WO2002058673A8 - Method of preparing pharmaceutical or dietary compositions for conveying labile substances into the intestine - Google Patents

Method of preparing pharmaceutical or dietary compositions for conveying labile substances into the intestine

Info

Publication number
WO2002058673A8
WO2002058673A8 PCT/EP2002/000515 EP0200515W WO02058673A8 WO 2002058673 A8 WO2002058673 A8 WO 2002058673A8 EP 0200515 W EP0200515 W EP 0200515W WO 02058673 A8 WO02058673 A8 WO 02058673A8
Authority
WO
WIPO (PCT)
Prior art keywords
intestine
conveying
dietary compositions
preparing pharmaceutical
labile substances
Prior art date
Application number
PCT/EP2002/000515
Other languages
French (fr)
Other versions
WO2002058673A1 (en
Inventor
Sergio Cecchetti
Valter Gatti
Original Assignee
Giuliani Spa
Sergio Cecchetti
Valter Gatti
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Giuliani Spa, Sergio Cecchetti, Valter Gatti filed Critical Giuliani Spa
Publication of WO2002058673A1 publication Critical patent/WO2002058673A1/en
Publication of WO2002058673A8 publication Critical patent/WO2002058673A8/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/40—Transferrins, e.g. lactoferrins, ovotransferrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Method of preparation of pharmaceutical or dietary compositions comprising a polysaccharide, a phospholipid and an active principle, characterized in that it comprises the following stages: a) dry mixing of the said polysaccharide, phospholipid and active principle; b) adding an aqueous solution containing a pH buffer, in a smaller amount by weight relative to the dry mixture obtained in the said stage a) and in a ratio not greater than 1:3, thus forming moist granules; c) drying of the said moist granules, thus obtaining the said compositions in the form of powder.
PCT/EP2002/000515 2001-01-26 2002-01-17 Method of preparing pharmaceutical or dietary compositions for conveying labile substances into the intestine WO2002058673A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI20010141 ITMI20010141A1 (en) 2001-01-26 2001-01-26 PROCEDURE FOR THE PREPARATION OF PHARMACEUTICAL OR DIETETIC COMPOSITIONS FOR VEHICULATION IN THE INTESTINE OF LABILE SUBSTANCES
ITMI01A000141 2001-01-26

Publications (2)

Publication Number Publication Date
WO2002058673A1 WO2002058673A1 (en) 2002-08-01
WO2002058673A8 true WO2002058673A8 (en) 2004-05-27

Family

ID=11446605

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/000515 WO2002058673A1 (en) 2001-01-26 2002-01-17 Method of preparing pharmaceutical or dietary compositions for conveying labile substances into the intestine

Country Status (2)

Country Link
IT (1) ITMI20010141A1 (en)
WO (1) WO2002058673A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008514198A (en) * 2004-09-27 2008-05-08 カーギル インコーポレイテッド Cyclodextrin inclusion complex and method for producing the same
USD736382S1 (en) 2011-09-08 2015-08-11 Ams Research Corporation Surgical indicator with backers
CN115349639B (en) * 2022-10-17 2023-04-14 天津市宝恒生物科技有限公司 Probiotic slow-release system for improving immunity and preparation method and application thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1537292A (en) * 1991-04-16 1992-11-17 Nippon Shinyaku Co. Ltd. Method of manufacturing solid dispersion
DE19619222A1 (en) * 1996-05-13 1997-11-20 Solvay Enzymes Gmbh & Co Kg Enzyme granules for food technology applications
JP2002521322A (en) * 1998-07-23 2002-07-16 ノボ ノルディスク アクティーゼルスカブ Wet granulation process for the production of stable pharmaceutical formulations
CA2360065A1 (en) * 1999-01-22 2000-07-27 Hunza Di Maria Carmela Marazzita S.A.S. Lipoprotein complexes and compositions containing them
JP2003521241A (en) * 1999-10-29 2003-07-15 フンツァ・ディ・ピストレシ・エルヴィラ・エ・チ・エッセ・ア・エッセ Fibrous-lipid nutritional composite and compositions containing it

Also Published As

Publication number Publication date
WO2002058673A1 (en) 2002-08-01
ITMI20010141A1 (en) 2002-07-26

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