WO2002062852A1 - Proteine receptrice exprimee sur des cellules - Google Patents

Proteine receptrice exprimee sur des cellules Download PDF

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Publication number
WO2002062852A1
WO2002062852A1 PCT/JP2002/000927 JP0200927W WO02062852A1 WO 2002062852 A1 WO2002062852 A1 WO 2002062852A1 JP 0200927 W JP0200927 W JP 0200927W WO 02062852 A1 WO02062852 A1 WO 02062852A1
Authority
WO
WIPO (PCT)
Prior art keywords
cells
receptor protein
protein expressed
seq
compound obtained
Prior art date
Application number
PCT/JP2002/000927
Other languages
English (en)
Japanese (ja)
Inventor
Kenji Yoshida
Tsukasa Oda
Hisashi Koga
Yasuhiko Masuho
Takao Isogai
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to JP2002563204A priority Critical patent/JPWO2002062852A1/ja
Publication of WO2002062852A1 publication Critical patent/WO2002062852A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

L'invention concerne un anticorps qui se lie de manière spécifique à des protéines TR430 (SEQ ID NO:2 ou SEQ ID NO:4) ou des analogues correspondants. Cette invention a également trait à une méthode criblage d'un composé d'essai régulant l'activité transcriptionnelle NF-KB dans des cellules, à l'intérieur desquelles une protéine TR430 est exprimée, ainsi qu'à un composé obtenu par le biais de cette méthode et à des compositions médicinales renfermant l'anticorps susmentionné ou le composé obtenu au moyen de la méthode de criblage précitée destinée à traiter des maladies afférentes à une augmentation ou diminution de l'activité NF-KB dans des cellules.
PCT/JP2002/000927 2001-02-05 2002-02-05 Proteine receptrice exprimee sur des cellules WO2002062852A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2002563204A JPWO2002062852A1 (ja) 2001-02-05 2002-02-05 細胞上に発現する受容体タンパク質

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2001028725 2001-02-05
JP2001-28725 2001-02-05
JP2001303223 2001-09-28
JP2001-303223 2001-09-28

Publications (1)

Publication Number Publication Date
WO2002062852A1 true WO2002062852A1 (fr) 2002-08-15

Family

ID=26608945

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2002/000927 WO2002062852A1 (fr) 2001-02-05 2002-02-05 Proteine receptrice exprimee sur des cellules

Country Status (2)

Country Link
JP (1) JPWO2002062852A1 (fr)
WO (1) WO2002062852A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007523346A (ja) * 2004-02-19 2007-08-16 イェール ユニバーシティ プロテオーム技術を使用した癌タンパク質バイオマーカーの同定

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052924A1 (fr) * 1998-04-09 1999-10-21 Millennium Pharmaceuticals, Inc. Nouvelles proteines de la famille des proteines t129 et leurs utilisations
WO2000023572A1 (fr) * 1998-10-20 2000-04-27 Human Genome Sciences, Inc. Gene 12 lie au recepteur de tnf (tnfr)
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001034643A1 (fr) * 1999-11-12 2001-05-17 Human Genome Sciences, Inc. 24 proteines humaines secretees
WO2001044472A1 (fr) * 1999-12-16 2001-06-21 Amgen, Inc. Molecules de type tnfr/opg et leurs utilisations

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999052924A1 (fr) * 1998-04-09 1999-10-21 Millennium Pharmaceuticals, Inc. Nouvelles proteines de la famille des proteines t129 et leurs utilisations
WO2000023572A1 (fr) * 1998-10-20 2000-04-27 Human Genome Sciences, Inc. Gene 12 lie au recepteur de tnf (tnfr)
EP1074617A2 (fr) * 1999-07-29 2001-02-07 Helix Research Institute Amorces pour la synthèse de cADN de pleine longueur et leur utilisation
WO2001034643A1 (fr) * 1999-11-12 2001-05-17 Human Genome Sciences, Inc. 24 proteines humaines secretees
WO2001044472A1 (fr) * 1999-12-16 2001-06-21 Amgen, Inc. Molecules de type tnfr/opg et leurs utilisations

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MICHAEL HAHNE ET AL.: "ARPIL, a new ligand of the tumor necrosis factor family, stimulates tumor cell growth", J. EXP. MED., vol. 188, no. 6, 1998, pages 1185 - 1190, XP002093077 *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2007523346A (ja) * 2004-02-19 2007-08-16 イェール ユニバーシティ プロテオーム技術を使用した癌タンパク質バイオマーカーの同定
JP4912894B2 (ja) * 2004-02-19 2012-04-11 イェール ユニバーシティー プロテオーム技術を使用した癌タンパク質バイオマーカーの同定
US8975379B2 (en) 2004-02-19 2015-03-10 Yale University Identification of cancer protein biomarkers using proteomic techniques
US9470688B2 (en) 2004-02-19 2016-10-18 Yale University Identification of cancer protein biomarkers using proteomic techniques
US10168334B2 (en) 2004-02-19 2019-01-01 Yale University Identification of cancer protein biomarkers using proteomic techniques

Also Published As

Publication number Publication date
JPWO2002062852A1 (ja) 2004-06-10

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