracting placental blood from the umbilical vein.
  • the opening 521 is aligned with the port 512
  • the opening 522 is aligned with the port 513, so that the port 512 of the tee is in communication with the port 513, the ports 511 and 512 and 513 are cut off, and placental blood can flow in from the port 513 512. Inhale the placental blood into the syringe.
  • FIG. 11 the opening 521
  • the opening 522 is aligned with the port 513
  • the opening 522 is aligned with the port 512, and the opening 521 is aligned with the port 511, so that the port 511 of the tee is in communication with the port 512, the ports 513 and 511 and 512 are cut off, and placental blood can flow from the port 512 511.
  • the placental blood is drained from the syringe to the blood collection bag.
  • each opening of the transfer switch is not aligned with any port on the housing, and the three-way joint is in a cut-off state. As shown in Fig.
  • the catheter wall of the port 26 of the catheter 2 in the venous vein of the umbilical section of the placenta is provided with at least one gap 23 to form a split structure to prevent the port of the catheter from being blocked by the wall of the umbilical vein.
  • At least one opening 22 is provided on the catheter wall near the end of the catheter in the umbilical vein inserted into the umbilical section of the placenta to prevent the port of the catheter from being blocked by the umbilical vein wall.
  • the portion of the catheter 2 inserted into the umbilical vein of the umbilical cord section of the placenta near the port 26 or a section of the catheter from the portion near the port 26 is set to the Chinese layer 241, 242, close to the port 26
  • the outer layer 241 of the duct 2 is partially set as a thin wall 243.
  • the outer layer 241 of the duct 2 is provided with an air inlet 21, and an air inlet check valve is provided at the air inlet 21. As shown in the figure, it can be an elastomer.
  • the center of the elastic body is provided with a vent hole 211, the vent hole is wedge-shaped, the outer end is gradually larger, the inner end is gradually smaller, and the innermost end is closed and abutted;
  • the air hole 211 is squeezed in, inflated into the interlayer, and the thin wall 243 is bulged. While maintaining the high pressure in the interlayer, the air needle or syringe is pulled out. At this time, the gas does not leak out, and the thin wall 243 remains bulged. status.
  • FIG. 4 is a schematic diagram of a second structure of the placenta residual blood collection device of the present invention.
  • the structure of this embodiment is basically the same as the collection device of the above embodiment, except that the structure of the bag body of the uterine simulation bag and the structure of the extraction device are different. At the same time, the tee joint is eliminated, and the blood collection bag is directly connected. On the air pump as a suction device.
  • the uterine simulation bag 1 has a flexible bag body, and the temperature of the bag body is controlled at
  • the uterine simulation bag 1 may be a silent layer made of a flexible material
  • the bag has an inner layer of 11 and an outer layer of 12.
  • the flexible material may be a material such as rubber, plastic, or plastic.
  • a polyvinyl chloride plastic used for preparing a blood collection bag may be selected.
  • the temperature of the uterine simulation bag is maintained by providing a heating device 17 or a heating device in the interlayer of the double-layer bag, such as a heating wire 17, or other methods known to those skilled in the art.
  • the extraction device 3 connected to the duct is an air pump provided with an air inlet 32 and an air outlet 33, and the air inlet 32 of the air exhaust pump is provided with an air inlet check valve 321
  • the air outlet 33 is provided with an air outlet check valve 331, the air inlet 32 is connected to one end 25 of the catheter 1 connected to the umbilical vein, and the air outlet 33 is connected to the blood collection bag 4.
  • the air pump is provided with a pump body 31, a piston 34 is provided in the pump body, and a push rod 35 is connected to the piston 34, and the push rod 35 protrudes from an end of the pump body opposite to the air inlet and the air outlet.
  • the push rod 35 is pulled to move the piston 34 outward, the check valve 331 in the air outlet 33 is closed, the check valve 321 in the air inlet 32 is opened, and placental blood flows from the air inlet 32 connected to the catheter 2 Then, push the push rod 35 to move the piston 34 inward, the one-way valve 331 in the air outlet 33 is opened, the one-way valve 321 in the air inlet 32 is closed, and the placental blood is connected to the blood collection bag 4 The air outlet 33 flows into the blood collection bag. Repeatedly, the blood in the placenta is continuously drawn into the blood collection bag.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • External Artificial Organs (AREA)

Abstract

La présente invention concerne un appareil et un procédé de recueil de sang résiduel à partir du placenta, comportant les étapes suivantes: on introduit un placenta qui vient d'être expulsé dans un sac de simulation d'utérus présentant une paroi flexible, la température à l'intérieur du sac étant comprise entre 30 °C et 45 °C ; on introduit une extrémité d'un cathéter dans les veines de section ombilicales du placenta, l'autre extrémité étant reliée à un moyen de pompe d'évacuation grâce auquel le sang résiduel du placenta est prélevé à partir des veines ombilicales, simultanément on effectue une compression locale et intermittente sur le placenta à travers le sac de simulation d'utérus.
PCT/CN2001/000124 2001-02-13 2001-02-13 Appareil et procede pour recueillir le sang residuel a partir du placenta WO2002064036A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CNA018226264A CN1489448A (zh) 2001-02-13 2001-02-13 胎盘余留血的采集方法及其采集装置
PCT/CN2001/000124 WO2002064036A1 (fr) 2001-02-13 2001-02-13 Appareil et procede pour recueillir le sang residuel a partir du placenta

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CN2001/000124 WO2002064036A1 (fr) 2001-02-13 2001-02-13 Appareil et procede pour recueillir le sang residuel a partir du placenta

Publications (1)

Publication Number Publication Date
WO2002064036A1 true WO2002064036A1 (fr) 2002-08-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2001/000124 WO2002064036A1 (fr) 2001-02-13 2001-02-13 Appareil et procede pour recueillir le sang residuel a partir du placenta

Country Status (2)

Country Link
CN (1) CN1489448A (fr)
WO (1) WO2002064036A1 (fr)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998032475A1 (fr) * 1997-01-28 1998-07-30 Crb Nederland B.V. Appareil pour collecter des fluides
US5915384A (en) * 1993-03-22 1999-06-29 Grossman; Michael D. Medical body fluid sampler device
US5993429A (en) * 1996-05-14 1999-11-30 Childen's Hospital Medical Center Of Northern California Apparatus and method for collecting blood from an umbilical cord

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5915384A (en) * 1993-03-22 1999-06-29 Grossman; Michael D. Medical body fluid sampler device
US5993429A (en) * 1996-05-14 1999-11-30 Childen's Hospital Medical Center Of Northern California Apparatus and method for collecting blood from an umbilical cord
WO1998032475A1 (fr) * 1997-01-28 1998-07-30 Crb Nederland B.V. Appareil pour collecter des fluides

Also Published As

Publication number Publication date
CN1489448A (zh) 2004-04-14

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