WO2002057455A3 - Nucleic acid sequences from drosophila melanogaster that encode proteins essential for larval viability and uses thereof - Google Patents

Nucleic acid sequences from drosophila melanogaster that encode proteins essential for larval viability and uses thereof Download PDF

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Publication number
WO2002057455A3
WO2002057455A3 PCT/US2002/001568 US0201568W WO02057455A3 WO 2002057455 A3 WO2002057455 A3 WO 2002057455A3 US 0201568 W US0201568 W US 0201568W WO 02057455 A3 WO02057455 A3 WO 02057455A3
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WO
WIPO (PCT)
Prior art keywords
drosophila melanogaster
nucleic acid
acid sequences
encode proteins
proteins
Prior art date
Application number
PCT/US2002/001568
Other languages
French (fr)
Other versions
WO2002057455A8 (en
WO2002057455A2 (en
Inventor
Lynn Stam
Jane Bachmann
Julie Broadus
Kim Puloma Kamdar
Original Assignee
Syngenta Participations Ag
Lynn Stam
Jane Bachmann
Julie Broadus
Kim Puloma Kamdar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syngenta Participations Ag, Lynn Stam, Jane Bachmann, Julie Broadus, Kim Puloma Kamdar filed Critical Syngenta Participations Ag
Publication of WO2002057455A2 publication Critical patent/WO2002057455A2/en
Publication of WO2002057455A8 publication Critical patent/WO2002057455A8/en
Publication of WO2002057455A3 publication Critical patent/WO2002057455A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C07K14/43581—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies from Drosophila

Abstract

Nucleotide sequences are isolated from Drosophila melanogaster that code for proteins essential for larval viability. These proteins are useful for discovering newinsecticides based on the essentiality of the nucleotide sequences for Drossophila larval viability. Further provided are recombinant proteins and methods for identifying inhibitors to these proteins. Protein inhibitors active in the methods disclosed herein are useful as insecticidal, ectoparasiticidal, antiparasitic, anthementhic and acaracidal agents.
PCT/US2002/001568 2001-01-18 2002-01-18 Nucleic acid sequences from drosophila melanogaster that encode proteins essential for larval viability and uses thereof WO2002057455A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US26235101P 2001-01-18 2001-01-18
US60/262,351 2001-01-18

Publications (3)

Publication Number Publication Date
WO2002057455A2 WO2002057455A2 (en) 2002-07-25
WO2002057455A8 WO2002057455A8 (en) 2002-12-19
WO2002057455A3 true WO2002057455A3 (en) 2003-12-11

Family

ID=22997129

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/001568 WO2002057455A2 (en) 2001-01-18 2002-01-18 Nucleic acid sequences from drosophila melanogaster that encode proteins essential for larval viability and uses thereof

Country Status (1)

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WO (1) WO2002057455A2 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060053499A1 (en) 2002-01-18 2006-03-09 Doris Kretzschmar An invertebrate animal model with neurodegenerative phenotype for screening and testing substances
US7384745B2 (en) 2003-05-08 2008-06-10 Board Of Regents Of The University Of Nebraska Nucleic acid sequences found in Drosophila melanogaster that encode proteins essential for viability and method of use

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013167A1 (en) * 1990-02-26 1991-09-05 The Board Of Trustees Of The Leland Stanford Junior University Identification and expression of insect steroid receptor dna sequences
WO1996022307A1 (en) * 1995-01-19 1996-07-25 The Research Foundation Of State University Of New York Genes encoding an insect calcium channel

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013167A1 (en) * 1990-02-26 1991-09-05 The Board Of Trustees Of The Leland Stanford Junior University Identification and expression of insect steroid receptor dna sequences
WO1996022307A1 (en) * 1995-01-19 1996-07-25 The Research Foundation Of State University Of New York Genes encoding an insect calcium channel

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
"FLY BASE REPORT", XP002226545, Retrieved from the Internet <URL:http://fly.ebi.ac.uk:7081/.bin/fbreslis> [retrieved on 20010117] *
DATABASE EMBL [online] 1 May 2000 (2000-05-01), XP002226403, retrieved from EBI Database accession no. Q9V9C7 *
LAM G ET AL: "INDUCIBLE EXPRESSION OF DOUBLE-STRANDED RNA DIRECTS SPECIFIC GENETIC INTERFERENCE IN DROSOPHILA", CURRENT BIOLOGY, CURRENT SCIENCE,, GB, vol. 10, 24 August 2000 (2000-08-24), pages 957 - 963, XP001022931, ISSN: 0960-9822 *
QUINN LEONIE M ET AL: "The Drosophila Geminin homolog: Roles for Geminin in limiting DNA replication, in anaphase and in neurogenesis.", GENES & DEVELOPMENT, vol. 15, no. 20, 15 October 2001 (2001-10-15), pages 2741 - 2754, XP002226399, ISSN: 0890-9369 *
ROCH F ET AL: "Screening of larval/pupal P-element induced lethals on the second chromosome in Drosophila melanogaster: Clonal analysis and morphology of imaging discs.", MOLECULAR & GENERAL GENETICS, vol. 257, no. 2, January 1998 (1998-01-01), pages 103 - 112, XP002226398, ISSN: 0026-8925 *
ROSAMOND JOHN ET AL: "Harnessing the power of the genome in the search for new antibiotics.", SCIENCE (WASHINGTON D C), vol. 287, no. 5460, 17 March 2000 (2000-03-17), pages 1973 - 1976, XP002226396, ISSN: 0036-8075 *
SCHNEIDER DAVID: "Using Drosophila as a model insect.", NATURE REVIEWS GENETICS, vol. 1, no. 3, December 2000 (2000-12-01), December, 2000, pages 218 - 226, XP002226397, ISSN: 1471-0056 *
WOHLSCHLEGEL JAMES A ET AL: "Inhibition of eukaryotic DNA replication by geminin binding to Cdt1.", SCIENCE (WASHINGTON D C), vol. 290, no. 5500, 2000, pages 2309 - 2312, XP002226395, ISSN: 0036-8075 *

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Publication number Publication date
WO2002057455A8 (en) 2002-12-19
WO2002057455A2 (en) 2002-07-25

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