WO2001070980A3 - Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets - Google Patents

Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets Download PDF

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Publication number
WO2001070980A3
WO2001070980A3 PCT/US2001/009341 US0109341W WO0170980A3 WO 2001070980 A3 WO2001070980 A3 WO 2001070980A3 US 0109341 W US0109341 W US 0109341W WO 0170980 A3 WO0170980 A3 WO 0170980A3
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WO
WIPO (PCT)
Prior art keywords
nucleic acid
acid molecules
gpcr proteins
isolated
molecules encoding
Prior art date
Application number
PCT/US2001/009341
Other languages
French (fr)
Other versions
WO2001070980A2 (en
WO2001070980A9 (en
Inventor
Anibal Cravchik
Original Assignee
Pe Corp Ny
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pe Corp Ny filed Critical Pe Corp Ny
Priority to AU2001250947A priority Critical patent/AU2001250947A1/en
Publication of WO2001070980A2 publication Critical patent/WO2001070980A2/en
Publication of WO2001070980A3 publication Critical patent/WO2001070980A3/en
Publication of WO2001070980A9 publication Critical patent/WO2001070980A9/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/43504—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates
    • C07K14/43563—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects
    • C07K14/43577—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from invertebrates from insects from flies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Insects & Arthropods (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

The present invention provides amino acid sequences of proteins that are encoded by genes within the Drosophila melanogaster genome, the GPCR proteins of the present invention. The present invention specifically provides isolated protein and nucleic acid molecules, methods of identifying orthologs and paralogs of the GPCR proteins and methods of identifying modulators of the GPCR proteins for use as insecticides.
PCT/US2001/009341 2000-03-23 2001-03-23 Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets WO2001070980A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2001250947A AU2001250947A1 (en) 2000-03-23 2001-03-23 Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19163800P 2000-03-23 2000-03-23
US60/191,638 2000-03-23
US61889300A 2000-07-18 2000-07-18
US09/618,893 2000-07-18

Publications (3)

Publication Number Publication Date
WO2001070980A2 WO2001070980A2 (en) 2001-09-27
WO2001070980A3 true WO2001070980A3 (en) 2002-04-18
WO2001070980A9 WO2001070980A9 (en) 2003-01-16

Family

ID=26887244

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/009341 WO2001070980A2 (en) 2000-03-23 2001-03-23 Isolated g-protein coupled receptors, nucleic acid molecules encoding gpcr proteins, and uses thereof as insecticidal targets

Country Status (2)

Country Link
AU (1) AU2001250947A1 (en)
WO (1) WO2001070980A2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7364866B2 (en) 1999-10-22 2008-04-29 Pharmacia & Upjohn Company Drosophila G protein coupled receptors, nucleic acids, and methods related to the same
DE19955408A1 (en) * 1999-11-18 2001-05-23 Bayer Ag New invertebrate gamma-aminobutyric acid receptor proteins, useful in screening for potential insecticides, for plant protection or medicine, also related nucleic acid
US20040248791A1 (en) * 2001-12-18 2004-12-09 Eric Spana Insect g protein-coupled receptor genes and uses thereof
DE10216738A1 (en) * 2002-04-16 2003-10-30 Bayer Cropscience Ag Helicokinin receptor from insects

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008006A1 (en) * 1992-09-30 1994-04-14 Zymogenetics, Inc. Human calcitonin receptor
WO1999001468A2 (en) * 1997-07-01 1999-01-14 Ontogeny, Inc. Vertebrate smoothened gene, gene products, and uses related thereto
EP1136501A2 (en) * 2000-03-18 2001-09-26 Bayer Aktiengesellschaft Receptors for peptides from insect origin

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1994008006A1 (en) * 1992-09-30 1994-04-14 Zymogenetics, Inc. Human calcitonin receptor
WO1999001468A2 (en) * 1997-07-01 1999-01-14 Ontogeny, Inc. Vertebrate smoothened gene, gene products, and uses related thereto
EP1136501A2 (en) * 2000-03-18 2001-09-26 Bayer Aktiengesellschaft Receptors for peptides from insect origin

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
ADAMS M D ET AL: "THE GENOME SEQUENCE OF DROSOPHILA MELANOGASTER", SCIENCE, AMERICAN ASSOCIATION FOR THE ADVANCEMENT OF SCIENCE,, US, vol. 287, no. 5461, 24 March 2000 (2000-03-24), pages 2185 - 2195, XP000961051, ISSN: 0036-8075 *
DATABASE EMBL SEQUENCE LIBRARY 24 March 2000 (2000-03-24), ADAMS, M.D:, ETAL.: "Drosophila melanogaster genomic scaffold 142000013386053 section 8 of 30 complete sequence", XP002182629 *
DATABASE EMBL SEQUENCE LIBRARY 6 January 2000 (2000-01-06), ADAMS, M. AND VENTER, J.C.: "Drosophila melanogaster, *** SEQUENCING IN PROGRESS ***, in ordered pieces", XP002182628 *
DATABASE TREMBLREL. DATABASE 1 May 2000 (2000-05-01), ADAMS, M.D., ET AL.: "The genome sequence of Drosophila melanogaster - cross-reference to EMBL accession no. AE003491, AAF48216.1", XP002182630 *
FENG G ET AL: "CLONING AND FUNCTIONAL CHARACTERIZATION OF A NOVEL DOPAMINE RECEPTOR FROM DROSOPHILA MELANOGASTER", JOURNAL OF NEUROSCIENCE, NEW YORK, NY, US, vol. 15, no. 12, 15 June 1995 (1995-06-15), pages 3925 - 3933, XP002919142, ISSN: 0270-6474 *
HAUSER FRANK ET AL: "Molecular cloning, genomic organization and developmental regulation of a novel receptor from Drosophila melanogaster structurally related to gonadotropin-releasing hormone receptors from vertebrates.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 249, no. 3, 28 August 1998 (1998-08-28), pages 822 - 828, XP002182627, ISSN: 0006-291X *
LI X-J ET AL: "CLONING, FUNCTIONAL EXPRESSION, AND DEVELOPMENTAL REGULATION OF A NEUROPEPTIDE Y RECEPTOR FROM DROSOPHILA MELANOGASTER", JOURNAL OF BIOLOGICAL CHEMISTRY, AMERICAN SOCIETY OF BIOLOGICAL CHEMISTS, BALTIMORE, MD, US, vol. 267, no. 1, 5 January 1992 (1992-01-05), pages 9 - 12, XP000877443, ISSN: 0021-9258 *

Also Published As

Publication number Publication date
AU2001250947A1 (en) 2001-10-03
WO2001070980A2 (en) 2001-09-27
WO2001070980A9 (en) 2003-01-16

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